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Volumn , Issue 79, 2013, Pages

A protocol for genetic induction and visualization of benign and invasive tumors in cephalic complexes of Drosophila melanogaster

Author keywords

Benign tumors; Cephalic complex; Drosophila; Drosophila melanogaster; Imaginal discs; Invasive tumors; Issue 79; Medicine; Mosaic Analysis with a Repressible Cell Marker technique; Neoplasm metastasis

Indexed keywords


EID: 84884189316     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/50624     Document Type: Article
Times cited : (4)

References (39)
  • 1
    • 0036406843 scopus 로고    scopus 로고
    • Hedgehog signaling and human disease
    • doi:10.1146/annurev.genom.3.022502.103031022502.103031 [pii]
    • Bale, A.E. Hedgehog signaling and human disease. Annu Rev Genomics Hum Genet. 3, 47-65, doi:10.1146/annurev.genom.3.022502.103031022502.103031 [pii] (2002).
    • (2002) Annu Rev Genomics Hum Genet , vol.3 , pp. 47-65
    • Bale, A.E.1
  • 2
    • 7644239149 scopus 로고    scopus 로고
    • Drosophila, an emerging model for cardiac disease
    • doi:S0378-1119(04)00459-7 [pii]10.1016/j.gene.2004.07.018
    • Bier, E. & Bodmer, R. Drosophila, an emerging model for cardiac disease. Gene 342, 1-11, doi:S0378-1119(04)00459-7 [pii]10.1016/j.gene.2004.07.018 (2004).
    • (2004) Gene , vol.342 , pp. 1-11
    • Bier, E.1    Bodmer, R.2
  • 3
    • 52449134519 scopus 로고    scopus 로고
    • Wnt signaling in development, disease and translational medicine
    • Coombs, G.S., Covey, T.M., & Virshup, D.M. Wnt signaling in development, disease and translational medicine. Curr Drug Targets. 9, 513-531 (2008).
    • (2008) Curr Drug Targets , vol.9 , pp. 513-531
    • Coombs, G.S.1    Covey, T.M.2    Virshup, D.M.3
  • 5
    • 33749242234 scopus 로고    scopus 로고
    • Drosophila in the study of neurodegenerative disease
    • doi:S0896-6273(06)00732-X [pii]10.1016/j.neuron.2006.09.025
    • Marsh, J.L. & Thompson, L.M. Drosophila in the study of neurodegenerative disease. Neuron 52, 169-178, doi:S0896-6273(06)00732-X [pii]10.1016/j.neuron.2006.09.025 (2006).
    • (2006) Neuron , vol.52 , pp. 169-178
    • Marsh, J.L.1    Thompson, L.M.2
  • 6
    • 0036072565 scopus 로고    scopus 로고
    • Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins
    • doi:10.1517/14728222.6.3.387
    • Reiter, L.T. & Bier, E. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert Opin Ther Targets. 6, 387-399, doi:10.1517/14728222.6.3.387 (2002).
    • (2002) Expert Opin Ther Targets , vol.6 , pp. 387-399
    • Reiter, L.T.1    Bier, E.2
  • 7
    • 84862171364 scopus 로고    scopus 로고
    • The many faces and functions of beta-catenin
    • doi:emboj2012150 [pii]10.1038/emboj.2012.150
    • Valenta, T., Hausmann, G., & Basler, K. The many faces and functions of beta-catenin. EMBO J. 31, 2714-2736, doi:emboj2012150 [pii]10.1038/emboj.2012.150 (2012).
    • (2012) EMBO J , vol.31 , pp. 2714-2736
    • Valenta, T.1    Hausmann, G.2    Basler, K.3
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • doi:S0092-8674(11)00127-9 [pii]10.1016/j.cell.2011.02.013
    • Hanahan, D. & Weinberg, R.A. Hallmarks of cancer: the next generation. Cell. 144, 646-674, doi:S0092-8674(11)00127-9 [pii]10.1016/j.cell.2011.02.013 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • doi:10.1126/science.10884741088474 [pii]
    • Pagliarini, R.A. & Xu, T. A genetic screen in Drosophila for metastatic behavior. Science. 302, 1227-1231, doi:10.1126/science.10884741088474 [pii] (2003).
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 10
    • 84988044061 scopus 로고    scopus 로고
    • A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila
    • doi:nprot.2006.320 [pii]10.1038/nprot.2006.320
    • Wu, J.S. & Luo, L. A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila. Nat Protoc. 1, 2583-2589, doi:nprot.2006.320 [pii]10.1038/nprot.2006.320 (2006).
    • (2006) Nat Protoc , vol.1 , pp. 2583-2589
    • Wu, J.S.1    Luo, L.2
  • 11
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • doi:nrc1912 [pii]10.1038/nrc1912
    • Boccaccio, C. & Comoglio, P.M. Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer. 6, 637-645, doi:nrc1912 [pii]10.1038/nrc1912 (2006).
    • (2006) Nat Rev Cancer , vol.6 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 12
    • 33847290444 scopus 로고    scopus 로고
    • Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion
    • doi:0611666104 [pii]10.1073/pnas.0611666104
    • Srivastava, A., Pastor-Pareja, J.C., Igaki, T., Pagliarini, R., & Xu, T. Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proc Natl Acad Sci U S A. 104, 2721-2726, doi:0611666104 [pii]10.1073/pnas.0611666104 (2007).
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2721-2726
    • Srivastava, A.1    Pastor-Pareja, J.C.2    Igaki, T.3    Pagliarini, R.4    Xu, T.5
  • 13
    • 34249281332 scopus 로고    scopus 로고
    • The cofilin pathway in breast cancer invasion and metastasis
    • doi:nrc2148 [pii]10.1038/nrc2148
    • Wang, W., Eddy, R., & Condeelis, J. The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer. 7, 429-440, doi:nrc2148 [pii]10.1038/nrc2148 (2007).
    • (2007) Nat Rev Cancer , vol.7 , pp. 429-440
    • Wang, W.1    Eddy, R.2    Condeelis, J.3
  • 14
    • 0032621294 scopus 로고    scopus 로고
    • GFP as a cell and developmental marker in the Drosophila nervous system
    • Brand, A. GFP as a cell and developmental marker in the Drosophila nervous system. Methods Cell Biol. 58, 165-181 (1999).
    • (1999) Methods Cell Biol , vol.58 , pp. 165-181
    • Brand, A.1
  • 15
    • 0028827602 scopus 로고
    • The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system
    • doi:0959-4388(95)80061-1 [pii]
    • Brand, A.H. & Dormand, E.L. The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system. Curr Opin Neurobiol. 5, 572-578, doi:0959-4388(95)80061-1 [pii] (1995).
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 572-578
    • Brand, A.H.1    Dormand, E.L.2
  • 16
    • 30644469503 scopus 로고    scopus 로고
    • Drosophila models for cancer research
    • doi:S0959-437X(05)00217-0 [pii]10.1016/j.gde.2005.12.004
    • Vidal, M. & Cagan, R.L. Drosophila models for cancer research. Curr Opin Genet Dev. 16, 10-16, doi:S0959-437X(05)00217-0 [pii]10.1016/j.gde.2005.12.004 (2006).
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 10-16
    • Vidal, M.1    Cagan, R.L.2
  • 17
    • 10744233572 scopus 로고    scopus 로고
    • Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
    • doi:10.1038/ng1312ng1312 [pii]
    • Parks, A.L., et al. Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat Genet. 36, 288-292, doi:10.1038/ng1312ng1312 [pii] (2004).
    • (2004) Nat Genet , vol.36 , pp. 288-292
    • Parks, A.L.1
  • 18
    • 0242550729 scopus 로고    scopus 로고
    • Genetic mosaic techniques for studying Drosophila development
    • doi:10.1242/dev.00774130/21/5065 [pii]
    • Blair, S.S. Genetic mosaic techniques for studying Drosophila development. Development. 130, 5065-5072, doi:10.1242/dev.00774130/21/5065 [pii] (2003).
    • (2003) Development , vol.130 , pp. 5065-5072
    • Blair, S.S.1
  • 19
    • 0027267041 scopus 로고
    • Analysis of genetic mosaics in developing and adult Drosophila tissues
    • Xu, T. & Rubin, G.M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development. 117, 1223-1237 (1993).
    • (1993) Development , vol.117 , pp. 1223-1237
    • Xu, T.1    Rubin, G.M.2
  • 20
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu, T., Wang, W., Zhang, S., Stewart, R.A., & Yu, W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development. 121, 1053-1063 (1995).
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 21
    • 0033962585 scopus 로고    scopus 로고
    • A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein
    • Rebay, I., et al. A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics. 154, 695-712 (2000).
    • (2000) Genetics , vol.154 , pp. 695-712
    • Rebay, I.1
  • 22
    • 0033756219 scopus 로고    scopus 로고
    • A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila
    • Therrien, M., Morrison, D.K., Wong, A.M., & Rubin, G.M. A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics. 156, 1231-1242 (2000).
    • (2000) Genetics , vol.156 , pp. 1231-1242
    • Therrien, M.1    Morrison, D.K.2    Wong, A.M.3    Rubin, G.M.4
  • 23
    • 0023187867 scopus 로고
    • A rapid in vitro assay for quantitating the invasive potential of tumor cells
    • Albini, A., et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 47, 3239-3245 (1987).
    • (1987) Cancer Res , vol.47 , pp. 3239-3245
    • Albini, A.1
  • 24
    • 0025788971 scopus 로고
    • A new direct-viewing chemotaxis chamber
    • Zicha, D., Dunn, G.A., & Brown, A.F. A new direct-viewing chemotaxis chamber. J Cell Sci. 99 (Pt 4), 769-775 (1991).
    • (1991) J Cell Sci , vol.99 , Issue.PART 4 , pp. 769-775
    • Zicha, D.1    Dunn, G.A.2    Brown, A.F.3
  • 25
    • 0026234344 scopus 로고
    • New developments in in vivo models of neoplasia
    • Fidler, I.J. New developments in in vivo models of neoplasia. Cancer Metastasis Rev. 10, 191-192 (1991).
    • (1991) Cancer Metastasis Rev , vol.10 , pp. 191-192
    • Fidler, I.J.1
  • 26
    • 0025848654 scopus 로고
    • Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor
    • Mueller, B.M., Romerdahl, C.A., Trent, J.M., & Reisfeld, R.A. Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor. Cancer Res. 51, 2193-2198 (1991).
    • (1991) Cancer Res , vol.51 , pp. 2193-2198
    • Mueller, B.M.1    Romerdahl, C.A.2    Trent, J.M.3    Reisfeld, R.A.4
  • 27
    • 84865358470 scopus 로고    scopus 로고
    • Zebrafish xenografts as a tool for in vivo studies on human cancer
    • doi:10.1111/j.1749-6632.2012.06575.x
    • Konantz, M., et al. Zebrafish xenografts as a tool for in vivo studies on human cancer. Ann N Y Acad Sci 1266, 124-137, doi:10.1111/j.1749-6632.2012.06575.x (2012).
    • (2012) Ann N Y Acad Sci , vol.1266 , pp. 124-137
    • Konantz, M.1
  • 28
    • 84858441210 scopus 로고    scopus 로고
    • Cancer gene discovery in the mouse
    • doi:S0959-437X(11)00185-7 [pii]10.1016/j.gde.2011.12.003
    • McIntyre, R.E., van der Weyden, L. & Adams, D.J. Cancer gene discovery in the mouse. Curr Opin Genet Dev. 22, 14-20, doi:S0959-437X(11)00185-7 [pii]10.1016/j.gde.2011.12.003 (2012).
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 14-20
    • McIntyre, R.E.1    van der Weyden, L.2    Adams, D.J.3
  • 29
    • 70349242219 scopus 로고    scopus 로고
    • Cancer gene discovery in mouse and man
    • doi:S0304-419X(09)00009-2 [pii]10.1016/j.bbcan.2009.03.001
    • Mattison, J., van der Weyden, L., Hubbard, T. & Adams, D.J. Cancer gene discovery in mouse and man. Biochim Biophys Acta. 1796, 140-161, doi:S0304-419X(09)00009-2 [pii]10.1016/j.bbcan.2009.03.001 (2009).
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 140-161
    • Mattison, J.1    van der Weyden, L.2    Hubbard, T.3    Adams, D.J.4
  • 30
    • 81455136725 scopus 로고    scopus 로고
    • Modeling tumor invasion and metastasis in Drosophila
    • doi:dmm.006908 [pii]10.1242/dmm.006908
    • Miles, W.O., Dyson, N.J. & Walker, J.A. Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech. 4, 753-761, doi:dmm.006908 [pii]10.1242/dmm.006908 (2011).
    • (2011) Dis Model Mech , vol.4 , pp. 753-761
    • Miles, W.O.1    Dyson, N.J.2    Walker, J.A.3
  • 31
    • 80054962143 scopus 로고    scopus 로고
    • Tumor invasion and metastasis in Drosophila: A bold past, a bright future
    • doi:S1673-8527(11)00165-2, [pii]10.1016/j.jgg.2011.09.004
    • Stefanatos, R.K. & Vidal, M. Tumor invasion and metastasis in Drosophila: a bold past, a bright future. J Genet Genomics. 38, 431-438, doi:S1673-8527(11)00165-2 [pii]10.1016/j.jgg.2011.09.004 (2011).
    • (2011) J Genet Genomics , vol.38 , pp. 431-438
    • Stefanatos, R.K.1    Vidal, M.2
  • 32
    • 33845805230 scopus 로고    scopus 로고
    • Drosophila brain tumor metastases express both neuronal and glial cell type markers
    • doi:S0012-1606(06)01220-6 [pii]10.1016/j.ydbio.2006.09.019
    • Beaucher, M., et al. Drosophila brain tumor metastases express both neuronal and glial cell type markers. Dev Biol. 301, 287-297, doi:S0012-1606(06)01220-6 [pii]10.1016/j.ydbio.2006.09.019 (2007).
    • (2007) Dev Biol , vol.301 , pp. 287-297
    • Beaucher, M.1
  • 33
    • 33847351560 scopus 로고    scopus 로고
    • Metastatic ability of Drosophila tumors depends on MMP activity
    • doi:S0012-1606(06)01401-1 [pii]10.1016/j.ydbio.2006.12.001
    • Beaucher, M., Hersperger, E., Page-McCaw, A., & Shearn, A. Metastatic ability of Drosophila tumors depends on MMP activity. Dev Biol. 303, 625-634, doi:S0012-1606(06)01401-1 [pii]10.1016/j.ydbio.2006.12.001 (2007).
    • (2007) Dev Biol , vol.303 , pp. 625-634
    • Beaucher, M.1    Hersperger, E.2    Page-McCaw, A.3    Shearn, A.4
  • 34
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • doi:nrc2618 [pii]10.1038/nrc2618
    • Joyce, J.A. & Pollard, J.W. Microenvironmental regulation of metastasis. Nat Rev Cancer. 9, 239-252, doi:nrc2618 [pii]10.1038/nrc2618 (2009).
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 35
    • 33744525123 scopus 로고    scopus 로고
    • Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila
    • doi:S0960-9822(06)01539-9 [pii]10.1016/j.cub.2006.04.042
    • Igaki, T., Pagliarini, R.A., & Xu, T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol. 16, 1139-1146, doi:S0960-9822(06)01539-9 [pii]10.1016/j.cub.2006.04.042 (2006).
    • (2006) Curr Biol , vol.16 , pp. 1139-1146
    • Igaki, T.1    Pagliarini, R.A.2    Xu, T.3
  • 36
    • 24944464907 scopus 로고    scopus 로고
    • Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model
    • doi:0504170102 [pii]10.1073/pnas.0504170102
    • Uhlirova, M., Jasper, H., & Bohmann, D. Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci U S A. 102, 13123-13128, doi:0504170102 [pii]10.1073/pnas.0504170102 (2005).
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13123-13128
    • Uhlirova, M.1    Jasper, H.2    Bohmann, D.3
  • 37
    • 33751111927 scopus 로고    scopus 로고
    • JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila
    • doi:7601401 [pii]10.1038/sj.emboj.7601401
    • Uhlirova, M. & Bohmann, D. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 25, 5294-5304, doi:7601401 [pii]10.1038/sj.emboj.7601401 (2006).
    • (2006) EMBO J , vol.25 , pp. 5294-5304
    • Uhlirova, M.1    Bohmann, D.2
  • 38
    • 37249086048 scopus 로고    scopus 로고
    • A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation
    • doi:genetics.107.078360 [pii]10.1534/genetics.107.078360
    • Menut, L., et al. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 177, 1667-1677, doi:genetics.107.078360 [pii]10.1534/genetics.107.078360 (2007).
    • (2007) Genetics , vol.177 , pp. 1667-1677
    • Menut, L.1
  • 39
    • 75749106942 scopus 로고    scopus 로고
    • Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion
    • doi:nature08702 [pii]10.1038/nature08702
    • Wu, M., Pastor-Pareja, J.C., & Xu, T. Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature. 463, 545-548, doi:nature08702 [pii]10.1038/nature08702 (2010).
    • (2010) Nature , vol.463 , pp. 545-548
    • Wu, M.1    Pastor-Pareja, J.C.2    Xu, T.3


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