Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B

Journal of Virology

Volumn 73, Issue 10, 1999, Pages 8053-8063

  Isegawa, Yuji ^a   Mukai, Tetsu ^a,b   Nakano, Kazushi ^a   Kagawa, Miwa ^a   Chen, Jiguo ^a   Mori, Yasuko ^a   Sunagawa, Tomimasa ^a   Kawanishi, Kazunobu ^a   Sashihara, Junji ^a   Hata, Atsuko ^a   Zou, Ping ^a   Kosuge, Haruhiko ^a   Yamanishi, Koichi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID COMPOSITION; ARTICLE; DNA SEQUENCE; EXANTHEMA SUBITUM; GENE DELETION; GENE EXPRESSION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; IMMEDIATE EARLY GENE; LATENT VIRUS INFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REGULATOR GENE; VIRUS GENOME;

EID: 0032850175     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.8053-8063.1999     Document Type: Article

References (76)

1. Ablashi, D. V., N. Balachandran, S. F. Josephs, C. L. Hung, G. R. Krueger, B. Kramarsky, S. Z. Salahuddin, and R. C. Gallo. 1991. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184:545-552.
2. Aubin, J. T., H. Collandre, D. Candotti, D. Ingrand, C. Rouzioux, M. Burgard, S. Richard, J. M. Huraux, and H. Agut. 1991. Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J. Clin. Microbiol. 29:367-372.
3. Aubin, J. T., H. Agut, H. Collandre, K. Yamanishi, B. Chandran, L. Montagnier, and J. M. Huraux, 1993. Antigenic and genetic differentiation of the two putative types of human herpes virus 6. J. Virol. Methods 41:223-234.
4. Baines, J. D., and B. Roizman. 1993. The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells. J. Virol. 67:1441-1452.
5. Berneman, Z. N., D. V. Ablashi, G. Li, M. Eger-Fleteher, M. S. Reitz, C. L. Hung, I. Brus, A. L. Komaroff, and R. C. Gallo. 1992. Human herpesvirus 7 is a T-lymphotrophic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc. Natl. Acad. Sci. USA 89:10552-10556.
6. Burns, W. H, and G. R. Sandford. 1990. Susceptibility of human herpesvirus 6 to antivirals in vitro. J. Infect. Dis. 162:634-637.
7. Chee, M. S., A, T. Bankier, S. Beck, R. Bohni, C. M. Brown, R. Cerny, T. Horsnell, C. A. Hutchinson, T. Kouzarides, J. A. Martignetti, E. Preddie, S. C. Satchwell, P. Tomlinson, K. M. Weston, and B. G. Barrell. 1990. Analysis of the protein coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. 154:125-169.
8. Chandran, B., S. Tirawatnapong, B. Pfeiffer, and D. V. Ablashi. 1992. Antigenic relationships among human herpesvirus-6 isolations. J. Med. Virol. 37:247-254.
9. Chou, S., and G. I. Marousek. 1994. Analysis of interstrain variation in a putative immediate-early region of human herpesvirus 6 DNA and definition of variant-specific sequences. Virology 198:370-376.
10. Clark, M. J., J. Gagnon, A. F. Williams, and A. N. Barklay. 1985. MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain. EMBO J. 4:113-118.
11. Downing, R. G., N. Sewankambo, D. Serwadda, R. Honess, D. Crawford, R. Jaret, and B. E. Griffin. 1987. Isolation of human lymphotropic herpesvirus from Uganda. Lancet ii:390.
12. Enders, G., M. Biber, G. Meyer, and E. Helftenbein. 1990. Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesvirus and HIV. Infection 18:12-15.
13. Geng, Y., B. Chandran, S. F. Josephs, and C. Wood. 1992. Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter. J. Virol. 66:1564-1570.
14. Geraghty, R. J., C. Krummenacher, G. H. Cohen, R. J. Elsenberg, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280:1618-1620.
15. Gompels, U. A., D. R. Carrigan, A. L. Carss, and J. Arno. 1993. Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients. J. Gen. Virol. 74:613-622.
16. Gompels, U. A., J. Nicholas, G. Lawrence, M. Jones, B. J. Thomson, M. E. Martin, S. Efstahiou, M. Craxton, and H. A. Macaulay. 1995. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209:29-51.
17. Inoue, N., T. R. Dambaugh, J. C. Rapp, and P. E. Pellett. 1994. Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesvirus. J. Virol. 68:4126-4136.
18. Isegawa, Y., et al. Unpublished data.
19. Isegawa, Y., Z. Ping, K. Nakano, N. Sugimoto, and K. Yamanishi. 1998. Human herpesvirus 6 open reading frame U12 encodes a functional β-chemokine receptor. J. Virol. 72:6104-6112.
20. Isegawa, Y., J. Sheng, Y. Sokawa, K. Yamanishi, O. Nakagomi, and S. Ueda. 1992. Selective amplification of cDNA sequence from total RNA by cassette-ligation mediated polymerase chain reaction (PCR): application to sequencing 6.5 kb genome segment of hantavirus strain B-1. Mol. Cell. Probes 6:467-475.
21. Iskenderian, A. C., L. Huang, A. Reilly, R. M. Stenberg, and D. G. Anders. 1996. Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes. J. Virol. 70:383-392.
22. Josephs, S. F., S. Z. Salahuddin, D. V. Ablashi, F. Schachter, F. Wong-Staal, and R. C. Gallo. 1986. Genomic analyses of the human B lymphotropic virus. Science 234:601-603.
23. Kondo, K., T. Kondo, T. Okuno, M. Takahashi, and K. Yamanishi. 1991. Latent human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 72:1401-1408.
24. Kosuge, H., Y. Isegawa, and K. Yamanishi. 1997. Nucleotide sequence analysis of a 30-kilobase-pair region of human herpesvirus-6B (HHV-6B) genome and strain-specific variations in major immediate-early genes. Virus Res. 52:1-14.
25. Lawrence, G. L., J. Nicholas, and B. G. Barrell. 1995. Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein. J. Gen. Virol. 76:147-152.
26. Lindquester, G. J., C. A. Greenamoyer, E. D. Anton, J. J. O'Brian, P. E. Pellett, and T. R Dambaugh. 1997. Comparison of a 20 kb region of human herpesvirus 6B with other human beta herpesviruses reveals conserved replication genes and adjacent divergent open reading frames. Arch. Virol. 142:193-204.
27. Lindquester, G. J., J. J. O'Brian, E. D. Anton, C. A. Greenamoyer, P. E. Pellett, and T. R. Dambaugh. 1997. Genetic content of a 20.9 kb segment of human herpesvirus 6B strain Z29 spanning the homologs of human herpesvirus 6A genes U40-51 and containing the origin of DNA replication. Arch. Virol. 142:103-123.
28. Littler, E., A. D. Stuart, and M. S. Chee. 1992. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the anti-viral nucleoside analogue ganciclovir. Nature (London) 358:160-162.
29. Liu, B., and M. F. Stinski. 1992. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J. Virol. 64:4434-4444.
30. Liu, D. X., U. A. Gompels, L. Foa-Tomasi, and G. Campadelli-Fiume. 1993. Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies. Virology 197:12-22.
31. Liu, D. X., U. A. Gompels, J. Nicholas, and G. Lelliot. 1993. Identification and expression of the human herpesvirus-6 glycoprotein H and interaction with an accessory 30 kilodalton glycoprotein. J. Gen. Virol. 74:1847-1857.
32. Lopetz, C., P. Pellett, J. Stewart, C. Goldsmith, K. Sanderlin, J. Black, D. Warfield, and P. Feorino. 1988. Characteristics of human herpesvirus-6. J. Infect. Dis. 157:1271-1273.
33. Lusso, P., P. D. Markham, E. Tschachler, F. di Marzo Veronese, S. Z. Salahuddin, D. V. Ablashi, S. Pahwa, K. Krohn, and R. C. Gallo. 1988. In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J. Exp. Med. 167:1659-1670.
34. Martin, M. E. D., J. Nicholas, B. J. Thomson, C. Newman, and R. W. Honess. 1991. Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6. J. Virol. 65:5381-5390.
35. Martin, M. E., B. J. Thomson, R. W. Honess, M. A. Craxton, U. A. Gompels, M. Y. Liu, E. Littler, J. R. Arrand, I. Teo, and M. D. Jones. 1991. The genome of human herpesvirus 6: maps of unit-length and concatemeric genomes for nine restriction endonucleases. J. Gen. Virol. 72:157-168.
36. McGeoch, D. J. 1989. The genomes of the human herpesviruses: contents, relationships, and evolution. Annu. Rev. Microbiol. 43:235-265.
37. McLauchlan, J., A. Phelan, C. Loney, R. M. Sandri-Goldin, and J. B. Clements. 1992. Herpes simplex virus IE63 acts at the posttranscriptional level stimulates viral mRNA 3′ processing. J. Virol. 66:6939-6945.
38. Megaw, A. G., D. Rapaport, B. Avidor, N. Frenkel, and A. J. Davison. 1998. The DNA sequence of the RK strain of human herpesvirus 7. Virology 244:119-132.
39. Mirandola, P., P. Menegazzi, S. Merighi, T. Ravaioli, E. Cassai, and D. Di Luca. 1998. Temporal mapping of transcripts in herpesvirus 6 variants. J. Virol. 72:3837-3844.
40. Montgomery, R. I., M. S. Warner, B. J. Lum, and P. G. Spear. 1996. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/ NGF receptor family. Cell 87:427-436.
41. Mookerjee, B. P., and G. Vogelsang. 1997. Human herpes virus-6 encephalitis after bone marrow transplantation: successful treatment with ganciclovir. Bone Marrow Transplant. 20:905-906.
42. Mori, Y., H. Yagi, T. Shimamoto, Y. Isegawa, T. Sunagawa, R. Inagi, K. Kondo, Y. Tano, and K. Yamanishi. 1998. Analysis of human herpesvirus 6 U3 gene, which is a positional homolog of human cytomegalovirus UL24 gene. Virology 249:129-139.
43. Mukai, T., T. Yamamoto, T. Kondo, K. Kondo, T. Okuno, H. Kosuge, and K. Yamanishi. 1994. Molecular epidemiological studies of human herpesvirus 6 in families. J. Med. Virol. 42:224-227.
44. Nicholas, J. 1996. Determination and analysis of the complete nucleotide sequence of human herpesvirus 7. J. Virol. 70:5975-5989.
45. Nicholas, J., K. R. Cameron, and R. W. Honess. 1992. Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nature (London) 355:362-365.
46. Nicholas, J., and M. Martin. 1994. Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions. J. Virol. 68:597-610.
47. Nipel, F., K. Ellinger, and B. Fleckenstein. 1992. Gene for the major antigenic structural protein (p100) of human herpesvirus 6. J. Virol. 66:3918-3924.
48. Peliett, P. E., D. Sanchez-Martinez, G. Dominguez, J. B. Black, E. Anton, C. Greenamoyer, and T. R. Dambaugh. 1993. A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope. Virology 195:521-531.
49. Pfeiffer, B., Z. N. Berneman, F. Neipel, C. K. Chang, S. Tirwatnapong, and B. Chandran. 1993. Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies. J. Virol. 67: 4611-4620.
50. Pfeiffer, B., B. Thomson, and B. Chandran. 1995. Identification and characterization of a cDNA derived from multiple splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6. J. Virol. 69:3490-3500.
51. Phelan, A., M. Carmo-Fonseca, J. McLauchlan, A. I. Lamond, and J. B. Clements. 1993. A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution. Proc. Natl. Acad. Sci. USA 90:9056-9060.
52. Pilling, A., A. J. Davison, E. Telford, and D. M. Meredith. 1994. The equine herpesvirus type 1 glycoprotein M is a major constitute of the virus particle. J. Gen. Virol. 75:439-442.
53. Salahuddin, S. Z., D. V. Ablashi, P. Markham, S. F. Josephs, S. Sturzegger, M. Kaplan, G. Halligan, P. Biberfeld, F. Wong-Staal, B. Kramarsky, and R. C. Gallo. 1986. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596-601.
54. Sato, S., T. Yamamoto, Y. Isegawa, and K. Yamanishi. 1994. Identification of human herpesvirus 6 uracil-DNA glycosylase gene. J. Gen. Virol. 75:2349-2354.
55. Schirmer, E. C., L. S. Wyatt, K. Yamanishi, W. J. Rodriguez, and N. Frenkel. 1991. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc. Natl. Acad. Sci. USA 88:5922-5926.
56. Secchiero, P., Z. N. Berneman, D. Sun, J. Nichlas, and M. S. Reitz, Jr. 1997. Identification of envelope glycoproteins H and B homologous of human herpesvirus 7. Intervirology 40:22-32.
57. Stasiak, P. C., and E. S. Mocarski. 1992. Transaction of the cytomegalovirus ICP36 gene promoter requires the a gene product TRS1 in addition to IE1 and IE2. J. Virol. 66:1050-1058.
58. Sullivan, V., C. L. Talarico, S. C. Stanat, M. Davis, D. M. Coen, and K. K. Biron. 1992. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalo-infected cells. Nature (London) 358:162-164.
59. Sunagawa, T., et al. Unpublished data.
60. Takahashi, K., S. Sonoda, K. Higashi, T. Kondo, H. Takahashi, M. Takahashi, and K. Yamanishi. 1989. Predominant CD4 T-lymphocyte tropism of human herpesvinis 6-related virus. J. Virol. 63:3161-3163.
61. Takeda, K., et al. Unpublished data.
62. Takeda, K., M. Haque, T. Sunagawa, T. Okuno, Y. Isegawa, and K. Yamanishi. 1997. Identification of a variant B-specific neutralization epitope on glycoprotein H of human herpesvirus-6. J. Gen. Virol. 78:2171-2178.
63. Takeda, K., N. Nakagawa, T. Yamamoto, R. Inagi, K. Kawanishi, Y. Isegawa, and K. Yamanishi. 1996. Prokaryotic expression of an immediate-early gene of human herpesvirus 6 and analysis of its viral antigen expression in human cells. Virus Res. 41:193-200.
64. Takeda, K., T. Okuno, Y. Isegawa, and K. Yamanishi. 1996. Identification of a variant A-specific neutralizing epitope on glycoprotein B (gB) of human herpesvirus-6 (HHV-6). Virology 222:176-183.
65. Taniguchi, T., et al. Unpublished data.
66. Thompson, J., S. Choudhury, F. Kashanchi, J. Doniger, Z. Berneman, N. Frenkel, and L. J. Rosenthal. 1994. A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1. Oncogene 9:1167-1175.
67. Thomson, B. J., F. W. Weindler, D. Gray, V. Schwaab, and R. Heilbronn. 1994. Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression. Virology 204:304-311.
68. Thomson, B. J., S. Efstathiou, and R. W. Honess. 1991. Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. Nature (London) 351:78-80.
69. Tigue, M. J., P. J. Matharu, N. A. Roberts, J. S. Mills, J. Kay, and R. Jupp. 1996. Cloning, expression, and characterization of the proteinase from human herpesvirus 6. J. Virol. 70:4136-4141.
70. Warner, M. S., R. J. Geraghty, W. M. Martinez, R. I. Montgomery, J. C. Whitbeck, R. Xu, R. J. Eisenberg, G. H. Cohen, and P. G. Spear. 1998. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 246:179-189.
71. Winkler, M., S. A. Rice, and T. Stamminger. 1994. UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression. J. Virol. 68:3942-3954.
72. Wyatt, L. S., N. Balachandran, and N. Frenkel. 1990. Variations in the replicafion and antigenic properties of human herpesvirus 6 strains. J. Infect. Dis. 162:852-857.
73. Yamamoto, T., T. Mukai, K. Kondo, and K. Yamanishi. 1994. Variation of DNA sequence in immediate-early gene of human herpesvirus 6 and variant identification by PCR. J. Clin. Microbiol. 32:473-476.
74. Yamanishi, K., T. Okuno, K. Shiraki, M. Takahashi, T. Kondo, Y. Asano, and T. Kurata. 1988. Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet 1:1065-1067.
75. Zhou, Y., C. K. Chang, G. Qian, B. Chandran, and C. Wood. 1994 Transactivation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6. Virology 199:311-322.
76. Zou, P., Y. Isegawa, K. Nakano, M. Haque, Y. Horiguchi, and K. Yamanishi. 1999. Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. J. Virol. 73:5926-5933.