Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein

Journal of Clinical Virology

Volumn 28, Issue 3, 2003, Pages 284-290

  Arsenault, Suzie ^a   Gravel, Annie ^b   Gosselin, Jean ^a   Flamand, Louis ^b  

^a Virocell Inc   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Human herpesvirus; Monoclonal antibody; Protein

Indexed keywords

IMMEDIATE EARLY 2 PROTEIN; IMMEDIATE EARLY PROTEIN; IMMUNOGLOBULIN G 1 MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT GLUTATHIONE S TRANSFERASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY ISOLATION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CELL FUSION; CONTROLLED STUDY; HUMAN HERPESVIRUS 6; IMMUNIZATION; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SPLEEN CELL; WESTERN BLOTTING;

EID: 0141428850     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(03)00050-7     Document Type: Article

References (30)

1. Ablashi D.V., Agut H., Berneman Z., Campadilli-Fiume G., Carrigan D., Ceccerini-Nelli L., Chandran B., Chou S., Collandre H., Cone R., Dambaugh T., Dewhurst S., DiLuca D., Foà-Tomasi L., Fleckeinstein B., Frenkel N., Gallo R., Gomples U., Hall C., Jone. Human herpesvirus-6 strain groups: a nomenclature. Arch. Virol. 129:(1-4):1993;363-366.
2. Ablashi D.V., Lapps W., Kaplan M., Whitman J.E., Richert J.R., Pearson G.R. Human herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary report. Mult. Scler. 4:(6):1998;490-496.
3. Asano Y., Yoshikawa T., Suga S., Yazaki T., Kondo K., Yamanishi K. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet. 335:(8693):1990;862-863.
4. Balachandran N., Amelse R.E., Zhou W.W., Chang C.K. Identification of proteins specific for human herpesvirus 6-infected human T cells. J. Virol. 63:(6):1989;2835-2840.
5. Campadelli-Fiume G., Guerrini S., Liu X., Foa-Tomasi L. Monoclonal antibodies to glycoprotein B differentiate human herpesvirus 6 into two clusters, variants A and B. J. Gen. Virol. 74:(Pt. 10):1993;2257-2262.
6. Challoner P.B., Smith K.T., Parker J.D., MacLeod D.L., Coulter S.N., Rose T.M., Schultz E.R., Bennett J.L., Garber R.L., Chang M., Schad P.A., Stewart P.M., Nowinski R.C., Brown J.P., Burmer G.C. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc. Natl. Acad. Sci. USA. 92:(16):1995;7440-7444.
7. Coates A.R., Bell J. HHV-6 and multiple sclerosis. Nat. Med. 4:(5):1998;537-538.
8. Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E. Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J. Virol. 73:(10):1999;8040-8452.
9. Downing R.G., Sewankambo N., Serwadda D., Honess R., Crawford D., Jarrett R., Griffin B.E. Isolation of human lymphotropic herpesviruses from Uganda. Lancet. 2:(8555):1987;390.
10. Fillet A.M., Lozeron P., Agut H., Lyon-Caen O., Liblau R. HHV-6 and multiple sclerosis. Nat. Med. 4:(5):1998;537-538.
11. Foa-Tomasi L., Guerrini S., Huang T., Campadelli-Fiume G. Characterization of human herpesvirus-6(U1102) and (GS) gp112 and identification of the Z29-specified homolog. Virology. 191:(1):1992;511-516.
12. Gravel A., Gosselin J., Flamand L. Human herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein co-localizing with promyelocityc leukemia protein-associated nuclear bodies. J. Biol. Chem. 277:2002;19679-19687.
13. Gravel A, Tomoiu A, Cloutier N, Gosselin J, Flamand L. Characterization of the immediate-early 2 protein of human herpesvirus 6, a promiscuous transcriptional activator, Virology 2003, in press.
14. Hall C.B., Long C.E., Schnabel K.C., Caserta M.T., McIntyre K.M., Costanzo M.A., Knott A., Dewhurst S., Insel R.A., Epstein L.G. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. New Engl. J. Med. 331:(7):1994;432-438.
15. Huang L.M., Lee C.Y., Lin K.H., Chuu W.M., Lee P.I., Chen R.L., Chen J.M., Lin D.T. Human herpesvirus-6 associated with fatal haemophagocytic syndrome. Lancet. 336:(8706):1990;60-61.
16. Huang L.M., Lee C.Y., Lee P.I., Chen J.M., Wang P.J. Meningitis caused by human herpesvirus-6. Arch. Dis. Child. 66:(12):1991;1443-1444.
17. Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T., Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K. Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J. Virol. 73:(10):1999;8053-8063.
18. Iyengar S., Levine P.H., Ablashi D., Neequaye J., Pearson G.R. Sero-epidemiological investigations on human herpesvirus 6 (HHV-6) infections using a newly developed early antigen assay. Int. J. Cancer. 49:(4):1991;551-557.
19. Kasolo F.C., Mpabalwani E., Gompels U.A. Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. J. Gen. Virol. 78:(Pt. 4):1997;847-855.
20. Liu D.X., Gompels U.A., Foa-Tomasi L., Campadelli-Fiume G. Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies. Virology. 197:(1):1993;12-22.
21. Lopez C., Pellett P., Stewart J., Goldsmith C., Sanderlin K., Black J., Warfield D., Feorino P. Characteristics of human herpesvirus-6. J. Infect. Dis. 157:(6):1988;1271-1273.
22. Okuno T., Shao H., Asada H., Shiraki K., Takahashi M., Yamanishi K. Analysis of human herpesvirus 6 glycoproteins recognized by monoclonal antibody OHV1. J. Gen. Virol. 73:(Pt 2):1992;443-447.
23. Oster B., Hollsberg P. Viral gene expression patterns in human herpesvirus 6B-infected T cells. J. Virol. 76:(15):2002;7578-7586.
24. Prezioso P.J., Cangiarella J., Lee M., Nuovo G.J., Borkowsky W., Orlow S.J., Greco M.A. Fatal disseminated infection with human herpesvirus-6. J. Pediatr. 120:(6):1992;921-923.
25. Salahuddin S.Z., Ablashi D.V., Markham P.D., Josephs S.F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B., et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 234:(4776):1986;596-601.
26. Soldan S.S., Berti R., Salem N., Secchiero P., Flamand L., Calabresi P.A., Brennan M.B., Maloni H.W., McFarland H.F., Lin H.C., Patnaik M., Jacobson S. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat. Med. 3:(12):1997;1394-1397.
27. Takeda K., Okuno T., Isegawa Y., Yamanishi K. Identification of a variant A-specific neutralizing epitope on glycoprotein B (gB) of human herpesvirus-6 (HHV-6). Virology. 222:(1):1996;176-183.
28. Takeda K., Haque M., Sunagawa T., Okuno T., Isegawa Y., Yamanishi K. Identification of a variant B-specific neutralizing epitope on glycoprotein H of human herpesvirus-6. J. Gen. Virol. 78:(Pt. 9):1997;2171-2178.
29. Weinshenker B.G., Wilton S., Rice G.P. Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in a monocytic cell line. J. Immunol. 140:(5):1988;1625-1631.
30. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1:(8594):1988;1065-1067.