The inevitability of unconditionally deleterious substitutions during adaptation

Evolution

Volumn 68, Issue 5, 2014, Pages 1351-1364

  Mccandlish, David M ^a   Epstein, Charles L ^a   Plotkin, Joshua B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Deleterious fixations; Fisher's geometric model; House of cards; Reversible Markov chain; Weak mutation

Indexed keywords

ADAPTATION; AMINO ACID SUBSTITUTION; ANIMAL; BIOLOGICAL MODEL; GENETICS; MOLECULAR EVOLUTION; MUTATION; REPRODUCTIVE FITNESS;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SUBSTITUTION; ANIMALS; EVOLUTION, MOLECULAR; GENETIC FITNESS; MODELS, GENETIC; MUTATION;

EID: 84899901450     PISSN: 00143820     EISSN: 15585646     Source Type: Journal    
DOI: 10.1111/evo.12350     Document Type: Article

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