Role of hMLH1 and E-cadherin promoter methylation in gastric cancer progression

Journal of Gastrointestinal Cancer

Volumn 45, Issue 1, 2014, Pages 40-47

  Moghbeli, Meysam ^a   Moaven, Omeed ^b   Memar, Bahram ^a   Raziei, Hamid Reza ^a   Aarabi, Azadeh ^a   Dadkhah, Ezzat ^a,c   Forghanifard, Mohammad Mahdi ^d   Manzari, Fatemeh ^a   Abbaszadegan, Mohammad Reza ^a,e  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c GEORGE MASON UNIVERSITY   (United States)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

^e MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Epigenetic; Expressional Analysis; Iran; Methylation Specific PCR; Mismatch Repair System

Indexed keywords

MESSENGER RNA; PROTEIN MLH1; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; DISEASE SEVERITY; DNA METHYLATION; DNA REPAIR; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR GENE; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CASE-CONTROL STUDIES; DISEASE PROGRESSION; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; NUCLEAR PROTEINS; PROGNOSIS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; STOMACH; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84896317944     PISSN: 19416628     EISSN: 19416636     Source Type: Journal    
DOI: 10.1007/s12029-013-9548-9     Document Type: Article

References (41)

1. Sadjadi A, Nouraie M, Mohagheghi MA, Mousavi-Jarrahi A, Malekezadeh R, Parkin DM. Cancer occurrence in Iran in 2002, an international perspective. Asian Pac J Cancer Prev. 2005;6(3):359-63.
2. Jemal A, Siegel R,Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59(4):225-49.
3. Wagner AD, Schneider PM, FleigWE. The role of chemotherapy in patients with established gastric cancer. Best Pract Res Clin Gastroenterol. 2006;20(4):789-99. (Pubitemid 44391328)
4. Pharoah PD, Dunning AM, Ponder BA, Easton DF. Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer. 2004;4(11):850-60. (Pubitemid 39472952)
5. Li GM. DNA mismatch repair and cancer. Front Biosci. 2003;8:d997-d1017.
6. Li GM. Mechanisms and functions of DNA mismatch repair. Cell Res. 2008;18(1):85-98.
7. Moghbeli M, Moaven O, Dadkhah E, Farzadnia M, Roshan NM, Asadzadeh-Aghdaee H, et al. High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran. Genet Mol Res. 2011;10(4):3520-9.
8. Strickler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR, Shibata D. p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res. 1994;54(17):4750-5.
9. Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, et al. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res. 1996;56(21):4836-40. (Pubitemid 26374414)
10. Xiao XQ, Gong WD, Wang SZ, Zhang ZD, Rui XP, Wu GZ, et al. Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population. Oncol Lett. 2012;3(3):591-8.
11. Abbaszadegan MR,Moaven O, Sima HR, Ghafarzadegan K, A'Rabi A, Forghani MN, et al. p16 promoter hypermethylation: a useful serum marker for early detection of gastric cancer. World J Gastroenterol. 2008;14(13):2055-60. (Pubitemid 351795826)
12. Mir MR, Shabir N, Wani KA, Shaff S, Hussain I, Banday MA, et al. Association between p16, hMLH1 and E-cadherin promoter hypermethylation and intake of local hot salted tea and sun-dried foods in Kashmiris with gastric tumors. Asian Pac J Cancer Prev. 2012;13(1):181-6.
13. Abbaszadegan MR, Raziee HR, Ghafarzadegan K, Shakeri MT, Afsharnezhad S, Ghavamnasiry MR. Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma. Int J Gastrointest Cancer. 2005;36(1):47-54.
14. Wijnhoven BP, Dinjens WN, Pignatelli M. E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg. 2000;87(8):992-1005. (Pubitemid 30496847)
15. Kim HJ, Karpeh MS. Surgical approaches and outcomes in the treatment of gastric cancer. Semin Radiat Oncol. 2002;12(2):162-9. (Pubitemid 34522352)
16. Ushijima T, Sasako M. Focus on gastric cancer. Cancer Cell. 2004;5(2):121-5. (Pubitemid 38283798)
17. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer. 2005;8(2):86-94. (Pubitemid 40655517)
18. Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M. DNA methylation and cancer pathways in gastrointestinal tumors. Pharmacogenomics. 2008;9(12):1917-28.
19. Moghbeli M, Abbaszadegan MR, Farshchian M, Montazer M, Raeisossadati R, Abdollahi A, et al. Association of PYGO2 and EGFR in esophageal squamous cell carcinoma. Med Oncol. 2013;30(2):516.
20. Rubie C, Kempf K, Hans J, Su T, Tilton B, Georg T, et al. Housekeeping gene variability in normal and cancerous colorectal, pancreatic, esophageal, gastric and hepatic tissues. Mol Cell Probes. 2005;19(2):101-9. (Pubitemid 40174728)
21. Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, et al. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Oncogene. 2001;20(3):329-35. (Pubitemid 32142322)
22. Kang GH, Shim YH, Ro JY. Correlation of methylation of the hMLH1 promoter with lack of expression of hMLH1 in sporadic gastric carcinomas with replication error. Lab Invest. 1999;79(7):903-9. (Pubitemid 29344503)
23. Kang YH, Bae SI, Kim WH. Comprehensive analysis of promoter methylation and altered expression of hMLH1 in gastric cancer cell lines with microsatellite instability. J Cancer Res Clin Oncol. 2002;128(3):119-24.
24. Peltomaki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol. 2003;21(6):1174-9. (Pubitemid 46594150)
25. Takai N, Kai K, Tsuno A, Nasu K, Kashima K, Narahara H. Synchronous ovarian endometrioid adenocarcinoma with a functioning stroma and endometrial endometrioid adenocarcinoma by different loss of heterozygosity findings. Arch Gynecol Obstet. 2011;284(4):951-5.
26. LiM, Liu L,Wang Z,Wang L, Liu Z, Xu G, et al. Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae. Oncol Rep. 2008;19(2):401-6.
27. Hamid AA, Mandai M, Konishi I, Nanbu K, Tsuruta Y, Kusakari T, et al. Cyclical change of hMSH2 protein expression in normal endometrium during the menstrual cycle and its overexpression in endometrial hyperplasia and sporadic endometrial carcinoma. Cancer. 2002;94(4):997-1005. (Pubitemid 34154878)
28. Starzynska T, Bromley M, Ghosh A, Stern PL. Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br J Cancer. 1992;66(3):558-62.
29. Chang DK, Ricciardiello L, Goel A, Chang CL, Boland CR. Steady-state regulation of the human DNA mismatch repair system. J Biol Chem. 2000;275(24):18424-31. (Pubitemid 30414800)
30. Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB, Liskay RM, et al. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell. 1996;87(1):65-73. (Pubitemid 26337391)
31. Chen F, Arseven OK, Cryns VL. Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis. J Biol Chem. 2004;279(26):27542-8. (Pubitemid 38812595)
32. Huang Q, Ai L, Zhang ZY, Fan CY, Weiss LM. Promoter hypermethylation and protein expression of the p16 gene: analysis of 43 cases of B-cell primary gastric lymphomas from China. Mod Pathol. 2004;17(4):416-22. (Pubitemid 41646596)
33. Ksiaa F, Ziadi S, Amara K, Korbi S, Trimeche M. Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. Clin Chim Acta. 2009;404(2):128-33.
34. Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, et al. Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. 2003;52(4):502-6. (Pubitemid 36363400)
35. Carvalho B, Pinto M, Cirnes L, Oliveira C, Machado JC, Suriano G, et al. Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. Eur J Cancer. 2003;39(9):1222-7. (Pubitemid 36579192)
36. Corn PG, Heath EI, Heitmiller R, Fogt F, Forastiere AA, Herman JG, et al. Frequent hypermethylation of the 5' CpGisland of E-cadherin in esophageal adenocarcinoma. Clin Cancer Res. 2001;7(9):2765-9. (Pubitemid 32911382)
37. Nass SJ, Herman JG, Gabrielson E, Iversen PW, Parl FF, Davidson NE, et al. Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer. Cancer Res. 2000;60(16):4346-8. (Pubitemid 32103608)
38. Rocha AS, Soares P, Seruca R, Maximo V, Matias-Guiu X, Cameselle-Teijeiro J, et al. Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J Pathol. 2001;194(3):358-66. (Pubitemid 32624563)
39. Nagini S. Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 2012;4(7):156-69.
40. Nobili S, Landini I, Mazzei T, Mini E. Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med Res Rev. 2012;32(6):1220-62.
41. Wani M, Afroze D, Makhdoomi M, Hamid I, Wani B, Bhat G, et al. Promoter methylation status of DNA repair gene (hMLH1) in gastric carcinoma patients of the Kashmir valley. Asian Pac J Cancer Prev. 2012;13(8):4177-81.