Potential release of in vivo trace metals from metallic medical implants in the human body: From ions to nanoparticles - A systematic analytical review

Acta Biomaterialia

Volumn 10, Issue 6, 2014, Pages 2379-2403

  Matusiewicz, Henryk ^a  

^a POZNAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Analytical methodology; Biological fluids and tissues; In vivo metal ion release; Metallic medical implants; Nanoparticles

Indexed keywords

DENTAL PROSTHESES; HISTOLOGY; METAL IMPLANTS; METAL IONS; METAL NANOPARTICLES; METALS; SURGERY; TISSUE; TRACE ELEMENTS;

ANALYTICAL METHODOLOGY; BIOLOGICAL FLUIDS; BIOLOGICAL TISSUES; IN VIVO METAL ION RELEASE; IN-VIVO; MEDICAL IMPLANTS; METAL-ION RELEASE; METALLIC MEDICAL IMPLANT; METALLICS; TRACE METAL;

BODY FLUIDS;

ALLOY; CHROMIUM; COBALT; DENTAL ALLOY; METAL ION; MOLYBDENUM; NIOBIUM; STAINLESS STEEL; TANTALUM; TITANIUM; TRACE METAL; ZIRCONIUM; METAL; NANOPARTICLE; TRACE ELEMENT;

ALLERGIC REACTION; ANALYTIC METHOD; BLOOD LEVEL; BODY FLUID; CLINICAL EVALUATION; CLINICAL STUDY; CORROSION; DILUTION; DISSOLUTION; HUMAN; IMPLANT; IN VIVO STUDY; MAGNETIC SECTOR MASS SPECTROMETRY; META ANALYSIS; METAL IMPLANTATION; METAL ON METAL JOINT PROSTHESIS; METALLIC MEDICAL IMPLANT; ORTHODONTIC DEVICE; ORTHOPEDIC SURGERY; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SPINE IMPLANT; STORAGE; SYSTEMATIC REVIEW; TISSUE LEVEL; TOOTH IMPLANT; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; URINE LEVEL; CHEMISTRY; PROSTHESES AND ORTHOSES;

HUMANS; METALS; NANOPARTICLES; PROSTHESES AND IMPLANTS; TRACE ELEMENTS;

EID: 84899623514     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.02.027     Document Type: Review

References (213)

1. Virtanen S, Milošev I, Gomez-Barrena E, Trebše R, Salo J, Konttinen YT. Special modes of corrosion under physiological and simulated physiological conditions. Acta Biomater 2008;4:468-76.
2. Kamachi Mudali U, Sridhar TM, Ray B. Corrosion of bio implants. Sadhana 2003;28:601-37.
3. Hanawa T. Metal ion release from metal implants. Mater Sci Eng 2004;C24:745-52.
4. Cadosch D, Chan E, Gautschi OP, Filgueira L. Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening - current concepts. J Biomed Mater Res Part A 2009;91:1252-62.
5. Singh R, Dahotre NB. Corrosion degradation and prevention by surface modification of biometallic materials. J Mater Sci Mater Med 2007;18:725-51.
6. Kirkland NT, Birbilis N, Staiger MP. Assessing the corrosion of biodegradable magnesium implants: a critical review of current methodologies and their limitations. Acta Biomater 2012;8:925-36.
7. Olmedo DG, Tasat DR, Duffo G, Guglielmotti MB, Cabrini RL. The issue of corrosion in dental implants: a review. Acta Odontol Latinoam 2009;22:3-9.
8. Bhola R, Bhola SM, Mishra B, Olson DL. Corrosion in titanium dental implants/ prostheses - a review. Trends Biomater Artif Organs 2011;25:34-6.
9. Antunes RA, Lopes de Oliveira MC. Corrosion fatigue of biomedical metallic alloys: mechanisms and mitigation. Acta Biomater 2012;8:937-62.
10. Bischoff UW, Freeman MAR, Smith D, Tuke MA, Gregson PJ. Wear induced by motion between bone and titanium or cobalt-chrome alloys. J Bone Joint Surg 1994;76-B:713-6.
11. Jacobs JJ, Gilbert JL, Urban RM. Current concepts review. Corrosion of metal orthopaedic implants. J Bone Joint Surg 1998;80-A:268-82.
12. Urban RM, Jacobs JJ, Gilbert JL, Galante JO. Migration of corrosion products from modular hip prostheses. J Bone Joint Surg 1994;76-A:1345-59.
13. Daley B, Doherty AT, Fairman B, Case CP. Wear debris from hip or knee replacements causes chromosomal damage in human cells in tissue culture. J Bone Joint Surg 2004;86-B:598-606.
14. Milošev I, Remškar M. In vivo production of nanosized metal wear debris formed by tribochemical reaction as confirmed by high-resolution TEM and XPS analyses. J Biomed Mater Res Part A 2008;90:1100-10.
15. Ichinose S, Muneta T, Sekiya I, Itoh S, Aoki H, Tagami M. The study of metal ion release and cytotoxicity in Co-Cr-Mo and Ti-Al-V alloy in total knee prosthesis - scanning electron microscopic observation. J Mater Sci: Mater Med 2003;14:79-86.
16. Urban RM, Jacobs JJ, Tomlinson MJ, Gavrilovic J, Black J, Peoc'h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J Bone Joint Surg 2000;82- A:457-77.
17. Oudadesse H, Irigaray JL, Chassot E. Detection of metallic elements migration around a prosthesis by neutron activation analysis and by the PIXE method. J Trace Microprobe Techniques 2000;18:505-10.
18. Doorn PF, Campbell PA, Worrall J, Benya PD, McKellop HA, Amstutz HC. Metal wear particle characterization from metal on metal total hip replacements: transmission electron microscopy study of periprosthetic tissues and isolated particles. J Biomed Mater Res 1998;42:103-11.
19. Basle MF, Bertrand G, Guyetant S, Chappard D, Lesourd M. Migration of metal and polyethylene particles from articular prostheses may generate lymphadenopathy with histiocytosis. J Biomed Mater Res 1996;30:157-64.
20. Campbell P, Urban RM, Catelas I, Skipor AK, Schmalzried TP. Autopsy analysis thirty years after metal-on-metal total hip replacement. J Bone Joint Surg Incorp 2003;85:2218-22.
21. Huber M, Reinisch G, Trettenhahn G, Zweymuller K, Lintner F. Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces. Acta Biomater 2009;5:172-80.
22. Al-Hajjar M, Fisher J, Williams S, Tipper JL, Jennings LM. Effect of femoral head size on the wear of metal on metal bearings in total hip replacements under adverse edge-loading conditions. J Biomed Mater Res B Appl Biomater 2013;101B:213-22.
23. Catelas I, Bobyn JD, Medley JB, Krygier JJ, Zukor DJ, Petit A, et al. Effects of digestion protocols on the isolation and characterization of metal-metal wear particles. I. Analysis of particle size and shape. J Biomed Mater Res 2001;55:320-9.
24. Catelas I, Bobyn JD, Medley JB, Krygier JJ, Zukor DJ, Petit A, et al. Effects of digestion protocols on the isolation and characterization of metal-metal wear particles. II. Analysis of ion release and particle composition. J Biomed Mater Res 2001;55:330-7.
25. Case CP, Langkamer VG, James C, Palmer MR, Kemp AJ, Heap PF, et al. Widespread dissemination of metal debris from implants. J Bone Joint Surg 1994;76-B:701-12.
26. Passi P, Zadro A, Galassini S, Rossi P, Moschini G. PIXE micro-beam mapping of metals in human peri-implant tissues. J Mater Sci Mater Med 2002;13:1083-9.
27. Niinomi M, Nakai M, Hieda J. Development of new metallic alloys for biomedical applications. Acta Biomaterialia 2012;8:3888-903.
28. Long M, Rack HJ. Titanium alloys in total joint replacement - a materials science perspective. Biomaterials 1998;19:1621-39.
29. Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: A review. Biomaterials 2006;27:1728-34.
30. Witte F. The history of biodegradable magnesium implants: a review. Acta Biomaterialia 2010;6:1680-92.
31. Bansiddhi A, Sargeant TD, Stupp SI, Dunand DC. Porous NiTi for bone implants: a review. Acta Biomater 2008;4:773-82.
32. Novikova GE. Introduction to corrosion of bioimplants. Protection Metals Phys Chem Surf 2011;47:372-80.
33. Buford A, Goswami T. Review of wear mechanisms in hip implants. Paper I. General. Mater Design 2004;25:385-93.
34. Milošev I. Metallic materials for biomedical applications: laboratory and clinical studies. Pure Appl Chem 2011;83:309-24.
35. Swiontkowski MF, Agel J, Schwappach J, McNair P, Welch M. Cutaneous metal sensitivity in patients with orthopaedic injuries. J. Orthop Trauma 2001;15:86-9.
36. Sargeant A, Goswami T. Hip implants. Paper VI. Ion concentrations. Mater Design 2007;28:155-71.
37. Afolaranmi GA, Tettey J, Meek RMD, Grant MH. Release of chromium from orthopaedic arthroplasties. Open Orthop J 2008;2:10-8.
38. Marti A. Cobalt-base alloys used in bone surgery. Injury Int J Care Injured 2000;31:S-D18-21.
39. Okazaki Y, Gotoh E. Comparison of metal release from various metallic biomaterials in vitro. Biomaterials 2005;26:11-21.
40. Sunderman Jr FW, Hopfer SM, Swift T, Rezuke WN, Ziebka L, Highman P, et al. Cobalt, chromium, and nickel concentrations in body fluids of patients with porous-coated knee or hip prostheses. J Orthop Res 1989;7:307-15.
41. Lugowski SJ, Smith DC, McHugh AD, Van Loon JC. Determination of chromium, cobalt and molybdenum in synovial fluid by GFAAS. J Trace Elem Electrolytes Health Dis 1991;5:23-9.
42. Leopold SS, Berger RA, Patterson L, Skipor AK, Urban RM, Jacobs JJ. Serum titanium level for diagnosis of a failed, metal-backed patellar component. J Arthroplasty 2000;15:938-43.
43. Lutzner J, Dinnebier G, Hartmann A, Gunther K-P, Kirschner S. Study rationale and protocol: prospective randomized comparison of metal ion concentrations in the patient's plasma after implantation of coated and uncoated total knee prostheses. BMC Musculoskeletal Dis 2009;10:128-33.
44. Luetzner J, Krummenauer F, Lengel AM, Ziegler J, Witzleb W-C. Serum metal ion exposure after total knee arthroplasty. Clin Orthop Relat Res 2007;461:136-42.
45. Friesenbichler J, Maurer-Ertl W, Sadoghi P, Lovse T, Windhager R, Leithner A. Serum metal ion levels after rotating-hinge knee arthroplasty: comparison between a standard device and a megaprosthesis. Int Orthop 2012;36:539-44.
46. Sarmiento-Gonzalez A, Marchante-Gayon JM, Tejerina-Lobo JM, Paz-Jimenez J, Sanz-Medel A. High-resolution ICP-MS determination of Ti, V, Cr Co, Ni, and Mo in human blood and urine of patients implanted with a hip or knee prosthesis. Anal Bioanal Chem 2008;391:2583-9.
47. Liu T-K, Liu S-H, Chang C-H, Yang R-S. Concentration of metal elements in the blood and urine in the patients with cementless total knee arthroplasty. Tohoku J Exp Med 1998;185:253-62.
48. Rello L, Lapena AC, Aramendia M, Belarra MA, Resano M. A dried urine spot test to simultaneously monitor Mo and Ti levels using solid sampling high- resolution continuum source graphite furnace atomic absorption spectrometry. Spectrochim Acta Part B 2013;81:11-9.
49. Coleman RF, Herrington J, Scales JT. Concentration of wear products in hair, blood, and urine after total hip replacement. Br Med J 1973;1:527-33.
50. Dumbleton JH, Manley MT. Metal-on-metal total hip replacement. What does the literature say? J Arthroplasty 2005;20:174-88.
51. Pazzaglia UE, Minoia C, Ceciliani L, Riccardi C. Metal determination in organic fluids of patients with stainless steel hip arthroplasty. Acta Orthop Scand 1983;54:574-9.
52. MacDonald SJ. Can a safe level for metal ions in patients with metal-on-metal total hip arthroplasties be determined? J Arthroplasty 2004;19:71-7.
53. Schaffer AW, Pilger A, Engelhardt C, Zweymueller K, Ruediger HW. Increased blood cobalt and chromium after total hip replacement. Clin Toxicol 1999;37:839-44.
54. Lhotka C, Szekeres T, Steffan I, Zhuber K, Zweymuller K. Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements. J Orthop Res 2003;21:189-95.
55. Masse A, Bosetti M, Buratti C, Visentin O, Bergadano D, Cannas M. Ion release and chromosomal damage from total hip prostheses with metal-on-metal articulation. J Biomed Mater Res 2003;67:750-7.
56. Ladon D, Doherty A, Newson R, Turner J, Bhamra M, Case CP. Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty. J Arthroplasty 2004;19:78-83.
57. Dunstan E, Sanghrajka AP, Tilley S, Unwin P, Blunn G, Cannon SR, et al. Metal ion levels after metal-on-metal proximal femoral replacements. A 30-year follow-up. J Bone Joint Surg 2005;87B:628-31.
58. Hart AJ, Hester T, Sinclair K, Powell JJ, Goodship AE, Pele L, et al. The association between metal ions from hip resurfacing and reduced T-cell counts. J Bone Joint Surg 2006;88-B:449-54.
59. Antoniou J, Zukor DJ, Mwale F, Minarik W, Petit A, Huk OL. Metal ion levels in the blood of patients after hip resurfacing: a comparison between twentyeight and thirty-six-millimeter-head metal-on-metal prostheses. J Bone Joint Surg Am 2008;90:142-8.
60. Daniel J, Ziaee H, Salama A, Pradhan C, McMinn DJW. The effect of the diameter of metal-on-metal bearings on systemic exposure to cobalt and chromium. J Bone Joint Surg 2006;88-B:443-8.
61. Vendittoli P-A. Mottard S, Roy AG, Dupont C, Lavigne M. Chromium and cobalt ion release following the Durom high carbon content, forged metal-onmetal surface replacement of the hip. J Bone Joint Surg 2007;89-B:441-8.
62. Vendittoli P-A, Roy A, Mottard S, Girard J, Lusignan D, Lavigne M. Metal ion release from bearing wear and corrosion with 28 mm and large-diameter metal-on-metal bearing articulations. A follow-up study. J Bone Joint Surg 2010;92-B:12-9.
63. Vendittoli P-A, Riviere C, Roy AG, Barry J, Lusignan D, Lavigne M. Metal-onmetal hip resurfacing compared with 28-mm diameter metal-on-metal total hip replacement. Bone Joint J 2013;95-B:1464-73.
64. Daniel J, Ziaee H, Pradhan C, Pynsent PB, McMinn DJW. Blood and urine metal ion levels in young and active patients after Birmingham hip resurfacing arthroplasty. J Bone Joint Surg 2007;89-B:169-73.
65. Daniel J, Ziaee H, Pradhan C, McMinn DJW. Six-year results of a prospective study of metal ion levels in young patients with metal-on-metal hip resurfacings. J Bone Joint Surg 2009;91-B:176-9.
66. Ziaee H, Daniel J, Datta AK, Blunt S, McMinn DJW. Transplacental transfer of cobalt and chromium in patients with metal-on-metal hip arthroplasty. A controlled study. J Bone Joint Surg 2007;89-B:301-5.
67. Daniel J, Ziaee H, Pynsent PB, McMinn DJW. The validity of serum levels as a surrogate measure of systemic exposure to metal ions in hip replacement. J Bone Joint Surg 2007;89-B:736-41.
68. Walter LR, Marel E, Harbury R, Wearne J. Distribution of chromium and cobalt ions in various blood fractions after resurfacing hip arthroplasty. J Arthroplasty 2008;23:814-21.
69. Smolders JMH, Bisseling P, Hol A, Van der Straeten C, Schreurs BW, van Susante JLC. Metal ion interpretation in resurfacing versus conventional hip arthroplasty and in whole blood versus serum. How should we interpret metal ion data? Hip Int 2011;21:587-95.
70. Smolders JMH, Hol A, Rijnberg WJ, van Susante JLC. Metal ion levels and functional results after either resurfacing hip arthroplasty or conventional metal-on-metal hip arthroplasty. Short-term outcome of a randomized controlled trial. Acta Orthop 2011;82:559-66.
71. Hart AJ, Sabah SA, Bandi AS, Maggiore P, Tarassoli P, Sampson B, et al. Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of metal-on-metal hip replacement. J Bone Joint Surg 2011;93-B:1308-13.
72. Hart AJ, Skinner JA, Henckel J, Sampson B, Gordon F. Insufficient acetabular version increases blood metal ion levels after meta-on-metal hip resurfacing. Clin Orthop Relat Res 2011;469:2590-7.
73. Newton AW, Ranganath L, Armstrong C, Peter V, Roberts NB. Differential distribution of cobalt, chromium, and nickel between whole blood, plasma and urine in patients after metal-on-metal (MoM) hip arthroplasty. J Orthop Res 2012;30:1640-6.
74. Hart AJ, Buddhdev P, Winship P, Faria N, Powell JJ, Skinner JA. Cup inclination angle of greater than 50 degrees increases whole blood concentrations of cobalt and chromium ions after metal-on-metal hip resurfacing. Hip Int 2008;18:212-9.
75. Davda K, Lali FV, Sampson B, Skinner JA, Hart AJ. An analysis of metal ion levels in th joint fluid of symptomatic patients with metal-on-metal hip replacements. J Bone Joint Surg 2011;93-B:738-45.
76. Langton DJ, Jameson SS, Joyce TJ, Webb J, Nargol AVF. The effect of component size and orientation on the concentrations of metal ions after resurfacing arthroplasty of the hip. J Bone Joint Surg 2008;90-B:1143-51.
77. Langton DJ, Jameson SS, Joyce TJ, Hallab NJ, Natu S, Webb J, et al. Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement. A consequence of excess wear. J Bone Joint Surg 2010;92:38-45.
78. Desy NM, Bergeron SG, Petit A, Huk OL, Antoniou J. Surgical variables influence metal ion levels after hip resurfacing. Clin Orthop Relat Res 2011;469:1635-41.
79. Vendittoli P-A, Amzica T, Roy AG, Lusignan D, Girard J, Lavigne M. Metal ion release with large-diameter metal-on-metal hip arthroplasty. J Arthroplasty 2011;26:282-8.
80. Omlor GW, Kretzer JP, Reinders J, Streit MR, Bruckner T, Gotterbarm T, et al. In vivo serum titanium ion levels following modular neck total hip arthroplasty - 10 year results in 67 patients. Acta Biomater 2013;9:6278-82.
81. Tkaczyk C, Petit A, Antoniou J, Zukor DJ, Tabrizian M, Huk OL. Significance of elevated blood metal ion levels in patients with metal-on-metal prostheses: an evaluation of oxidative stress markers. Open Orthop J 2010;4:221-7.
82. Case CP, Ellis L, Turner JC, Fairman B. Development of a routine method for the determination of trace metals in whole blood by magnetic sector inductively coupled plasma mass spectrometry with particular relevance to patients with total hip and knee arthroplasty. Clin Chem 2011;47:275-80.
83. Isaac GH, Siebel T, Oakeshott RD, McLennan-Smith R, Cobb AG, Schmalzried TP, et al. Changes in whole blood metal ion levels following resurfacing: serial measurements in a multi-centre study. Hip Int 2009;19:330-7.
84. Berstein M, Walsh A, Petit A, Zukor DJ, Antoniou J. Femoral head size does not affect ion values in metal-on-metal total hips. Clin Orthop Relat Res 2011;469:1642-50.
85. Pattyn CA, Lauwagie SN, Verdonk RC. Whole blood metal ion concentrations in correlation with activity level in three different metal-on-metal bearings. J Arthroplasty 2011;26:58-64.
86. Lavigne M, Belzile EL, Roy A, Morin F, Amzica T, Vendittoli P-A. Comparison of whole-blood metal ion levels in four types of metal-on-metal large-diameter femoral head total hip arthroplasty: the potential influence of the adapter sleeve. J Bone Joint Surg 2011;93:128-36.
87. Moroni A, Savarino L, Hoque M, Cadossi M, Baldini N. Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm? Clin Orthop Relat Res 2011;469:180-7.
88. Savarino L, Cadossi M, Chiarello E, Baldini N, Giannini S. Do ion levels in metal-on-metal hip resurfacing differ from those in metal-on-metal THA at long-term followup? Clin Orthop Relat Res 2013;471:2964-71.
89. Ball ST, Severns D, Linn M, Meyer RS, Swenson FC. What happens to serum metal ion levels after a metal-on-metal bearing is removed? J Arthroplasty 2013;28(Suppl.):53-5.
90. Skipor AK, Campbell PA, Patterson LM, Anstutz HC, Schmalzried TP, Jacobs JJ. Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. J Mater Sci Mater Med 2002;13:1227-34.
91. Brodner W, Bitzan P, Meisinger V, Kaider A, Gottsauner-Wolf F, Kotz R. Elevated serum cobalt with metal-on-metal articulating surfaces. J Bone Joint Surg 1997;79-B:316-21.
92. Brodner W, Bitzan P, Meisinger V, Kaider A, Gottsauner-Wolf F, Kotz R. Serum cobalt levels after metal-on-metal total hip arthroplasty. J Bone Joint Surg Incorporated 2003;85:2168-73.
93. Gleizes V, Poupon J, Lazennec JY. Value and limits of determining serum cobalt levels in patients with metal on metal articulating prostheses. Rev Chir Orthop Reparatrice Appar Mot 1999;85:217-24.
94. Clarke MT, Lee PTH, Arora A, Villar RN. Levels of metal ions after small- and large-diameter metal-on-metal hip arthroplasty. J Bone Joint Surg 2003;85- B:913-7.
95. Savarino L, Granchi D, Ciapetti G, Cenni E, Greco M, Rotini R, et al. Ion release in stable hip arthroplasties using metal-on-metal articulating surfaces: a comparison between short- and medium-term results. J. Biomed Mater Res 2003;66-A:450-6.
96. Patton MS, Lyon TDB, Ashcroft GP. Levels of systemic metal ions in patients with intramedullary nails. Acta Orthop 2008;79:820-5.
97. Damie F, Favard L. Metal serum levels in 48 patients bearing a chromium- cobalt total hip arthroplasty with a metal-on-polyethylene combination. Rev Chir Orthop Reparatrice Appar Mot 2004;90:241-8.
98. Maezawa K, Nozawa M, Matsuda K, Yasuma M, Mori K, Enomoto F, et al. Chronological changes of serum chromium levels after modern metal-onmetal total hip arthroplasty. Acta Orthop Scand 2004;75:422-6.
99. Maezawa K, Nozawa M, Yuasa T, Aritomi K, Matsuda K, Shitoto K. Seven years of chronological changes of serum chromium levels after metasul metal-onmetal total hip arthroplasty. J Arthroplasty 2010;25:1196-200.
100. Hasegawa M, Yoshida K, Wakabayashi H, Sudo A. Cobalt and chromium ion release after large-diameter metal-on-metal total hip arthroplasty. J Arthroplasty 2012;27:990-6.
101. Maezawa K, Nozawa M, Hirose T, Matsuda K, Yasuma M, Shitoto K, et al. Cobalt and chromium concentrations in patients with metal-on-metal and other cementless total hip arthroplasty. Arch Orthop Trauma Surg 2002;122:283-7.
102. Heisel C, Silva M, Skipor AK, Jacobs JJ, Schmalzried TP. The relationship between activity and ions in patients with metal-on-metal bearing hip prostheses. J Bone Joint Surg Incorporated 2005;87:781-7.
103. Milošev I, Pišot V, Campbell P. Serum levels of cobalt and chromium in patients with Sikomet metal-metal total hip replacements. J Orthop Res 2005;23:526-35.
104. Iavicoli I, Falcone G, Alessandrelli M, Cresti R, de Santis V, Alimonti A, et al. The release of metals from metal-on-metal surface arthroplasty of the hip. J Trace Elem Med Biol 2006;20:25-31.
105. Rasquinha VJ, Ranawat CS, Weiskopf J, Rodriguez JA, Skipor AK, Jacobs JJ. Serum metal levels and bearing surfaces in total hip arthroplasty. J Arthroplasty 2006;21:47-52.
106. Black J, Maitin EC, Gelman H, Morris DM. Serum concentrations of chromium, cobalt and nickel after total hip replacement: a six month study. Biomaterials 1983;4:160-4.
107. Witzleb W-C, Ziegler J, Krummenauer F, Neumeister V, Guenther K-P. Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty. Acta Orthop 2006;77:697-705.
108. Grubl A, Weissinger M, Brodner W, Gleiss A, Giurea A, Gruber M, et al. Serum aluminium and cobalt levels after ceramic-on-ceramic and metal-on-metal total hip replacement. J Bone Joint Surg 2006;88-B:1003-5.
109. Sauve P, Mountney J, Khan T, de Beer J, Higgins B, Grover M. Metal ion levels after metal-on-metal Ring total hip replacement. A 30-year follow-up study. J Bone Joint Surg 2007;89-B:586-90.
110. Grubl A, Marker M, Brodner W, Giurea A, Heinze G, Meisinger V, et al. Longterm follow-up of metal-on-metal total hip replacement. J Orthop Res 2007;25:841-8.
111. de Haan R, Pattyn C, Gill HS, Murray DW, Campbell PA, de Smet K. Correlation between inclination of the acetabular component and metal ion levels in metal-on-metal hip resurfacing replacement. J Bone Joint Surg 2008;90- B:1291-7.
112. Hartmann A, Lutzner J, Kirschener S, Witzleb W-C, Gunther K-P. Do survival rate and serum ion concentrations 10 years after metal-on-metal hip resurfacing provide evidence for continued use? Clin Orthop Relat Res 2012;470:3118-26.
113. Langton DJ, Sprowson AP, Joyce TJ, Reed M, Carluke I, Partington P, et al. Blood metal ion concentrations after hip resurfacing arthroplasty. A comparative study of articular surface replacement and Birmingham hip resurfacing arthroplasties. J Bone Joint Surg 2009;91-B:1287-95.
114. Lazennec J-Y, Boyer P, Poupon J, Rousseau M-A, Roy C, Ravaud P, et al. Outcome and serum ion determination up to 11 years after implantation of a cemented metal-on-metal hip prosthesis. Acta Orthop 2009;80:168-73.
115. Engh Jr CA, MacDonald SJ, Sritulanondha S, Thompson A, Naudie D, Engh CA. Metal ion levels after metal-on-metal total hip arthroplasty: a randomized trial. Clin Orthop Relat Res 2009;467:101-11.
116. Van der Straeten C, Grammatopoulos G, Beng HSG, Calistri A, Campbell P, de Smet KA. The interpretation of metal ion levels in unilateral and bilateral hip resurfacing. Clin Orthop Relat Res 2013;471:377-85.
117. Van der Straeten C, Van Quickenborne B, De Roest B, Calistri A, Victor J, De Smet K. Metal ion levels from well-functioning Birmingham hip resurfacings decline significantly at ten years. Bone Joint J 2013;95-B:1332-8.
118. Savarino L, Padovani G, Ferretti M, Greco M, Cenni E, Perrone G, et al. Serum ion levels after ceramic-on-ceramic and metal-on metal total hip arthroplasty: 8-Year minimum follow-up. J Orthop Res 2008;26:1569-76.
119. Ordonez YN, Montes-Bayon M, Blanco-Gonzalez E, Paz-Jimenez J, Tejerina- Lobo JM, Pena-Lopez JM, et al. Metal release in patients with total hip arthroplasty by DF-ICP-MS and their association to serum proteins. J Anal At Spectrom 2009;24:1037-43.
120. Hallab NJ, Caicedo M, McAllister K, Skipor A, Amstutz H, Jacobs JJ. Asymptomatic prospective and retrospective cohorts with metal-on-metal hip arthroplasty indicate acquired lymphocyte reactivity varies with metal ion levels on a group basis. J Orthop Res 2013;31:173-82.
121. Yoon JP, Le Duff MJ, Johnson AJ, Takamura KM, Ebramzadeh E, Amstutz HC. Contact patch to rim distance predicts metal ion levels in hip resurfacing. Clin Orthop Relat Res 2013;471:1615-21.
122. Levine BR, Hsu AR, Skipor AK, Hallab NJ, Paprosky WG, Galante JO, et al. Tenyear outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report. J Bone Joint Surg Am 2013;95:512-8.
123. Vundelinckx BJ, Verhelst LA, De Schepper J. Taper corrosion in modular hip prostheses analysis of serum metal ions in 19 patients. J Arthroplasty 2013;28:1218-23.
124. Nelis R, de Waal Malefijt J, Gosens T. Breast milk metal ion levels in a young and active patient with a metal-on-metal hip prosthesis. J Arthroplasty 2013;28:19-22.
125. Nuevo-Ordonez Y, Montes-Bayon M, Gonzalez E, Paz-Aparicio J, Raimundez JD, Tejerina JM, et al. Titanium release in serum of patients with different bone fixation implants and its interaction with serum biomolecules at physiological levels. Anal Bioanal Chem 2011;401:2747-54.
126. Granchi D, Savarino L, Ciapetti G, Cenni E, Rotini R, Mieti M, et al. Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement. Bone Joint Surg 2003;85-B:758-64.
127. Johnson AJ, Le Duff MJ, Yoon JP, Al-Hamad M, Amstutz HC. Metal ion levels in total hip arthroplasty versus hip resurfacing. J Arthroplasty 2013;28: 1235-7.
128. Amstutz HC, Campbell PA, Dorey FJ, Johnson AJ, Skipor AK, Jacobs JJ. Do ion concentrations after metal-on-metal hip resurfacing increase over time? A prospective study. J Arthroplasty 2013;28:695-700.
129. Jacobs JJ, Skipor AK, Doom PF, Campbell P, Schmalzried TP, Black J, et al. Cobalt an chromium concentrations in patients with metal on metal total hip replacements. Clin Orthop Relat Res 1996;329(Suppl.):S256-63.
130. Moroni A, Savarino L, Cadossi M, Baldini N, Giannini S. Does ion release differ between hip resurfacing and metal-on-metal THA? Clin Orthop Relat Res 2008;466:700-7.
131. Heisel C, Streich N, Krachler M, Jakubowitz E, Kretzer JP. Characterization of the running-in period in total hip resurfacing arthroplasty: an in vivo and in vitro metal ion analysis. J Bone Joint Surg 2008;90:125-33.
132. Dahlstrand H, Stark A, Anissian L, Hailer NP. Elevated serum concentrations of cobalt, chromium, nickel, and manganese after metal-on-metal alloarthroplasty of the hip: a prospective randomized study. J Arthroplasty 2009;24:837-45.
133. de Souza RM, Parsons NR, Oni T, Dalton P, Costa M, Krikler S. Metal ion levels following resurfacing arthroplasty of the hip. Serial results over a ten-year period. J Bone Joint Surg 2010;92-B:1642-7.
134. Yang J, Shen B, Zhou ZK, Pei F, Kang PD. Changes in cobalt and chromium levels after metal-on-metal hip resurfacing in young, active Chinese patients. J Arthroplasty 2011;26:65-70.
135. Lardanchet J-F, Taviaux J, Arnalsteen D, Gabrion A, Mertl P. One-year prospective comparative study of three large-diameter metal-on-metal total hip prostheses: serum metal ion levels and clinical outcomes. Orthop Traumatol Surg Res 2012;98:265-74.
136. Imanishi T, Hasegawa M, Sudo A. Serum metal ion levels after secondgeneration metal-on-metal total hip arthroplasty. Arch Orthop Trauma Surg 2010;130:1447-50.
137. Allan DG, Trammell R, Dyrstad B, Bamhart B, Milbrandt JC. Serum cobalt and chromium elevations following hip resurfacing with the Cormet 2000 device. J Surg Orthop Adv 2007;16:12-8.
138. Beale PE, Kim PR, Hamdi A, Fazekas A. A prospective metal ion study of largehead metal-on-metal bearing: a matched-pair analysis of hip resurfacing versus total hip replacement. Orthop Clin North Am 2011;42:251-7.
139. Garbuz DS, Tanzer M, Greidanus NV, Masri BA, Duncan CP. Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal total hip arthroplasty. Clin Orthop Relat Res 2010;468:318-25.
140. Brien WW, Salvati EA, Betts F, Bullough P, Wright T, Rimnac C, et al. Metal levels in cemented total hip arthroplasty: a comparison of well-fixed and loose implants. Clin Orthop Relat Res 1992;276:66-74.
141. Nikolaou VS, Petit A, Zukor DJ, Papanastasiou C, Huk OL, Antoniou J. Presence of cobalt and chromium ions in the seminal fluid of young patients with metal-on-metal total hip arthroplasty. J Arthroplasty 2013;28:161-7.
142. Savarino L, Greco M, Cenni E, Cavasinni L, Rotini R, Baldini N, Giunti A. Differences in ion release after ceramic-on-ceramic and metal-on-metal total hip replacement. Medium-term follow-up. J Bone Joint Surg 2006;88-B:472- 6.
143. Lux F, Zeisler R. Investigations of the corrosive deposition of components of metal implants and of the behavior of biological trace elements in metallosis tissue by means of instrumental multi-element activation analysis. J Radioanal Chem 1974;19:289-97.
144. Schnabel C, Herpers U, Michel R, Loer F, Buchhorn G, Willert H-G. Changes of concentrations of the elements Co, Cr, Sb, and Sc in tissues of persons with joint implants. Biol Trace Elem Res 1994;43:389-95.
145. Agins HJ, Alcock NW, Bansal M, Salvati EA, Wilson PD, Pellicci PM, Bullough PG. Metallic wear in failed titanium-alloy total hip replacements. J Bone Joint Surg 1988;70-A:347-56.
146. Zeiner M, Zenz P, Lintner F, Schuster E, Schwagerl W, Steffan I. Influence on elemental status by hip-endoprostheses. Microchem J 2007;85:145-8.
147. Rodriguez de la Flor M, Hernandez-Vaquero D, Fernandez-Carreira JM. Metal presence in hair after metal-on-metal resurfacing arthroplasty. J Orthop Res 2013;31:2015-31.
148. Vieweg U, Van Roost D, Wolf HK, Schyma CA, Schramm J. Corrosion on an internal spinal fixator system. Spine 1999;24:946-51.
149. Wang JC, Yu WD, Sandhu HS, Betts F, Bhuta S, Delamarter RB. Metal debris from titanium spinal implants. Spine 1999:899-903.
150. Kim Y-J, Kassab F, Berven SH, Zurakowski D, Hresko MT, Emans JB, et al. Serum levels of nickel and chromium after instrumented posterior spinal arthrodesis. Spine 2005;30:923-6.
151. del Rio J, Beguiristain J, Duart J. Metal levels in corrosion of spinal implants. Eur Spine J 2007;16:1055-61.
152. Rylander LS, Milbrandt JC, Armington E, Wilson M, Olysav DJ. Trace metal analysis following locked volar plating for unstable fractures of the distal radius. Iowa Orthop J 2010;30:89-93.
153. Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P. Serum titanium levels after instrumental spinal arthrodesis. Spine; 33:792-6.
154. Kasai Y, Iida R, Uchida A. Metal concentrations in the serum and hair of patients with titanium alloy spinal implants. Spine; 28:1320-6.
155. Schliephake H, Scharnweber D. Chemical and biological functionalization of titanium for dental implants. J Mater Chem 2008;18:2404-14.
156. Conrad HJ, Seong WJ, Pesun IJ. Current ceramic materials and systems with clinical recommendations: a systematic review. J Prosthet Dent 2007;98:389-404.
157. Schmalz G, Garhammer P. Biological interactions of dental cast alloys with oral tissues. Dent Mater 2002;18:396-406.
158. Geurtsen W. Biocompatibility of dental casting alloys. Crit Rev Oral Biol Med 2002;13:71-84.
159. House K, Sernetz F, Dymock D, Sandy JR, Ireland AJ. Corrosion of orthodontic appliances - should we care? Am J Orthod Dentofacial Orthop 2008;133:584-92.
160. Adya N, Alam M, Ravindranath T, Mubeen A, Saluja B. Corrosion in titanium dental implants: literature review. J Indian Prosthod Soc 2005;5:126-31.
161. Siddiqi A, Payne AGT, De Silva RK, Duncan WJ. Titanium allergy: could it affect dental implant integration? Clin Oral Impl Res 2011;22:673-80.
162. Brownawell AM, Berent S, Brent RL, Bruckner JV, Doull J, Gershwin EM, et al. The potential adverse health effects of dental amalgam. Toxicol Rev 2005;24:1-10.
163. Roberts HW, Charlton DG. The release of mercury from amalgam restorations and its health effects: a review. Oper Dent 2009;34:605-14.
164. Rathore M, Singh A, Pant VA. The dental amalgam toxicity fear: a myth or actuality. Toxicol Int 2012;19:81-8.
165. Green NT, Machtei EE, Horwitz J, Peled M. Fracture of dental implants: literature review and report of a case. Impl Dent 2002;11:137-43.
166. Amini F, Jafari A, Amini P, Sepasi S. Metal Ion release from fixed orthodontic appliances - an in vivo study. Eur J Orthod 2012;34:126-30.
167. Eliades T, Athanasiou AE. In vivo aging of orthodontic alloys: implications for corrosion potential, nickel release, and biocompatibility. Angle Orthod 2002;72:222-37.
168. Eliades T, Trapalis C, Eliades G, Katsavrias E. Salivary metal levels of orthodontic patients: a novel methodological and analytical approach. Eur J Orthod 2003;25:103-6.
169. Amini F, Farahani AB, Jafari A, Rabbani M. In vivo study of metal content of oral mucosa cells in patients with and without fixed orthodontic appliances. Orthod Craniofac Res 2008;11:51-6.
170. Kerosuo H, Moe G, Hensten-Pettersen A. Salivary nickel and chromium in subjects with different types of fixed orthodontic appliances. Am J Orthod Dentofac Orthop 1997;111:595-8.
171. Kocadereli I, Atac A, Kale S, Ozer D. Salivary nickel and chromium in patients with fixed orthodontic appliances. Angle Orthod 2000;70:431-4.
172. Ag?aog?lu G, Arun T, Izgu B, Yarat A. Nickel and chromium levels in the saliva and serum of patients with fixed orthodontic appliances. Angle Orthod 2001;71:375-9.
173. Faccioni F, Franceschetti P, Cerpelloni M, Francasso ME. In vivo study on metal release from fixed orthodontic appliances and DNA damage in oral mucosa cells. Am J Orthod Dentofac Orthop 2003;124:687-93.
174. Fors R, Persson M. Nickel in dental plaque and saliva in patients with and without orthodontic appliances. Eur J Orthod 2006;28:292-7.
175. Sarmiento-Gonzalez A, Marchante-Gayon JM, Tejerina-Lobo JM, Paz-Jimenez J, Sanz-Medel A. ICP-MS multielemental determination of metals potentially released from dental implants and articular prostheses in human biological fluids. Anal Bioanal Chem 2005;382:1001-9.
176. Singh DP, Sehgal V, Pradhan KL, Chandna A, Gupta R. Estimation of nickel and chromium in saliva of patients with fixed orthodontic appliances. World J Orthod 2008;9:196-202.
177. Petoumenou E, Arndt M, Keilig L, Reimann S, Hoederath H, Eliades T, et al. Nickel concentration in the saliva of patients with nickel-titanium orthodontic appliances. Am J Orthod Dentofac Orthop 2009;135:59-65.
178. Matos de Souza R, Macedo de Menezes L. Nickel, chromium and iron levels in the saliva of patients with simulated fixed orthodontic appliances. Angle Orthod 2008;78:345-50.
179. Elshahawy W, Ajlouni R, James W, Abdellatif H, Watanabe I. Elemental ion release from fixed restorative materials into patient saliva. J Oral Rehabil 2013;40:381-8.
180. Begerow J, Neuendorf J, Turfeld M, Raab W, Dunemann L. Long-term urinary platinum, palladium, and gold excretion of patients after insertion of noblemetal dental alloys. Biomarkers 1999;4:27-36.
181. Berglund F, Carlmark B. Titanium, sinusitis, and the yellow nail syndrome. Biol Trace Elem Res 2011;143:1-7.
182. Meningaud J-P, Poupon J, Bertrand J-Ch, Chenevier C, Galliot-Guilley M, Guilbert F. Dynamic study about metal release from titanium miniplates in maxillofacial surgery. Int J Oral Maxillofac Surg 2001;30:185-8.
183. Zaffe D, Bertoldi C, Consolo U. Element release from titanium devices used in oral and maxillofacial surgery. Biomaterials 2003;24:1093-9.
184. Templeton DM, Ariese F, Cornelis R, Danielsson L-G, Muntau H, Van Leeuwen HP, et al. Guidelines for terms related to chemical speciation and fractionation of elements. Definitions, structural aspects, and methodological approaches. Pure Appl Chem 2000;72:1453-70.
185. Merritt K, Brown SA. Release of hexavalent chromium from corrosion of stainless steel and cobalt-chromium alloys. J Biomed Mater Res 1995;29:627-33.
186. Afolaranmi GA, Tettey JNA, Murray HM, Meek RMD, Grant MH. The effect of anticoagulants on the distribution of chromium VI in blood fractions. J Arthroplasty 2010;25:118-20.
187. Ektessabi A, Shikine S, Kitamura N, Rokkum M, Johansson C. Distribution and chemical states of iron and chromium released from orthopedic implants into human tissues. X-Ray Spectrom 2011;30:44-8.
188. Savarino L, Granchi D, Ciapetti G, Cenni E, Pantoli AN, Rotini R, et al. Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings. J Biomed Mater Res 2002;63:467-74.
189. Hart AJ, Muirhead-Allwood S, Porter M, Matthies A, Ilo K, Maggiore P, Underwood R, etc. Which factors determine the wear rate of large-diameter metal-on-metal hip replacements? J Bone Joint Surg Am 2013;95:678-85.
190. Barry J, Lavigne M, Vendittoli P-A. Evaluation of the method for analyzing chromium, cobalt and titanium ion levels in the blood following hip replacement with a metal-on-metal prosthesis. J Anal Toxicol 2013;37:90-6.
191. Smolders JMH, Hol A, van Susante JLC. Metal ion trend may be more predictive for malfunctioning metal-on-metal implants than a single measurement. Hip Int 2013;23:434-40.
192. Mester Z, Sturgeon R, editors. Sample preparation for trace element analysis. Amsterdam: Elsevier; 2003.
193. Rodushkin I, Engstrom E, Baxter DC. Sources of contamination and remedial strategies in the multi-elemental trace analysis laboratory. Anal Bioanal Chem 2010;396:365-77.
194. Sanchez Misiego A, Garcia-Monco Carra RM, Ambel Carracedo MP. Traceelement analysis in biological fluids: evaluation of contamination in samples collected with metallic needles. Anal Chim Acta 2003;494:167-76.
195. Cornelis R, Heinzow B, Herber RFM, Molin Christensen J, Poulsen OM, Sabbioni E, Templeton DM, et al. Sample collection guidelines for trace elements in blood and urine. J Trace Elements, Med Biol 1996;10:103-27.
196. Anand VD, White JM, Nino HV. Some aspects of specimen collection and stability in trace element analysis of body fluids. Clin Chem 1975;21:595-602.
197. Musteata FM. Recent progress in in-vivo sampling and analysis. Trends Anal Chem 2013;45:154-68.
198. Caroli S, Alimonti A, Coni E, Petrucci F, Senofonte O, Violante N. The assessment of reference values for elements in human biological tissues and fluids: a systematic review. Crit Rev Anal Chem 1994;24:363-98.
199. Roelandts I. Biological and environmental reference materials: update 1996. Spectrochim Acta Part B 1997;52:1073-86.
200. Sariego Muniz S, Fernandez-Martin JL, Marchante-Gayon JM, Garcia Alonso JI, Cannata-Andia JB, Sanz-Medel A. Reference values for trace and ultratrace elements in human serum determined by double-focusing ICP-MS. Biol Trace Elem Res 2001;82:259-72.
201. Cornelis R, Fuentes-Arderiu X, Bruunshuus I, Templeton D. International Union of Pure and Applied Chemistry. Clinical Chemistry Division, Commission on Toxicology, Commission on Nomenclature, Properties and Units and International Federation of Clinical Chemistry, Scientific Division Committee on Nomenclature, Properties and Units. Properties and Units in the Clinical Laboratory Sciences IX. Properties and Units in Trace Elements. Clin Chim Acta 1997;268:S75-89.
202. MacDonald SJ, Brodner W, Jacobs JJ. A consensus paper on metal ions in metal-on-metal hip arthroplasties. J Arthroplasty 2004;19:12-6.
203. Jacobs JJ, Skipor AK, Campbell PA, Hallab NJ, Urban RM, Amstutz HC. Can metal levels be used to monitor metal-on-metal hip arthroplasties. J Arthroplasty 2004;19:59-65.
204. Jacobs JJ, Hallab NJ, Skipor AK, Urban RM. Metal degradation products. A cause for concern in metal-metal bearings? Clin Orthop Relat Res 2003;417:139-47.
205. Delaunay C, Petit I, Learmonth ID, Oger P, Vendittoli PA. Metal-on-metal bearings total hip arthroplasty: the cobalt and chromium ions release concern. Orthop Traumat Surg Res 2010;96:894-904.
206. Jantzen C, Jorgensen HL, Duus BR, Sporring SL, Lauritzen JB. Chromium and cobalt ion concentrations in blood and serum following various types of metal-on-metal hip arthroplasties. Acta Orthop 2013;84:229-36.
207. Balcaen L, Bolea-Fernandez E, Resano M, Vanhaecke F. Accurate determination of ultra-trace levels of Ti in blood serum using ICP-MS/MS. Anal Chim Acta 2013;doi.org/10.1016/j.aca.2013.10.017.
208. Chen J, Dong X, Zhao J, Tang G. In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection. J Appl Toxicol 2009;29:330-7.
209. Nazarenko Y, Zhen H, Han T, Lioy P, Mainelis G. Potential for inhalation exposure to engineered nanoparticles from nanotechnology-based cosmetic powders. Environ Health Perspect 2012;120:885-92.
210. Zachariadis GA, Sahanidou E. Analytical performance of a fast multi-element method for titanium and trace elements determination in cosmetics and pharmaceuticals by ICP-AES. Cent Eur J Chem 2011;9:213-7.
211. Avula B, Wang Y-H, Duzgoren-Aydin NS, Khan IA. Inorganic elemental compositions of commercial multivitamin/mineral dietary supplements: application of collision/reaction cell inductively coupled - mass spectroscopy. Food Chem 2011;127:54-62.
212. Lomer MCE, Thompson RPH, Commisso J, Keen CL, Powell JJ. Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry. Analyst 2000;125:2339-43.
213. Macnair RD, Wynn-Jones H, Wimhurst JA, Toms A, Cahir J. Metal ion levels not sufficient as a screening measure for adverse reactions in metal-on-metal hip arthroplasties. J Arthroplasty 2013;28:78-83.