HHV-6A in syncytial giant-cell hepatitis

New England Journal of Medicine

Volumn 359, Issue 6, 2008, Pages 593-602

  Potenza, Leonardo ^a   Luppi, Mario ^a   Barozzi, Patrizia ^a   Rossi, Giulio ^a   Cocchi, Stefania ^a   Codeluppi, Mauro ^a   Pecorari, Monica ^a   Masetti, Michele ^a   Di Benedetto, Fabrizio ^a   Gennari, William ^a   Portolani, Marinella ^a   Gerunda, Giorgio Enrico ^a   Lazzarotto, Tiziana ^b   Landini, Maria Paola ^b   Schulz, Thomas F ^c   Torelli, Giuseppe ^a   Guaraldi, Giovanni ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; GANCICLOVIR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISONE; SYNAPTOPHYSIN; TACROLIMUS; VIRUS DNA;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BLOOD CELL COUNT; CASE REPORT; CHOLANGITIS; COOMBS TEST; DRUG DOSE REDUCTION; DRUG MEGADOSE; ECHOGRAPHY; GIANT CELL HEPATITIS; HEPATITIS; HERPES VIRUS; HUMAN; HUMAN HERPESVIRUS 6A; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER TRANSPLANTATION; MALE; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROLOGY; THROMBOTIC THROMBOCYTOPENIC PURPURA; VIRUS DETECTION;

EID: 49249137995     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa074479     Document Type: Article

References (33)

1. Phillips MJ, Blendis LM, Poucell S, et al. Syncytial giant-cell hepatitits: sporadic hepatitis with distinctive pathologic features, a severe clinical course, and paramyxoviral features. N Engl J Med 1991;324:455-60.
2. Lau JYN, Koukoulis G, Mieli-Vergani G, Portmann BC, Williams R. Syncytial giant-cell hepatitis - a specific disease entity? J Hepatol 1992;15:216-9.
3. Devaney K, Goodman ZD, Ishak KG. Postinfantile giant-cell transformation in hepatitis. Hepatology 1992;16:327-33.
4. Fimmel CJ, Guo L, Compans RW, et al. A case of syncytial giant cell hepatitis with features of a paramyxoviral infection. Am J Gastroenterol 1998;93:1931-7.
5. Pappo O, Yunis E, Jordan JA, et al. Recurrent and de novo giant cell hepatitis after orthotopic liver transplantation. Am J Surg Pathol 1994;18:804-13.
6. Maciejewski JP, Luppi M, Torelli G. Human cytomegalovirus, human herpesvirus 8, and other herpesviruses. In: Young NS, Gerson ST, High KA. Clinical hematology. St. Louis: Mosby, 2006:967-80.
7. Zerr DM, Meier AS, Selke SS, et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med 2005;352:768-76.
8. Ljungman P. β-Herpesvirus challenges in the transplant recipient. J Infect Dis 2002;186:Suppl 1:S99-S109.
9. Demetris AJ, Batts KP, Dhillon AP, et al. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997;25:658-63.
10. Ward KN, Gray JJ, Joslin ME, Sheldon MJ. Avidity of IgG antibodies to human herpesvirus-6 distinguishes primary from recurrent infection in organ transplant recipients and excludes cross-reactivity with other herpesviruses. J Med Virol 1993;39:44-9.
11. Maric I, Bryant R, Abu-Asab M, et al. Human herpesvirus-6-associated acute lymphadenitis in immunocompetent adults. Mod Pathol 2004;17:1427-33.
12. Luppi M, Barozzi P, Garber R, et al. Expression of human herpesvirus-6 antigens in benign and malignant lymphoproliferative diseases. Am J Pathol 1998;153:815-23.
13. Portolani M, Tamassia MG, Gennari W, et al. Post-mortem diagnosis of encephalitis in a 75-year-old man associated with human herpesvirus-6 variant A. J Med Virol 2005;77:244-8.
14. Barozzi P, Luppi M, Facchetti F, et al. Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nat Med 2003;9:554-61. [Erratum, Nat Med 2003;9:975.]
15. Wang FZ, Dahl H, Linde A, Brytting M, Ehrnst A, Ljungman P. Lymphotropic herpesviruses in allogeneic bone marrow transplantation. Blood 1996;88:3615-20.
16. MacKenzie J, Perry J, Ford AM, Jarrett RF, Greaves M. JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukaemia. Br J Cancer 1999;81:898-9.
17. Bültmann BD, Klingel K, Sotlar K, Bock T, Kandolf R. Parvovirus B19: a pathogen responsible for more than hematologic disorders. Virchows Arch 2003;442:8-17.
18. Boutolleau D, Duros C, Bonnafous C, et al. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol 2006;35:257-63.
19. Kuntzen T, Friedrichs N, Fisher PH, Eis-Hubinger AM, Sauerbruch T, Spengler U. Postinfantile giant-cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction. Eur J Gastoenterol Hepatol 2005;17:1131-4.
20. Mori Y, Seya T, Huang HL, Akkapaiboon P, Dhepakson P, Yamanishi K. Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J Virol 2002;76:6750-61.
21. Pedersen SM, Oster B, Bundgaard B, Höllsberg P. Induction of cell-cell fusion from without by human herpevirus 6B. J Virol 2006;80:9916-20.
22. Randhawa PS, Jenkins FJ, Nalesnik MA, et al. Herpesvirus 6 variant A infection after heart transplantation with giant cell transformation in bile ductular and gastroduodenal epithelium. Am J Surg Pathol 1997;21:847-53.
23. Zerr DM, Corey L, Huang ML, Kim HW, Nguy L, Boeckh M. Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 2005;40:932-40.
24. Secchiero P, Carrigan DR, Asano Y, et al. Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 1995;171:273-80.
25. Ward KN, Leong HN, Thiruchelvam AD, Atkinson CE, Clark DA. Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. J Clin Microbiol 2007;45:1298-304.
26. Razonable RR, Fanning C, Brown RA, et al. Selective reactivation of human herpesvirus 6 variant A occurs in critically ill immunocompetent hosts. J Infect Dis 2002;185:110-3.
27. Wang FZ, Dahl H, Ljungman P, Linde A. Lymphoproliferative responses to human herpesvirus-6 variant A and variant B in healthy adults. J Med Virol 1999;57:134-9.
28. De Bolle L, Naesens L, De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 2005;18:217-45.
29. Yasukawa M, Yakushijin Y, Furukawa M, Fujita S. Specificity analysis of human CD4+ T-cell clones directed against human herpesvirus 6 (HHV-6), HHV-7, and human cytomegalovirus. J Virol 1993;67:6259-64.
30. Roberts E, Ford-Jones EL, Phillips JM. Ribavirin for syncytial giant cell hepatitis. Lancet 1993;341:640-1.
31. Moreno A, Moreno A, Pérez-Elías MJ, et al. Syncytial giant cell hepatitis in human immunodeficiency virus-infected patients with chronic hepatitits C: 2 cases and review of the literature. Hum Pathol 2006;37:1344-9.
32. Razonable RR, van Cruijsen H, Brown RA, et al. Dynamics of cytomegalovirus replication during preemptive therapy with oral ganciclovir. J Infect Dis 2003;187:1801-8.
33. Singh N, Bentlejewski C, Carrigan DR, Gayowski T, Knox KK, Zeevi A. Persistent lack of human herpesvirus-6 specific T-helper cell response in liver transplant recipients. Transpl Infect Dis 2002;4:59-63.