Compensatory nearly neutral mutations: Selection without adaptation

Journal of Theoretical Biology

Volumn 182, Issue 3, 1996, Pages 303-309

  Hartl, Daniel L ^a   Taubes, Clifford H ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ENZYME ACTIVITY; GENE MUTATION; METABOLISM; NATURAL SELECTION; NEUTRAL GENE THEORY; PRIORITY JOURNAL; REVIEW;

EID: 0030574072     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0168     Document Type: Article

References (16)

1. BROOKFIELD, J. F. Y. & SHARP, P. M. (1994). Neutralism and selectionism face up to DNA data. Trends Genet. 10, 109-111.
2. CROW, J. F. & KIMURA, M. (1970). An Introduction to Population Genetics Theory. New York: Harper & Row.
3. DEAN, A. M. (1994). Fitness, flux and phantoms in temporally variable environments. Genetics 136, 1481-1495.
4. DEAN, A. M., DYKHUIZEN, D. E. & HARTL, D. L. (1986). Fitness as a function of β-galactosidase activity in Escherichia coli. Genetics 48, 1-8.
5. DEAN, A. M., DYKHUIZEN, D. E. & HARTL, D. L. (1988). Theories of metabolic control in quantitative genetics. In: Proc. 2nd Int. Conf. Quantitative Genetics (Weir, B. S., Eisen, E. J., Goodman, M. M. & Namkoong, G., ed). pp. 536-548. Sunderland, MA: Sinauer.
6. FISHER, R. A. (1930). The Genetical Theory of Natural Selection. Oxford: Oxford University Press.
7. HARTL, D. L., DYKHUIZEN, D. E. & DEAN, A. M. (1985). Limits of adaptation: The evolution of selective neutrality. Genetics 111, 655-674.
8. KACSER, H. & ACERENZA, L. (1993). A universal method for achieving increases in metabolite production. Eur. J. Biochem. 216, 361-367.
9. KACSER, H. & BURNS, J. A. (1973). The control of flux. Symp. Soc. Exp. Biol. 32, 65-104.
10. KACSER, H. & BURNS, J. A. (1979). Molecular democracy: who shares the controls? Biochem. Rev. 7, 1150-1160.
11. KACSER, H. & BURNS, J. A. (1981). The molecular basis of dominance. Genetics 97, 639-666.
12. KEIGHTLEY, P. D. & H. KACSER, H. (1987). Dominance, pleiotropy and metabolic structure. Genetics 117, 319-329.
13. KIMURA, M. (1983). The Neutral Theory of Molecular Evolution. Cambridge: Cambridge University Press.
14. OHTA, T. (1973). Slightly deleterious mutant substitutions in evolution. Nature 246, 96-98.
15. OHTA, T. (1992). The nearly neutral theory of molecular evolution. Annu. Rev. Ecol. Syst. 23, 263-286.
16. OHTA, T. & TACHIDA, H. (1990). Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution. Genetics 126, 219-229.