No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome

American Journal of Translational Research

Volumn 4, Issue 4, 2012, Pages 443-451

  Burbelo, Peter D ^a   Bayat, Ahmad ^a   Wagner, Jason ^a   Nutman, Thomas B ^b   Baraniuk, James N ^c   Iadarola, Michael J ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

Chronic Fatigue Syndrome (CFS); Human Herpes Virus 6 (HHV6); Luciferase immunoprecipitation systems (LIPS)

Indexed keywords

LUCIFERASE; RECOMBINANT ANTIGEN; RENILLA LUCIFERIN 2 MONOOXYGENASE; VIRUS ANTIGEN;

AFRICA; ANTIBODY RESPONSE; ARTICLE; CHRONIC FATIGUE SYNDROME; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; SEROEPIDEMIOLOGY; SEROLOGY; SINGLE BLIND PROCEDURE; STATISTICAL SIGNIFICANCE; VIRUS DETECTION;

HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 6A; HUMAN HERPESVIRUS 6B; RENILLA LUCIFERASE;

EID: 84868008191     PISSN: None     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Braun DK, Dominguez G, Pellett PE. Human herpesvirus 6. Clin Microbiol Rev 1997; 10: 521-567.
2. Tanaka-Taya K, Kondo T, Mukai T, Miyoshi H, Yamamoto Y, Okada S, Yamanishi K. Seroepidemiological study of human herpesvirus-6 and -7 in children of different ages and detection of these two viruses in throat swabs by polymerase chain reaction. J Med Virol 1996; 48: 88-94.
3. Aberle SW, Mandl CW, Kunz C, Popow-Kraupp T. Presence of human herpesvirus 6 variants A and B in saliva and peripheral blood mononu- clear cells of healthy adults. J Clin Microbiol 1996; 34: 3223-3225.
4. Boutolleau D, Duros C, Bonnafous P, Caiola D, Karras A, Castro ND, Ouachee M, Narcy P, Gueudin M, Agut H, Gautheret-Dejean A. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol 2006; 35: 257-263.
5. Dewhurst S, McIntyre K, Schnabel K, Hall CB. Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J Clin Microbiol 1993; 31: 416-418.
6. Bates M, Monze M, Bima H, Kapambwe M, Clark D, Kasolo FC, Gompels UA. Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa. J Med Virol 2009; 81: 779-789.
7. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988; 1: 1065-1067.
8. Yao K, Crawford JR, Komaroff A., Ablashi DV, Jacobson S. Review part 2: Human herpesvirus6 in central nervous system diseases. J Med Virol 2010; 82: 1669-1678.
9. Isaacson E, Glaser CA, Forghani B, Amad Z, Wallace M, Armstrong RW, Exner MM, Schmid S. Evidence of human herpesvirus 6 infection in 4 immunocompetent patients with encephalitis. Clin Infect Dis 2005; 40: 890-893.
10. Tavakoli NP, Nattanmai S, Hull R, Fusco H, Dzigua L, Wang H, Dupuis M. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. J Clin Microbiol 2007; 45: 3972-3978.
11. Yao K, Honarmand S, Espinosa A, Akhyani N, Glaser C, Jacobson S. Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Ann Neurol 2009; 65: 257-267.
12. Donati D, Akhyani N, Fogdell-Hahn A, Cermelli C, Cassiani-Ingoni R, Vortmeyer A, Heiss JD, Cogen P, Gaillard WD, Sato S, Theodore WH, Jacobson S. Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections. Neurology 2003; 61: 1405-1411.
13. Fotheringham J, Donati D, Akhyani N, FogdellHahn A, Vortmeyer A, Heiss JD, Williams E, Weinstein S, Bruce DA, Gaillard WD, Sato S, Theodore WH, Jacobson S. Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS Med 2007; 4: e180.
14. Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, Rose TM, Schultz ER, Bennett JL, Garber RL, Chang M, Schad PA, Stewart PM, Nowinski RC, Brown JP, Burmer GC. Plaqueassociated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA 1995: 92: 7440-7444.
15. Cermelli C, Berti R, Soldan SS, Mayne M, D'Ambrosia JM, Ludwin SK, Jacobson S. High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection. J Infect Dis 2003; 187: 1377-1387.
16. Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 1997; 3: 1394-1397.
17. Villoslada P, Juste C, Tintore M, Llorenc V, Codina G, Pozo-Rosich P, Montalban X. The immune response against herpesvirus is more prominent in the early stages of MS. Neurology 2003; 60: 1944-1948.
18. Buchwald D, Cheney PR, Peterson DL, Henry B, Wormsley SB, Geiger A, Ablashi DV, Salahuddin SZ, Saxinger C, Biddle R, Kikinis R, Jolesz FA, Folks T, Balachandran N, Peter JB, Gallo RC, Komaroff AL. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann Intern Med 1992; 116: 103-113.
19. Reeves WC, Stamey FR, Black JB, Mawle AC, Stewart JA, Pellett PE. Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study. Clin Infect Dis 2000; 31: 48-52.
20. Wallace HL 2nd, Natelson B, Gause W, Hay J. Human herpesviruses in chronic fatigue syndrome. Clin Diagn Lab Immunol 1999; 6: 216-223.
21. Pellett PE, Sanchez-Martinez D, Dominguez G, Black JB, Anton E, Greenamoyer C, Dambaugh TR. A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope. Virology 1993; 195: 521-531.
22. Yamamoto M, Black JB, Stewart JA, Lopez C, Pellett PE. Identification of a nucleocapsid protein as a specific serological marker of human herpesvirus 6 infection. J Clin Microbiol 1990; 28: 1957-1962.
23. Higashimoto Y, Ohta A, Nishiyama Y, Ihira M, Sugata K, Asano Y, Peterson DL, Ablashi DV, Lusso P, Yoshikawa T. Development of a human herpesvirus 6 species-specific immunoblotting assay. J Clin Microbiol 2012; 50: 1245-1251.
24. Burbelo PD, Hoshino Y, Leahy H, Krogmann T, Hornung RL, ladarola MJ, Cohen JI. Serological diagnosis of human herpes simplex virus type 1 and 2 infections by luciferase immunoprecipitation system assay. Clin Vaccine Immunol 2009; 16: 366-371.
25. Burbelo PD, Issa AT, Ching KH, Exner M, Drew WL, Alter HJ, ladarola MJ. Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies. Virol J 2009: 6: 45.
26. Burbelo PD, Bren KE, Ching KH, Gogineni ES, Kottilil S, Cohen JI, Kovacs JA, ladarola MJ. LIPS arrays for simultaneous detection of antibodies against partial and whole proteomes of HCV, HIV and EBV. Mol Biosyst 2011; 7: 1453-1462.
27. Cohen JI, Jaffe ES, Dale JK, Pittaluga S, Heslop HE, Rooney CM, Gottschalk S, Bollard CM, Rao VK, Marques A, Burbelo PD, Turk SP, Fulton R, Wayne AS, Little RF, Cairo MS, El-Mallawany NK, Fowler D, Sportes C, Bishop MR, Wilson W, Straus SE. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States. Blood 2011; 117: 5835-5849.
28. Burbelo PD, Leahy HP, Groot S, Bishop LR, Miley W, ladarola MJ, Whitby D, Kovacs JA. Four -antigen mixture containing v-cyclin for serological screening of human herpesvirus 8 infection. Clin Vaccine Immunol 2009; 16: 621-627.
29. Burbelo PD, Issa AT, Ching KH, Wyvill KM, Little RF, ladarola MJ, Kovacs JA, Yarchoan R. Distinct profiles of antibodies to Kaposi sarcomaassociated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma. J Infect Dis 2010; 201: 1919-1922.
30. Sashihara J, Hoshino Y, Bowman JJ, Krogmann T, Burbelo PD, Coffield VM, Kamrud K, Cohen JI. Soluble rhesus lymphocryptovirus gp350 protects against infection and reduces viral loads in animals that become infected with virus after challenge. PLoS Pathog 2011; 7: e1002308.
31. Bowman JJ, Lacayo JC, Burbelo P, Fischer ER, Cohen JI. Rhesus and human cytomegalovirus glycoprotein L are required for infection and cell -to-cell spread of virus but cannot complement each other. J Virol 2011; 85: 2089-2099.
32. Ravindran MK, Zheng Y, Timbol C, Merck SJ, Baraniuk JN. Migraine headaches in chronic fatigue syndrome (CFS): comparison of two prospective cross-sectional studies. BMC Neurol 2011; 11: 30.
33. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 1994; 121: 953-959.
34. Burbelo PD, Ching KH, Klimavicz CM, ladarola MJ. Antibody profiling by Luciferase Immunoprecipitation Systems (LIPS). J Vis Exp 2009.
35. Thader-Voigt A, Jacobs E, Lehmann W, Bandt D. Development of a microwell adapted immunoblot system with recombinant antigens for distinguishing human herpesvirus (HHV)6A and HHV6B and detection of human cytomegalovirus. Clin Chem Lab Med 2011; 49: 1891-1898.
36. Davenport FM, Hennessy AV, Francis T Jr. Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus. J Exp Med 1953; 98: 641-656.