메뉴 건너뛰기




Volumn 33, Issue 21, 2014, Pages 2737-2747

EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells

Author keywords

EphA2; epithelial mensenchymal transition; gastric cancer; Wnt catenin

Indexed keywords

BETA CATENIN; CYCLIN D1; EPHRIN RECEPTOR A2; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; WNT PROTEIN;

EID: 84901502942     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.238     Document Type: Article
Times cited : (183)

References (31)
  • 1
    • 36849068465 scopus 로고    scopus 로고
    • Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy
    • Amit I Wides R Yarden Y. Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy. Mol Syst Biol 2007; 3: 151.
    • (2007) Mol Syst Biol , vol.3 , pp. 151
    • Amit, I.1    Wides, R.2    Yarden, Y.3
  • 2
    • 0031105418 scopus 로고    scopus 로고
    • ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers
    • DOI 10.1006/geno.1996.4569
    • Sulman EP Tang XX Allen C Biege l JA Pleasure DE Brodeur GM et al. ECK a human EPH-related gene maps to 1p36.1 a common region of alteration in human cancers. Genomics 1997; 40: 371-374. (Pubitemid 27124104)
    • (1997) Genomics , vol.40 , Issue.2 , pp. 371-374
    • Sulman, E.P.1    Tang, X.X.2    Allen, C.3    Biegel, J.A.4    Pleasure, D.E.5    Brodeur, G.M.6    Ikegaki, N.7
  • 4
    • 67650403368 scopus 로고    scopus 로고
    • Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer
    • Brannan JM Dong W Prudkin L Behrens C Lotan R Bekele BN et al. Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer. Clin Cancer Res 2009; 15: 4423-4430.
    • (2009) Clin Cancer Res , vol.15 , pp. 4423-4430
    • Brannan, J.M.1    Dong, W.2    Prudkin, L.3    Behrens, C.4    Lotan, R.5    Bekele, B.N.6
  • 5
    • 74049148760 scopus 로고    scopus 로고
    • EFNA1 ligand and its receptor EphA2: Potential biomarkers for hepatocellular carcinoma
    • Cui XD Lee MJ Yu GR Kim IH Yu HC Song EY et al. EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma. Int J Cancer 2010; 126: 940-949.
    • (2010) Int J Cancer , vol.126 , pp. 940-949
    • Cui, X.D.1    Lee, M.J.2    Yu, G.R.3    Kim, I.H.4    Yu, H.C.5    Song, E.Y.6
  • 6
    • 78049494241 scopus 로고    scopus 로고
    • Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma
    • Li X Wang L Gu JW Li B Liu WP Wang YG et al. Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma. Tumour Biol 2010; 31: 477-488.
    • (2010) Tumour Biol , vol.31 , pp. 477-488
    • Li, X.1    Wang, L.2    Gu, J.W.3    Li, B.4    Liu, W.P.5    Wang, Y.G.6
  • 7
  • 8
    • 70350247569 scopus 로고    scopus 로고
    • Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients
    • Yuan WJ Ge J Chen ZK Wu SB Shen H Yang P et al. Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients. Dig Dis Sci 2009; 54: 2410-2417.
    • (2009) Dig Dis Sci , vol.54 , pp. 2410-2417
    • Yuan, W.J.1    Ge, J.2    Chen, Z.K.3    Wu, S.B.4    Shen, H.5    Yang, P.6
  • 9
    • 78650193841 scopus 로고    scopus 로고
    • Emerging strategies for EphA2 receptor targeting for cancer therapeutics
    • Tandon M Vemula SV Mittal SK. Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Expert Opin Therap Targets 2011; 15: 31-51.
    • (2011) Expert Opin Therap Targets , vol.15 , pp. 31-51
    • Tandon, M.1    Vemula, S.V.2    Mittal, S.K.3
  • 11
    • 84863748989 scopus 로고    scopus 로고
    • Silencing of EphA2 inhibits invasion of human gastric cancer SGC-7901 cells in vitro and in vivo
    • Yuan W Chen Z Wu S Guo J Ge J Yang P et al. Silencing of EphA2 inhibits invasion of human gastric cancer SGC-7901 cells in vitro and in vivo. Neoplasma 2012; 59: 105-113.
    • (2012) Neoplasma , vol.59 , pp. 105-113
    • Yuan, W.1    Chen, Z.2    Wu, S.3    Guo, J.4    Ge, J.5    Yang, P.6
  • 13
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP Acloque H Huang RY Nieto MA. Epithelial-mesenchymal transitions in development and disease Cell 2009 139 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 14
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • DOI 10.1016/j.ceb.2005.08.001, PII S0955067405001043
    • Huber MA Kraut N Beug H. Molecular requirements for epithelial- mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005; 17: 548-558. (Pubitemid 41267170)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.5 SPEC. ISS. , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 15
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: Mechanisms markers and strategies to overcome drug resistance in the clinic
    • Voulgari A Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 2009; 1796: 75-90.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 16
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 17
    • 80052338841 scopus 로고    scopus 로고
    • A positive role of cadherin in Wnt/betacatenin signalling during epithelial-mesenchymal transition
    • Howard S Deroo T Fujita Y Itasaki N. A positive role of cadherin in Wnt/betacatenin signalling during epithelial-mesenchymal transition. PLoS One 2011; 6: e23899.
    • (2011) PLoS One , vol.6
    • Howard, S.1    Deroo, T.2    Fujita, Y.3    Itasaki, N.4
  • 18
    • 38449116871 scopus 로고    scopus 로고
    • RTK/Ras/MAPK signaling
    • Sundaram MV. RTK/Ras/MAPK signaling. WormBook 2006; 1-19.
    • (2006) WormBook , pp. 1-19
    • Sundaram, M.V.1
  • 19
    • 73449147672 scopus 로고    scopus 로고
    • Expression of EphA2 and E-cadherin in gastric cancer: Corre lated with tumor progression and lymphogenous metastasis
    • Yuan W Chen Z Wu S Ge J Chang S Wang X et al. Expression of EphA2 and E-cadherin in gastric cancer: corre lated with tumor progression and lymphogenous metastasis. Pathol Oncol Res 2009; 15: 473-478.
    • (2009) Pathol Oncol Res , vol.15 , pp. 473-478
    • Yuan, W.1    Chen, Z.2    Wu, S.3    Ge, J.4    Chang, S.5    Wang, X.6
  • 20
    • 0030272281 scopus 로고    scopus 로고
    • Cadherins and catenins in development
    • DOI 10.1016/S0955-0674(96)80110-4
    • Huber O Bierkamp C Kemler R. Cadherins and catenins in development. Curr Opin Cell Biol 1996; 8: 685-691. (Pubitemid 26381726)
    • (1996) Current Opinion in Cell Biology , vol.8 , Issue.5 , pp. 685-691
    • Huber, O.1    Bierkamp, C.2    Kemler, R.3
  • 21
    • 79951863284 scopus 로고    scopus 로고
    • EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate c arcinoma cells
    • Taddei ML Parri M Angelucci A Bianchini F Marconi C Giannoni E et al. EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate c arcinoma cells. Mol Cancer Res 2011; 9: 149-160.
    • (2011) Mol Cancer Res , vol.9 , pp. 149-160
    • Taddei, M.L.1    Parri, M.2    Angelucci, A.3    Bianchini, F.4    Marconi, C.5    Giannoni, E.6
  • 23
    • 42949095922 scopus 로고    scopus 로고
    • 2 receptor
    • DOI 10.1038/sj.onc.1210957, PII 1210957
    • Menges CW McCance DJ. Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor. Oncogene 2008; 27: 2934-2940. (Pubitemid 351620455)
    • (2008) Oncogene , vol.27 , Issue.20 , pp. 2934-2940
    • Menges, C.W.1    McCance, D.J.2
  • 25
    • 0037206953 scopus 로고    scopus 로고
    • Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade
    • DOI 10.1038/sj.onc.1205758
    • Pr att RL Kinch MS. Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade. Oncogene 2002; 21: 7690-7699. (Pubitemid 35398815)
    • (2002) Oncogene , vol.21 , Issue.50 , pp. 7690-7699
    • Pratt, R.L.1    Kinch, M.S.2
  • 26
    • 40949107439 scopus 로고    scopus 로고
    • EphA2 is an essential mediator of UV radiation-induced apoptosis
    • DOI 10.1158/0008-5472.CAN-07-2372
    • Zhang G Njauw CN Park JM Naruse C Asano M Tsao H. EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res 2008; 68: 1691-1696. (Pubitemid 351416553)
    • (2008) Cancer Research , vol.68 , Issue.6 , pp. 1691-1696
    • Zhang, G.1    Njauw, C.-N.2    Jong, M.P.3    Naruse, C.4    Asano, M.5    Tsao, H.6
  • 27
    • 53649084334 scopus 로고    scopus 로고
    • Mutated in colorectal cancer a putative tumor suppressor for serrated colorectal cancer selectively represses beta-catenin-dependent transcription
    • Fukuyama R Niculaita R Ng KP Obusez E Sanchez J Kalady M et al. Mutated in colorectal cancer a putative tumor suppressor for serrated colorectal cancer selectively represses beta-catenin-dependent transcription. Oncogene 2008; 27: 6044-6055.
    • (2008) Oncogene , vol.27 , pp. 6044-6055
    • Fukuyama, R.1    Niculaita, R.2    Ng, K.P.3    Obusez, E.4    Sanchez, J.5    Kalady, M.6
  • 29
    • 77958594159 scopus 로고    scopus 로고
    • Stabilisation of beta-catenin downstream of T cell receptor signalling
    • Lovatt M Bijlmakers MJ. Stabilisation of beta-catenin downstream of T cell receptor signalling. PLoS One 2010; 5: pii: e12794.
    • (2010) PLoS One , vol.5
    • Lovatt, M.1    Bijlmakers, M.J.2
  • 30
    • 60549098654 scopus 로고    scopus 로고
    • Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity
    • Song S Mazurek N Liu C Sun Y Din g QQ Liu K et al. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res 2009; 69: 1343-1349.
    • (2009) Cancer Res , vol.69 , pp. 1343-1349
    • Song, S.1    Mazurek, N.2    Liu, C.3    Sun, Y.4    Din, G.Q.Q.5    Liu, K.6
  • 31
    • 73849115202 scopus 로고    scopus 로고
    • Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells
    • Wang Q Sun ZX Allgayer H Yang HS. Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. Oncogene 2010; 29: 128-138.
    • (2010) Oncogene , vol.29 , pp. 128-138
    • Wang, Q.1    Sun, Z.X.2    Allgayer, H.3    Yang, H.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.