메뉴 건너뛰기




Volumn 20, Issue 18, 2014, Pages 5403-5410

Role of epithelial-mesenchymal transition in gastric cancer initiation and progression

Author keywords

Cancer stem cells; Epithelial mesenchymal transition; Gastric cancer; Tumor progression; Tumorigenesis

Indexed keywords

HERMES ANTIGEN; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMAD PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; TUMOR MARKER;

EID: 84900386296     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i18.5403     Document Type: Article
Times cited : (172)

References (85)
  • 2
    • 77955739215 scopus 로고    scopus 로고
    • Gastric carcinoma in China: Current status and future perspectives (Review)
    • [PMID: 22966316]
    • Zhu X, Li J. Gastric carcinoma in China: Current status and future perspectives (Review). Oncol Lett 2010; 1: 407-412 [PMID: 22966316]
    • (2010) Oncol Lett , vol.1 , pp. 407-412
    • Zhu, X.1    Li, J.2
  • 3
    • 31144445320 scopus 로고    scopus 로고
    • Incidence and mortality of gastric cancer in China
    • [PMID: 16440411]
    • Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol 2006; 12: 17-20 [PMID: 16440411]
    • (2006) World J Gastroenterol , vol.12 , pp. 17-20
    • Yang, L.1
  • 4
    • 34250722637 scopus 로고    scopus 로고
    • Diet and the risk of gastric cancer: Review of epidemiological evidence
    • [PMID: 17577615]
    • Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 2007; 10: 75-83 [PMID: 17577615]
    • (2007) Gastric Cancer , vol.10 , pp. 75-83
    • Tsugane, S.1    Sasazuki, S.2
  • 5
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • [PMID: 15937929]
    • Hay ED. The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn 2005; 233: 706-720 [PMID: 15937929]
    • (2005) Dev Dyn , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 6
    • 33645302628 scopus 로고    scopus 로고
    • The epithelialmesenchymal transition: New insights in signaling, development, and disease
    • [PMID: 16567498]
    • Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelialmesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172: 973-981 [PMID: 16567498]
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 8
    • 84886929234 scopus 로고    scopus 로고
    • CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
    • [PMID: 24121667 DOI: 10.1038/srep02932]
    • Liang Q, Li L, Zhang J, Lei Y, Wang L, Liu DX, Feng J, Hou P, Yao R, Zhang Y, Huang B, Lu J. CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep 2013; 3: 2932 [PMID: 24121667 DOI: 10.1038/srep02932]
    • (2013) Sci Rep , vol.3 , pp. 2932
    • Liang, Q.1    Li, L.2    Zhang, J.3    Lei, Y.4    Wang, L.5    Liu, D.X.6    Feng, J.7    Hou, P.8    Yao, R.9    Zhang, Y.10    Huang, B.11    Lu, J.12
  • 9
    • 84890283718 scopus 로고    scopus 로고
    • JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis
    • [PMID: 24077348]
    • Zhao L, Li W, Zang W, Liu Z, Xu X, Yu H, Yang Q, Jia J. JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis. Clin Cancer Res 2013; 19: 6419-6429 [PMID: 24077348]
    • (2013) Clin Cancer Res , vol.19 , pp. 6419-6429
    • Zhao, L.1    Li, W.2    Zang, W.3    Liu, Z.4    Xu, X.5    Yu, H.6    Yang, Q.7    Jia, J.8
  • 10
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • [PMID: 19945376 DOI: 10.1016/j.cell.2009.11.007]
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890 [PMID: 19945376 DOI: 10.1016/j.cell.2009.11.007]
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 11
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • [PMID: 19487819 DOI: 10.1172/JCI36183]
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-1437 [PMID: 19487819 DOI: 10.1172/JCI36183]
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 12
    • 54349108903 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract
    • [PMID: 18609701]
    • Natalwala A, Spychal R, Tselepis C. Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract. World J Gastroenterol 2008; 14: 3792-3797 [PMID: 18609701]
    • (2008) World J Gastroenterol , vol.14 , pp. 3792-3797
    • Natalwala, A.1    Spychal, R.2    Tselepis, C.3
  • 13
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • [PMID: 16098727]
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005; 17: 548-558 [PMID: 16098727]
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 14
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • [PMID: 19262571 DOI: 10.1038/nrc2620]
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-273 [PMID: 19262571 DOI: 10.1038/nrc2620]
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 15
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • [PMID: 14679171]
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-1784 [PMID: 14679171]
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 16
    • 79954577486 scopus 로고    scopus 로고
    • FOXQ1 regulates epithelial-mesenchymal transition in human cancers
    • [PMID: 21346143 DOI: 10.1158/0008-5472]
    • Qiao Y, Jiang X, Lee ST, Karuturi RK, Hooi SC, Yu Q. FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res 2011; 71: 3076-3086 [PMID: 21346143 DOI: 10.1158/0008-5472]
    • (2011) Cancer Res , vol.71 , pp. 3076-3086
    • Qiao, Y.1    Jiang, X.2    Lee, S.T.3    Karuturi, R.K.4    Hooi, S.C.5    Yu, Q.6
  • 17
    • 77953811725 scopus 로고    scopus 로고
    • Cancer stem cells: Back to Darwin?
    • [PMID: 20359535 DOI: 10.1016/ j.semcancer]
    • Greaves M. Cancer stem cells: back to Darwin? Semin Cancer Biol 2010; 20: 65-70 [PMID: 20359535 DOI: 10.1016/ j.semcancer]
    • (2010) Semin Cancer Biol , vol.20 , pp. 65-70
    • Greaves, M.1
  • 18
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • [PMID: 11689955]
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111 [PMID: 11689955]
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 20
    • 84858156106 scopus 로고    scopus 로고
    • Combination of epithelial-mesenchymal transition and cancer stem celllike phenotypes has independent prognostic value in gastric cancer
    • [PMID: 22018628 DOI: 10.1016/j.humpath]
    • Ryu HS, Park do J, Kim HH, Kim WH, Lee HS. Combination of epithelial-mesenchymal transition and cancer stem celllike phenotypes has independent prognostic value in gastric cancer. Hum Pathol 2012; 43: 520-528 [PMID: 22018628 DOI: 10.1016/j.humpath]
    • (2012) Hum Pathol , vol.43 , pp. 520-528
    • Ryu, H.S.1    do Park, J.2    Kim, H.H.3    Kim, W.H.4    Lee, H.S.5
  • 21
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • [PMID: 17081971]
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469-480 [PMID: 17081971]
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 22
    • 77951833781 scopus 로고    scopus 로고
    • Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells
    • [PMID: 20417836 DOI: 10.1053/j.gastro.2010.03.002]
    • Barker N, Clevers H. Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology 2010; 138: 1681-1696 [PMID: 20417836 DOI: 10.1053/j.gastro.2010.03.002]
    • (2010) Gastroenterology , vol.138 , pp. 1681-1696
    • Barker, N.1    Clevers, H.2
  • 25
    • 84881517035 scopus 로고    scopus 로고
    • EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway
    • [PMID: 23950932 DOI: 10.1371/journal.pone.0070427]
    • Voon DC, Wang H, Koo JK, Chai JH, Hor YT, Tan TZ, Chu YS, Mori S, Ito Y. EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway. PLoS One 2013; 8: e70427 [PMID: 23950932 DOI: 10.1371/journal.pone.0070427]
    • (2013) PLoS One , vol.8
    • Voon, D.C.1    Wang, H.2    Koo, J.K.3    Chai, J.H.4    Hor, Y.T.5    Tan, T.Z.6    Chu, Y.S.7    Mori, S.8    Ito, Y.9
  • 26
    • 84876457158 scopus 로고    scopus 로고
    • WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells
    • [PMID: 23615002 DOI: 10.1159/000346843]
    • Kanzawa M, Semba S, Hara S, Itoh T, Yokozaki H. WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells. Pathobiology 2013; 80: 235-244 [PMID: 23615002 DOI: 10.1159/000346843]
    • (2013) Pathobiology , vol.80 , pp. 235-244
    • Kanzawa, M.1    Semba, S.2    Hara, S.3    Itoh, T.4    Yokozaki, H.5
  • 27
    • 79958739240 scopus 로고    scopus 로고
    • Epithelial tumor, invasion and stroma
    • [PMID: 21747608 DOI: 10.5021/ ad.2011.23.2.125]
    • Furue M. Epithelial tumor, invasion and stroma. Ann Dermatol 2011; 23: 125-131 [PMID: 21747608 DOI: 10.5021/ ad.2011.23.2.125]
    • (2011) Ann Dermatol , vol.23 , pp. 125-131
    • Furue, M.1
  • 28
    • 84885915873 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity in carcinoma metastasis
    • [PMID: 24142872 DOI: 10.1101/gad.225334.113]
    • Tsai JH, Yang J. Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev 2013; 27: 2192-2206 [PMID: 24142872 DOI: 10.1101/gad.225334.113]
    • (2013) Genes Dev , vol.27 , pp. 2192-2206
    • Tsai, J.H.1    Yang, J.2
  • 29
    • 33644787381 scopus 로고    scopus 로고
    • E-cadherin in gastric cancer
    • [PMID: 16482618]
    • Chan AO. E-cadherin in gastric cancer. World J Gastroenterol 2006; 12: 199-203 [PMID: 16482618]
    • (2006) World J Gastroenterol , vol.12 , pp. 199-203
    • Chan, A.O.1
  • 30
    • 84886601220 scopus 로고    scopus 로고
    • CD133 promotes the invasion and metastasis of gastric cancer via epithelial-mesenchymal transition
    • [PMID: 23888452]
    • Cai C, Yu JW, Wu JG, Lu RQ, Ni XC, Wang SL, Jiang BJ. [CD133 promotes the invasion and metastasis of gastric cancer via epithelial-mesenchymal transition]. Zhonghua Wei Chang Wai Ke Zazhi 2013; 16: 662-667 [PMID: 23888452]
    • (2013) Zhonghua Wei Chang Wai Ke Zazhi , vol.16 , pp. 662-667
    • Cai, C.1    Yu, J.W.2    Wu, J.G.3    Lu, R.Q.4    Ni, X.C.5    Wang, S.L.6    Jiang, B.J.7
  • 33
    • 84863242623 scopus 로고    scopus 로고
    • Overexpression of Snail accelerates adriamycin induction of multidrug resistance in breast cancer cells
    • [PMID: 22320957]
    • Li W, Liu C, Tang Y, Li H, Zhou F, Lv S. Overexpression of Snail accelerates adriamycin induction of multidrug resistance in breast cancer cells. Asian Pac J Cancer Prev 2011; 12: 2575-2580 [PMID: 22320957]
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 2575-2580
    • Li, W.1    Liu, C.2    Tang, Y.3    Li, H.4    Zhou, F.5    Lv, S.6
  • 35
    • 33947664420 scopus 로고    scopus 로고
    • Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin
    • [PMID: 17299729]
    • Castro Alves C, Rosivatz E, Schott C, Hollweck R, Becker I, Sarbia M, Carneiro F, Becker KF. Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin. J Pathol 2007; 211: 507-515 [PMID: 17299729]
    • (2007) J Pathol , vol.211 , pp. 507-515
    • Castro Alves, C.1    Rosivatz, E.2    Schott, C.3    Hollweck, R.4    Becker, I.5    Sarbia, M.6    Carneiro, F.7    Becker, K.F.8
  • 36
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • [PMID: 11994736]
    • Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002; 3: 155-166 [PMID: 11994736]
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 37
    • 0346363757 scopus 로고    scopus 로고
    • Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
    • [PMID: 14673164]
    • Peinado H, Ballestar E, Esteller M, Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol 2004; 24: 306-319 [PMID: 14673164]
    • (2004) Mol Cell Biol , vol.24 , pp. 306-319
    • Peinado, H.1    Ballestar, E.2    Esteller, M.3    Cano, A.4
  • 38
    • 43249086048 scopus 로고    scopus 로고
    • The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAILdependent transcriptional repression
    • [PMID: 18347060 DOI: 10.1128/MCB.01435-07]
    • Hou Z, Peng H, Ayyanathan K, Yan KP, Langer EM, Longmore GD, Rauscher FJ. The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAILdependent transcriptional repression. Mol Cell Biol 2008; 28: 3198-3207 [PMID: 18347060 DOI: 10.1128/MCB.01435-07]
    • (2008) Mol Cell Biol , vol.28 , pp. 3198-3207
    • Hou, Z.1    Peng, H.2    Ayyanathan, K.3    Yan, K.P.4    Langer, E.M.5    Longmore, G.D.6    Rauscher, F.J.7
  • 40
    • 77953107054 scopus 로고    scopus 로고
    • The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    • [PMID: 20389281 DOI: 10.1038/emboj.2010.63]
    • Lin Y, Wu Y, Li J, Dong C, Ye X, Chi YI, Evers BM, Zhou BP. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J 2010; 29: 1803-1816 [PMID: 20389281 DOI: 10.1038/emboj.2010.63]
    • (2010) EMBO J , vol.29 , pp. 1803-1816
    • Lin, Y.1    Wu, Y.2    Li, J.3    Dong, C.4    Ye, X.5    Chi, Y.I.6    Evers, B.M.7    Zhou, B.P.8
  • 41
    • 15944363787 scopus 로고    scopus 로고
    • Unraveling signalling cascades for the Snail family of transcription factors
    • [PMID: 15683729]
    • De Craene B, van Roy F, Berx G. Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal 2005; 17: 535-547 [PMID: 15683729]
    • (2005) Cell Signal , vol.17 , pp. 535-547
    • De Craene, B.1    van Roy, F.2    Berx, G.3
  • 43
    • 80051667402 scopus 로고    scopus 로고
    • Upregulation of Twist in gastric carcinoma associated with tumor invasion and poor prognosis
    • [PMID: 21104359 DOI: 10.1007/s12253-010-9332-0]
    • Ru GQ, Wang HJ, Xu WJ, Zhao ZS. Upregulation of Twist in gastric carcinoma associated with tumor invasion and poor prognosis. Pathol Oncol Res 2011; 17: 341-347 [PMID: 21104359 DOI: 10.1007/s12253-010-9332-0]
    • (2011) Pathol Oncol Res , vol.17 , pp. 341-347
    • Ru, G.Q.1    Wang, H.J.2    Xu, W.J.3    Zhao, Z.S.4
  • 44
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • [PMID: 15294153]
    • Kang Y, Massagué J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004; 118: 277-279 [PMID: 15294153]
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massagué, J.2
  • 45
    • 70350012437 scopus 로고    scopus 로고
    • A twist of insight-the role of Twistfamily bHLH factors in development
    • [PMID: 19378251 DOI: 10.1387/ijdb.082747rb]
    • Barnes RM, Firulli AB. A twist of insight-the role of Twistfamily bHLH factors in development. Int J Dev Biol 2009; 53: 909-924 [PMID: 19378251 DOI: 10.1387/ijdb.082747rb]
    • (2009) Int J Dev Biol , vol.53 , pp. 909-924
    • Barnes, R.M.1    Firulli, A.B.2
  • 47
    • 47849086547 scopus 로고    scopus 로고
    • Effect and mechanism of the Twist gene on invasion and metastasis of gastric carcinoma cells
    • [PMID: 18442194]
    • Luo GQ, Li JH, Wen JF, Zhou YH, Hu YB, Zhou JH. Effect and mechanism of the Twist gene on invasion and metastasis of gastric carcinoma cells. World J Gastroenterol 2008; 14: 2487-2493 [PMID: 18442194]
    • (2008) World J Gastroenterol , vol.14 , pp. 2487-2493
    • Luo, G.Q.1    Li, J.H.2    Wen, J.F.3    Zhou, Y.H.4    Hu, Y.B.5    Zhou, J.H.6
  • 49
    • 84890835024 scopus 로고    scopus 로고
    • Epigenetic regulation of epithelial to mesenchymal transition
    • [PMID: 24168185]
    • Huangyang P, Shang Y. Epigenetic regulation of epithelial to mesenchymal transition. Curr Cancer Drug Targets 2013; 13: 973-985 [PMID: 24168185]
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 973-985
    • Huangyang, P.1    Shang, Y.2
  • 50
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • [PMID: 2423876]
    • Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986; 321: 209-213 [PMID: 2423876]
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 51
    • 80054790080 scopus 로고    scopus 로고
    • DNA methylation: Superior or subordinate in the epigenetic hierarchy?
    • [PMID: 21941617 DOI: 10.1177/1947601910393957]
    • Jin B, Li Y, Robertson KD. DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer 2011; 2: 607-617 [PMID: 21941617 DOI: 10.1177/1947601910393957]
    • (2011) Genes Cancer , vol.2 , pp. 607-617
    • Jin, B.1    Li, Y.2    Robertson, K.D.3
  • 53
    • 84867535767 scopus 로고    scopus 로고
    • Promoter methylation of tumor-related genes in gastric carcinogenesis
    • [PMID: 22936446]
    • Zhao C, Bu X. Promoter methylation of tumor-related genes in gastric carcinogenesis. Histol Histopathol 2012; 27: 1271-1282 [PMID: 22936446]
    • (2012) Histol Histopathol , vol.27 , pp. 1271-1282
    • Zhao, C.1    Bu, X.2
  • 55
    • 84885014198 scopus 로고    scopus 로고
    • Frequent promoter methylation of CDH1 in non-neoplastic mucosa of sporadic diffuse gastric cancer
    • [PMID: 24023308]
    • Lee KH, Hwang D, Kang KY, Lee S, Kim DY, Joo YE, Lee JH. Frequent promoter methylation of CDH1 in non-neoplastic mucosa of sporadic diffuse gastric cancer. Anticancer Res 2013; 33: 3765-3774 [PMID: 24023308]
    • (2013) Anticancer Res , vol.33 , pp. 3765-3774
    • Lee, K.H.1    Hwang, D.2    Kang, K.Y.3    Lee, S.4    Kim, D.Y.5    Joo, Y.E.6    Lee, J.H.7
  • 56
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • [PMID: 17320507]
    • Kouzarides T. Chromatin modifications and their function. Cell 2007; 128: 693-705 [PMID: 17320507]
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 57
    • 41349104897 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells
    • [PMID: 18377425 DOI: 10.1111/j.1349-7006.2008.00743.x]
    • Fujii S, Ochiai A. Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells. Cancer Sci 2008; 99: 738-746 [PMID: 18377425 DOI: 10.1111/j.1349-7006.2008.00743.x]
    • (2008) Cancer Sci , vol.99 , pp. 738-746
    • Fujii, S.1    Ochiai, A.2
  • 58
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • [PMID: 17060944]
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6: 846-856 [PMID: 17060944]
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    van Lohuizen, M.2
  • 59
    • 0037423933 scopus 로고    scopus 로고
    • Polycomb, epigenomes, and control of cell iden-tity
    • [PMID: 12628181]
    • Orlando V. Polycomb, epigenomes, and control of cell iden-tity. Cell 2003; 112: 599-606 [PMID: 12628181]
    • (2003) Cell , vol.112 , pp. 599-606
    • Orlando, V.1
  • 60
    • 0035313803 scopus 로고    scopus 로고
    • Histone acetyltransferases: Function, structure, and catalysis
    • [PMID: 11250138]
    • Marmorstein R, Roth SY. Histone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev 2001; 11: 155-161 [PMID: 11250138]
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 155-161
    • Marmorstein, R.1    Roth, S.Y.2
  • 61
    • 32844465287 scopus 로고    scopus 로고
    • Regulatory mechanisms controlling human E-cadherin gene expression
    • [PMID: 16116478]
    • Liu YN, Lee WW, Wang CY, Chao TH, Chen Y, Chen JH. Regulatory mechanisms controlling human E-cadherin gene expression. Oncogene 2005; 24: 8277-8290 [PMID: 16116478]
    • (2005) Oncogene , vol.24 , pp. 8277-8290
    • Liu, Y.N.1    Lee, W.W.2    Wang, C.Y.3    Chao, T.H.4    Chen, Y.5    Chen, J.H.6
  • 63
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • [PMID: 15372042]
    • Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-355 [PMID: 15372042]
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 64
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • [PMID: 17060945]
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-866 [PMID: 17060945]
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 66
    • 84888437742 scopus 로고    scopus 로고
    • How microRNAs influence both hereditary and inflammatory-mediated colon cancers
    • [PMID: 24042167 DOI: 10.1016/j.cancergen.2013.06.005]
    • Hutchison J, Cohen Z, Onyeagucha BC, Funk J, Nelson MA. How microRNAs influence both hereditary and inflammatory-mediated colon cancers. Cancer Genet 2013; 206: 309-316 [PMID: 24042167 DOI: 10.1016/j.cancergen.2013.06.005]
    • (2013) Cancer Genet , vol.206 , pp. 309-316
    • Hutchison, J.1    Cohen, Z.2    Onyeagucha, B.C.3    Funk, J.4    Nelson, M.A.5
  • 67
    • 84884971476 scopus 로고    scopus 로고
    • Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway
    • [PMID: 24041653 DOI: 10.1016/j.cellsig]
    • Sun X, He Y, Huang C, Ma TT, Li J. Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway. Cell Signal 2013; 25: 2805-2811 [PMID: 24041653 DOI: 10.1016/j.cellsig]
    • (2013) Cell Signal , vol.25 , pp. 2805-2811
    • Sun, X.1    He, Y.2    Huang, C.3    Ma, T.T.4    Li, J.5
  • 68
    • 84892376937 scopus 로고    scopus 로고
    • A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition
    • [PMID: 24122292 DOI: 10.1002/path.4289]
    • Díaz-Martín J, Díaz-López A, Moreno-Bueno G, Castilla MÁ, Rosa-Rosa JM, Cano A, Palacios J. A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition. J Pathol 2014; 232: 319-329 [PMID: 24122292 DOI: 10.1002/path.4289]
    • (2014) J Pathol , vol.232 , pp. 319-329
    • Díaz-Martín, J.1    Díaz-López, A.2    Moreno-Bueno, G.3    Castilla, M.A.4    Rosa-Rosa, J.M.5    Cano, A.6    Palacios, J.7
  • 69
    • 84874669506 scopus 로고    scopus 로고
    • Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma
    • [PMID: 23381389 DOI: 10.3892/or.2013.2267]
    • Cong N, Du P, Zhang A, Shen F, Su J, Pu P, Wang T, Zjang J, Kang C, Zhang Q. Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. Oncol Rep 2013; 29: 1579-1587 [PMID: 23381389 DOI: 10.3892/or.2013.2267]
    • (2013) Oncol Rep , vol.29 , pp. 1579-1587
    • Cong, N.1    Du, P.2    Zhang, A.3    Shen, F.4    Su, J.5    Pu, P.6    Wang, T.7    Zjang, J.8    Kang, C.9    Zhang, Q.10
  • 71
    • 84856006660 scopus 로고    scopus 로고
    • miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition
    • [PMID: 22018270 DOI: 10.1016/j.cancergen.2011.07.004]
    • Zhang Z, Liu S, Shi R, Zhao G. miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. Cancer Genet 2011; 204: 486-491 [PMID: 22018270 DOI: 10.1016/j.cancergen.2011.07.004]
    • (2011) Cancer Genet , vol.204 , pp. 486-491
    • Zhang, Z.1    Liu, S.2    Shi, R.3    Zhao, G.4
  • 72
    • 84860250156 scopus 로고    scopus 로고
    • PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma
    • [PMID: 22531720 DOI: 10.1038/bjc.2012.107]
    • Matsuoka T, Yashiro M, Nishioka N, Hirakawa K, Olden K, Roberts JD. PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma. Br J Cancer 2012; 106: 1535-1542 [PMID: 22531720 DOI: 10.1038/bjc.2012.107]
    • (2012) Br J Cancer , vol.106 , pp. 1535-1542
    • Matsuoka, T.1    Yashiro, M.2    Nishioka, N.3    Hirakawa, K.4    Olden, K.5    Roberts, J.D.6
  • 73
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • [PMID: 12040186]
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657 [PMID: 12040186]
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 74
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • [PMID: 14585353]
    • Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 2003; 4: 257-262 [PMID: 14585353]
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 75
    • 41049093982 scopus 로고    scopus 로고
    • Wnt/Frizzled signaling in angiogenesis
    • [PMID: 18253847 DOI: 10.1007/s10456-008-9095-3]
    • Zerlin M, Julius MA, Kitajewski J. Wnt/Frizzled signaling in angiogenesis. Angiogenesis 2008; 11: 63-69 [PMID: 18253847 DOI: 10.1007/s10456-008-9095-3]
    • (2008) Angiogenesis , vol.11 , pp. 63-69
    • Zerlin, M.1    Julius, M.A.2    Kitajewski, J.3
  • 76
    • 50649103964 scopus 로고    scopus 로고
    • Snail promotes Wnt target gene expression and interacts with beta-catenin
    • [PMID: 18469861 DOI: 10.1038/ onc.2008.140]
    • Stemmer V, de Craene B, Berx G, Behrens J. Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene 2008; 27: 5075-5080 [PMID: 18469861 DOI: 10.1038/ onc.2008.140]
    • (2008) Oncogene , vol.27 , pp. 5075-5080
    • Stemmer, V.1    de Craene, B.2    Berx, G.3    Behrens, J.4
  • 78
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • [PMID: 9393997]
    • Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-471 [PMID: 9393997]
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 79
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • [PMID: 18662538 DOI: 10.1016/j.cell.2008.07.001]
    • Massagué J. TGFbeta in Cancer. Cell 2008; 134: 215-230 [PMID: 18662538 DOI: 10.1016/j.cell.2008.07.001]
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 80
    • 77649274997 scopus 로고    scopus 로고
    • Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells
    • [PMID: 20145621 DOI: 10.1038/sj.bjc.6605561]
    • Shinto O, Yashiro M, Kawajiri H, Shimizu K, Shimizu T, Miwa A, Hirakawa K. Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. Br J Cancer 2010; 102: 844-851 [PMID: 20145621 DOI: 10.1038/sj.bjc.6605561]
    • (2010) Br J Cancer , vol.102 , pp. 844-851
    • Shinto, O.1    Yashiro, M.2    Kawajiri, H.3    Shimizu, K.4    Shimizu, T.5    Miwa, A.6    Hirakawa, K.7
  • 81
    • 84878183437 scopus 로고    scopus 로고
    • Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion
    • [PMID: 23618854 DOI: 10.1016/j.bbrc]
    • Naber HP, Drabsch Y, Snaar-Jagalska BE, ten Dijke P, van Laar T. Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion. Biochem Biophys Res Commun 2013; 435: 58-63 [PMID: 23618854 DOI: 10.1016/j.bbrc]
    • (2013) Biochem Biophys Res Commun , vol.435 , pp. 58-63
    • Naber, H.P.1    Drabsch, Y.2    Snaar-Jagalska, B.E.3    ten Dijke, P.4    van Laar, T.5
  • 82
    • 84856500296 scopus 로고    scopus 로고
    • Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling
    • [PMID: 22034928 DOI: 10.1111/j.1349-7006.2011.02133.x]
    • Ono Y, Hayashida T, Konagai A, Okazaki H, Miyao K, Kawachi S, Tanabe M, Shinoda M, Jinno H, Hasegawa H, Kitajima M, Kitagawa Y. Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling. Cancer Sci 2012; 103: 317-324 [PMID: 22034928 DOI: 10.1111/j.1349-7006.2011.02133.x]
    • (2012) Cancer Sci , vol.103 , pp. 317-324
    • Ono, Y.1    Hayashida, T.2    Konagai, A.3    Okazaki, H.4    Miyao, K.5    Kawachi, S.6    Tanabe, M.7    Shinoda, M.8    Jinno, H.9    Hasegawa, H.10    Kitajima, M.11    Kitagawa, Y.12
  • 83
    • 84884136226 scopus 로고    scopus 로고
    • Notch signaling: Targeting cancer stem cells and epithelial-tomesenchymal transition
    • [PMID: 24043949]
    • Espinoza I, Pochampally R, Xing F, Watabe K, Miele L. Notch signaling: targeting cancer stem cells and epithelial-tomesenchymal transition. Onco Targets Ther 2013; 6: 1249-1259 [PMID: 24043949]
    • (2013) Onco Targets Ther , vol.6 , pp. 1249-1259
    • Espinoza, I.1    Pochampally, R.2    Xing, F.3    Watabe, K.4    Miele, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.