-
1
-
-
0022472879
-
Induction of drug-metabolizing enzymes: mechanisms and consequences
-
10.1016/S0009-9120(86)80060-1, 3518989
-
Okey AB, Roberts EA, Harper PA, Denison MS. Induction of drug-metabolizing enzymes: mechanisms and consequences. Clin Biochem 1986, 19:132-141. 10.1016/S0009-9120(86)80060-1, 3518989.
-
(1986)
Clin Biochem
, vol.19
, pp. 132-141
-
-
Okey, A.B.1
Roberts, E.A.2
Harper, P.A.3
Denison, M.S.4
-
2
-
-
11144300283
-
Structural and functional diversity in heme monooxygenases
-
Poulos TL. Structural and functional diversity in heme monooxygenases. Drug Metab Dispos 2005, 33:10-18.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 10-18
-
-
Poulos, T.L.1
-
3
-
-
0346099111
-
Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes
-
10.2165/00003088-200342150-00003, 14674787
-
Wang H, LeCluyse EL. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet 2003, 42:1331-1357. 10.2165/00003088-200342150-00003, 14674787.
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 1331-1357
-
-
Wang, H.1
LeCluyse, E.L.2
-
4
-
-
23344450788
-
Induction of phase I, II and III drug metabolism/transport by xenobiotics
-
10.1007/BF02977789, 15832810
-
Xu C, Li CY, Kong AN. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 2005, 28:249-268. 10.1007/BF02977789, 15832810.
-
(2005)
Arch Pharm Res
, vol.28
, pp. 249-268
-
-
Xu, C.1
Li, C.Y.2
Kong, A.N.3
-
5
-
-
0346100571
-
Enterohepatic bile salt transporters in normal physiology and liver disease
-
10.1053/j.gastro.2003.06.005, 14699511
-
Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 2004, 126:322-342. 10.1053/j.gastro.2003.06.005, 14699511.
-
(2004)
Gastroenterology
, vol.126
, pp. 322-342
-
-
Kullak-Ublick, G.A.1
Stieger, B.2
Meier, P.J.3
-
6
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
10.1073/pnas.051551698, 30660, 11248085
-
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A 2001, 98:3369-3374. 10.1073/pnas.051551698, 30660, 11248085.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
Willson, T.M.11
Koller, B.H.12
Kliewer, S.A.13
-
7
-
-
0033395836
-
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways
-
discussion 367-348
-
Kliewer SA, Lehmann JM, Milburn MV, Willson TM. The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways. Recent Prog Horm Res 1999, 54:345-367. discussion 367-348.
-
(1999)
Recent Prog Horm Res
, vol.54
, pp. 345-367
-
-
Kliewer, S.A.1
Lehmann, J.M.2
Milburn, M.V.3
Willson, T.M.4
-
8
-
-
4944247161
-
Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?
-
10.1161/01.RES.0000143422.83209.be, 15459087
-
Ory DS. Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?. Circ Res 2004, 95:660-670. 10.1161/01.RES.0000143422.83209.be, 15459087.
-
(2004)
Circ Res
, vol.95
, pp. 660-670
-
-
Ory, D.S.1
-
9
-
-
34248561199
-
The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology
-
10.1016/j.ctrv.2007.02.003, 17451886
-
Harmsen S, Meijerman I, Beijnen JH, Schellens JH. The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. Cancer Treat Rev 2007, 33:369-380. 10.1016/j.ctrv.2007.02.003, 17451886.
-
(2007)
Cancer Treat Rev
, vol.33
, pp. 369-380
-
-
Harmsen, S.1
Meijerman, I.2
Beijnen, J.H.3
Schellens, J.H.4
-
10
-
-
84862813487
-
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters
-
10.1016/j.bcp.2012.01.030, 3339266, 22326308
-
Chen Y, Tang Y, Guo C, Wang J, Boral D, Nie D. Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochem Pharmacol 2012, 83:1112-1126. 10.1016/j.bcp.2012.01.030, 3339266, 22326308.
-
(2012)
Biochem Pharmacol
, vol.83
, pp. 1112-1126
-
-
Chen, Y.1
Tang, Y.2
Guo, C.3
Wang, J.4
Boral, D.5
Nie, D.6
-
11
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
10.1172/JCI3703, 508967, 9727070
-
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 1998, 102:1016-1023. 10.1172/JCI3703, 508967, 9727070.
-
(1998)
J Clin Invest
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
12
-
-
0034685779
-
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
-
10.1074/jbc.M001215200, 10748001
-
Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 2000, 275:15122-15127. 10.1074/jbc.M001215200, 10748001.
-
(2000)
J Biol Chem
, vol.275
, pp. 15122-15127
-
-
Moore, L.B.1
Parks, D.J.2
Jones, S.A.3
Bledsoe, R.K.4
Consler, T.G.5
Stimmel, J.B.6
Goodwin, B.7
Liddle, C.8
Blanchard, S.G.9
Willson, T.M.10
Collins, J.L.11
Kliewer, S.A.12
-
13
-
-
0034676513
-
Use of the nuclear receptor PXR to predict drug interactions
-
10.1016/S0300-483X(00)00300-0, 11090943
-
Moore JT, Kliewer SA. Use of the nuclear receptor PXR to predict drug interactions. Toxicology 2000, 153:1-10. 10.1016/S0300-483X(00)00300-0, 11090943.
-
(2000)
Toxicology
, vol.153
, pp. 1-10
-
-
Moore, J.T.1
Kliewer, S.A.2
-
14
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
10.1016/S0092-8674(00)80900-9, 9489701
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, Perimann T, Lehmann JM. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 1998, 92:73-82. 10.1016/S0092-8674(00)80900-9, 9489701.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perimann, T.11
Lehmann, J.M.12
-
15
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
10.1101/gad.12.20.3195, 317212, 9784494
-
Blumberg B, Sabbagh W, Juguilon H, Bolado J, van Meter CM, Ong ES, Evans RM. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 1998, 12:3195-3205. 10.1101/gad.12.20.3195, 317212, 9784494.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh, W.2
Juguilon, H.3
Bolado, J.4
van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
16
-
-
0029906308
-
Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
-
10.1073/pnas.93.10.4666, 39336, 8643461
-
Huss JM, Wang SI, Astrom A, McQuiddy P, Kasper CB. Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc Natl Acad Sci U S A 1996, 93:4666-4670. 10.1073/pnas.93.10.4666, 39336, 8643461.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 4666-4670
-
-
Huss, J.M.1
Wang, S.I.2
Astrom, A.3
McQuiddy, P.4
Kasper, C.B.5
-
17
-
-
0028917364
-
Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase
-
10.1006/abbi.1995.1206, 7726576
-
Miyata M, Nagata K, Yamazoe Y, Kato R. Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase. Arch Biochem Biophys 1995, 318:71-79. 10.1006/abbi.1995.1206, 7726576.
-
(1995)
Arch Biochem Biophys
, vol.318
, pp. 71-79
-
-
Miyata, M.1
Nagata, K.2
Yamazoe, Y.3
Kato, R.4
-
18
-
-
0028789188
-
A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids
-
10.1074/jbc.270.48.28917, 7499421
-
Quattrochi LC, Mills AS, Barwick JL, Yockey CB, Guzelian PS. A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. J Biol Chem 1995, 270:28917-28923. 10.1074/jbc.270.48.28917, 7499421.
-
(1995)
J Biol Chem
, vol.270
, pp. 28917-28923
-
-
Quattrochi, L.C.1
Mills, A.S.2
Barwick, J.L.3
Yockey, C.B.4
Guzelian, P.S.5
-
19
-
-
0025812291
-
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
-
10.1016/0092-8674(91)90020-Y, 1648450
-
Umesono K, Murakami KK, Thompson CC, Evans RM. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 1991, 65:1255-1266. 10.1016/0092-8674(91)90020-Y, 1648450.
-
(1991)
Cell
, vol.65
, pp. 1255-1266
-
-
Umesono, K.1
Murakami, K.K.2
Thompson, C.C.3
Evans, R.M.4
-
20
-
-
17844366538
-
The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion
-
10.1210/me.2004-0434, 15650019
-
Masuyama H, Suwaki N, Tateishi Y, Nakatsukasa H, Segawa T, Hiramatsu Y. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol Endocrinol 2005, 19:1170-1180. 10.1210/me.2004-0434, 15650019.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 1170-1180
-
-
Masuyama, H.1
Suwaki, N.2
Tateishi, Y.3
Nakatsukasa, H.4
Segawa, T.5
Hiramatsu, Y.6
-
21
-
-
0036431890
-
Identification of the novel splicing variants for the hPXR in human livers
-
10.1016/S0006-291X(02)02469-5, 12413960
-
Fukuen S, Fukuda T, Matsuda H, Sumida A, Yamamoto I, Inaba T, Azuma J. Identification of the novel splicing variants for the hPXR in human livers. Biochem Biophys Res Commun 2002, 298:433-438. 10.1016/S0006-291X(02)02469-5, 12413960.
-
(2002)
Biochem Biophys Res Commun
, vol.298
, pp. 433-438
-
-
Fukuen, S.1
Fukuda, T.2
Matsuda, H.3
Sumida, A.4
Yamamoto, I.5
Inaba, T.6
Azuma, J.7
-
22
-
-
0035857453
-
The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse
-
10.1016/S0303-7207(00)00395-6, 11165039
-
Masuyama H, Hiramatsu Y, Mizutani Y, Inoshita H, Kudo T. The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse. Mol Cell Endocrinol 2001, 172:47-56. 10.1016/S0303-7207(00)00395-6, 11165039.
-
(2001)
Mol Cell Endocrinol
, vol.172
, pp. 47-56
-
-
Masuyama, H.1
Hiramatsu, Y.2
Mizutani, Y.3
Inoshita, H.4
Kudo, T.5
-
23
-
-
0038575830
-
Transgenic mouse models of human CYP3A4 gene regulation
-
10.1124/mol.64.1.42, 12815159
-
Robertson GR, Field J, Goodwin B, Bierach S, Tran M, Lehnert A, Liddle C. Transgenic mouse models of human CYP3A4 gene regulation. Mol Pharmacol 2003, 64:42-50. 10.1124/mol.64.1.42, 12815159.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 42-50
-
-
Robertson, G.R.1
Field, J.2
Goodwin, B.3
Bierach, S.4
Tran, M.5
Lehnert, A.6
Liddle, C.7
-
24
-
-
0032807743
-
The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
-
Dotzlaw H, Leygue E, Watson P, Murphy LC. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin Cancer Res 1999, 5:2103-2107.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2103-2107
-
-
Dotzlaw, H.1
Leygue, E.2
Watson, P.3
Murphy, L.C.4
-
25
-
-
4444264038
-
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
-
10.1016/j.taap.2003.12.027, 15364541
-
Lamba V, Yasuda K, Lamba JK, Assem M, Davila J, Strom S, Schuetz EG. PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol Appl Pharmacol 2004, 199:251-265. 10.1016/j.taap.2003.12.027, 15364541.
-
(2004)
Toxicol Appl Pharmacol
, vol.199
, pp. 251-265
-
-
Lamba, V.1
Yasuda, K.2
Lamba, J.K.3
Assem, M.4
Davila, J.5
Strom, S.6
Schuetz, E.G.7
-
26
-
-
31644436285
-
Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma
-
10.1158/0008-5472.CAN-05-1070, 16397270
-
Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B, Sasano H. Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res 2006, 66:535-542. 10.1158/0008-5472.CAN-05-1070, 16397270.
-
(2006)
Cancer Res
, vol.66
, pp. 535-542
-
-
Miki, Y.1
Suzuki, T.2
Kitada, K.3
Yabuki, N.4
Shibuya, R.5
Moriya, T.6
Ishida, T.7
Ohuchi, N.8
Blumberg, B.9
Sasano, H.10
-
27
-
-
47349093089
-
Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha
-
2442113, 18565212
-
Conde I, Lobo MV, Zamora J, Perez J, Gonzalez FJ, Alba E, Fraile B, Paniagua R, Arenas MI. Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. BMC Cancer 2008, 8:174. 2442113, 18565212.
-
(2008)
BMC Cancer
, vol.8
, pp. 174
-
-
Conde, I.1
Lobo, M.V.2
Zamora, J.3
Perez, J.4
Gonzalez, F.J.5
Alba, E.6
Fraile, B.7
Paniagua, R.8
Arenas, M.I.9
-
28
-
-
0141564528
-
Expression and potential roles of pregnane X receptor in endometrial cancer
-
10.1210/jc.2003-030203, 12970323
-
Masuyama H, Hiramatsu Y, Kodama J, Kudo T. Expression and potential roles of pregnane X receptor in endometrial cancer. J Clin Endocrinol Metab 2003, 88:4446-4454. 10.1210/jc.2003-030203, 12970323.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4446-4454
-
-
Masuyama, H.1
Hiramatsu, Y.2
Kodama, J.3
Kudo, T.4
-
29
-
-
84856499075
-
Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer
-
10.1111/j.1349-7006.2011.02143.x, 22050110
-
Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K, Obinata D, Murata T, Horie-Inoue K, Kodama T, Ouchi Y, Homma Y, Inoue S. Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer. Cancer Sci 2012, 103:176-180. 10.1111/j.1349-7006.2011.02143.x, 22050110.
-
(2012)
Cancer Sci
, vol.103
, pp. 176-180
-
-
Fujimura, T.1
Takahashi, S.2
Urano, T.3
Tanaka, T.4
Zhang, W.5
Azuma, K.6
Takayama, K.7
Obinata, D.8
Murata, T.9
Horie-Inoue, K.10
Kodama, T.11
Ouchi, Y.12
Homma, Y.13
Inoue, S.14
-
30
-
-
77951930753
-
Steroid and xenobiotic receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer
-
10.1111/j.1440-1827.2010.02546.x, 20518891
-
Yue X, Akahira J, Utsunomiya H, Miki Y, Takahashi N, Niikura H, Ito K, Sasano H, Okamura K, Yaegashi N. Steroid and xenobiotic receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer. Pathol Int 2010, 60:400-406. 10.1111/j.1440-1827.2010.02546.x, 20518891.
-
(2010)
Pathol Int
, vol.60
, pp. 400-406
-
-
Yue, X.1
Akahira, J.2
Utsunomiya, H.3
Miki, Y.4
Takahashi, N.5
Niikura, H.6
Ito, K.7
Sasano, H.8
Okamura, K.9
Yaegashi, N.10
-
31
-
-
78149307649
-
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line
-
10.1007/s00280-009-1221-4, 2904455, 20041327
-
Harmsen S, Meijerman I, Febus CL, Maas-Bakker RF, Beijnen JH, Schellens JH. PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line. Cancer Chemother Pharmacol 2010, 66:765-771. 10.1007/s00280-009-1221-4, 2904455, 20041327.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 765-771
-
-
Harmsen, S.1
Meijerman, I.2
Febus, C.L.3
Maas-Bakker, R.F.4
Beijnen, J.H.5
Schellens, J.H.6
-
32
-
-
35948961894
-
Human pregnane X receptor and resistance to chemotherapy in prostate cancer
-
10.1158/0008-5472.CAN-06-4758, 17974979
-
Chen Y, Tang Y, Wang MT, Zeng S, Nie D. Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res 2007, 67:10361-10367. 10.1158/0008-5472.CAN-06-4758, 17974979.
-
(2007)
Cancer Res
, vol.67
, pp. 10361-10367
-
-
Chen, Y.1
Tang, Y.2
Wang, M.T.3
Zeng, S.4
Nie, D.5
-
33
-
-
53049083219
-
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer
-
10.1158/1078-0432.CCR-08-1033, 18765524
-
Gupta D, Venkatesh M, Wang H, Kim S, Sinz M, Goldberg GL, Whitney K, Longley C, Mani S. Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Clin Cancer Res 2008, 14:5332-5340. 10.1158/1078-0432.CCR-08-1033, 18765524.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5332-5340
-
-
Gupta, D.1
Venkatesh, M.2
Wang, H.3
Kim, S.4
Sinz, M.5
Goldberg, G.L.6
Whitney, K.7
Longley, C.8
Mani, S.9
-
34
-
-
23444453717
-
Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes
-
10.1016/j.bbamcr.2005.02.005, 16085054
-
Zucchini N, de Sousa G, Bailly-Maitre B, Gugenheim J, Bars R, Lemaire G, Rahmani R. Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes. Biochim Biophys Acta 2005, 1745:48-58. 10.1016/j.bbamcr.2005.02.005, 16085054.
-
(2005)
Biochim Biophys Acta
, vol.1745
, pp. 48-58
-
-
Zucchini, N.1
de Sousa, G.2
Bailly-Maitre, B.3
Gugenheim, J.4
Bars, R.5
Lemaire, G.6
Rahmani, R.7
-
35
-
-
41649111966
-
The antiapoptotic role of pregnane X receptor in human colon cancer cells
-
10.1210/me.2007-0197, 2276464, 18096695
-
Zhou J, Liu M, Zhai Y, Xie W. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol Endocrinol 2008, 22:868-880. 10.1210/me.2007-0197, 2276464, 18096695.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 868-880
-
-
Zhou, J.1
Liu, M.2
Zhai, Y.3
Xie, W.4
-
36
-
-
34748865948
-
Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells
-
10.1124/mol.107.037937, 17636047
-
Masuyama H, Nakatsukasa H, Takamoto N, Hiramatsu Y. Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. Mol Pharmacol 2007, 72:1045-1053. 10.1124/mol.107.037937, 17636047.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 1045-1053
-
-
Masuyama, H.1
Nakatsukasa, H.2
Takamoto, N.3
Hiramatsu, Y.4
-
37
-
-
59249083801
-
Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells
-
2631587, 19123943
-
Verma S, Tabb MM, Blumberg B. Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. BMC Cancer 2009, 9:3. 2631587, 19123943.
-
(2009)
BMC Cancer
, vol.9
, pp. 3
-
-
Verma, S.1
Tabb, M.M.2
Blumberg, B.3
-
38
-
-
0031793335
-
Expression and hormonal regulation of coactivator and corepressor genes
-
10.1210/endo.139.5.5971, 9564863
-
Misiti S, Schomburg L, Yen PM, Chin WW. Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology 1998, 139:2493-2500. 10.1210/endo.139.5.5971, 9564863.
-
(1998)
Endocrinology
, vol.139
, pp. 2493-2500
-
-
Misiti, S.1
Schomburg, L.2
Yen, P.M.3
Chin, W.W.4
-
39
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
10.1073/pnas.95.21.12208, 22810, 9770465
-
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, Berkenstam A. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A 1998, 95:12208-12213. 10.1073/pnas.95.21.12208, 22810, 9770465.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
40
-
-
0033178677
-
Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation
-
10.1006/abbi.1999.1307, 10415106
-
Zhang H, LeCulyse E, Liu L, Hu M, Matoney L, Zhu W, Yan B. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch Biochem Biophys 1999, 368:14-22. 10.1006/abbi.1999.1307, 10415106.
-
(1999)
Arch Biochem Biophys
, vol.368
, pp. 14-22
-
-
Zhang, H.1
LeCulyse, E.2
Liu, L.3
Hu, M.4
Matoney, L.5
Zhu, W.6
Yan, B.7
-
41
-
-
0033526864
-
Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
-
10.1006/bbrc.1999.0745, 10403778
-
Pascussi JM, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, Vilarem MJ. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochem Biophys Res Commun 1999, 260:377-381. 10.1006/bbrc.1999.0745, 10403778.
-
(1999)
Biochem Biophys Res Commun
, vol.260
, pp. 377-381
-
-
Pascussi, J.M.1
Jounaidi, Y.2
Drocourt, L.3
Domergue, J.4
Balabaud, C.5
Maurel, P.6
Vilarem, M.J.7
-
42
-
-
0032437889
-
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
-
3662300, 9855641
-
Schuetz EG, Brimer C, Schuetz JD. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. Mol Pharmacol 1998, 54:1113-1117. 3662300, 9855641.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 1113-1117
-
-
Schuetz, E.G.1
Brimer, C.2
Schuetz, J.D.3
-
43
-
-
0038347333
-
Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle
-
10.1124/dmd.31.1.1, 12485945
-
Sarkar MA, Vadlamuri V, Ghosh S, Glover DD. Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle. Drug Metab Dispos 2003, 31:1-6. 10.1124/dmd.31.1.1, 12485945.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1-6
-
-
Sarkar, M.A.1
Vadlamuri, V.2
Ghosh, S.3
Glover, D.D.4
-
44
-
-
0027223454
-
Amplification of fgfr4 gene in human breast and gynecological cancers
-
10.1002/ijc.2910540305, 8099571
-
Jaakkola S, Salmikangas P, Nylund S, Partanen J, Armstrong E, Pyrhonen S, Lehtovirta P, Nevanlinna H. Amplification of fgfr4 gene in human breast and gynecological cancers. Int J Cancer 1993, 54:378-382. 10.1002/ijc.2910540305, 8099571.
-
(1993)
Int J Cancer
, vol.54
, pp. 378-382
-
-
Jaakkola, S.1
Salmikangas, P.2
Nylund, S.3
Partanen, J.4
Armstrong, E.5
Pyrhonen, S.6
Lehtovirta, P.7
Nevanlinna, H.8
-
45
-
-
0030922231
-
Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
-
10.1038/ng0797-260, 3901950, 9207791
-
Chesi M, Nardini E, Brents LA, Schrock E, Ried T, Kuehl WM, Bergsagel P. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997, 16:260-264. 10.1038/ng0797-260, 3901950, 9207791.
-
(1997)
Nat Genet
, vol.16
, pp. 260-264
-
-
Chesi, M.1
Nardini, E.2
Brents, L.A.3
Schrock, E.4
Ried, T.5
Kuehl, W.M.6
Bergsagel, P.7
-
46
-
-
0036468871
-
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
-
Bange J, Prechtl D, Cheburkin Y, Specht K, Harbeck N, Schmitt M, Knyazeva T, Muller S, Gartner S, Sures I, Wang H, Imyanitov E, Häring HU, Knayzev P, Iacobelli S, Höfler H, Ullrich A. Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res 2002, 62:840-847.
-
(2002)
Cancer Res
, vol.62
, pp. 840-847
-
-
Bange, J.1
Prechtl, D.2
Cheburkin, Y.3
Specht, K.4
Harbeck, N.5
Schmitt, M.6
Knyazeva, T.7
Muller, S.8
Gartner, S.9
Sures, I.10
Wang, H.11
Imyanitov, E.12
Häring, H.U.13
Knayzev, P.14
Iacobelli, S.15
Höfler, H.16
Ullrich, A.17
-
47
-
-
0036045353
-
Fibroblast growth factors in cancer: therapeutic possibilities
-
10.1517/14728222.6.4.469, 12223061
-
Jeffers M, LaRochelle WJ, Lichenstein HS. Fibroblast growth factors in cancer: therapeutic possibilities. Expert Opin Ther Targets 2002, 6:469-482. 10.1517/14728222.6.4.469, 12223061.
-
(2002)
Expert Opin Ther Targets
, vol.6
, pp. 469-482
-
-
Jeffers, M.1
LaRochelle, W.J.2
Lichenstein, H.S.3
-
48
-
-
79960980435
-
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice
-
10.1172/JCI41514, 3148718, 21747170
-
Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest 2011, 121:3220-3232. 10.1172/JCI41514, 3148718, 21747170.
-
(2011)
J Clin Invest
, vol.121
, pp. 3220-3232
-
-
Wang, H.1
Venkatesh, M.2
Li, H.3
Goetz, R.4
Mukherjee, S.5
Biswas, A.6
Zhu, L.7
Kaubisch, A.8
Wang, L.9
Pullman, J.10
Whitney, K.11
Kuro-o, M.12
Roig, A.I.13
Shay, J.W.14
Mohammadi, M.15
Mani, S.16
-
49
-
-
66149142211
-
Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1
-
10.1074/jbc.M806193200, 2666572, 19144646
-
Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem 2009, 284:9199-9205. 10.1074/jbc.M806193200, 2666572, 19144646.
-
(2009)
J Biol Chem
, vol.284
, pp. 9199-9205
-
-
Xie, Y.1
Ke, S.2
Ouyang, N.3
He, J.4
Xie, W.5
Bedford, M.T.6
Tian, Y.7
-
50
-
-
77953260492
-
Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells
-
10.1038/sj.bjc.6605677, 2883694, 20531417
-
Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, Laffins B, Yao H, Zhou B, Tian Y. Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. Br J Cancer 2010, 102:1753-1761. 10.1038/sj.bjc.6605677, 2883694, 20531417.
-
(2010)
Br J Cancer
, vol.102
, pp. 1753-1761
-
-
Ouyang, N.1
Ke, S.2
Eagleton, N.3
Xie, Y.4
Chen, G.5
Laffins, B.6
Yao, H.7
Zhou, B.8
Tian, Y.9
-
51
-
-
31444453271
-
Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells
-
10.1210/me.2005-0205, 16195250
-
Gong H, Singh SV, Singh SP, Mu Y, Lee JH, Saini SP, Toma D, Ren S, Kagan VE, Day BW, Zimniak P, Xie W. Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 2006, 20:279-290. 10.1210/me.2005-0205, 16195250.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 279-290
-
-
Gong, H.1
Singh, S.V.2
Singh, S.P.3
Mu, Y.4
Lee, J.H.5
Saini, S.P.6
Toma, D.7
Ren, S.8
Kagan, V.E.9
Day, B.W.10
Zimniak, P.11
Xie, W.12
-
52
-
-
84877803927
-
Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity
-
10.1124/mol.113.085092, 23536728
-
Elias A, Wu J, Chen T. Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Mol Pharmacol 2013, 83:1229-1236. 10.1124/mol.113.085092, 23536728.
-
(2013)
Mol Pharmacol
, vol.83
, pp. 1229-1236
-
-
Elias, A.1
Wu, J.2
Chen, T.3
-
53
-
-
33751530274
-
Steroid receptors and their role in the biology and control of breast cancer growth
-
10.1053/j.seminoncol.2006.08.020, 17145341
-
Cordera F, Jordan VC. Steroid receptors and their role in the biology and control of breast cancer growth. Semin Oncol 2006, 33:631-641. 10.1053/j.seminoncol.2006.08.020, 17145341.
-
(2006)
Semin Oncol
, vol.33
, pp. 631-641
-
-
Cordera, F.1
Jordan, V.C.2
-
54
-
-
33645110538
-
Pharmacogenomics of human OATP transporters
-
10.1007/s00210-006-0040-y, 16525793
-
Konig J, Seithel A, Gradhand U, Fromm MF. Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol 2006, 372:432-443. 10.1007/s00210-006-0040-y, 16525793.
-
(2006)
Naunyn Schmiedebergs Arch Pharmacol
, vol.372
, pp. 432-443
-
-
Konig, J.1
Seithel, A.2
Gradhand, U.3
Fromm, M.F.4
-
55
-
-
56449083452
-
Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer
-
10.1158/0008-5472.CAN-08-0265, 2597047, 19010908
-
Meyer zu Schwabedissen HE, Tirona RG, Yip CS, Ho RH, Kim RB. Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Cancer Res 2008, 68:9338-9347. 10.1158/0008-5472.CAN-08-0265, 2597047, 19010908.
-
(2008)
Cancer Res
, vol.68
, pp. 9338-9347
-
-
Meyer zu Schwabedissen, H.E.1
Tirona, R.G.2
Yip, C.S.3
Ho, R.H.4
Kim, R.B.5
-
56
-
-
0020283614
-
Estrogen synthesis in normal and malignant human endometrium
-
10.1210/jcem-55-5-1029, 7119084
-
Tseng L, Mazella J, Mann WJ, Chumas J. Estrogen synthesis in normal and malignant human endometrium. J Clin Endocrinol Metab 1982, 55:1029-1031. 10.1210/jcem-55-5-1029, 7119084.
-
(1982)
J Clin Endocrinol Metab
, vol.55
, pp. 1029-1031
-
-
Tseng, L.1
Mazella, J.2
Mann, W.J.3
Chumas, J.4
-
57
-
-
0021921969
-
Aromatization of androstenedione by normal and neoplastic endometrium of the uterus
-
10.1016/0022-4731(85)90142-6, 3974228
-
Yamaki J, Yamamoto T, Okada H. Aromatization of androstenedione by normal and neoplastic endometrium of the uterus. J Steroid Biochem 1985, 22:63-66. 10.1016/0022-4731(85)90142-6, 3974228.
-
(1985)
J Steroid Biochem
, vol.22
, pp. 63-66
-
-
Yamaki, J.1
Yamamoto, T.2
Okada, H.3
-
58
-
-
0031712804
-
Intratumoral aromatase in human breast, endometrial, and ovarian malignancies
-
Sasano H, Harada N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr Rev 1998, 19:593-607.
-
(1998)
Endocr Rev
, vol.19
, pp. 593-607
-
-
Sasano, H.1
Harada, N.2
-
59
-
-
0027299609
-
Estrogen productivity of endometrium and endometrial cancer tissue; influence of aromatase on proliferation of endometrial cancer cells
-
10.1016/0960-0760(93)90251-Q, 8476761
-
Yamamoto T, Kitawaki J, Urabe M, Honjo H, Tamura T, Noguchi T, Okada H, Sasaki H, Tada A, Terashima Y, Nakamura J, Yoshihama M. Estrogen productivity of endometrium and endometrial cancer tissue; influence of aromatase on proliferation of endometrial cancer cells. J Steroid Biochem Mol Biol 1993, 44:463-468. 10.1016/0960-0760(93)90251-Q, 8476761.
-
(1993)
J Steroid Biochem Mol Biol
, vol.44
, pp. 463-468
-
-
Yamamoto, T.1
Kitawaki, J.2
Urabe, M.3
Honjo, H.4
Tamura, T.5
Noguchi, T.6
Okada, H.7
Sasaki, H.8
Tada, A.9
Terashima, Y.10
Nakamura, J.11
Yoshihama, M.12
-
60
-
-
4644361194
-
Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes
-
10.1124/dmd.104.000299, 15269186
-
Zhou C, Tabb MM, Sadatrafiei A, Grun F, Blumberg B. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab Dispos 2004, 32:1075-1082. 10.1124/dmd.104.000299, 15269186.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1075-1082
-
-
Zhou, C.1
Tabb, M.M.2
Sadatrafiei, A.3
Grun, F.4
Blumberg, B.5
-
61
-
-
0034650893
-
The coregulator exchange in transcriptional functions of nuclear receptors
-
Glass CK, Rosenfeld MG. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 2000, 14:121-141.
-
(2000)
Genes Dev
, vol.14
, pp. 121-141
-
-
Glass, C.K.1
Rosenfeld, M.G.2
-
62
-
-
69249110003
-
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
-
10.1038/nrc2695, 2908510, 19701241
-
Xu J, Wu RC, O'Malley BW. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 2009, 9:615-630. 10.1038/nrc2695, 2908510, 19701241.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 615-630
-
-
Xu, J.1
Wu, R.C.2
O'Malley, B.W.3
-
63
-
-
0036132097
-
Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues
-
10.1002/ijc.1568, 11774254
-
Miyoshi Y, Ando A, Takamura Y, Taguchi T, Tamaki Y, Noguchi S. Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues. Int J Cancer 2002, 97:129-132. 10.1002/ijc.1568, 11774254.
-
(2002)
Int J Cancer
, vol.97
, pp. 129-132
-
-
Miyoshi, Y.1
Ando, A.2
Takamura, Y.3
Taguchi, T.4
Tamaki, Y.5
Noguchi, S.6
-
64
-
-
33846230463
-
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
-
10.1038/sj.onc.1209788, 16819505
-
Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene 2007, 26:258-268. 10.1038/sj.onc.1209788, 16819505.
-
(2007)
Oncogene
, vol.26
, pp. 258-268
-
-
Huang, H.1
Wang, H.2
Sinz, M.3
Zoeckler, M.4
Staudinger, J.5
Redinbo, M.R.6
Teotico, D.G.7
Locker, J.8
Kalpana, G.V.9
Mani, S.10
-
65
-
-
0037031809
-
Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics
-
10.1074/jbc.M111245200, 12072427
-
Takeshita A, Taguchi M, Koibuchi N, Ozawa Y. Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. J Biol Chem 2002, 277:32453-32458. 10.1074/jbc.M111245200, 12072427.
-
(2002)
J Biol Chem
, vol.277
, pp. 32453-32458
-
-
Takeshita, A.1
Taguchi, M.2
Koibuchi, N.3
Ozawa, Y.4
-
66
-
-
33745253791
-
Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor
-
Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, Vilarem MJ, Maurel P, Gerbal-Chaloin S. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Mol Pharmacol 2006, 70:329-339.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 329-339
-
-
Duret, C.1
Daujat-Chavanieu, M.2
Pascussi, J.M.3
Pichard-Garcia, L.4
Balaguer, P.5
Fabre, J.M.6
Vilarem, M.J.7
Maurel, P.8
Gerbal-Chaloin, S.9
-
67
-
-
34247871463
-
Activated pregnenolone X-receptor is a target for ketoconazole and its analogs
-
10.1158/1078-0432.CCR-06-1592, 17438109
-
Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clin Cancer Res 2007, 13:2488-2495. 10.1158/1078-0432.CCR-06-1592, 17438109.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2488-2495
-
-
Wang, H.1
Huang, H.2
Li, H.3
Teotico, D.G.4
Sinz, M.5
Baker, S.D.6
Staudinger, J.7
Kalpana, G.8
Redinbo, M.R.9
Mani, S.10
-
68
-
-
0022532815
-
Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo
-
10.1016/0006-2952(86)90072-9, 3006695
-
Beetens JR, Loots W, Somers Y, Coene MC, De Clerck F. Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo. Biochem Pharmacol 1986, 35:883-891. 10.1016/0006-2952(86)90072-9, 3006695.
-
(1986)
Biochem Pharmacol
, vol.35
, pp. 883-891
-
-
Beetens, J.R.1
Loots, W.2
Somers, Y.3
Coene, M.C.4
De Clerck, F.5
-
69
-
-
0029144976
-
Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice
-
Culo F, Renic M, Sabolovic D, Rados M, Bilic A, Jagic V. Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. Eur J Gastroenterol Hepatol 1995, 7:757-762.
-
(1995)
Eur J Gastroenterol Hepatol
, vol.7
, pp. 757-762
-
-
Culo, F.1
Renic, M.2
Sabolovic, D.3
Rados, M.4
Bilic, A.5
Jagic, V.6
-
70
-
-
0028011118
-
Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene
-
10.1016/0005-2760(94)90236-4, 8305487
-
Ellsworth JL, Carlstrom AJ, Deikman J. Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene. Biochim Biophys Acta 1994, 1210:321-328. 10.1016/0005-2760(94)90236-4, 8305487.
-
(1994)
Biochim Biophys Acta
, vol.1210
, pp. 321-328
-
-
Ellsworth, J.L.1
Carlstrom, A.J.2
Deikman, J.3
-
71
-
-
0020531983
-
Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes
-
10.1172/JCI110903, 437014, 6304148
-
Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 1983, 71:1495-1499. 10.1172/JCI110903, 437014, 6304148.
-
(1983)
J Clin Invest
, vol.71
, pp. 1495-1499
-
-
Loose, D.S.1
Kan, P.B.2
Hirst, M.A.3
Marcus, R.A.4
Feldman, D.5
-
72
-
-
0022997519
-
Ketoconazole pharmacokinetics during chronic dosing in adults with haematological malignancy
-
10.1007/BF02017693, 3465533
-
Stockley RJ, Daneshmend TK, Bredow MT, Warnock DW, Richardson MD, Slade RR. Ketoconazole pharmacokinetics during chronic dosing in adults with haematological malignancy. Eur J Clin Microbiol 1986, 5:513-517. 10.1007/BF02017693, 3465533.
-
(1986)
Eur J Clin Microbiol
, vol.5
, pp. 513-517
-
-
Stockley, R.J.1
Daneshmend, T.K.2
Bredow, M.T.3
Warnock, D.W.4
Richardson, M.D.5
Slade, R.R.6
-
73
-
-
0035987895
-
CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
-
10.1124/dmd.30.7.795, 12065438
-
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E, Gan LS. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos 2002, 30:795-804. 10.1124/dmd.30.7.795, 12065438.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 795-804
-
-
Luo, G.1
Cunningham, M.2
Kim, S.3
Burn, T.4
Lin, J.5
Sinz, M.6
Hamilton, G.7
Rizzo, C.8
Jolley, S.9
Gilbert, D.10
Downey, A.11
Mudra, D.12
Graham, R.13
Carroll, K.14
Xie, J.15
Madan, A.16
Parkinson, A.17
Christ, D.18
Selling, B.19
LeCluyse, E.20
Gan, L.S.21
more..
-
74
-
-
40849083767
-
A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
-
Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG, Kim RB. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor. Drug Metab Dispos 2008, 36:500-507.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 500-507
-
-
Healan-Greenberg, C.1
Waring, J.F.2
Kempf, D.J.3
Blomme, E.A.4
Tirona, R.G.5
Kim, R.B.6
-
75
-
-
41649100943
-
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor
-
10.1210/me.2007-0218, 18096694
-
Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Mol Endocrinol 2008, 22:838-857. 10.1210/me.2007-0218, 18096694.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 838-857
-
-
Wang, H.1
Li, H.2
Moore, L.B.3
Johnson, M.D.4
Maglich, J.M.5
Goodwin, B.6
Ittoop, O.R.7
Wisely, B.8
Creech, K.9
Parks, D.J.10
Collins, J.L.11
Willson, T.M.12
Kalpana, G.V.13
Venkatesh, M.14
Xie, W.15
Cho, S.Y.16
Roboz, J.17
Redinbo, M.18
Moore, J.T.19
Mani, S.20
more..
-
76
-
-
50449109998
-
Computational discovery of novel low micromolar human pregnane X receptor antagonists
-
10.1124/mol.108.049437, 18579710
-
Ekins S, Kholodovych V, Ai N, Sinz M, Gal J, Gera L, Welsh WJ, Bachmann K, Mani S. Computational discovery of novel low micromolar human pregnane X receptor antagonists. Mol Pharmacol 2008, 74:662-672. 10.1124/mol.108.049437, 18579710.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 662-672
-
-
Ekins, S.1
Kholodovych, V.2
Ai, N.3
Sinz, M.4
Gal, J.5
Gera, L.6
Welsh, W.J.7
Bachmann, K.8
Mani, S.9
-
77
-
-
79959288391
-
In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation
-
10.1124/mol.111.071787, 3127530, 21464197
-
Venkatesh M, Wang H, Cayer J, Leroux M, Salvail D, Das B, Wrobel JE, Mani S. In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation. Mol Pharmacol 2011, 80:124-135. 10.1124/mol.111.071787, 3127530, 21464197.
-
(2011)
Mol Pharmacol
, vol.80
, pp. 124-135
-
-
Venkatesh, M.1
Wang, H.2
Cayer, J.3
Leroux, M.4
Salvail, D.5
Das, B.6
Wrobel, J.E.7
Mani, S.8
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