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Volumn 8, Issue 3, 2013, Pages 273-287

Immunomodulation and immunosuppression by human herpesvirus 6A and 6B

Author keywords

antigen presenting cells; CD46; chemokines; cytokines; HHV 6A; HHV 6B; immunomodulation; immunosuppression; receptors; T cells

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD14 ANTIGEN; CD161 ANTIGEN; CUTANEOUS T CELL ATTRACTING CHEMOKINE; EOTAXIN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEMBRANE COFACTOR PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TOLL LIKE RECEPTOR 9; VIRUS DNA;

EID: 84874678413     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.13.7     Document Type: Review
Times cited : (48)

References (117)
  • 1
    • 34447323277 scopus 로고    scopus 로고
    • Virus-encoded chemokines, chemokine receptors and chemokine-binding proteins: New paradigms for future therapy
    • Dagna L, Lusso P. Virus-encoded chemokines, chemokine receptors and chemokine-binding proteins: new paradigms for future therapy. Future Virol. 2(4), 353-368 (2007).
    • (2007) Future Virol. , vol.2 , Issue.4 , pp. 353-368
    • Dagna, L.1    Lusso, P.2
  • 2
    • 0033831421 scopus 로고    scopus 로고
    • Viral mechanisms of immune evasion
    • Alcami A, Koszinowski UH. Viral mechanisms of immune evasion. Immunol. Today 21(9), 447-455 (2000).
    • (2000) Immunol. Today , vol.21 , Issue.9 , pp. 447-455
    • Alcami, A.1    Koszinowski, U.H.2
  • 4
    • 84863109422 scopus 로고    scopus 로고
    • Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012)
    • Adams MJ, Carstens EB. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012). Arch. Virol. 157(7), 1411-1422 (2012).
    • (2012) Arch. Virol. , vol.157 , Issue.7 , pp. 1411-1422
    • Adams, M.J.1    Carstens, E.B.2
  • 5
    • 0025953657 scopus 로고
    • Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates
    • Ablashi DV, Balachandran N, Josephs SF et al. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184(2), 545-552 (1991).
    • (1991) Virology , vol.184 , Issue.2 , pp. 545-552
    • Ablashi, D.V.1    Balachandran, N.2    Josephs, S.F.3
  • 8
    • 0035168719 scopus 로고    scopus 로고
    • Suppression of CCR5-but not CXCR4-tropic HIV-1 in lymphoid tissue by human herpesvirus 6
    • Grivel JC, Ito Y, Faga G et al. Suppression of CCR5-but not CXCR4-tropic HIV-1 in lymphoid tissue by human herpesvirus 6. Nat. Med. 7(11), 1232-1235 (2001).
    • (2001) Nat. Med. , vol.7 , Issue.11 , pp. 1232-1235
    • Grivel, J.C.1    Ito, Y.2    Faga, G.3
  • 9
    • 0033211252 scopus 로고    scopus 로고
    • Altered cytokine production after human herpes virus type 6 infection
    • Arena A, Liberto MC, Iannello D, Capozza AB, Foca A. Altered cytokine production after human herpes virus type 6 infection. New Microbiol. 22(4), 293-300 (1999).
    • (1999) New Microbiol. , vol.22 , Issue.4 , pp. 293-300
    • Arena, A.1    Liberto, M.C.2    Iannello, D.3    Capozza, A.B.4    Foca, A.5
  • 10
    • 0029936476 scopus 로고    scopus 로고
    • Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15
    • Flamand L, Stefanescu I, Menezes J. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest. 97(6), 1373-1381 (1996).
    • (1996) J. Clin. Invest , vol.97 , Issue.6 , pp. 1373-1381
    • Flamand, L.1    Stefanescu, I.2    Menezes, J.3
  • 11
    • 0026063319 scopus 로고
    • Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures
    • Flamand L, Gosselin J, D'Addario M et al. Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures. J. Virol. 65(9), 5105-5110 (1991).
    • (1991) J. Virol. , vol.65 , Issue.9 , pp. 5105-5110
    • Flamand, L.1    Gosselin, J.2    D'Addario, M.3
  • 12
    • 0023887853 scopus 로고
    • In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6)
    • Lusso P, Markham PD, Tschachler E et al. In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J. Exp. Med. 167(5), 1659-1670 (1988).
    • (1988) J. Exp. Med. , vol.167 , Issue.5 , pp. 1659-1670
    • Lusso, P.1    Markham, P.D.2    Tschachler, E.3
  • 13
    • 0024344381 scopus 로고
    • Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus
    • Takahashi K, Sonoda S, Higashi K et al. Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J. Virol. 63(7), 3161-3163 (1989).
    • (1989) J. Virol. , vol.63 , Issue.7 , pp. 3161-3163
    • Takahashi, K.1    Sonoda, S.2    Higashi, K.3
  • 14
    • 0024022807 scopus 로고
    • Characteristics of human herpesvirus-6
    • Lopez C, Pellett P, Stewart J et al. Characteristics of human herpesvirus-6. J. Infect. Dis. 157(6), 1271-1273 (1988).
    • (1988) J. Infect. Dis. , vol.157 , Issue.6 , pp. 1271-1273
    • Lopez, C.1    Pellett, P.2    Stewart, J.3
  • 15
    • 0023008773 scopus 로고
    • Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders
    • Salahuddin SZ, Ablashi DV, Markham PD et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234(4776), 596-601 (1986).
    • (1986) Science , vol.234 , Issue.4776 , pp. 596-601
    • Salahuddin, S.Z.1    Ablashi, D.V.2    Markham, P.D.3
  • 16
    • 0024204769 scopus 로고
    • Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6)
    • Ablashi DV, Lusso P, Hung CL et al. Utilization of human hematopoietic cell lines for the propagation and characterization of HBLV (human herpesvirus 6). Int. J. Cancer 42(5), 787-791 (1988).
    • (1988) Int. J. Cancer , vol.42 , Issue.5 , pp. 787-791
    • Ablashi, D.V.1    Lusso, P.2    Hung, C.L.3
  • 17
    • 0030835257 scopus 로고    scopus 로고
    • Human herpesvirus 6 (HHV-6)-positive Burkitt's lymphoma: Establishment of a novel cell line infected with HHV-6
    • Bandobashi K, Daibata M, Kamioka M et al. Human herpesvirus 6 (HHV-6)-positive Burkitt's lymphoma: establishment of a novel cell line infected with HHV-6. Blood 90(3), 1200-1207 (1997).
    • (1997) Blood , vol.90 , Issue.3 , pp. 1200-1207
    • Bandobashi, K.1    Daibata, M.2    Kamioka, M.3
  • 18
    • 0027194513 scopus 로고
    • Human herpesvirus 6 (HHV-6)-associated dysfunction of blood monocytes
    • Burd EM, Carrigan DR. Human herpesvirus 6 (HHV-6)-associated dysfunction of blood monocytes. Virus Res. 29(1), 79-90 (1993).
    • (1993) Virus Res. , vol.29 , Issue.1 , pp. 79-90
    • Burd, E.M.1    Carrigan, D.R.2
  • 19
    • 0025865176 scopus 로고
    • Latent human herpesvirus 6 infection of human monocytes/macrophages
    • Kondo K, Kondo T, Okuno T, Takahashi M, Yamanishi K. Latent human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 72 (Pt 6), 1401-1408 (1991).
    • (1991) J. Gen. Virol. , vol.72 , Issue.PART 6 , pp. 1401-1408
    • Kondo, K.1    Kondo, T.2    Okuno, T.3    Takahashi, M.4    Yamanishi, K.5
  • 20
    • 0141923890 scopus 로고    scopus 로고
    • Selective suppression of IL-12 production by human herpesvirus 6
    • Smith A, Santoro F, Di Lullo G, Dagna L, Verani A, Lusso P. Selective suppression of IL-12 production by human herpesvirus 6. Blood 102(8), 2877-2884 (2003).
    • (2003) Blood , vol.102 , Issue.8 , pp. 2877-2884
    • Smith, A.1    Santoro, F.2    Di Lullo, G.3    Dagna, L.4    Verani, A.5    Lusso, P.6
  • 22
    • 0036275849 scopus 로고    scopus 로고
    • Strong interaction between human herpesvirus 6 and peripheral blood monocytes/macrophages during acute infection
    • Kondo K, Kondo T, Shimada K, Amo K, Miyagawa H, Yamanishi K. Strong interaction between human herpesvirus 6 and peripheral blood monocytes/macrophages during acute infection. J. Med. Virol. 67(3), 364-369 (2002).
    • (2002) J. Med. Virol. , vol.67 , Issue.3 , pp. 364-369
    • Kondo, K.1    Kondo, T.2    Shimada, K.3    Amo, K.4    Miyagawa, H.5    Yamanishi, K.6
  • 23
    • 17344365850 scopus 로고    scopus 로고
    • Human herpesvirus 6 latently infects early bone marrow progenitors in vivo
    • Luppi M, Barozzi P, Morris C et al. Human herpesvirus 6 latently infects early bone marrow progenitors in vivo. J. Virol. 73(1), 754-759 (1999).
    • (1999) J. Virol. , vol.73 , Issue.1 , pp. 754-759
    • Luppi, M.1    Barozzi, P.2    Morris, C.3
  • 24
    • 0038700552 scopus 로고    scopus 로고
    • Interaction of human herpesvirus 6 with human CD34 positive cells
    • Isomura H, Yoshida M, Namba H, Yamada M. Interaction of human herpesvirus 6 with human CD34 positive cells. J. Med. Virol. 70(3), 444-450 (2003).
    • (2003) J. Med. Virol. , vol.70 , Issue.3 , pp. 444-450
    • Isomura, H.1    Yoshida, M.2    Namba, H.3    Yamada, M.4
  • 25
    • 0033952994 scopus 로고    scopus 로고
    • Suppressive effects of human herpesvirus-6 on thrombopoietin-inducible megakaryocytic colony formation in vitro
    • Isomura H, Yoshida M, Namba H et al. Suppressive effects of human herpesvirus-6 on thrombopoietin-inducible megakaryocytic colony formation in vitro. J. Gen. Virol. 81(Pt 3), 663-673 (2000).
    • (2000) J. Gen. Virol. , vol.81 , Issue.PART 3 , pp. 663-673
    • Isomura, H.1    Yoshida, M.2    Namba, H.3
  • 26
    • 0026539282 scopus 로고
    • In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection
    • Knox KK, Carrigan DR. In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection. J. Infect. Dis. 165(5), 925-929 (1992).
    • (1992) J. Infect. Dis. , vol.165 , Issue.5 , pp. 925-929
    • Knox, K.K.1    Carrigan, D.R.2
  • 27
    • 0030873349 scopus 로고    scopus 로고
    • Suppressive effects of human herpesvirus 6 on in vitro colony formation of hematopoietic progenitor cells
    • Isomura H, Yamada M, Yoshida M et al. Suppressive effects of human herpesvirus 6 on in vitro colony formation of hematopoietic progenitor cells. J. Med. Virol. 52(4), 406-412 (1997).
    • (1997) J. Med. Virol. , vol.52 , Issue.4 , pp. 406-412
    • Isomura, H.1    Yamada, M.2    Yoshida, M.3
  • 28
    • 0032934031 scopus 로고    scopus 로고
    • Latent infection and reactivation of human herpesvirus 6 in two novel myeloid cell lines
    • Yasukawa M, Ohminami H, Sada E et al. Latent infection and reactivation of human herpesvirus 6 in two novel myeloid cell lines. Blood 93(3), 991-999 (1999).
    • (1999) Blood , vol.93 , Issue.3 , pp. 991-999
    • Yasukawa, M.1    Ohminami, H.2    Sada, E.3
  • 29
    • 0027458632 scopus 로고
    • Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: Evidence of a marrow-suppressive role for HHV-6 in vivo
    • Drobyski WR, Dunne WM, Burd EM et al. Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: evidence of a marrow-suppressive role for HHV-6 in vivo. J. Infect. Dis. 167(3), 735-739 (1993).
    • (1993) J. Infect. Dis. , vol.167 , Issue.3 , pp. 735-739
    • Drobyski, W.R.1    Dunne, W.M.2    Burd, E.M.3
  • 30
    • 0032992228 scopus 로고    scopus 로고
    • HHV-6-related secondary graft failure following allogeneic bone marrow transplantation
    • Johnston RE, Geretti AM, Prentice HG et al. HHV-6-related secondary graft failure following allogeneic bone marrow transplantation. Br. J. Haematol. 105(4), 1041-1043 (1999).
    • (1999) Br. J. Haematol. , vol.105 , Issue.4 , pp. 1041-1043
    • Johnston, R.E.1    Geretti, A.M.2    Prentice, H.G.3
  • 31
    • 84862138711 scopus 로고    scopus 로고
    • Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: A large-scale clinical study
    • Dulery R, Salleron J, Dewilde A et al. Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study. Biol. Blood Marrow Transplant. 18(7), 1080-1089 (2012).
    • (2012) Biol. Blood Marrow Transplant. , vol.18 , Issue.7 , pp. 1080-1089
    • Dulery, R.1    Salleron, J.2    Dewilde, A.3
  • 32
    • 80755177511 scopus 로고    scopus 로고
    • The complex relationship between human herpesvirus 6 and acute graft-versus-host disease
    • Pichereau C, Desseaux K, Janin A et al. The complex relationship between human herpesvirus 6 and acute graft-versus-host disease. Biol. Blood Marrow Transplant. 18(1), 141-144 (2012).
    • (2012) Biol. Blood Marrow Transplant. , vol.18 , Issue.1 , pp. 141-144
    • Pichereau, C.1    Desseaux, K.2    Janin, A.3
  • 33
    • 84867541229 scopus 로고    scopus 로고
    • HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation
    • Zerr DM, Boeckh M, Delaney C et al. HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation. Biol. Blood Marrow Transplant. 18(11), 1700-1708 (2012).
    • (2012) Biol. Blood Marrow Transplant. , vol.18 , Issue.11 , pp. 1700-1708
    • Zerr, D.M.1    Boeckh, M.2    Delaney, C.3
  • 34
    • 0025895083 scopus 로고
    • Productive infection of CD4+ and CD8+ mature human T cell populations and clones by human herpesvirus 6. Transcriptional down-regulation of CD3
    • Lusso P, Malnati M, De Maria A et al. Productive infection of CD4+ and CD8+ mature human T cell populations and clones by human herpesvirus 6. Transcriptional down-regulation of CD3. J. Immunol. 147(2), 685-691 (1991).
    • (1991) J. Immunol. , vol.147 , Issue.2 , pp. 685-691
    • Lusso, P.1    Malnati, M.2    De Maria, A.3
  • 36
    • 0028986361 scopus 로고
    • Infection of gamma/delta T lymphocytes by human herpesvirus 6: Transcriptional induction of CD4 and susceptibility to HIV infection
    • Lusso P, Garzino-Demo A, Crowley RW, Malnati MS. Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. J. Exp. Med. 181(4), 1303-1310 (1995).
    • (1995) J. Exp. Med. , vol.181 , Issue.4 , pp. 1303-1310
    • Lusso, P.1    Garzino-Demo, A.2    Crowley, R.W.3    Malnati, M.S.4
  • 37
    • 84863182935 scopus 로고    scopus 로고
    • Human herpesvirus 6A infects human embryonic fibroblasts and induces G2/M arrest and cell death
    • Li L, Gu B, Zhou F et al. Human herpesvirus 6A infects human embryonic fibroblasts and induces G2/M arrest and cell death. J. Med. Virol. 84(4), 657-663 (2012).
    • (2012) J. Med. Virol. , vol.84 , Issue.4 , pp. 657-663
    • Li, L.1    Gu, B.2    Zhou, F.3
  • 38
    • 66149153505 scopus 로고    scopus 로고
    • Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsets
    • Gupta S, Agrawal S, Gollapudi S. Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsets. J. Virol. 83(11), 5442-5450 (2009).
    • (2009) J. Virol. , vol.83 , Issue.11 , pp. 5442-5450
    • Gupta, S.1    Agrawal, S.2    Gollapudi, S.3
  • 39
    • 0025968894 scopus 로고
    • Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6
    • Lusso P, De Maria A, Malnati M et al. Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6. Nature 349(6309), 533-535 (1991).
    • (1991) Nature , vol.349 , Issue.6309 , pp. 533-535
    • Lusso, P.1    De Maria, A.2    Malnati, M.3
  • 40
    • 0038447910 scopus 로고    scopus 로고
    • Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo
    • Grivel JC, Santoro F, Chen S et al. Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J. Virol. 77(15), 8280-8289 (2003).
    • (2003) J. Virol. , vol.77 , Issue.15 , pp. 8280-8289
    • Grivel, J.C.1    Santoro, F.2    Chen, S.3
  • 41
    • 60649091271 scopus 로고    scopus 로고
    • Role of dendritic cells infected with human herpesvirus 6 in virus transmission to CD4+ T cells
    • Takemoto M, Imasawa T, Yamanishi K, Mori Y. Role of dendritic cells infected with human herpesvirus 6 in virus transmission to CD4+ T cells. Virology 385(2), 294-302 (2009).
    • (2009) Virology , vol.385 , Issue.2 , pp. 294-302
    • Takemoto, M.1    Imasawa, T.2    Yamanishi, K.3    Mori, Y.4
  • 42
    • 0031984784 scopus 로고    scopus 로고
    • Apoptosis of CD4+ T lymphocytes in human herpesvirus-6 infection
    • Yasukawa M, Inoue Y, Ohminami H, Terada K, Fujita S. Apoptosis of CD4+ T lymphocytes in human herpesvirus-6 infection. J. Gen. Virol. 79 (Pt 1), 143-147 (1998).
    • (1998) J. Gen. Virol. , vol.79 , Issue.PART 1 , pp. 143-147
    • Yasukawa, M.1    Inoue, Y.2    Ohminami, H.3    Terada, K.4    Fujita, S.5
  • 44
    • 13744251701 scopus 로고    scopus 로고
    • Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells
    • Oster B, Bundgaard B, Hollsberg P. Human herpesvirus 6B induces cell cycle arrest concomitant with p53 phosphorylation and accumulation in T cells. J. Virol. 79(3), 1961-1965 (2005).
    • (2005) J. Virol. , vol.79 , Issue.3 , pp. 1961-1965
    • Oster, B.1    Bundgaard, B.2    Hollsberg, P.3
  • 45
    • 1842854077 scopus 로고    scopus 로고
    • Productive human herpesvirus 6 infection causes aberrant accumulation of p53 and prevents apoptosis
    • Takemoto M, Mori Y, Ueda K, Kondo K, Yamanishi K. Productive human herpesvirus 6 infection causes aberrant accumulation of p53 and prevents apoptosis. J. Gen. Virol. 85(Pt 4), 869-879 (2004).
    • (2004) J. Gen. Virol. , vol.85 , Issue.PART 4 , pp. 869-879
    • Takemoto, M.1    Mori, Y.2    Ueda, K.3    Kondo, K.4    Yamanishi, K.5
  • 46
    • 80052074000 scopus 로고    scopus 로고
    • Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected cells in the G2/M phase
    • Li L, Gu B, Zhou F et al. Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected cells in the G2/M phase. J. Virol. 85(13), 6774-6783 (2011).
    • (2011) J. Virol. , vol.85 , Issue.13 , pp. 6774-6783
    • Li, L.1    Gu, B.2    Zhou, F.3
  • 47
    • 82355191617 scopus 로고    scopus 로고
    • The role of MAPK in CD4+ T cells Toll-like receptor 9-mediated signaling following HHV-6 infection
    • Chi J, Wang F, Li L et al. The role of MAPK in CD4+ T cells Toll-like receptor 9-mediated signaling following HHV-6 infection. Virology 422(1), 92-98 (2012).
    • (2012) Virology , vol.422 , Issue.1 , pp. 92-98
    • Chi, J.1    Wang, F.2    Li, L.3
  • 48
    • 37849048268 scopus 로고    scopus 로고
    • The U95 protein of human herpesvirus 6B interacts with human GRIM-19: Silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential
    • Yeo WM, Isegawa Y, Chow VT. The U95 protein of human herpesvirus 6B interacts with human GRIM-19: silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential. J. Virol. 82(2), 1011-1020 (2008).
    • (2008) J. Virol. , vol.82 , Issue.2 , pp. 1011-1020
    • Yeo, W.M.1    Isegawa, Y.2    Chow, V.T.3
  • 49
    • 33746150019 scopus 로고    scopus 로고
    • Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6
    • Janelle ME, Flamand L. Phenotypic alterations and survival of monocytes following infection by human herpesvirus-6. Arch. Virol. 151(8), 1603-1614 (2006).
    • (2006) Arch. Virol. , vol.151 , Issue.8 , pp. 1603-1614
    • Janelle, M.E.1    Flamand, L.2
  • 50
    • 0032905921 scopus 로고    scopus 로고
    • Induction of apoptosis in cord blood lymphocytes by HHV-6
    • Ichimi R, Jin-No T, Ito M. Induction of apoptosis in cord blood lymphocytes by HHV-6. J. Med. Virol. 58(1), 63-68 (1999).
    • (1999) J. Med. Virol. , vol.58 , Issue.1 , pp. 63-68
    • Ichimi, R.1    Jin-No, T.2    Ito, M.3
  • 51
    • 0025847781 scopus 로고
    • Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster
    • Liszewski MK, Post TW, Atkinson JP. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9, 431-455 (1991).
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 431-455
    • Liszewski, M.K.1    Post, T.W.2    Atkinson, J.P.3
  • 52
    • 0027184631 scopus 로고
    • Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus
    • Naniche D, Varior-Krishnan G, Cervoni F et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67(10), 6025-6032 (1993).
    • (1993) J. Virol. , vol.67 , Issue.10 , pp. 6025-6032
    • Naniche, D.1    Varior-Krishnan, G.2    Cervoni, F.3
  • 53
    • 0037131262 scopus 로고    scopus 로고
    • Human Herpesvirus 6 and measles virus employ distinct CD46 domains for receptor function
    • Greenstone HL, Santoro F, Lusso P, Berger EA. Human Herpesvirus 6 and measles virus employ distinct CD46 domains for receptor function. J. Bio. Chem. 277(42), 39112-39118 (2002).
    • (2002) J. Bio. Chem. , vol.277 , Issue.42 , pp. 39112-39118
    • Greenstone, H.L.1    Santoro, F.2    Lusso, P.3    Berger, E.A.4
  • 54
    • 0037830588 scopus 로고    scopus 로고
    • Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46
    • Santoro F, Greenstone HL, Insinga A et al. Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. J. Bio. Chem. 278(28), 25964-25969 (2003).
    • (2003) J. Bio. Chem. , vol.278 , Issue.28 , pp. 25964-25969
    • Santoro, F.1    Greenstone, H.L.2    Insinga, A.3
  • 55
    • 0037321973 scopus 로고    scopus 로고
    • The human herpesvirus 6 U100 gene product is the third component of the gH-gL glycoprotein complex on the viral envelope
    • Mori Y, Akkapaiboon P, Yang X, Yamanishi K. The human herpesvirus 6 U100 gene product is the third component of the gH-gL glycoprotein complex on the viral envelope. J. Virol. 77(4), 2452-2458 (2003).
    • (2003) J. Virol. , vol.77 , Issue.4 , pp. 2452-2458
    • Mori, Y.1    Akkapaiboon, P.2    Yang, X.3    Yamanishi, K.4
  • 56
    • 13944254323 scopus 로고    scopus 로고
    • Viral replication-independent blockade of dendritic cell maturation and interleukin-12 production by human herpesvirus 6
    • Smith AP, Paolucci C, Di Lullo G, Burastero SE, Santoro F, Lusso P. Viral replication-independent blockade of dendritic cell maturation and interleukin-12 production by human herpesvirus 6. J. Virol. 79(5), 2807-2813 (2005).
    • (2005) J. Virol. , vol.79 , Issue.5 , pp. 2807-2813
    • Smith, A.P.1    Paolucci, C.2    Di Lullo, G.3    Burastero, S.E.4    Santoro, F.5    Lusso, P.6
  • 57
    • 33646115689 scopus 로고    scopus 로고
    • Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells
    • Niiya H, Lei J, Guo Y et al. Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells. Exp. Hematol. 34(5), 642-653 (2006).
    • (2006) Exp. Hematol. , vol.34 , Issue.5 , pp. 642-653
    • Niiya, H.1    Lei, J.2    Guo, Y.3
  • 58
    • 0347895101 scopus 로고    scopus 로고
    • Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    • Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421(6921), 388-392 (2003).
    • (2003) Nature , vol.421 , Issue.6921 , pp. 388-392
    • Kemper, C.1    Chan, A.C.2    Green, J.M.3    Brett, K.A.4    Murphy, K.M.5    Atkinson, J.P.6
  • 59
    • 33750366566 scopus 로고    scopus 로고
    • Human herpesvirus-6-specific interleukin 10-producing CD4+ T cells suppress the CD4+ T-cell response in infected individuals
    • Wang F, Yao K, Yin QZ et al. Human herpesvirus-6-specific interleukin 10-producing CD4+ T cells suppress the CD4+ T-cell response in infected individuals. Microbiol. Immunol. 50(10), 787-803 (2006).
    • (2006) Microbiol. Immunol. , vol.50 , Issue.10 , pp. 787-803
    • Wang, F.1    Yao, K.2    Yin, Q.Z.3
  • 60
    • 0036281966 scopus 로고    scopus 로고
    • Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46
    • Mori Y, Seya T, Huang HL, Akkapaiboon P, Dhepakson P, Yamanishi K. Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J. Virol. 76(13), 6750-6761 (2002).
    • (2002) J. Virol. , vol.76 , Issue.13 , pp. 6750-6761
    • Mori, Y.1    Seya, T.2    Huang, H.L.3    Akkapaiboon, P.4    Dhepakson, P.5    Yamanishi, K.6
  • 61
    • 0028946673 scopus 로고
    • Measles virus-induced down-regulation of CD46 is associated with enhanced sensitivity to complement-mediated lysis of infected cells
    • Schnorr JJ, Dunster LM, Nanan R, Schneider-Schaulies J, Schneider-Schaulies S, Ter Meulen V. Measles virus-induced down-regulation of CD46 is associated with enhanced sensitivity to complement-mediated lysis of infected cells. Eur. J. Immunol. 25(4), 976-984 (1995).
    • (1995) Eur. J. Immunol. , vol.25 , Issue.4 , pp. 976-984
    • Schnorr, J.J.1    Dunster, L.M.2    Nanan, R.3    Schneider-Schaulies, J.4    Schneider-Schaulies, S.5    Ter Meulen, V.6
  • 62
    • 4544377425 scopus 로고    scopus 로고
    • Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells
    • Niiya H, Azuma T, Jin L et al. Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells. J. Gen. Virol. 85(Pt 9), 2639-2642 (2004).
    • (2004) J. Gen. Virol. , vol.85 , Issue.PART 9 , pp. 2639-2642
    • Niiya, H.1    Azuma, T.2    Jin, L.3
  • 63
    • 0028305851 scopus 로고
    • Induction of G protein-coupled peptide receptor EBI 1 by human herpesvirus 6 and 7 infection in CD4+ T cells
    • Hasegawa H, Utsunomiya Y, Yasukawa M, Yanagisawa K, Fujita S. Induction of G protein-coupled peptide receptor EBI 1 by human herpesvirus 6 and 7 infection in CD4+ T cells. J. Virol. 68(8), 5326-5329 (1994).
    • (1994) J. Virol. , vol.68 , Issue.8 , pp. 5326-5329
    • Hasegawa, H.1    Utsunomiya, Y.2    Yasukawa, M.3    Yanagisawa, K.4    Fujita, S.5
  • 64
    • 0034798122 scopus 로고    scopus 로고
    • Human herpesvirus 6 downregulates major histocompatibility complex class i in dendritic cells
    • Hirata Y, Kondo K, Yamanishi K. Human herpesvirus 6 downregulates major histocompatibility complex class I in dendritic cells. J. Med. Virol. 65(3), 576-583 (2001).
    • (2001) J. Med. Virol. , vol.65 , Issue.3 , pp. 576-583
    • Hirata, Y.1    Kondo, K.2    Yamanishi, K.3
  • 65
    • 34250165758 scopus 로고    scopus 로고
    • Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class i MHC molecules
    • Glosson NL, Hudson AW. Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class I MHC molecules. Virology 365(1), 125-135 (2007).
    • (2007) Virology , vol.365 , Issue.1 , pp. 125-135
    • Glosson, N.L.1    Hudson, A.W.2
  • 66
    • 37849017715 scopus 로고    scopus 로고
    • Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein
    • Sullivan BM, Coscoy L. Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein. J. Virol. 82(2), 602-608 (2008).
    • (2008) J. Virol. , vol.82 , Issue.2 , pp. 602-608
    • Sullivan, B.M.1    Coscoy, L.2
  • 67
    • 0031686753 scopus 로고    scopus 로고
    • CD4 promoter transactivation by human herpesvirus 6
    • Flamand L, Romerio F, Reitz MS, Gallo RC. CD4 promoter transactivation by human herpesvirus 6. J. Virology 72(11), 8797-8805 (1998).
    • (1998) J. Virology , vol.72 , Issue.11 , pp. 8797-8805
    • Flamand, L.1    Romerio, F.2    Reitz, M.S.3    Gallo, R.C.4
  • 68
    • 0028944399 scopus 로고
    • Immunosuppressive effect of human herpesvirus 6 on T-cell functions: Suppression of interleukin-2 synthesis and cell proliferation
    • Flamand L, Gosselin J, Stefanescu I, Ablashi D, Menezes J. Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation. Blood 85(5), 1263-1271 (1995).
    • (1995) Blood , vol.85 , Issue.5 , pp. 1263-1271
    • Flamand, L.1    Gosselin, J.2    Stefanescu, I.3    Ablashi, D.4    Menezes, J.5
  • 69
    • 0029884143 scopus 로고    scopus 로고
    • Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2
    • Inagi R, Guntapong R, Nakao M et al. Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2. J. Med. Virol. 49(1), 34-40 (1996).
    • (1996) J. Med. Virol. , vol.49 , Issue.1 , pp. 34-40
    • Inagi, R.1    Guntapong, R.2    Nakao, M.3
  • 70
    • 0035158948 scopus 로고    scopus 로고
    • Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: Induction of proinflammatory mechanisms
    • Mayne M, Cheadle C, Soldan SS et al. Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms. J. Virol. 75(23), 11641-11650 (2001).
    • (2001) J. Virol. , vol.75 , Issue.23 , pp. 11641-11650
    • Mayne, M.1    Cheadle, C.2    Soldan, S.S.3
  • 71
    • 84867512112 scopus 로고    scopus 로고
    • Human herpesvirus 6 latent infection in patients with glioma
    • Chi J, Gu B, Zhang C et al. Human herpesvirus 6 latent infection in patients with glioma. J. Infect. Dis. 206(9), 1394-1398 (2012).
    • (2012) J. Infect. Dis. , vol.206 , Issue.9 , pp. 1394-1398
    • Chi, J.1    Gu, B.2    Zhang, C.3
  • 72
    • 84861312490 scopus 로고    scopus 로고
    • Human CD4+ T cell response to human herpesvirus 6
    • Nastke MD, Becerra A, Yin L et al. Human CD4+ T cell response to human herpesvirus 6. J. Virol. 86(9), 4776-4792 (2012).
    • (2012) J. Virol. , vol.86 , Issue.9 , pp. 4776-4792
    • Nastke, M.D.1    Becerra, A.2    Yin, L.3
  • 73
    • 77955982744 scopus 로고    scopus 로고
    • Mechanism of neuroinflammation: Enhanced cytotoxicity and IL-17 production via CD46 binding
    • Yao K, Graham J, Akahata Y, Oh U, Jacobson S. Mechanism of neuroinflammation: enhanced cytotoxicity and IL-17 production via CD46 binding. J. Neuroimmune Pharmacol. 5(3), 469-478 (2010).
    • (2010) J. Neuroimmune Pharmacol. , vol.5 , Issue.3 , pp. 469-478
    • Yao, K.1    Graham, J.2    Akahata, Y.3    Oh, U.4    Jacobson, S.5
  • 74
    • 0038700534 scopus 로고    scopus 로고
    • Human herpesvirus-6 modulates RANTES production in primary human endothelial cell cultures
    • Caruso A, Favilli F, Rotola A et al. Human herpesvirus-6 modulates RANTES production in primary human endothelial cell cultures. J. Med. Virol. 70(3), 451-458 (2003).
    • (2003) J. Med. Virol. , vol.70 , Issue.3 , pp. 451-458
    • Caruso, A.1    Favilli, F.2    Rotola, A.3
  • 75
    • 34249776953 scopus 로고    scopus 로고
    • Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein
    • Jaworska J, Gravel A, Fink K, Grandvaux N, Flamand L. Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein. J. Virol. 81(11), 5737-5748 (2007).
    • (2007) J. Virol. , vol.81 , Issue.11 , pp. 5737-5748
    • Jaworska, J.1    Gravel, A.2    Fink, K.3    Grandvaux, N.4    Flamand, L.5
  • 76
    • 77956588686 scopus 로고    scopus 로고
    • Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy
    • Kawabe S, Ito Y, Ohta R et al. Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy. J. Med. Virol. 82(8), 1410-1415 (2010).
    • (2010) J. Med. Virol. , vol.82 , Issue.8 , pp. 1410-1415
    • Kawabe, S.1    Ito, Y.2    Ohta, R.3
  • 77
    • 84868135879 scopus 로고    scopus 로고
    • Specific CD8+ T cells recognize human herpesvirus 6B
    • Martin LK, Schub A, Dillinger S, Moosmann A. Specific CD8+ T cells recognize human herpesvirus 6B. Eur. J. Immunol. 42(11), 2901-2912 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , Issue.11 , pp. 2901-2912
    • Martin, L.K.1    Schub, A.2    Dillinger, S.3    Moosmann, A.4
  • 78
    • 78650927641 scopus 로고    scopus 로고
    • Kinetics of cytokine and chemokine responses in patients with primary human herpesvirus 6 infection
    • Yoshikawa T, Kato Y, Ihira M et al. Kinetics of cytokine and chemokine responses in patients with primary human herpesvirus 6 infection. J. Clin. Virol. 50(1), 65-68 (2011).
    • (2011) J. Clin. Virol. , vol.50 , Issue.1 , pp. 65-68
    • Yoshikawa, T.1    Kato, Y.2    Ihira, M.3
  • 79
    • 0034162736 scopus 로고    scopus 로고
    • RANTES binding and down-regulation by a novel human herpesvirus-6 beta chemokine receptor
    • Milne RS, Mattick C, Nicholson L, Devaraj P, Alcami A, Gompels UA. RANTES binding and down-regulation by a novel human herpesvirus-6 beta chemokine receptor. J. Immunol. 164(5), 2396-2404 (2000).
    • (2000) J. Immunol. , vol.164 , Issue.5 , pp. 2396-2404
    • Milne, R.S.1    Mattick, C.2    Nicholson, L.3    Devaraj, P.4    Alcami, A.5    Gompels, U.A.6
  • 80
    • 0033568367 scopus 로고    scopus 로고
    • Novel, nonconsensus cellular splicing regulates expression of a gene encoding a chemokine-like protein that shows high variation and is specific for human herpesvirus 6
    • French C, Menegazzi P, Nicholson L, Macaulay H, Diluca D, Gompels UA. Novel, nonconsensus cellular splicing regulates expression of a gene encoding a chemokine-like protein that shows high variation and is specific for human herpesvirus 6. Virology 262(1), 139-151 (1999).
    • (1999) Virology , vol.262 , Issue.1 , pp. 139-151
    • French, C.1    Menegazzi, P.2    Nicholson, L.3    Macaulay, H.4    Diluca, D.5    Gompels, U.A.6
  • 81
    • 0031747583 scopus 로고    scopus 로고
    • Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor
    • Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K. Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. J. Virol. 72(7), 6104-6112 (1998).
    • (1998) J. Virol. , vol.72 , Issue.7 , pp. 6104-6112
    • Isegawa, Y.1    Ping, Z.2    Nakano, K.3    Sugimoto, N.4    Yamanishi, K.5
  • 82
    • 0032991719 scopus 로고    scopus 로고
    • Human herpesvirus 6 open reading frame U83 encodes a functional chemokine
    • Zou P, Isegawa Y, Nakano K, Haque M, Horiguchi Y, Yamanishi K. Human herpesvirus 6 open reading frame U83 encodes a functional chemokine. J. Virol. 73(7), 5926-5933 (1999).
    • (1999) J. Virol. , vol.73 , Issue.7 , pp. 5926-5933
    • Zou, P.1    Isegawa, Y.2    Nakano, K.3    Haque, M.4    Horiguchi, Y.5    Yamanishi, K.6
  • 83
    • 43649102882 scopus 로고    scopus 로고
    • Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes
    • Catusse J, Spinks J, Mattick C et al. Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes. Eur. J. Immunol. 38(3), 763-777 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , Issue.3 , pp. 763-777
    • Catusse, J.1    Spinks, J.2    Mattick, C.3
  • 84
    • 33644848660 scopus 로고    scopus 로고
    • Chemokine-directed trafficking of receptor stimulus to different g proteins: Selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51
    • Fitzsimons CP, Gompels UA, Verzijl D et al. Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51. Mol. Pharmacol. 69(3), 888-898 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , Issue.3 , pp. 888-898
    • Fitzsimons, C.P.1    Gompels, U.A.2    Verzijl, D.3
  • 85
    • 24644465000 scopus 로고    scopus 로고
    • The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro
    • Zhen Z, Bradel-Tretheway B, Sumagin S, Bidlack JM, Dewhurst S. The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro. J. Virol. 79(18), 11914-11924 (2005).
    • (2005) J. Virol. , vol.79 , Issue.18 , pp. 11914-11924
    • Zhen, Z.1    Bradel-Tretheway, B.2    Sumagin, S.3    Bidlack, J.M.4    Dewhurst, S.5
  • 87
    • 34247350370 scopus 로고    scopus 로고
    • Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization
    • Catusse J, Parry CM, Dewin DR, Gompels UA. Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization. Blood 109(9), 3633-3639 (2007).
    • (2007) Blood , vol.109 , Issue.9 , pp. 3633-3639
    • Catusse, J.1    Parry, C.M.2    Dewin, D.R.3    Gompels, U.A.4
  • 88
    • 29644445595 scopus 로고    scopus 로고
    • Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform
    • Dewin DR, Catusse J, Gompels UA. Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform. J. Immunol. 176(1), 544-556 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.1 , pp. 544-556
    • Dewin, D.R.1    Catusse, J.2    Gompels, U.A.3
  • 89
    • 79960280196 scopus 로고    scopus 로고
    • Autoimmune hemolytic anemia and autoimmune neutropenia in a child with erythroblastopenia of childhood (TEC) caused by human herpesvirus-6 (HHV-6)
    • Yagasaki H, Kato M, Shimizu N, Shichino H, Chin M, Mugishima H. Autoimmune hemolytic anemia and autoimmune neutropenia in a child with erythroblastopenia of childhood (TEC) caused by human herpesvirus-6 (HHV-6). Ann. Hematol. 90(7), 851-852 (2011).
    • (2011) Ann. Hematol. , vol.90 , Issue.7 , pp. 851-852
    • Yagasaki, H.1    Kato, M.2    Shimizu, N.3    Shichino, H.4    Chin, M.5    Mugishima, H.6
  • 90
    • 84868136851 scopus 로고    scopus 로고
    • Severe hepatitis with autoimmune features following a HHV-6: A case report
    • Grima P, Chiavaroli R, Calabrese P, Tundo P, Grima P. Severe hepatitis with autoimmune features following a HHV-6: a case report. Cases J. 1(1), 110 (2008).
    • (2008) Cases J. , vol.1 , Issue.1 , pp. 110
    • Grima, P.1    Chiavaroli, R.2    Calabrese, P.3    Tundo, P.4    Grima, P.5
  • 91
    • 0037309220 scopus 로고    scopus 로고
    • Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis
    • Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Ann. Neurol. 53(2), 189-197 (2003).
    • (2003) Ann. Neurol , vol.53 , Issue.2 , pp. 189-197
    • Tejada-Simon, M.V.1    Zang, Y.C.2    Hong, J.3    Rivera, V.M.4    Zhang, J.Z.5
  • 92
    • 67949099185 scopus 로고    scopus 로고
    • Reactivation of human herpesvirus 6 (HHV 6) infection in patients with connective tissue diseases
    • Broccolo F, Drago F, Paolino S et al. Reactivation of human herpesvirus 6 (HHV 6) infection in patients with connective tissue diseases. J. Clin. Virol. 46(1), 43-46 (2009).
    • (2009) J. Clin. Virol. , vol.46 , Issue.1 , pp. 43-46
    • Broccolo, F.1    Drago, F.2    Paolino, S.3
  • 93
    • 84868096065 scopus 로고    scopus 로고
    • Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto's thyroiditis
    • Caselli E, Zatelli MC, Rizzo R et al. Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto's thyroiditis. PLoS Pathog. 8(10), e1002951 (2012).
    • (2012) PLoS Pathog , vol.8 , Issue.10
    • Caselli, E.1    Zatelli, M.C.2    Rizzo, R.3
  • 94
    • 0025848879 scopus 로고
    • Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseases
    • Krueger GR, Sander C, Hoffmann A, Barth A, Koch B, Braun M. Isolation of human herpesvirus-6 (HHV-6) from patients with collagen vascular diseases. In Vivo 5(3), 217-225 (1991).
    • (1991) Vivo , vol.5 , Issue.3 , pp. 217-225
    • Krueger, G.R.1    Sander, C.2    Hoffmann, A.3    Barth, A.4    Koch, B.5    Braun, M.6
  • 95
    • 34548022324 scopus 로고    scopus 로고
    • HHV-6 and the immune system: Mechanisms of immunomodulation and viral escape
    • Lusso P. HHV-6 and the immune system: mechanisms of immunomodulation and viral escape. J. Clin. Virol. 37(Suppl. 1), S4-10 (2006).
    • (2006) J. Clin. Virol , vol.37 , Issue.SUPPL. 1
    • Lusso, P.1
  • 96
    • 34548015191 scopus 로고    scopus 로고
    • Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients
    • Alvarez-Lafuente R, Garcia-Montojo M, De Las Heras V, Bartolome M, Arroyo R. Clinical parameters and HHV-6 active replication in relapsing-remitting multiple sclerosis patients. J. Clin. Virol. 37(Suppl. 1), S24-S26 (2006).
    • (2006) J. Clin. Virol. , vol.37 , Issue.SUPPL. 1
    • Alvarez-Lafuente, R.1    Garcia-Montojo, M.2    De Las Heras, V.3    Bartolome, M.4    Arroyo, R.5
  • 97
    • 15944363765 scopus 로고    scopus 로고
    • Co localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue
    • Virtanen JO, Zabriskie JB, Siren V et al. Co localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue. Med. Sci. Monit. 11(3), BR84-BR87 (2005).
    • (2005) Med. Sci. Monit. , vol.11 , Issue.3
    • Virtanen, J.O.1    Zabriskie, J.B.2    Siren, V.3
  • 98
    • 0032728026 scopus 로고    scopus 로고
    • The association of the human herpesvirus-6 and MS
    • Friedman JE, Lyons MJ, Cu G et al. The association of the human herpesvirus-6 and MS. Mult. Scler. 5(5), 355-362 (1999).
    • (1999) Mult. Scler. , vol.5 , Issue.5 , pp. 355-362
    • Friedman, J.E.1    Lyons, M.J.2    Cu, G.3
  • 99
    • 0029142819 scopus 로고
    • Plaque-associated expression of human herpesvirus 6 in multiple sclerosis
    • Challoner PB, Smith KT, Parker JD et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc. Natl Acad. Sci. USA 92(16), 7440-7444 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , Issue.16 , pp. 7440-7444
    • Challoner, P.B.1    Smith, K.T.2    Parker, J.D.3
  • 100
    • 0033791290 scopus 로고    scopus 로고
    • Tissue distribution and variant characterization of human herpesvirus (HHV)-6: Increased prevalence of HHV-6A in patients with multiple sclerosis
    • Akhyani N, Berti R, Brennan MB et al. Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis. J. Infect. Dis. 182(5), 1321-1325 (2000).
    • (2000) J. Infect. Dis. , vol.182 , Issue.5 , pp. 1321-1325
    • Akhyani, N.1    Berti, R.2    Brennan, M.B.3
  • 101
  • 102
    • 4344618797 scopus 로고    scopus 로고
    • Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease
    • Rotola A, Merlotti I, Caniatti L et al. Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease. Mult. Scler. 10(4), 348-354 (2004).
    • (2004) Mult. Scler , vol.10 , Issue.4 , pp. 348-354
    • Rotola, A.1    Merlotti, I.2    Caniatti, L.3
  • 103
    • 0034057501 scopus 로고    scopus 로고
    • Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients
    • Ablashi DV, Eastman HB, Owen CB et al. Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients. J. Clin. Virol. 16(3), 179-191 (2000).
    • (2000) J. Clin. Virol , vol.16 , Issue.3 , pp. 179-191
    • Ablashi, D.V.1    Eastman, H.B.2    Owen, C.B.3
  • 104
    • 0027255071 scopus 로고
    • Human herpesvirus 6 and multiple sclerosis: Survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction
    • Sola P, Merelli E, Marasca R et al. Human herpesvirus 6 and multiple sclerosis: survey of anti-HHV-6 antibodies by immunofluorescence analysis and of viral sequences by polymerase chain reaction. J. Neurol. Neurosurg. Psychiatry 56(8), 917-919 (1993).
    • (1993) J. Neurol. Neurosurg. Psychiatry , vol.56 , Issue.8 , pp. 917-919
    • Sola, P.1    Merelli, E.2    Marasca, R.3
  • 106
    • 17444453701 scopus 로고    scopus 로고
    • Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA
    • Soldan SS, Berti R, Salem N et al. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat. Med. 3(12), 1394-1397 (1997).
    • (1997) Nat. Med. , vol.3 , Issue.12 , pp. 1394-1397
    • Soldan, S.S.1    Berti, R.2    Salem, N.3
  • 107
    • 0036841708 scopus 로고    scopus 로고
    • Detection of antibodies directed against human herpesvirus 6 U94/REP in sera of patients affected by multiple sclerosis
    • Caselli E, Boni M, Bracci A et al. Detection of antibodies directed against human herpesvirus 6 U94/REP in sera of patients affected by multiple sclerosis. J. Clin. Microbiol. 40(11), 4131-4137 (2002).
    • (2002) J. Clin. Microbiol , vol.40 , Issue.11 , pp. 4131-4137
    • Caselli, E.1    Boni, M.2    Bracci, A.3
  • 108
    • 84873684527 scopus 로고    scopus 로고
    • Prevalence of human herpesvirus U94/REP antibodies and DNA in Tunisian multiple sclerosis patients
    • Ben-Fredj N, Ben-Selma W, Rotola A et al. Prevalence of human herpesvirus U94/REP antibodies and DNA in Tunisian multiple sclerosis patients. J. Neurovirol. 19(1), 42-47 (2013).
    • (2013) J. Neurovirol. , vol.19 , Issue.1 , pp. 42-47
    • Ben-Fredj, N.1    Ben-Selma, W.2    Rotola, A.3
  • 109
    • 84861795775 scopus 로고    scopus 로고
    • Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis
    • Simpson S, Jr., Taylor B, Dwyer DE et al. Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis. Mult. Scler. 18(6), 799-806 (2012).
    • (2012) Mult. Scler , vol.18 , Issue.6 , pp. 799-806
    • Simpson Jr., S.1    Taylor, B.2    Dwyer, D.E.3
  • 110
    • 0036779194 scopus 로고    scopus 로고
    • Human herpesvirus 6 and multiple sclerosis: A study of T cell cross-reactivity to viral and myelin basic protein antigens
    • Cirone M, Cuomo L, Zompetta C et al. Human herpesvirus 6 and multiple sclerosis: a study of T cell cross-reactivity to viral and myelin basic protein antigens. J. Med. Virol. 68(2), 268-272 (2002).
    • (2002) J. Med. Virol. , vol.68 , Issue.2 , pp. 268-272
    • Cirone, M.1    Cuomo, L.2    Zompetta, C.3
  • 111
    • 81255187863 scopus 로고    scopus 로고
    • Herpesvirus active replication in multiple sclerosis: A genetic control?
    • Garcia-Montojo M, Martinez A, De Las Heras V et al. Herpesvirus active replication in multiple sclerosis: a genetic control? J. Neurol. Sci. 311(1-2), 98-102 (2011).
    • (2011) J. Neurol. Sci. , vol.311 , Issue.1-2 , pp. 98-102
    • Garcia-Montojo, M.1    Martinez, A.2    De Las Heras, V.3
  • 112
    • 84866548088 scopus 로고    scopus 로고
    • MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up
    • Dominguez-Mozo MI, Garcia-Montojo M, De Las Heras V et al. MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up. BMC Neurol. 12(1), 107 (2012).
    • (2012) BMC Neurol. , vol.12 , Issue.1 , pp. 107
    • Dominguez-Mozo, M.I.1    Garcia-Montojo, M.2    De Las Heras, V.3
  • 113
    • 0034796166 scopus 로고    scopus 로고
    • Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis
    • Soldan SS, Fogdell-Hahn A, Brennan MB et al. Elevated serum and cerebrospinal fluid levels of soluble human herpesvirus type 6 cellular receptor, membrane cofactor protein, in patients with multiple sclerosis. Ann. Neurol. 50(4), 486-493 (2001).
    • (2001) Ann. Neurol , vol.50 , Issue.4 , pp. 486-493
    • Soldan, S.S.1    Fogdell-Hahn, A.2    Brennan, M.B.3
  • 114
    • 35848964590 scopus 로고    scopus 로고
    • Abnormal Tr1 differentiation in multiple sclerosis
    • Astier AL, Hafler DA. Abnormal Tr1 differentiation in multiple sclerosis. J. Neuroimmunol. 191(1-2), 70-78 (2007).
    • (2007) J. Neuroimmunol. , vol.191 , Issue.1-2 , pp. 70-78
    • Astier, A.L.1    Hafler, D.A.2
  • 115
    • 80053394440 scopus 로고    scopus 로고
    • CD46 in a Spanish cohort of multiple sclerosis patients: Genetics, mRNA expression and response to interferon-beta treatment
    • Alvarez-Lafuente R, Blanco-Kelly F, Garcia-Montojo M et al. CD46 in a Spanish cohort of multiple sclerosis patients: genetics, mRNA expression and response to interferon-beta treatment. Mult. Scler. 17(5), 513-520 (2011).
    • (2011) Mult. Scler , vol.17 , Issue.5 , pp. 513-520
    • Alvarez-Lafuente, R.1    Blanco-Kelly, F.2    Garcia-Montojo, M.3
  • 116
    • 17444375727 scopus 로고    scopus 로고
    • Co-purification of soluble membrane cofactor protein (CD46) and human herpesvirus 6 variant A genome in serum from multiple sclerosis patients
    • Fogdell-Hahn A, Soldan SS, Shue S et al. Co-purification of soluble membrane cofactor protein (CD46) and human herpesvirus 6 variant A genome in serum from multiple sclerosis patients. Virus Res. 110(1-2), 57-63 (2005).
    • (2005) Virus Res. , vol.110 , Issue.1-2 , pp. 57-63
    • Fogdell-Hahn, A.1    Soldan, S.S.2    Shue, S.3
  • 117


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