-
2
-
-
77958549663
-
Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells
-
Hooks SB, Callihan P, Altman MK, Hurst JH, Ali MW, et al. (2010) Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells. Mol Cancer 9: 289.
-
(2010)
Mol Cancer
, vol.9
, pp. 289
-
-
Hooks, S.B.1
Callihan, P.2
Altman, M.K.3
Hurst, J.H.4
Ali, M.W.5
-
3
-
-
77949429770
-
Ovarian cancer immunotherapy: Opportunities, progresses and challenges
-
Liu B, Nash J, Runowicz C, Swede H, Stevens R, et al. (2010) Ovarian cancer immunotherapy: opportunities, progresses and challenges. J Hematol Oncol 3: 7.
-
(2010)
J Hematol Oncol
, vol.3
, pp. 7
-
-
Liu, B.1
Nash, J.2
Runowicz, C.3
Swede, H.4
Stevens, R.5
-
4
-
-
84876679294
-
The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells
-
Cai H, Xu Y (2013) The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells. Cell Commun Signal 11: 31.
-
(2013)
Cell Commun Signal
, vol.11
, pp. 31
-
-
Cai, H.1
Xu, Y.2
-
5
-
-
84878219891
-
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
-
O'Hayre M, Vazquez-Prado J, Kufareva I, Stawiski EW, Handel TM, et al. (2013) The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer 13: 412-424.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 412-424
-
-
O'Hayre, M.1
Vazquez-Prado, J.2
Kufareva, I.3
Stawiski, E.W.4
Handel, T.M.5
-
6
-
-
65449185457
-
Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: Distinct roles for Gi- and Rho-dependent pathways
-
Hurst JH, Hooks SB (2009) Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways. Pharmacology 83: 333-347.
-
(2009)
Pharmacology
, vol.83
, pp. 333-347
-
-
Hurst, J.H.1
Hooks, S.B.2
-
8
-
-
2142760845
-
Toll-Like Receptor Signaling Alters the Expression of Regulator of G Protein Signaling Proteins in Dendritic Cells: Implications for G Protein-Coupled Receptor Signaling
-
Shi GX, Harrison K, Han SB, Moratz C, Kehrl JH (2004) Toll-like receptor signaling alters the expression of regulator of G protein signaling proteins in dendritic cells: implications for G protein-coupled receptor signaling. J Immunol 172: 5175-5184. (Pubitemid 38542013)
-
(2004)
Journal of Immunology
, vol.172
, Issue.9
, pp. 5175-5184
-
-
Shi, G.-X.1
Harrison, K.2
Han, S.-B.3
Moratz, C.4
Kehrl, J.H.5
-
9
-
-
0031916822
-
Mammalian RGS proteins: Barbarians at the gate
-
DOI 10.1074/jbc.273.3.1269
-
Berman DM, Gilman AG (1998) Mammalian RGS proteins: barbarians at the gate. J Biol Chem 273: 1269-1272. (Pubitemid 28133638)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.3
, pp. 1269-1272
-
-
Berman, D.M.1
Gilman, A.G.2
-
10
-
-
70349473057
-
Regulator of G-protein signaling (RGS) proteins in cancer biology
-
Hurst JH, Hooks SB (2009) Regulator of G-protein signaling (RGS) proteins in cancer biology. Biochem Pharmacol 78: 1289-1297.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 1289-1297
-
-
Hurst, J.H.1
Hooks, S.B.2
-
11
-
-
67651006540
-
Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4
-
Xie Y, Wolff DW, Wei T, Wang B, Deng C, et al. (2009) Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res 69: 5743-5751.
-
(2009)
Cancer Res
, vol.69
, pp. 5743-5751
-
-
Xie, Y.1
Wolff, D.W.2
Wei, T.3
Wang, B.4
Deng, C.5
-
12
-
-
69249124530
-
RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling
-
Liang G, Bansal G, Xie Z, Druey KM (2009) RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. J Biol Chem 284: 21719-21727.
-
(2009)
J Biol Chem
, vol.284
, pp. 21719-21727
-
-
Liang, G.1
Bansal, G.2
Xie, Z.3
Druey, K.M.4
-
13
-
-
84878714395
-
RGS17: An emerging therapeutic target for lung and prostate cancers
-
Bodle CR, Mackie DI, Roman DL (2013) RGS17: an emerging therapeutic target for lung and prostate cancers. Future Med Chem 5: 995-1007.
-
(2013)
Future Med Chem
, vol.5
, pp. 995-1007
-
-
Bodle, C.R.1
Mackie, D.I.2
Roman, D.L.3
-
14
-
-
33745561778
-
Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells
-
DOI 10.1038/sj.onc.1209408, PII 1209408
-
Cao X, Qin J, Xie Y, Khan O, Dowd F, et al. (2006) Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells. Oncogene 25: 3719-3734. (Pubitemid 43980493)
-
(2006)
Oncogene
, vol.25
, Issue.26
, pp. 3719-3734
-
-
Cao, X.1
Qin, J.2
Xie, Y.3
Khan, O.4
Dowd, F.5
Scofield, M.6
Lin, M.-F.7
Tu, Y.8
-
15
-
-
84875321814
-
Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells
-
Ali MW, Cacan E, Liu Y, Pierce JY, Creasman WT, et al. (2013) Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells. PLoS One 8: e60185.
-
(2013)
PLoS One
, vol.8
-
-
Ali, M.W.1
Cacan, E.2
Liu, Y.3
Pierce, J.Y.4
Creasman, W.T.5
-
16
-
-
84863306278
-
RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells
-
Lee JK, Chung J, Druey KM, Tansey MG (2012) RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells. J Neurochem 122: 333-343.
-
(2012)
J Neurochem
, vol.122
, pp. 333-343
-
-
Lee, J.K.1
Chung, J.2
Druey, K.M.3
Tansey, M.G.4
-
17
-
-
84877107254
-
Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment
-
Berl
-
Rivero G, Gabilondo AM, Garcia-Sevilla JA, Callado LF, La Harpe R, et al. (2013) Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment. Psychopharmacology (Berl) 226: 177-188.
-
(2013)
Psychopharmacology
, vol.226
, pp. 177-188
-
-
Rivero, G.1
Gabilondo, A.M.2
Garcia-Sevilla, J.A.3
Callado, L.F.4
La Harpe, R.5
-
18
-
-
80051631548
-
RGS10 restricts upregulation by chemokines of T cell adhesion mediated by alpha4beta1 and alphaLbeta2 integrins
-
Garcia-Bernal D, Dios-Esponera A, Sotillo-Mallo E, Garcia-Verdugo R, Arellano-Sanchez N, et al. (2011) RGS10 restricts upregulation by chemokines of T cell adhesion mediated by alpha4beta1 and alphaLbeta2 integrins. J Immunol 187: 1264-1272.
-
(2011)
J Immunol
, vol.187
, pp. 1264-1272
-
-
Garcia-Bernal, D.1
Dios-Esponera, A.2
Sotillo-Mallo, E.3
Garcia-Verdugo, R.4
Arellano-Sanchez, N.5
-
19
-
-
56949101468
-
PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate
-
Lu J, Gosslau A, Liu AY, Chen KY (2008) PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. Eur J Pharmacol 601: 66-72.
-
(2008)
Eur J Pharmacol
, vol.601
, pp. 66-72
-
-
Lu, J.1
Gosslau, A.2
Liu, A.Y.3
Chen, K.Y.4
-
20
-
-
0034720284
-
CpG methylation is maintained in human cancer cells lacking DNMT1
-
DOI 10.1038/35010000
-
Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, et al. (2000) CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404: 1003-1007. (Pubitemid 30243595)
-
(2000)
Nature
, vol.404
, Issue.6781
, pp. 1003-1007
-
-
Rhee, I.1
Jalr, K.-W.2
Yen, R.-W.C.3
Lengauer, C.4
Herman, J.G.5
Kinzler, K.W.6
Vogelstein, B.7
Baylin, S.B.8
Schuebel, K.E.9
-
21
-
-
0005693310
-
Histone acetylation and deacetylation
-
Ito K, P JB, I MA (2000) Histone acetylation and deacetylation. Methods Mol Med 44: 309-319.
-
(2000)
Methods Mol Med
, vol.44
, pp. 309-319
-
-
Ito, K.1
B, P.J.2
A, I.M.3
-
22
-
-
0036889153
-
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure
-
DOI 10.1128/MCB.22.23.8302-8319.2002
-
Ghoshal K, Datta J, Majumder S, Bai S, Dong X, et al. (2002) Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol 22: 8302-8319. (Pubitemid 35304062)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.23
, pp. 8302-8319
-
-
Ghoshal, K.1
Datta, J.2
Majumder, S.3
Bai, S.4
Dong, X.5
Parthun, M.6
Jacob, S.T.7
-
23
-
-
84899634504
-
The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes
-
Cai Y, Geutjes EJ, de Lint K, Roepman P, Bruurs L, et al. (2013) The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Oncogene.
-
(2013)
Oncogene
-
-
Cai, Y.1
Geutjes, E.J.2
De Lint, K.3
Roepman, P.4
Bruurs, L.5
-
24
-
-
0033988813
-
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
-
DOI 10.1038/71750
-
Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24: 88-91. (Pubitemid 30041428)
-
(2000)
Nature Genetics
, vol.24
, Issue.1
, pp. 88-91
-
-
Fuks, F.1
Burgers, W.A.2
Brehm, A.3
Hughes-Davies, L.4
Kouzarides, T.5
-
25
-
-
0021815179
-
Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine
-
Louie KG, Behrens BC, Kinsella TJ, Hamilton TC, Grotzinger KR, et al. (1985) Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. Cancer Res 45: 2110-2115. (Pubitemid 15024393)
-
(1985)
Cancer Research
, vol.45
, Issue.5
, pp. 2110-2115
-
-
Louie, K.G.1
Behrens, B.C.2
Kinsella, T.J.3
-
26
-
-
0015455019
-
Cell-mediated immunity to human malignant cells. A brief review and further studies with two gynecologic tumors
-
DiSaia PJ, Sinkovics JG, Rutledge FN, Smith JP (1972) Cell-mediated immunity to human malignant cells. A brief review and further studies with two gynecologic tumors. Am J Obstet Gynecol 114: 979-989.
-
(1972)
Am J Obstet Gynecol
, vol.114
, pp. 979-989
-
-
DiSaia, P.J.1
Sinkovics, J.G.2
Rutledge, F.N.3
Smith, J.P.4
-
27
-
-
0022384738
-
Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion
-
Andrews PA, Murphy MP, Howell SB (1985) Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion. Cancer Res 45: 6250-6253. (Pubitemid 16224789)
-
(1985)
Cancer Research
, vol.45
, Issue.12
, pp. 6250-6253
-
-
Andrews, P.A.1
Murphy, M.P.2
Howell, S.B.3
-
28
-
-
77950510166
-
Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: Results from RTOG 9704
-
Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, et al. (2010) Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol 28: 1358-1365.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1358-1365
-
-
Manuyakorn, A.1
Paulus, R.2
Farrell, J.3
Dawson, N.A.4
Tze, S.5
-
29
-
-
65649142216
-
Global levels of histone modifications predict prognosis in different cancers
-
Seligson DB, Horvath S, McBrian MA, Mah V, Yu H, et al. (2009) Global levels of histone modifications predict prognosis in different cancers. Am J Pathol 174: 1619-1628.
-
(2009)
Am J Pathol
, vol.174
, pp. 1619-1628
-
-
Seligson, D.B.1
Horvath, S.2
McBrian, M.A.3
Mah, V.4
Yu, H.5
-
30
-
-
0031043059
-
Pathophysiologic implications of membrane phospholipid asymmetry in blood cells
-
Zwaal RF, Schroit AJ (1997) Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89: 1121-1132. (Pubitemid 27079974)
-
(1997)
Blood
, vol.89
, Issue.4
, pp. 1121-1132
-
-
Zwaal, R.F.A.1
Schroit, A.J.2
-
31
-
-
0031985647
-
Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
-
DOI 10.1002/(SICI)1097-0320(19980101)31:1<1::AID-C
-
van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9. (Pubitemid 28050057)
-
(1998)
Cytometry
, vol.31
, Issue.1
, pp. 1-9
-
-
Van Engeland, M.1
Nieland, L.J.W.2
Ramaekers, F.C.S.3
Schutte, B.4
Reutelingsperger, C.P.M.5
-
32
-
-
0016016796
-
7-Substituted actinomycin D (NSC-3053) analogs as fluorescent DNA-binding and experimental antitumor agents
-
Modest EJ, Sengupta SK (1974) 7-Substituted actinomycin D (NSC-3053) analogs as fluorescent DNA-binding and experimental antitumor agents. Cancer Chemother Rep 58: 35-48.
-
(1974)
Cancer Chemother Rep
, vol.58
, pp. 35-48
-
-
Modest, E.J.1
Sengupta, S.K.2
-
33
-
-
0036312756
-
The impact of chromatin in human cancer: Linking DNA methylation to gene silencing
-
Ballestar E, Esteller M (2002) The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis 23: 1103-1109. (Pubitemid 34814766)
-
(2002)
Carcinogenesis
, vol.23
, Issue.7
, pp. 1103-1109
-
-
Ballestar, E.1
Esteller, M.2
-
34
-
-
0033919595
-
DNMT1 forms a complex with RB, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
-
DOI 10.1038/77124
-
Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, et al. (2000) DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25: 338-342. (Pubitemid 30437325)
-
(2000)
Nature Genetics
, vol.25
, Issue.3
, pp. 338-342
-
-
Robertson, K.D.1
Ait-Si-Ali, S.2
Yokochi, T.3
Wade, P.A.4
Jones, P.L.5
Wolffe, A.P.6
-
35
-
-
0038527642
-
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
-
DOI 10.1126/science.1065173
-
Di Croce L, Raker VA, Corsaro M, Fazi F, Fanelli M, et al. (2002) Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295: 1079-1082. (Pubitemid 34132239)
-
(2002)
Science
, vol.295
, Issue.5557
, pp. 1079-1082
-
-
Di, C.L.1
Raker, V.A.2
Corsaro, M.3
Fazi, F.4
Fanelli, M.5
Faretta, M.6
Fuks, F.7
Lo, C.F.8
Kouzarides, T.9
Nervi, C.10
Minucci, S.11
Pelicci, P.G.12
-
36
-
-
0035873225
-
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
-
DOI 10.1093/emboj/20.10.2536
-
Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T (2001) Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 20: 2536-2544. (Pubitemid 32452872)
-
(2001)
EMBO Journal
, vol.20
, Issue.10
, pp. 2536-2544
-
-
Fuks, F.1
Burgers, W.A.2
Godin, N.3
Kasai, M.4
Kouzarides, T.5
-
37
-
-
51049117752
-
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells
-
Zhou Q, Agoston AT, Atadja P, Nelson WG, Davidson NE (2008) Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells. Mol Cancer Res 6: 873-883.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 873-883
-
-
Zhou, Q.1
Agoston, A.T.2
Atadja, P.3
Nelson, W.G.4
Davidson, N.E.5
-
38
-
-
47849083984
-
Epigenetic interplay between histone modifications and DNA methylation in gene silencing
-
Vaissiere T, Sawan C, Herceg Z (2008) Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res 659: 40-48.
-
(2008)
Mutat Res
, vol.659
, pp. 40-48
-
-
Vaissiere, T.1
Sawan, C.2
Herceg, Z.3
-
39
-
-
0031837109
-
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
-
DOI 10.1038/561
-
Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, et al. (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19: 187-191. (Pubitemid 28248804)
-
(1998)
Nature Genetics
, vol.19
, Issue.2
, pp. 187-191
-
-
Jones, P.L.1
Veenstra, G.J.C.2
Wade, P.A.3
Vermaak, D.4
Kass, S.U.5
Landsberger, N.6
Strouboulis, J.7
Wolffe, A.P.8
-
40
-
-
8644220071
-
Purification of the MeCP2/histone deacetylase complex from Xenopus laevis
-
Jones PL, Wade PA, Wolffe AP (2001) Purification of the MeCP2/histone deacetylase complex from Xenopus laevis. Methods Mol Biol 181: 297-307.
-
(2001)
Methods Mol Biol
, vol.181
, pp. 297-307
-
-
Jones, P.L.1
Wade, P.A.2
Wolffe, A.P.3
-
41
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
DOI 10.1038/30764
-
Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, et al. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-389. (Pubitemid 28269714)
-
(1998)
Nature
, vol.393
, Issue.6683
, pp. 386-389
-
-
Nan, X.1
Ng, H.-H.2
Johnson, C.A.3
Laherty, C.D.4
Turner, B.M.5
Eisenman, R.N.6
Bird, A.7
-
42
-
-
84878778709
-
Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology
-
Carrieri A, Perez-Nueno VI, Lentini G, Ritchie DW (2013) Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology. Curr Top Med Chem 13: 1069-1097.
-
(2013)
Curr Top Med Chem
, vol.13
, pp. 1069-1097
-
-
Carrieri, A.1
Perez-Nueno, V.I.2
Lentini, G.3
Ritchie, D.W.4
-
43
-
-
84876679729
-
Identification of upregulated phosphoinositide 3-kinase gamma as a target to suppress breast cancer cell migration and invasion
-
Xie Y, Abel PW, Kirui JK, Deng C, Sharma P, et al. (2013) Identification of upregulated phosphoinositide 3-kinase gamma as a target to suppress breast cancer cell migration and invasion. Biochem Pharmacol 85: 1454-1462.
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 1454-1462
-
-
Xie, Y.1
Abel, P.W.2
Kirui, J.K.3
Deng, C.4
Sharma, P.5
-
44
-
-
0036678234
-
Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures
-
Gold SJ, Heifets BD, Pudiak CM, Potts BW, Nestler EJ (2002) Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. J Neurochem 82: 828-838.
-
(2002)
J Neurochem
, vol.82
, pp. 828-838
-
-
Gold, S.J.1
Heifets, B.D.2
Pudiak, C.M.3
Potts, B.W.4
Nestler, E.J.5
-
45
-
-
0029830014
-
RGS10 is a selective activator of Galpha(i) GTPase activity
-
DOI 10.1038/383175a0
-
Hunt TW, Fields TA, Casey PJ, Peralta EG (1996) RGS10 is a selective activator of G alpha i GTPase activity. Nature 383: 175-177. (Pubitemid 26303981)
-
(1996)
Nature
, vol.383
, Issue.6596
, pp. 175-177
-
-
Hunt, T.W.1
Fields, T.A.2
Casey, P.J.3
Peralta, E.G.4
-
46
-
-
0030738476
-
The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro
-
DOI 10.1073/pnas.94.14.7216
-
Popov S, Yu K, Kozasa T, Wilkie TM (1997) The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro. Proc Natl Acad Sci U S A 94: 7216-7220. (Pubitemid 27345295)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.14
, pp. 7216-7220
-
-
Popov, S.1
Yu, K.2
Kozasa, T.3
Wilkie, T.M.4
-
47
-
-
22844457491
-
DNA methylation and human disease
-
Robertson KD (2005) DNA methylation and human disease. Nat Rev Genet 6: 597-610.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 597-610
-
-
Robertson, K.D.1
-
48
-
-
24344466882
-
DNA methylation and histone modifications: Teaming up to silence genes
-
Fuks F (2005) DNA methylation and histone modifications: teaming up to silence genes. Curr Opin Genet Dev 15: 490-495.
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 490-495
-
-
Fuks, F.1
-
49
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, et al. (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343: 1350-1354.
-
(2000)
N Engl J Med
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
Garcia-Foncillas, J.2
Andion, E.3
Goodman, S.N.4
Hidalgo, O.F.5
-
50
-
-
56249128582
-
Epigenome: A new target in cancer therapy
-
Giacinti L, Vici P, Lopez M (2008) Epigenome: a new target in cancer therapy. Clin Ter 159: 347-360.
-
(2008)
Clin Ter
, vol.159
, pp. 347-360
-
-
Giacinti, L.1
Vici, P.2
Lopez, M.3
-
51
-
-
84867743287
-
Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
-
Zeller C, Dai W, Steele NL, Siddiq A, Walley AJ, et al. (2012) Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene 31: 4567-4576.
-
(2012)
Oncogene
, vol.31
, pp. 4567-4576
-
-
Zeller, C.1
Dai, W.2
Steele, N.L.3
Siddiq, A.4
Walley, A.J.5
-
52
-
-
79959895071
-
HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer
-
Stronach EA, Alfraidi A, Rama N, Datler C, Studd JB, et al. (2011) HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res 71: 4412-4422.
-
(2011)
Cancer Res
, vol.71
, pp. 4412-4422
-
-
Stronach, E.A.1
Alfraidi, A.2
Rama, N.3
Datler, C.4
Studd, J.B.5
-
53
-
-
12144288983
-
Epigenetic Inactivation of TMS1/ASC in Ovarian Cancer
-
DOI 10.1158/1078-0432.CCR-0932-03
-
Terasawa K, Sagae S, Toyota M, Tsukada K, Ogi K, et al. (2004) Epigenetic inactivation of TMS1/ASC in ovarian cancer. Clin Cancer Res 10: 2000-2006. (Pubitemid 38375559)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.6
, pp. 2000-2006
-
-
Terasawa, K.1
Sagae, S.2
Toyota, M.3
Tsukada, K.4
Ogi, K.5
Satoh, A.6
Mita, H.7
Imai, K.8
Tokino, T.9
Kudo, R.10
-
54
-
-
84869880178
-
Histone deacetylases and cancer
-
Barneda-Zahonero B, Parra M (2012) Histone deacetylases and cancer. Mol Oncol 6: 579-589.
-
(2012)
Mol Oncol
, vol.6
, pp. 579-589
-
-
Barneda-Zahonero, B.1
Parra, M.2
-
55
-
-
0031244521
-
Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs
-
Hassig CA, Schreiber SL (1997) Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr Opin Chem Biol 1: 300-308. (Pubitemid 127437155)
-
(1997)
Current Opinion in Chemical Biology
, vol.1
, Issue.3
, pp. 300-308
-
-
Hassig, C.A.1
Schreibert, S.L.2
-
56
-
-
0035851143
-
Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin
-
Kruhlak MJ, Hendzel MJ, Fischle W, Bertos NR, Hameed S, et al. (2001) Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. J Biol Chem 276: 38307-38319.
-
(2001)
J Biol Chem
, vol.276
, pp. 38307-38319
-
-
Kruhlak, M.J.1
Hendzel, M.J.2
Fischle, W.3
Bertos, N.R.4
Hameed, S.5
-
58
-
-
36148966966
-
R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies
-
DOI 10.1038/sj.bjc.6604025, PII 6604025
-
Arts J, Angibaud P, Marien A, Floren W, Janssens B, et al. (2007) R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. Br J Cancer 97: 1344-1353. (Pubitemid 350114783)
-
(2007)
British Journal of Cancer
, vol.97
, Issue.10
, pp. 1344-1353
-
-
Arts, J.1
Angibaud, P.2
Marien, A.3
Floren, W.4
Janssens, B.5
King, P.6
Van Dun, J.7
Janssen, L.8
Geerts, T.9
Tuman, R.W.10
Johnson, D.L.11
Andries, L.12
Jung, M.13
Janicot, M.14
Van Emelen, K.15
-
60
-
-
80055098514
-
Thailandepsins: Bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities
-
Wang C, Henkes LM, Doughty LB, He M, Wang D, et al. (2011) Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. J Nat Prod 74: 2031-2038.
-
(2011)
J Nat Prod
, vol.74
, pp. 2031-2038
-
-
Wang, C.1
Henkes, L.M.2
Doughty, L.B.3
He, M.4
Wang, D.5
-
61
-
-
70349742486
-
DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer
-
Jin B, Yao B, Li JL, Fields CR, Delmas AL, et al. (2009) DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. Cancer Res 69: 7412-7421.
-
(2009)
Cancer Res
, vol.69
, pp. 7412-7421
-
-
Jin, B.1
Yao, B.2
Li, J.L.3
Fields, C.R.4
Delmas, A.L.5
-
62
-
-
84876795104
-
Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer-overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression
-
Muller BM, Jana L, Kasajima A, Lehmann A, Prinzler J, et al. (2013) Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer-overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression. BMC Cancer 13: 215.
-
(2013)
BMC Cancer
, vol.13
, pp. 215
-
-
Muller, B.M.1
Jana, L.2
Kasajima, A.3
Lehmann, A.4
Prinzler, J.5
-
63
-
-
0345357773
-
Gene Silencing in Cancer in Association with Promoter Hypermethylation
-
DOI 10.1056/NEJMra023075
-
Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054. (Pubitemid 37448928)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.21
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
64
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
Esteller M (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8: 286-298.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
65
-
-
0035890665
-
Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: Correlation of accessibility, methylation, MeCP2 binding and acetylation
-
Nguyen CT, Gonzales FA, Jones PA (2001) Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res 29: 4598-4606. (Pubitemid 33095020)
-
(2001)
Nucleic Acids Research
, vol.29
, Issue.22
, pp. 4598-4606
-
-
Nguyen, C.T.1
Gonzales, F.A.2
Jones, P.A.3
-
66
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer
-
DOI 10.1038/5047
-
Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21: 103-107. (Pubitemid 29036293)
-
(1999)
Nature Genetics
, vol.21
, Issue.1
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
67
-
-
80053107306
-
DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells
-
Meng CF, Su B, Li W (2011) DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. Mol Med Rep 4: 1273-1278.
-
(2011)
Mol Med Rep
, vol.4
, pp. 1273-1278
-
-
Meng, C.F.1
Su, B.2
Li, W.3
-
68
-
-
84871537487
-
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues
-
Gu Y, Yang P, Shao Q, Liu X, Xia S, et al. (2013) Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues. Oncol Lett 5: 452-458.
-
(2013)
Oncol Lett
, vol.5
, pp. 452-458
-
-
Gu, Y.1
Yang, P.2
Shao, Q.3
Liu, X.4
Xia, S.5
-
69
-
-
0038136913
-
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
-
DOI 10.1074/jbc.M209923200
-
Kimura H, Shiota K (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J Biol Chem 278: 4806-4812. (Pubitemid 36800984)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.7
, pp. 4806-4812
-
-
Kimura, H.1
Shiota, K.2
-
70
-
-
79951579430
-
A phase II study of two topotecan regimens evaluated in recurrent platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer: A Gynecologic Oncology Group Study (GOG 146Q)
-
Herzog TJ, Sill MW, Walker JL, O'Malley D, Shahin M, et al. (2011) A phase II study of two topotecan regimens evaluated in recurrent platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer: a Gynecologic Oncology Group Study (GOG 146Q). Gynecol Oncol 120: 454-458.
-
(2011)
Gynecol Oncol
, vol.120
, pp. 454-458
-
-
Herzog, T.J.1
Sill, M.W.2
Walker, J.L.3
O'Malley, D.4
Shahin, M.5
-
71
-
-
77951221128
-
Recurrent ovarian cancer: Treatment with pegylated liposomal doxorubicin; a Westmead Cancer Care Centre experience
-
Dear RF, Gao B, Harnett P (2010) Recurrent ovarian cancer: treatment with pegylated liposomal doxorubicin; a Westmead Cancer Care Centre experience. Asia Pac J Clin Oncol 6: 66-73.
-
(2010)
Asia Pac J Clin Oncol
, vol.6
, pp. 66-73
-
-
Dear, R.F.1
Gao, B.2
Harnett, P.3
-
72
-
-
78650955928
-
Histone deacetylase inhibitors: Recent insights from basic to clinical knowledge & patenting of anti-cancer actions
-
Carafa V, Nebbioso A, Altucci L (2011) Histone deacetylase inhibitors: recent insights from basic to clinical knowledge & patenting of anti-cancer actions. Recent Pat Anticancer Drug Discov 6: 131-145.
-
(2011)
Recent Pat Anticancer Drug Discov
, vol.6
, pp. 131-145
-
-
Carafa, V.1
Nebbioso, A.2
Altucci, L.3
-
73
-
-
26444446597
-
Histone modifications as a platform for cancer therapy
-
DOI 10.1002/jcb.20387
-
Espino PS, Drobic B, Dunn KL, Davie JR (2005) Histone modifications as a platform for cancer therapy. J Cell Biochem 94: 1088-1102. (Pubitemid 41420232)
-
(2005)
Journal of Cellular Biochemistry
, vol.94
, Issue.6
, pp. 1088-1102
-
-
Espino, P.S.1
Drobic, B.2
Dunn, K.L.3
Davie, J.R.4
-
74
-
-
0037276902
-
The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells
-
Zhu WG, Otterson GA (2003) The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. Curr Med Chem Anticancer Agents 3: 187-199.
-
(2003)
Curr Med Chem Anticancer Agents
, vol.3
, pp. 187-199
-
-
Zhu, W.G.1
Otterson, G.A.2
-
75
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1: 287-299.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
76
-
-
1042267223
-
Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells
-
DOI 10.1158/1078-0432.CCR-03-0100
-
Takai N, Desmond JC, Kumagai T, Gui D, Said JW, et al. (2004) Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. Clin Cancer Res 10: 1141-1149. (Pubitemid 38198916)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.3
, pp. 1141-1149
-
-
Takai, N.1
Desmond, J.C.2
Kumagai, T.3
Gui, D.4
Said, J.W.5
Whittaker, S.6
Miyakawa, I.7
Koeffler, H.P.8
-
77
-
-
27144509196
-
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
-
DOI 10.1093/jnci/dji311
-
Lyko F, Brown R (2005) DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 97: 1498-1506. (Pubitemid 41631949)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.20
, pp. 1498-1506
-
-
Lyko, F.1
Brown, R.2
-
78
-
-
84879639347
-
Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3
-
Meng F, Sun G, Zhong M, Yu Y, Brewer MA (2013) Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. Int J Oncol 43: 495-502.
-
(2013)
Int J Oncol
, vol.43
, pp. 495-502
-
-
Meng, F.1
Sun, G.2
Zhong, M.3
Yu, Y.4
Brewer, M.A.5
-
79
-
-
84884812613
-
Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies
-
Falchook GS, Fu S, Naing A, Hong DS, Hu W, et al. (2013) Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies. Invest New Drugs.
-
(2013)
Invest New Drugs
-
-
Falchook, G.S.1
Fu, S.2
Naing, A.3
Hong, D.S.4
Hu, W.5
|