Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 1038-1050

  Miller, Corey J ^a   Gounder, Sellamuthu S ^a   Kannan, Sankaranarayanan ^b   Goutam, Karan ^c   Muthusamy, Vasanthi R ^a   Firpo, Matthew A ^c   Symons, J David ^d   Paine, Robert ^c   Hoidal, John R ^c   Rajasekaran, Namakkal Soorappan ^a,c  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

Aging; ARE signaling; EPR; Nrf2; ROS; Ubiquitination

Indexed keywords

GLUTATHIONE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; MOUSE; MUSCLE ATROPHY; MYOPATHY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CYTOSKELETAL PROTEINS; GLUTATHIONE; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUSCULAR DISEASES; MUSCULAR DYSTROPHY, ANIMAL; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; RNA, MESSENGER; SARCOPENIA; SIGNAL TRANSDUCTION; UBIQUITINATION;

MUS;

EID: 84859033290     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.02.007     Document Type: Article

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