Understanding Lunasin's biology and potential as a cancer therapeutic by utilizing Drosophila genetics

Experimental Biology and Medicine

Volumn 239, Issue 5, 2014, Pages 519-528

  Jones, Gillian ^a   Srivastava, Ajay ^a  

^a WESTERN KENTUCKY UNIVERSITY   (United States)

Author keywords

cancer; Drosophila; Lunasin; metastasis; tumors

Indexed keywords

CYCLIN DEPENDENT KINASE; LUNASIN; MATRIX METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P21; PROTEIN P27; SOYBEAN PROTEIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL GENETICS; APOPTOSIS; BREAST CANCER; CARCINOGENESIS; COLON CANCER; DROSOPHILA; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC MODEL; HISTONE ACETYLATION; INFLAMMATION; LIVER CELL CARCINOMA; METASTASIS; NEOPLASM; NONHUMAN; PROTEIN STRUCTURE; REVIEW; SOLANUM NIGRUM; SOYBEAN; TUMOR GROWTH; TUMOR MODEL; UPREGULATION;

CANCER; DROSOPHILA; LUNASIN; METASTASIS; TUMORS;

ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE MODELS, ANIMAL; DROSOPHILA; HUMANS; MOLECULAR BIOLOGY; SOYBEAN PROTEINS;

EID: 84899678194     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214522180     Document Type: Review

References (77)

1. Sirtori CR,Lovati MR,Manzone C,Monetti M,Pazzucconi F,Gatti E.Soy and Cholesterol Reduction: Clinical Experience.J Nutr. 1995;125:598S-605S.
2. Carroll KK,Kurowska E.Soy consumption and cholesterol reduction: review of animal and human studies.J Nutr. 1995;152:594S-S.
3. Liu C-F,Pan T-M.Recombinant expression of bioactive peptide lunasin in Escherichia coli.Appl Microbiol Biotechnol. 2010;88:177-86.
4. Messina MJ,Barnes S.The role of soy products in reducing risk of cancer.J Natl Cancer Inst. 1991;83:541-7.
5. Odani S,Koide T,Ono T.Amino acid sequence of a soybean (Glycine max) seed polypeptide having a poly (L-aspartic acid) structure.J Biol Chem. 1987;262:10502-5.
6. Galvez A,Revilleza M,De Lumen B.A novel methionine-rich protein from soybean cotyledon: cloning and characterization of cDNA (accession no. AF005030). plant gene Register# PGR97-103.Plant Physiol. 1997;114:1567-9.
7. Jeong HJ,Jeong JB,Kim DS,Park JH,Lee JB,Kweon DH,Chung GY,Seo EW,de Lumen BO.The cancer preventive peptide lunasin from wheat inhibits core histone acetylation.Cancer Lett. 2007;255:42-8.
8. Jeong HJ,Jeong JB,Hsieh CC,Hernández-Ledesma B,de Lumen BO.Lunasin is prevalent in barley and is bioavailable and bioactive in in vivo and in vitro studies.Nutr Cancer. 2010;62:1113-9.
9. Silva-Sánchez C,de la Rosa AB,León-Galván M,De Lumen B,de Leon-Rodriguez A,de Mejía EG.Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed.J Agric Food Chem. 2008;56:1233-40.
10. Hernández-Ledesma B,De Lumen BO.Lunasin: a novel cancer preventive seed peptide.Perspect Med Chem. 2008;2:75-80.
11. Jeong HJ,Lee JR,Jeong JB,Park JH,Cheong Y-K,de Lumen BO.The cancer preventive seed peptide lunasin from rye is bioavailable and bioactive.Nutr Cancer. 2009;61:680-6.
12. Nakurte I, Kirhnere I, Namniece J, Saleniece K, Krigere L, Mekss P, Vicupe Z, Bleidere M, Legzdina L, Muceniece R. Detection of the lunasin peptide in oats (Avena sativa L). J Cereal Sci 2013.
13. Jeong J,Jeong H,Park JH,Lee SH,Lee JR,Lee HK,Chung GY,Choi JD,de Lumen BO.Cancer-preventive peptide lunasin from Solanum nigrum L. Inhibits acetylation of core hisotones H3 and H4 and phosphorylation of retinoblastoma protein (Rb).J Agric Food Chem. 2007;55:10707-13.
14. Galvez A,de Lumen BO.A Soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells.Nature Biotechnol. 1999;17:495-500.
15. Lam Y,Galvez A,de Lumen BO.Lunasin™ suppresses E1A-mediated transformation of mammalian cells but does not inhibit growth of immortalized and established cancer cell lines.Nutr Cancer. 2003;47:88-94.
16. Galvez A,Chen N,Macasieb J,deLumen BO.Chemopreventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation.Cancer Res. 2001;61:7473-8.
17. Jeong HJ,Park JH,Lam Y,de Lumen BO.Characterization of lunasin isolated from soybean.J Agric Food Chem. 2003;51:7901-6.
18. Dia VP,Gonzalez de Mejia E.Lunasin induces apiptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells.Mol Nutr Food Res. 2011;55:623-34.
19. Pabona JMP,Dave B,Su Y,Montales MT,Rahal OM,Simmen RC.The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein.Genes Nutr. 2012;8:79-90.
20. de Lumen BO.Lunasin: a cancer-preventive soy peptide.Nutr Rev. 2005;63:16-21.
21. Malumbres M,Barbacid M.Cell cycle, CDKs and cancer: a changing paradigm.Nat Rev Cancer. 2009;9:153-66.
22. Xiong Y,Hannon G,Zhang H,Casso D,Kobayashi R,Beach D.p21 is a universal inhibitor of cyclin kinases.Nature. 1993;366:701-4.
23. Steeg P,Abrams J.Cancer prognostics: past, present, and p27.Nat Med. 1997;3:152-152.
24. Abukhdeir A,Vitolo M,Argani P,De Marzo AM,Karakas B,Konishi H,Gustin JP,Lauring J,Garay JP,Pendleton C,Konishi Y,Blair BG,Brenner K,Garrett-Mayer E,Carraway H,Bachman KE,Park BH.Tamoxifen-stimulated growth of breast cancer due to p21 loss.PNAS. 2008;105:288-93.
25. Chu I,Sun J,Arnaout A,Kahn H,Hanna W,Narod S,Sun P,Tan CK,Hengst L,Slingerland J.p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.Cell. 2007;128:281-94.
26. Justilien V,Regala RP,Tseng I,Walsh MP,Batra J,Radisky ES,Murray NR,Fields AP.Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.PloS one. 2012;7:e35040-e35040.
27. Lu X,Lu D,Scully M,Kakkar V.Integrins in drug targeting-RGD templates in toxins.Curr Pharm Des. 2006;12:2749-69.
28. Gong J,Wang D,Sun L,Zborowska E,Willson J,Brattain MG.Role of alpha 5 beta 1 integrin in determining malignant properties of colon carcinoma cells.Cell Growth Differ. 1997;8:83-90.
29. Stoeltzing O,Liu W,Reinmuth N,Fan F,Parry GC,Parikh AA,McCarty MF,Bucana CD,Mazar AP,Ellis LM.Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice.Int J Cancer. 2003;104:496-503.
30. Tsujimoto Y,Nakagawa T,Shimizu S.Mitochondrial membrane permeability transition and cell death.Biochim Biophys Acta. 2006;1757:1297-300.
31. Coussens L,Werb Z.Inflammation and cancer.Nature. 2002;420:860-7.
32. Tamura M,Gu J,Matsumoto K,Aota S,Parsons R,Yamada K.Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.Science. 1998;280:1614-7.
33. Simpson L,Parsons R.PTEN: life as a tumor suppressor.Exp Cell Res. 2001;264:29-41.
34. Dave B,Eason R,Till S,Geng Y,Velarde MC,Badger TM,Simmen RC.The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.Carcinogenesis. 2005;26:1793-803.
35. Rahal O,Simmen R.Tumor suppressor PTEN signaling is up-regulated in mammary epithelial cells by soy isoflavone genistein: Implications for breast cancer protection.Cancer Res. 2009;69:4069-4069.
36. Hanson FB,Ferris F.A quantitative study of fecundity in Drosophila melanogaster.J Exp Zool. 1929;54:485-506.
37. Beckingham K,Armstrong DJ,Texada M,Munjaal R,Baker DA.Drosophila melanogaster - the model organism of choice for the complex biology of multi-cellular organisms.Gravit Space Biol. 2005;18:17-30.
38. Adams M,Celniker S,Holt R, et al.The genome sequence of Drosophila melanogaster.Science. 2000;287:2185-95.
39. Venter JC,Adams MD,Myers EW, et al.The sequence of the human genome.Sci Signal. 2001;291:1304-1304.
40. Page-McCaw A,Serano J,Santé JM,Rubin GM.Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.Dev Cell. 2003;4:95-106.
41. St. John MAR,Xu T.Insights from model systems understanding human cancer in a fly?.Am J Hum Genet. 1997;61:1006-10.
42. Reiter LT,Potocki L,Chien S,Gribskov M.A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster.Genome Res. 2001;11:1114-25.
43. Roberts DBDrosophila. 2 ed. Oxford: Oxford University Press, 1998.Oxford: Oxford University Press; 1998:.
44. Ryder E,Russell S.Transposable elements as tools for genomics and genetics in Drosophila.Brief Funct Genomics Proteomic. 2003;2:57-71.
45. Golic KG,Lindquist S.The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome.Cell. 1989;59:499-509.
46. Duffy JB.GAL4 system in Drosophila: a fly geneticist's swiss army knife.Genesis. 2002;34:1-15.
47. Wu JS,Luo L.A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila.Nat Protoc. 2007;1:2583-9.
48. Bellen HJ,Tong C,Tsuda H.100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.Nat Rev Neurosci. 2010;11:514-23.
49. Greenspan RJFly pushing: the theory and practice of Drosophila genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2004:191-191.
50. Thummel CS,Boulet AM,Lipshitz HD.Vectors for Drosophila P-element-mediated transformation and tissue culture transfection.Gene. 1988;74:445-56.
51. O'Kane CJ,Gehring WJ.Detection in situ of genomic regulatory elements in Drosophila.Proc Natl Acad Sci. 1987;84:9123-7.
52. Brand A,Perrimon N.Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.Development. 1993;118:401-15.
53. Potter CJ,Turenchalk GS,Xu T.Drosophila in cancer research: an expanding role.Trends Genet. 2000;16:33-9.
54. Lee T,Luo L.Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.Neuron. 1999;22:451-61.
55. Miles WO, Dyson JJ, Walker JA. Modeling tumor invasion and metastisis in Drosophila. Dis Models Mech 2011;4:753-61.
56. Srivastava A. A protocol for genetic induction and visualization of benign and invasive tumors in cephalic complexes of Drosophila melanogaster. J Vis Exp 2013;79. DOI: 10.3791/50624.
57. Michno K,van de Hoef D,Wu H,Boulianne GL.Modeling age related diseases in drosophila: can this fly?.Curr Topics Dev Biol. 2005;71:199-223.
58. Muqit MM,Feany MB.Modelling neurodegenerative diseases in Drosophila: a fruitful approach?.Nat Rev Neurosci. 2002;3:237-43.
59. Tanenbaum D.What's all th buzz? Fruit flies provide unique model for cancer research.J Natl Cancer Inst. 2003;95:1742-4.
60. Bissler J,McCormack F,Young L,Elwing J,Chuck G.Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis.New Engl J Med. 2008;358:140-51.
61. Zhang K,Chaillet JR,Perkins LA,Halazonetis TD,Perrimon N.Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells.Proc Natl Acad Sci. 1990;87:6281-5.
62. Bischoff JR,Anderson L,Zhu Y,Mossie K,Ng L,Souza B,Schryver B,Flanagan P,Clairvoyant F,Ginther C,Chan CS,Novotny M,Slamon DJ,Plowman GD.A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers.EMBO J. 1998;17:3052-65.
63. Aster J, Pear W, Hasserjian R, Erba H, Davi F, Luo B, Scott M, Baltimore D, Sklar J. Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harb Symp Quant Biol 1994;5:125-36.
64. Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse R.The Drosophila homology of the mouse mammary oncogene-1 is identical to the segment polarity gene wingless.Cell. 1987;50:649-57.
65. Zeidler MP,Bach EA,Perrimon N.The roles of the Drosophila JAK/STAT pathway.Oncogene. 2000;19:2598-606.
66. Polesello C,Huelsmann S,Brown NH,Tapon N.The Drosophila RASSF homolog antagonizes the hippo pathway.Curr Biol. 2006;16:2459-65.
67. Wu X,Yamada-Mabuchi M,Morris EJ,Tanwar PS,Dobens L,Gluderer S,Khan S,Cao J,Stocker H,Hafen E,Dyson NJ,Raftery LA.The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.Proc Natl Acad Sci. 2008;105:5414-9.
68. Frese KK,Latorre IJ,Chung S-H,Caruana G,Bernstein A,Jones SN,Donehower LA,Justice MJ,Garner CC,Javier RT.Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.EMBO J. 2006;25:1406-17.
69. Tao W,Zhang S,Turenchalk GS,Stewart RA,St John MA,Chen W,Xu T.Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.Nat Genet. 1999;21:177-81.
70. Humbert P,Grzeschik N,Brumby A,Galea R,Elsum I,Richardson H.Control of tumourigenesis by the scribble/Dlg/Lgl polarity module.Oncogene. 2008;27:6888-907.
71. Smolich B,McMahon J,McMahon A,Papkoff J.Wnt family proteins are secreted and associated with the cell surface.Mol Biol Cell. 1993;4:1267-1267.
72. Allenspach E,Maillard I,Aster J,Pear W.Notch signaling in cancer.Cancer Biol Ther. 2002;1:466-76.
73. Watkins N,Berman DM,Burkholder S,Wang B,Beachy P,Baylin S.Hedgehog signalling withing airway epithelial progenitors and in small-cell lung cancer.Natuer. 2003;422:413-7.
74. Chambers AF,Groom AC,MacDonald IC.Metastasis: dissemination and growth of cancer cells in metastatic sites.Nat Rev Cancer. 2002;2:563-72.
75. Pagliarini RA,Xu T.A genetic screen in Drosophila for metastatic behavior.Science. 2003;302:1227-31.
76. Singh SR,Hou S.Lessons learned about adult kidney stem cells from the malpighian tubules of Drosophila.J Am Soc Nephrol. 2008;19:660-6.
77. Roelink H, Augsburger A, Heemskerk J, Korzh V, Norlin S, Ruiz I Altaba A, Tanabe Y, Placzek M, Edlund T, Jessell TM, Dodd J. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 1994;76:761-75.