The role of MAPK in CD4 + T cells toll-like receptor 9-mediated signaling following HHV-6 infection

Virology

Volumn 422, Issue 1, 2012, Pages 92-98

  Chi, Jing ^a   Wang, Fang ^b   Li, Lingyun ^a   Feng, Dongju ^a   Qin, Jian ^c   Xie, Fangyi ^a   Zhou, Feng ^a   Chen, Yun ^a   Wang, Jinfeng ^a   Yao, Kun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c HOHAI UNIVERSITY   (China)

Author keywords

Human herpesvirus 6; Mitogen activated protein kinase; Toll like receptor 9

Indexed keywords

INTERLEUKIN 6; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; IN VITRO STUDY; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANNEXIN A5; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL PROLIFERATION; HERPESVIRUS 6, HUMAN; HUMANS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; RNA, VIRAL; ROSEOLOVIRUS INFECTIONS; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA;

HUMAN HERPESVIRUS 6;

EID: 82355191617     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.09.026     Document Type: Article

References (44)

1. Akula S.M., Ford P.W., Whitman A.G., Hamden K.E., Shelton J.G., McCubrey J.A. Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection. Oncogene 2004, 23(30):5227-5241.
2. Bernasconi N.L., Onai N., Lanzavecchia A. A role for toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003, 101(11):4500-4504.
3. Bonny C., Oberson A., Negri S., Sauser C., Schorderet D.F. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 2001, 50(1):77-82.
4. Campadelli-Fiume G., Mirandola P., Menotti L. Human herpesvirus 6: an emerging pathogen. Emerg. Infect. Dis. 1999, 5(3):353-366.
5. Dhepakson P., Mori Y., Jiang Y.B., Huang H.L., Akkapaiboon P., Okuno T., Yamanishi K. Human herpesvirus-6 rep/U94 gene product has single-stranded DNA-binding activity. J. Gen. Virol. 2002, 83(Pt 4):847-854.
6. Fischer M., Ehlers M. Toll-like receptors in autoimmunity. Ann. N. Y. Acad. Sci. 2008, 1143:21-34.
7. Gaur P., Munjhal A., Lal S.K. Influenza virus and cell signaling pathways. Med. Sci. Monit. 2011, 17(6):RA148-RA154.
8. Gupta S., Campbell D., Derijard B., Davis R.J. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995, 267(5196):389-393.
9. Hall S.J., Canfield S.E., Yan Y., Hassen W., Selleck W.A., Chen S.H. A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer. Gene Ther. 2002, 9(8):511-517.
10. Hayashi F., Means T.K., Luster A.D. Toll-like receptors stimulate human neutrophil function. Blood 2003, 102(7):2660-2669.
11. Henkart P.A. ICE family proteases: mediators of all apoptotic cell death?. Immunity 1996, 4(3):195-201.
12. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., Endres S., Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002, 168(9):4531-4537.
13. Ichimi R., Jin-no T., Ito M. Induction of apoptosis in cord blood lymphocytes by HHV-6. J. Med. Virol. 1999, 58(1):63-68.
14. Inoue Y., Yasukawa M., Fujita S. Induction of T-cell apoptosis by human herpesvirus 6. J. Virol. 1997, 71(5):3751-3759.
15. Janssens S., Beyaert R. Role of toll-like receptors in pathogen recognition. Clin. Microbiol. Rev. 2003, 16(4):637-646.
16. Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Curr. Opin. Immunol. 2007, 19(1):39-45.
17. Krug A., Towarowski A., Britsch S., Rothenfusser S., Hornung V., Bals R., Giese T., Engelmann H., Endres S., Krieg A.M., Hartmann G. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 2001, 31(10):3026-3037.
18. Kumar A., Manna S.K., Dhawan S., Aggarwal B.B. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1. J. Immunol. 1998, 161(2):776-781.
19. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994, 369(6476):156-160.
20. Lehmann M., Jiang C., Ip Y.T., Thummel C.S. AP-1, but not NF-kappa B, is required for efficient steroid-triggered cell death in Drosophila. Cell Death Differ. 2002, 9(5):581-590.
21. Leppa S., Bohmann D. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene 1999, 18(45):6158-6162.
22. Li L., Gu B., Zhou F., Chi J., Wang F., Peng G., Xie F., Qing J., Feng D., Lu S., Yao K. Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected Cells in the G2/M phase. J. Virol. 2011, 85(13):6774-6783.
23. Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 2003, 25(1):17-24.
24. Liu J., Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 2005, 15(1):36-42.
25. Lusso P. HHV-6 and the immune system: mechanisms of immunomodulation and viral escape. J. Clin. Virol. 2006, 37(Suppl. 1):S4-S10.
26. Mc Gee M.M., Campiani G., Ramunno A., Nacci V., Lawler M., Williams D.C., Zisterer D.M. Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells. J. Biol. Chem. 2002, 277(21):18383-18389.
27. McCluskie M.J., Cartier J.L., Patrick A.J., Sajic D., Weeratna R.D., Rosenthal K.L., Davis H.L. Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848). Antiviral Res. 2006, 69(2):77-85.
28. Murakami Y., Tanimoto K., Fujiwara H., An J., Suemori K., Ochi T., Hasegawa H., Yasukawa M. Human herpesvirus 6 infection impairs toll-like receptor signaling. Virol. J. 2010, 7:91.
29. Raftery M.J., Behrens C.K., Muller A., Krammer P.H., Walczak H., Schonrich G. Herpes simplex virus type 1 infection of activated cytotoxic T cells: induction of fratricide as a mechanism of viral immune evasion. J. Exp. Med. 1999, 190(8):1103-1114.
30. Rodems S.M., Spector D.H. Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection. J. Virol. 1998, 72(11):9173-9180.
31. Salahuddin S.Z., Ablashi D.V., Markham P.D., Josephs S.F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B., et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986, 234(4776):596-601.
32. Samuelsson C., Hausmann J., Lauterbach H., Schmidt M., Akira S., Wagner H., Chaplin P., Suter M., O'Keeffe M., Hochrein H. Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection. J. Clin. Invest. 2008, 118(5):1776-1784.
33. Sedger L.M., Shows D.M., Blanton R.A., Peschon J.J., Goodwin R.G., Cosman D., Wiley S.R. IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression. J. Immunol. 1999, 163(2):920-926.
34. Shaulian E., Karin M. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 2002, 4(5):E131-E136.
35. Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., Beutler B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U. S. A. 2004, 101(10):3516-3521.
36. Takeda K., Kaisho T., Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003, 21:335-376.
37. Takeuchi O., Akira S. Signaling pathways activated by microorganisms. Curr. Opin. Cell Biol. 2007, 19(2):185-191.
38. Thompson A.J., Locarnini S.A. Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol. Cell Biol. 2007, 85(6):435-445.
39. Xu X.N., Laffert B., Screaton G.R., Kraft M., Wolf D., Kolanus W., Mongkolsapay J., McMichael A.J., Baur A.S. Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain. J. Exp. Med. 1999, 189(9):1489-1496.
40. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988, 1(8594):1065-1067.
41. Yasukawa M., Inoue Y., Ohminami H., Terada K., Fujita S. Apoptosis of CD4+ T lymphocytes in human herpesvirus-6 infection. J. Gen. Virol. 1998, 79(Pt 1):143-147.
42. Yeh C.J., Lin P.Y., Liao M.H., Liu H.J., Lee J.W., Chiu S.J., Hsu H.Y., Shih W.L. TNF-alpha mediates pseudorabies virus-induced apoptosis via the activation of p38 MAPK and JNK/SAPK signaling. Virology 2008, 381(1):55-66.
43. Zachos G., Clements B., Conner J. Herpes simplex virus type 1 infection stimulates p38/c-Jun N-terminal mitogen-activated protein kinase pathways and activates transcription factor AP-1. J. Biol. Chem. 1999, 274(8):5097-5103.
44. Zhu J., Mohan C. Toll-like receptor signaling pathways-therapeutic opportunities. Mediators Inflamm. 2010, 2010:781235.