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Volumn 29, Issue 4, 2013, Pages 1579-1587

Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Author keywords

Epithelial mesenchymal transition; Gastric adenocarcinoma; MiRNA 200a; Wnt catenin pathway

Indexed keywords

BETA CATENIN; MICRORNA 200A; MICRORNA 200B; MICRORNA 200C; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNAIL2; TRANSCRIPTION FACTOR TWIST1; TRANSCRIPTION FACTOR ZEB1; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

EID: 84874669506     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2267     Document Type: Article
Times cited : (151)

References (38)
  • 1
    • 84868136612 scopus 로고    scopus 로고
    • Microrna-181a promotes gastric cancer by negatively regulating tumor suppressor klf6
    • Zhang X, Nie Y, Du Y, Cao J, Shen B and Li Y: MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6. Tumour Biol 33: 1589-1597, 2012.
    • (2012) Tumour Biol , vol.33 , pp. 1589-1597
    • Zhang, X.1    Nie, Y.2    Du, Y.3    Cao, J.4    Shen, B.5    Li, Y.6
  • 2
    • 84864287425 scopus 로고    scopus 로고
    • Down-regulated mir-625 suppresses invasion and metastasis of gastric cancer by targeting ilk
    • Wang M, Li C, Nie H, et al: Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK. FEBS Lett 586: 2382-2388, 2012.
    • (2012) FEBS Lett , vol.586 , pp. 2382-2388
    • Wang, M.1    Li, C.2    Nie, H.3
  • 3
    • 84861807243 scopus 로고    scopus 로고
    • Mir-495 and mir-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with prl-3
    • Li Z, Cao Y, Jie Z, et al: miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3. Cancer Lett 323: 41-47, 2012.
    • (2012) Cancer Lett , vol.323 , pp. 41-47
    • Li, Z.1    Cao, Y.2    Jie, Z.3
  • 4
    • 80055038382 scopus 로고    scopus 로고
    • Mirconnect: Identifying effector genes of mirnas and mirna families in cancer cells
    • Hua Y, Duan S, Murmann AE, et al: miRConnect: identifying effector genes of miRNAs and miRNA families in cancer cells. PLoS One 6: e26521, 2011.
    • (2011) PLoS One , vol.6
    • Hua, Y.1    Duan, S.2    Murmann, A.E.3
  • 5
    • 58249088751 scopus 로고    scopus 로고
    • Micrornas: Target recognition and regulatory functions
    • Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233, 2009.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 53549097349 scopus 로고    scopus 로고
    • Micrornas: Key players in the immune system, differentiation, tumorigenesis and cell death
    • Schickel R, Boyerinas B, Park SM and Peter ME: MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27: 5959-5974, 2008.
    • (2008) Oncogene , vol.27 , pp. 5959-5974
    • Schickel, R.1    Boyerinas, B.2    Park, S.M.3    Peter, M.E.4
  • 8
    • 0347444723 scopus 로고    scopus 로고
    • Micrornas: Genomics, biogenesis, mechanism, and function
    • Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 9
    • 66049130038 scopus 로고    scopus 로고
    • Micrornas and cancer-new paradigms in molecular oncology
    • Negrini M, Nicoloso MS and Calin GA: MicroRNAs and cancer-new paradigms in molecular oncology. Curr Opin Cell Biol 21: 470-479, 2009.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 470-479
    • Negrini, M.1    Nicoloso, M.S.2    Calin, G.A.3
  • 10
    • 41649091906 scopus 로고    scopus 로고
    • The mir-200 family determines the epithelial phenotype of cancer cells by targeting the e-cadherin repressors zeb1 and zeb2
    • Park SM, Gaur AB, Lengyel E and Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22: 894-907, 2008.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 11
    • 79955102595 scopus 로고    scopus 로고
    • Targets of mir-200c mediate suppression of cell motility and anoikis resistance
    • Howe EN, Cochrane DR and Richer JK: Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res 13: R45, 2011.
    • (2011) Breast Cancer Res , vol.13
    • Howe, E.N.1    Cochrane, D.R.2    Richer, J.K.3
  • 12
    • 84255191994 scopus 로고    scopus 로고
    • Targets of the tumor suppressor mir-200 in regulation of the epithelial-mesen¬chymal transition in cancer
    • Schliekelman MJ, Gibbons DL, Faca VM, et al: Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesen¬chymal transition in cancer. Cancer Res 71: 7670-7682, 2011.
    • (2011) Cancer Res , vol.71 , pp. 7670-7682
    • Schliekelman, M.J.1    Gibbons, D.L.2    Faca, V.M.3
  • 13
    • 79960705270 scopus 로고    scopus 로고
    • Tgf-beta1-induced emt of non-transformed prostate hyperplasia cells is characterized by early induction of snai2/slug
    • Slabakova E, Pernicova Z, Slavickova E, Starsichova A, Kozubik A and Soucek K: TGF-beta1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNAI2/Slug. Prostate 71: 1332-1343, 2011.
    • (2011) Prostate , vol.71 , pp. 1332-1343
    • Slabakova, E.1    Pernicova, Z.2    Slavickova, E.3    Starsichova, A.4    Kozubik, A.5    Soucek, K.6
  • 14
    • 59449090107 scopus 로고    scopus 로고
    • Tgf-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S and Derynck R: TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172, 2009.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 15
    • 84859911725 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation of the microrna-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    • Davalos V, Moutinho C and Villanueva A, et al: Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 31: 2062-2074, 2011.
    • (2011) Oncogene , vol.31 , pp. 2062-2074
    • Davalos, V.1    Moutinho, C.2    Villanueva, A.3
  • 16
    • 77956926254 scopus 로고    scopus 로고
    • Suppression of matrix metallo¬proteinase-9 expression by rna interference inhibits sgc7901 gastric adenocarcinoma cell growth and invasion in vitro and in vivo
    • Zhao F, Zhang Q, Kang C, et al: Suppression of matrix metallo¬proteinase-9 expression by RNA interference inhibits SGC7901 gastric adenocarcinoma cell growth and invasion in vitro and in vivo. Med Oncol 27: 774-784, 2010.
    • (2010) Med Oncol , vol.27 , pp. 774-784
    • Zhao, F.1    Zhang, Q.2    Kang, C.3
  • 17
    • 84863372530 scopus 로고    scopus 로고
    • Microrna-200a suppresses the wnt/ß-catenin signaling pathway by interacting with ß-catenin
    • Su J, Zhang A, Shi Z, et al: MicroRNA-200a suppresses the Wnt/ß-catenin signaling pathway by interacting with ß-catenin. Int J Oncol 40: 1162-1170, 2012.
    • (2012) Int J Oncol , vol.40 , pp. 1162-1170
    • Su, J.1    Zhang, A.2    Shi, Z.3
  • 18
    • 43049103824 scopus 로고    scopus 로고
    • The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting zeb1 and sip1
    • Gregory PA, Bert AG, Paterson EL, et al: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601, 2008.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3
  • 19
    • 47249091921 scopus 로고    scopus 로고
    • The mir-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of e-cadherin transcriptional repressors zeb1 and zeb2
    • Korpal M, Lee ES, Hu G and Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283: 14910-14914, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 20
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between zeb1 and members of the mir-200 family promotes emt and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, et al: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9: 582-589, 2008.
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3
  • 21
    • 79551469293 scopus 로고    scopus 로고
    • Coordinated epigen¬etic repression of the mir-200 family and mir-205 in invasive bladder cancer
    • Wiklund ED, Bramsen JB, Hulf T, et al: Coordinated epigen¬etic repression of the miR-200 family and miR-205 in invasive bladder cancer. Int J Cancer 128: 1327-1334, 2011.
    • (2011) Int J Cancer , vol.128 , pp. 1327-1334
    • Wiklund, E.D.1    Bramsen, J.B.2    Hulf, T.3
  • 22
    • 84862863817 scopus 로고    scopus 로고
    • Biochemical relapses following radical prostatectomy and mir-200a levels in prostate cancer
    • Barron N, Keenan J, Gammell P, et al: Biochemical relapses following radical prostatectomy and miR-200a levels in prostate cancer. Prostate 7: 1193-1199, 2011.
    • (2011) Prostate , vol.7 , pp. 1193-1199
    • Barron, N.1    Keenan, J.2    Gammell, P.3
  • 23
    • 84856447171 scopus 로고    scopus 로고
    • Eralpha micrornas and the epithelial-mesenchymal transition in breast cancer
    • Guttilla IK, Adams BD and White BA: ERalpha, microRNAs, and the epithelial-mesenchymal transition in breast cancer. Trends Endocrinol Metab 23: 73-82, 2012.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 73-82
    • Guttilla, I.K.1    Adams, B.D.2    White, B.A.3
  • 24
    • 78751561435 scopus 로고    scopus 로고
    • Mir-200 inhibits lung adenocarcinoma cell invasion and metastasis by targeting flt1vegfr1
    • Roybal JD, Zang Y, Ahn YH, et al: miR-200 inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1. Mol Cancer Res 9: 25-35, 2011.
    • (2011) Mol Cancer Res , vol.9 , pp. 25-35
    • Roybal, J.D.1    Zang, Y.2    Ahn, Y.H.3
  • 26
    • 84856111309 scopus 로고    scopus 로고
    • Mir-141 and mir-200a act on ovarian tumorigenesis by controlling oxidative stress response
    • Mateescu B, Batista L, Cardon M, et al: miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med 17: 1627-1635, 2011.
    • (2011) Nat Med , vol.17 , pp. 1627-1635
    • Mateescu, B.1    Batista, L.2    Cardon, M.3
  • 27
    • 70350532244 scopus 로고    scopus 로고
    • Downregulated microrna-200a in meningiomas promotes tumor growth by reducing e-cadherin and activating the wnt/beta-catenin signaling pathway
    • Saydam O, Shen Y, Wurdinger T, et al: Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol Cell Biol 29: 5923-5940, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 5923-5940
    • Saydam, O.1    Shen, Y.2    Wurdinger, T.3
  • 28
    • 72949119530 scopus 로고    scopus 로고
    • Mir-200a-mediated downregulation of zeb2 and ctnnb1 differentially inhibits nasopharyngeal carcinoma cell growth migration and invasion
    • Xia H, Ng SS, Jiang S, et al: miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem Biophys Res Commun 391: 535-541, 2010.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 535-541
    • Xia, H.1    Ng, S.S.2    Jiang, S.3
  • 29
    • 79251624612 scopus 로고    scopus 로고
    • Inactivation of pi3kakt signaling inhibits glioma cell growth through modulation of beta-catenin-mediated transcription
    • Han L, Yang Y, Yue X, et al: Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of beta-catenin-mediated transcription. Brain Res 1366: 9-17, 2010.
    • (2010) Brain Res , vol.1366 , pp. 9-17
    • Han, L.1    Yang, Y.2    Yue, X.3
  • 30
    • 8444251784 scopus 로고    scopus 로고
    • The wnt signaling pathway in develop¬ment and disease
    • Logan CY and Nusse R: The Wnt signaling pathway in develop¬ment and disease. Annu Rev Cell Dev Biol 20: 781-810, 2004.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 31
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of twist1-induced epithelial mesenchymal transition and metastasis
    • Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ and Yang J: Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res 71: 245-254, 2011.
    • (2011) Cancer Res , vol.71 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3    Ohno-Machado, L.4    Wolfe, C.J.5    Yang, J.6
  • 32
    • 0026722283 scopus 로고
    • Dorsal-twist interactions establish snail expression in the presumptive mesoderm of the drosophila embryo
    • Ip YT, Park RE, Kosman D, Yazdanbakhsh K and Levine M: Dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev 6: 1518-1530, 1992.
    • (1992) Genes Dev , vol.6 , pp. 1518-1530
    • Ip, Y.T.1    Park, R.E.2    Kosman, D.3    Yazdanbakhsh, K.4    Levine, M.5
  • 33
    • 0026009094 scopus 로고
    • Twist and snail as positive and negative regulators during drosophila mesoderm development
    • Leptin M: Twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev 5: 1568 1576, 1991.
    • (1991) Genes Dev , vol.5 , pp. 1568-1576
    • Leptin, M.1
  • 34
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939, 2004.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 35
    • 33644982685 scopus 로고    scopus 로고
    • The wnt-inducible transcription factor twist1 inhibits chondrogen¬esis
    • Reinhold MI, Kapadia RM, Liao Z and Naski MC: The Wnt-inducible transcription factor Twist1 inhibits chondrogen¬esis. J Biol Chem 281: 1381-1388, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 1381-1388
    • Reinhold, M.I.1    Kapadia, R.M.2    Liao, Z.3    Naski, M.C.4
  • 36
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of e-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, slug, and mapk
    • Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P and Ben-Ze'Ev A: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 163: 847-857, 2003.
    • (2003) J Cell Biol , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1    Simcha, I.2    Ben-Yedidia, T.3    Blechman, J.4    Savagner, P.5    Ben-Ze'Ev, A.6
  • 37
    • 84864966395 scopus 로고    scopus 로고
    • Microrna-200b regulates cell proliferation invasion and migration by directly targeting zeb2 in gastric carcinoma
    • Kurashige J, Kamohara H, Watanabe M, et al: MicroRNA-200b regulates cell proliferation, invasion, and migration by directly targeting ZEB2 in gastric carcinoma. Ann Surg Oncol 19: 656-664, 2012.
    • (2012) Ann Surg Oncol , vol.19 , pp. 656-664
    • Kurashige, J.1    Kamohara, H.2    Watanabe, M.3
  • 38
    • 84860390484 scopus 로고    scopus 로고
    • Mir-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype
    • Radisky DC: miR-200c at the nexus of epithelial-mesenchymal transition, resistance to apoptosis, and the breast cancer stem cell phenotype. Breast Cancer Res 13: 110, 2011.
    • (2011) Breast Cancer Res , vol.13 , pp. 110
    • Radisky, D.C.1


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