Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb)

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 26, 2007, Pages 10707-10713

  Jin, Boo Jeong ^a   Hyung, Jin Jeong ^a   Jae, Ho Park ^a   Sun, Hee Lee ^a   Jeong, Rak Lee ^a   Hee, Kyeong Lee ^a   Gyu, Young Chung ^a   Jeong, Doo Choi ^b   De Lumen, Ben O ^c  

^a Andong National University   (South Korea)

^b Gyeongbuk Institute for Bio industry   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Core histone acetylation; Histone acetyltransferases; Lunasin; Phosphorylation; Retinoblastoma protein (Rb); Solanum nigrum L. (SNL)

Indexed keywords

ANTINEOPLASTIC AGENT; HISTONE; PANCREATIN; PEPSIN A; RETINOBLASTOMA PROTEIN; VEGETABLE PROTEIN;

ACETYLATION; ANIMAL; ARTICLE; CELL STRAIN 3T3; CHEMISTRY; DRUG EFFECT; DRUG STABILITY; METABOLISM; MOUSE; PHOSPHORYLATION; SOLANUM NIGRUM;

ACETYLATION; ANIMALS; ANTICARCINOGENIC AGENTS; DRUG STABILITY; HISTONES; MICE; NIH 3T3 CELLS; PANCREATIN; PEPSIN A; PHOSPHORYLATION; PLANT PROTEINS; RETINOBLASTOMA PROTEIN; SOLANUM NIGRUM;

GLYCINE MAX; HORDEUM; MAGNOLIOPHYTA; MAMMALIA; SOLANACEAE; SOLANUM NIGRUM; TRITICUM AESTIVUM;

EID: 38049023482     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf072363p     Document Type: Article

References (34)

1. Farr, D. R. Functional foods. Cancer Lett. 1997, 114, 59-63.
2. Wang, H.; Cao, G.; Prior, R. L. Oxygen radical absorbing capacity of anthrocyanins. J. Agric. Food Chem. 1997, 45, 304-309.
3. Kujala, T. S.; Loponen, J. M.; Klika, K. D.; Pihlaja, K. Phenolics and betacyanins in red beetroot (Beta vulgaris) root: Distribution and effect of cold storage on the content of total phenolics and three individual compounds. J. Agric. Food. Chem. 2000, 48, 5338-5342.
4. van Poppel, G.; van den Berg, H. Vitamins and cancer. Cancer Lett. 1997, 114, 195-202.
5. Perez, R. M.; Perez, J. A.; Garcia, L. M.; Sossa, H. Neuropharmacological activity of Solanum nigrum fruit. J. Ethnopharmacol. 1998, 62, 43-48.
6. Galvez, A. F.; Chen, N.; Macasieb, J.; de Lumen, B. O. Chemopreventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation. Cancer Res. 2001, 61, 7473-7478.
7. Jeong, H. J.; Lam, Y.; de Lumen, B. O. Barley lunasin suppresses ras-induced colony formation and histone acetylation in mammalian cells. J. Agric. Food. Chem. 2002, 50, 5903-5908.
8. Jeong, H. J.; Jeong, J. B.; Kim, D. S.; Park, J. H.; Lee, J. B.; Kweon, D. H.; Chung, G. Y.; Seo, E. W.; de Lumen, B. O. The cancer preventive peptide lunasin from wheat inhibits core histone acetylation. Cancer Lett. 2007, 255, 42-48.
9. Ruoslahti, E.; Pierschbacher, M. D. Arg-Gly-Asp: A versatile cell recognition signal. Cell 1986, 44, 517-518.
10. Akiyama, S. K.; Olden, K; Yamada, K. M. Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev. 1986, 14, 173-189.
11. Revilleza, M. J.; Galvez, A. F.; Krenz, D. C.; de Lumen, B. O. An 8 kDa methionine-rich protein from soybean (Glycine max) cotyledon: Identification, purification, and N-terminal sequence. J. Agric. Food. Chem. 1996, 44, 930-2935.
12. de Lumen, B. O. Lunasin: A cancer preventive soy peptide. Nutr. Rev. 2005, 63, 16-21.
13. Lam, Y.; Galvez, A. F.; de Lumen, B. O. Lunasin suppresses E1A-mediated transformation of mammalian cells but does not inhibit growth of immortalized and established cancer cell line. Nutr. Cancer 2003, 47, 88-94.
14. Shogren-Knaak, M.; Ishii, H.; Sun, J. M.; Pazin, M. J.; Davie, J. R.; Peterson, C. L. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 2006, 311, 844-847.
15. Yang, X.-J.; Ogryzko, V. V.; Nishikawa, J.; Howard, B. H.; Nakatani, Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 1996, 382, 319-324.
16. Archer, S. Y.; Hodin, R. A. Histone acetylation and cancer. Curr. Opin. Genet. Dev. 1999, 9, 171-174.
17. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 1995, 81, 323-330.
18. Riley, D. J.; Lee, E. Y.; Lee, W. H. The retinoblastoma protein: More than a tumor suppressor. Annu. Rev. Cell Dev. Biol. 1994, 10, 1-29.
19. Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998, 12, 2245-2262.
20. Helin, K. Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 1998, 8, 28-35.
21. Bartek, J.; Bartkova, J.; Lukas, J. The retinoblastoma protein pathway in cell cycle control and cancer. Exp. Cell Res. 1997, 237, 1-6.
22. Sherr, C. J. Cancer cell cycles. Science 1996, 274, 1672-1677.
23. Wang, J. Y.; Knudsen, E. S.; Welch, P. J. The retinoblastoma tumor suppressor protein. Adv. Cancer Res. 1994, 64, 25-85.
24. DePinho, R. A. Transcriptional repression. The cancer-chromatin connection. Nature 1998, 391, 535-536.
25. Yasui, W.; Oue, N.; Ono, S.; Mitani Ito, R.; Nakayama, H. Histone acetylation and gastrointestinal carcinogenesis. Ann. N. Y. Acad. Sci. 2003, 983, 220-231.
26. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248.
27. Kim, Y.; Tanner, K. G.; Denu, L. M. A continuous, nonradioactive assay for histone acetyltransfeases. Anal. Biochem. 2000, 280, 308-314.
28. Tanner, K. G.; Langer, M. R.; Kim, Y.; Denu, J. M. Kinetic mechanism of the histone acetyltranferase GCN5 from yeast. J. Biol. Chem. 2000, 29, 22048-22055.
29. Jeong, H. J.; Jeong, J. B.; Kim, D. S.; de Lumen, B. O. Inhibition of core histone acetylation by the cancer preventive peptide lunasin. J. Agric. Food Chem. 2007, 55, 632-637.
30. Siavoshian, S.; Blottiere, H. M.; Cherbut, C.; Galmiche, J.-P. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. Biophys. Biochem. Res. Commun. 1997, 232, 169-172.
31. Geng, Y.; Yu, Q.; Sicinska, E.; Das, M.; Bronson, R. T.; Sicinski, P. Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 194-199.
32. Jeong, H. J.; Park, J. H.; Lam, Y.; de Lumen, B. O. Characterization of lunasin isolated from soybean. J. Agric. Food. Chem. 2003, 51, 7901-7906.
33. Odani, O.; Koide, T.; Ono, T. Amino acid sequence of a soybean (Glycine max) seed polypeptide having a poly (L-aspartic acid) structure. J. Biol. Chem. 1987, 262, 10502-10505.
34. Spencer, D.; Higgins, T. J. V. Molecular aspects of seed protein biosynthesis. In Commentaries in Plant Science; Smith, H., Ed.; Pergamon: New York, 1981; pp 175-189.