Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

Journal of Virology

Volumn 77, Issue 8, 2003, Pages 4992-4999

  Mori, Yasuko ^a   Yang, Xuwei ^a   Akkapaiboon, Pilailuk ^a   Okuno, Toshiomi ^b   Yamanishi, Koichi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CELL RECEPTOR; GENE PRODUCT; GLYCOPROTEIN H; GLYCOPROTEIN L; GLYCOPROTEIN Q; ISOPROTEIN; LIGAND; MEMBRANE COFACTOR PROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ARTICLE; CONTROLLED STUDY; HERPES VIRUS INFECTION; HOST CELL; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; VIRUS TRANSMISSION;

ANTIGENS, CD; ANTIGENS, CD46; BACULOVIRIDAE; CELL FUSION; CELL LINE; HERPESVIRUS 6, HUMAN; HUMANS; LIGANDS; MEMBRANE FUSION; MEMBRANE GLYCOPROTEINS; RECEPTORS, VIRUS; RECOMBINANT PROTEINS; VIRAL ENVELOPE PROTEINS;

EID: 0037383517     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.8.4992-4999.2003     Document Type: Article

References (40)

1. Ablashi, D. V., N. Balachandran, S. F. Josephs, C. L. Hung, G. R. Krueger, B. Kramarsky, S. Z. Salahuddin, and R. C. Gallo. 1991. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184:545-552.
2. Anderson, R. A., and U. A. Gompels. 1999. N- and C-terminal external domains of human herpesvirus-6 glycoprotein H affect a fusion-associated conformation mediated by glycoprotein L binding the N terminus. J. Gen. Virol. 80:1485-1494.
3. Aubin, J. T., H. Collandre, D. Candotti, D. Ingrand, C. Rouzioux, M. Burgard, S. Richard, J. M. Huraux, and H. Agut. 1991. Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J. Clin. Microbiol. 29:367-372.
4. Babic, N., B. G. Klupp, B. Makoschey, A. Karger, A. Flamand, and T. C. Mettenleiter. 1996. Glycoprotein gH of pseudorabies virus is essential for penetration and propagation in cell culture and in the nervous system of mice. J. Gen. Virol. 77:2277-2285.
5. Campadelli-Fiume, G., S. Guerrini, X. Liu, and L. Foa-Tomasi. 1993. Monoclonal antibodies to glycoprotein B differentiate human herpesvirus 6 into two clusters, variants A and B. J. Gen. Virol. 74:2257-2262.
6. Duus, K. M., C. Hatfield, and C. Grose. 1995. Cell surface expression and fusion by the varicella-zoster virus gH:gL glycoprotein complex: analysis by laser scanning confocal microscopy. Virology 210:429-440.
7. Foa-Tomasi, L., A. Boscaro, S. di Gaeta, and G. Campadelli-Fiume. 1991. Monoclonal antibodies to gp100 inhibit penetration of human herpesvirus 6 and polykaryocyte formation in susceptible cells. J. Virol. 65:4124-4129.
8. Gompels, U. A., J. Nicholas, G. Lawrence, M. Jones, B. J. Thomson, M. E. Martin, S. Efstathiou, M. Craxton, and H. A. Macaulay. 1995. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology 209:29-51.
9. Greenstone, H. L., F. Santoro, P. Lusso, and E. A. Berger. 2002. Human herpesvirus 6 and measles virus employ distinct CD46 domains for receptor function. J. Biol. Chem. 277:39112-39118.
10. Iwata, K., T. Seya, Y. Yanagi, J. M. Pesando, P. M. Johnson, M. Okabe, S. Ueda, H. Ariga, and S. Nagasawa. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270:15148-15152.
11. Keay, S., and B. Baldwin. 1991. Anti-idiotype antibodies that mimic gp86 of human cytomegalovirus inhibit viral fusion but not attachment. J. Virol. 65:5124-5128.
12. Klupp, B. G., W. Fuchs, E. Weiland, and T. C. Mettenleiter. 1997. Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virion localization of glycoprotein H. J. Virol. 71:7687-7695.
13. Li, Q., M. K. Spriggs, S. Kovats, S. M. Turk, M. R. Comeau, B. Nepom, and L. M. Hutt-Fletcher. 1997. Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes. J. Virol. 71:4657-4662.
14. Li, Q., S. M. Turk, and L. M. Hutt-Fletcher. 1995. The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells. J. Virol. 69:3987-3994.
15. Liu, D. X., U. A. Gompels, L. Foa-Tomasi, and G. Campadelli-Fiume. 1993. Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies. Virology 197:12-22.
16. Liu, D. X., U. A. Gompels, J. Nicholas, and C. Lelliott. 1993. Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein. J. Gen. Virol. 74:1847-1857.
17. Lublin, D. M., M. K. Liszewski, T. W. Post, M. A. Arce, M. M. Le Beau, M. B. Rebentisch, L. S. Lemons, T. Seya, and J. P. Atkinson. 1988. Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
18. Miller, N., and L. M. Hutt-Fletcher. 1988. A monoclonal antibody to glycoprotein gp85 inhibits fusion but not attachment of Epstein-Barr virus. J. Virol. 62:2366-2372.
19. Milne, R. S., D. A. Paterson, and J. C. Booth. 1998. Human cytomegalovirus glycoprotein H/glycoprotein L complex modulates fusion-from-without. J. Gen. Virol. 79:855-865.
20. Mori, Y., T. Seya, H. L. Huang, P. Akkapaiboon, P. Dhepakson, and K. Yamanishi. 2002. Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J. Virol. 76:6750-6761.
21. Mori, Y., P. Akkapaiboon, X. Yang, and K. Yamanishi. 2003. The human herpesvirus 6 U100 gene product is the third component of the gH-gL glycoprotein complex on the viral envelope. J. Virol. 77:2452-2458.
22. Novotny, M. J., M. L. Parish, and P. G. Spear. 1996. Variability of herpes simplex virus 1 gL and anti-gL antibodies that inhibit cell fusion but not viral infectivity. Virology 221:1-13.
23. Okuno, T., H. Sao, H. Asada, K. Shiraki, M. Takahashi, and K. Yamanishi. 1990. Analysis of a glycoprotein of human herpesvirus 6 (HHV-6) using monoclonal antibodies. Virology 176:625-628.
24. Okuno, T., H. Shao, H. Asada, K. Shiraki, M. Takahashi, and K. Yamanishi. 1992. Analysis of human herpesvirus 6 glycoproteins recognized by monoclonal antibody OHV1. J. Gen. Virol. 73:443-447.
25. Papanikolaou, E., V. Kouvatsis, G. Dimitriadis, N. Inoue, and M. Arsenakis. 2002. Identification and characterization of the gene products of open reading frame U86/87 of human herpesvirus 6. Virus Res. 89:89-101.
26. Pfeiffer, B., Z. N. Berneman, F. Neipel, C. K. Chang, S. Tirwatnapong, and B. Chandran. 1993. Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies. J. Virol. 67: 4611-4620.
27. Pfeiffer, B., B. Thomson, and B. Chandran. 1995. Identification and characterization of a cDNA derived from multiple splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6. J. Virol. 69:3490-3500.
28. Qian, G., C. Wood, and B. Chandran. 1993. Identification and characterization of glycoprotein gH of human herpesvirus-6. Virology 194:380-386.
29. Rasmussen, L., S. Resta, and T. Merigan. 1991. Human cytomegalovirus glycoprotein-receptor interactions. Transplant. Proc. 23:60-63.
30. Sakisaka, T., T. Taniguchi, H. Nakanishi, K. Takahashi, M. Miyahara, W. Ikeda, S. Yokoyama, Y.-F. Peng, K. Yamanishi, and Y. Takai. 2001. Requirement of interaction of nectin-1α/HveC with afadin for efficient cell-cell spread of herpes simplex virus type 1. J. Virol. 75:4734-4743.
31. Salahuddin, S. Z., D. V. Ablashi, P. D. Markham, S. F. Josephs, S. Sturzenegger, M. Kaplan, G. Halligan, P. Biberfeld, F. Wong-Staal, B. Kramarsky, et al. 1986. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596-601.
32. Santoro, F., P. E. Kennedy, G. Locatelli, M. S. Malnati, E. A. Berger, and P. Lusso. 1999. CD46 is a cellular receptor for human herpesvirus 6. Cell 99:817-827.
33. Spriggs, M. K., R. J. Armitage, M. R. Comeau, L. Strockbine, T. Farrah, B. Macduff, D. Ulrich, M. R. Alderson, J. Mfillberg, and J. I. Cohen. 1996. The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR β chain and inhibits antigen presentation. J. Virol. 70:5557-5563.
34. Stanton, R., J. D. Fox, R. Caswell, E. Sherratt, and G. W. Wilkinson. 2002. Analysis of the human herpesvirus-6 immediate-early 1 protein. J. Gen. Virol. 83:2811-2820.
35. Strnad, B. C., T. Schuster, R. Klein, R. F. Hopkins III, T. Witmer, R. H. Neubauer, and H. Rabin. 1982. Production and characterization of monoclonal antibodies against the Epstein-Barr virus membrane antigen. J. Virol. 41:258-264.
36. Takeda, K., M. Haque, T. Sunagawa, T. Okuno, Y. Isegawa, and K. Yamanishi. 1997. Identification of a variant B-specific neutralizing epitope on glycoprotein H of human herpesvirus-6. J. Gen. Virol. 78:2171-2178.
37. van Drunen Littel-van den Hurk, S., S. Khattar, S. K. Tikoo, L. A. Babiuk, E. Baranowski, D. Plainchamp, and E. Thiry. 1996. Glycoprotein H (gII/gp108) and glycoprotein L form a functional complex which plays a role in penetration, but not in attachment, of bovine herpesvirus 1. J. Gen. Virol. 77:1515-1520.
38. Wang, X., and L. M. Hutt-Fletcher. 1998. Epstein-Barr virus lacking glycoprotein gp42 can bind to B cells but is not able to infect. J. Virol. 72:158-163.
39. Wyatt, L. S., N. Balachandran, and N. Frenkel. 1990. Variations in the replication and antigenic properties of human herpesvirus 6 strains. J. Infect. Dis. 162:852-857.
40. Yamanishi, K., T. Okuno, K. Shiraki, M. Takahashi, T. Kondo, Y. Asano, and T. Kurata. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i:1065-1067.