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Volumn 6, Issue 3, 2014, Pages 291-308

Monoclonal antibodies against human cancer stem cells

Author keywords

cancer stem cells; cancer therapy; CD123; CD133; CD44; CD47; EpCAM; IGF receptor I; monoclonal antibody; Notch; Wnt

Indexed keywords

7G 3; ADECATUMUMAB; AVE 1642; B 6H 12; B 6H 122; BII 022; BORTEZOMIB; CATUMAXOMAB; CD123 ANTIBODY; CD44 ANTIBODY; CD47 ANTIBODY; CIXUTUMUMAB; CSL 360; CYTOSTATIC AGENT; DALOTUZUMAB; DEMCIZUMAB; EDRECOLOMAB; FIGITUMUMAB; GANITUMAB; INSULIN LIKE GROWTH FACTOR RECEPTOR 1 ANTIBODY; IRINOTECAN; MONOCLONAL ANTIBODY; MT 110; OMP 18R 5; OMP 21M 18; OMP 52M 51; PACLITAXEL; REGN 421; RG 7356; RO 5429083; SOLITOMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANTICTUMAB; IMMUNOGLOBULIN G; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; TUMOR PROTEIN;

EID: 84899546885     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.14.4     Document Type: Review
Times cited : (37)

References (127)
  • 2
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: Impact, heterogeneity, and uncertainty
    • Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: Impact, heterogeneity, and uncertainty. Cancer Cell 21, 283-296 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 3
    • 84867878045 scopus 로고    scopus 로고
    • Cancer stem cell definitions and terminology: The devil is in the detail
    • Valent P, Bonnet D, De Maria R et al. Cancer stem cell definitions and terminology: The devil is in the detail. Nat. Rev. Cancer 12, 767-775 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 767-775
    • Valent, P.1    Bonnet, D.2    De Maria, R.3
  • 4
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB et al. Cancer stem cells-perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res. 66, 9339-9344 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 6
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesemchymal as well as tumor-initiating features
    • Creighton CJ, Li X, Landis M et al. Residual breast cancers after conventional therapy display mesemchymal as well as tumor-initiating features. Proc. Natl Acad. Sci. USA 106, 13820-13825 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3
  • 7
    • 77956516658 scopus 로고    scopus 로고
    • Persistant malignant stem cells in del(5q) myelodysplasia in remission
    • Tehranchi R, Woll PS, Anderson K et al. Persistant malignant stem cells in del(5q) myelodysplasia in remission. N. Engl. J. Med. 363, 1025-1037 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1025-1037
    • Tehranchi, R.1    Woll, P.S.2    Anderson, K.3
  • 8
    • 84859854912 scopus 로고    scopus 로고
    • A clinically relevant population of leukemic CD34+CD38-cells in acute myeloid leukemia
    • Gerber JM, Smith BD, Ngwang B et al. A clinically relevant population of leukemic CD34+CD38-cells in acute myeloid leukemia. Blood 119, 3571-3577 (2012).
    • (2012) Blood , vol.119 , pp. 3571-3577
    • Gerber, J.M.1    Smith, B.D.2    Ngwang, B.3
  • 9
    • 84887872183 scopus 로고    scopus 로고
    • Targeting cancer stem cells with defined compounds and drugs
    • Naujokat C, Laufer S. Targeting cancer stem cells with defined compounds and drugs. J. Cancer Res. Updates 2, 36-67 (2013).
    • (2013) J. Cancer Res. Updates , vol.2 , pp. 36-67
    • Naujokat, C.1    Laufer, S.2
  • 10
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F, Yao H, Zhu P et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131, 1109-1123 (2007).
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3
  • 11
    • 44049100934 scopus 로고    scopus 로고
    • Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
    • Li X, Lewis MT, Huang J et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J. Natl Cancer Inst. 100, 672-679 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , pp. 672-679
    • Li, X.1    Lewis, M.T.2    Huang, J.3
  • 12
    • 0038454621 scopus 로고    scopus 로고
    • Persistance of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R, Holtz M, Niu N et al. Persistance of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101, 4701-4707 (2003).
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 13
    • 79959891134 scopus 로고    scopus 로고
    • Stromal niche cells protect early leukemic FLT3-ITD+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors
    • 2011
    • Parmar A, Marz S, Rushton S et al. (2011) Stromal niche cells protect early leukemic FLT3-ITD+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors. Cancer Res. 71, 4696-4706 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 4696-4706
    • Parmar, A.1    Marz, S.2    Rushton, S.3
  • 14
    • 70350238323 scopus 로고    scopus 로고
    • Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: Selective escape of CD44high/ CD24low/HER2low breast cancer stem cells
    • Reim F, Dombrowski Y, Ritter C et al. Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: Selective escape of CD44high/ CD24low/HER2low breast cancer stem cells. Cancer Res. 69, 8058-8066 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8058-8066
    • Reim, F.1    Dombrowski, Y.2    Ritter, C.3
  • 15
    • 84864536555 scopus 로고    scopus 로고
    • Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
    • Cufi S, Corominas-Faja B, Vazquez-Martin A et al. Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts. Oncotarget 3, 395-398 (2012).
    • (2012) Oncotarget , vol.3 , pp. 395-398
    • Cufi, S.1    Corominas-Faja, B.2    Vazquez-Martin, A.3
  • 16
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • Weiner LM, Surana R, Wang S. Monoclonal antibodies: Versatile platforms for cancer immunotherapy. Nat. Rev. Immunol. 10, 317-327 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 17
    • 84858797619 scopus 로고    scopus 로고
    • Trial watch: Monoclonal antobodies in cancer therapy
    • Galluzzi L, Vacchelli E, Fridman WH et al. Trial watch: Monoclonal antobodies in cancer therapy. Oncoimmunology 1, 28-37 (2012).
    • (2012) Oncoimmunology , vol.1 , pp. 28-37
    • Galluzzi, L.1    Vacchelli, E.2    Fridman, W.H.3
  • 18
    • 84899511684 scopus 로고    scopus 로고
    • Targeting human cancer stem cells with monoclonal antibodies
    • Naujokat C. Targeting human cancer stem cells with monoclonal antibodies. Clin. Cell. Immunol. S5, 007 (2012).
    • (2012) Clin. Cell. Immunol. , vol.S5 , Issue.7
    • Naujokat, C.1
  • 19
    • 49349095724 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for B-cell non-Hodgkins lymphoma
    • Cheson BD, Leonard JP. Monoclonal antibody therapy for B-cell non-Hodgkins lymphoma. N. Engl. J. Med. 359, 613-626 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 613-626
    • Cheson, B.D.1    Leonard, J.P.2
  • 20
    • 79952240423 scopus 로고    scopus 로고
    • Anti-DLL4 inhibits and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations
    • Fischer M, Yen WC, Kapoun AM et al. Anti-DLL4 inhibits and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Res. 71, 1520-1525 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1520-1525
    • Fischer, M.1    Yen, W.C.2    Kapoun, A.M.3
  • 21
    • 84863938543 scopus 로고    scopus 로고
    • Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
    • Gurney A, Axelrod F, Bond CJ et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc. Natl Acad. Sci. USA 109, 11717-11722 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 11717-11722
    • Gurney, A.1    Axelrod, F.2    Bond, C.J.3
  • 23
    • 84863423782 scopus 로고    scopus 로고
    • Role of CD44 in tumour progression and strategies for targeting
    • Negi LM, Talegaonkar S, Jaggi M et al. Role of CD44 in tumour progression and strategies for targeting. J. Drug Target 20, 561-573 (2012).
    • (2012) J. Drug Target , vol.20 , pp. 561-573
    • Negi, L.M.1    Talegaonkar, S.2    Jaggi, M.3
  • 24
    • 84867987242 scopus 로고    scopus 로고
    • Cancer stem cells, microRNAs, and therapeutic strategies including natural products
    • Vira D, Basak SK, Veena MS et al. Cancer stem cells, microRNAs, and therapeutic strategies including natural products. Cancer Metastasis Rev. 31, 733-751 (2012).
    • (2012) Cancer Metastasis Rev. , vol.31 , pp. 733-751
    • Vira, D.1    Basak, S.K.2    Veena, M.S.3
  • 25
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med. 2, 1167-1174 (2006).
    • (2006) Nat. Med. , vol.2 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 28
    • 0033067551 scopus 로고    scopus 로고
    • Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia
    • Charrad RS, Li Y, Delpech B et al. Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Nat. Med. 5, 669-676 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 669-676
    • Charrad, R.S.1    Li, Y.2    Delpech, B.3
  • 29
    • 0036095957 scopus 로고    scopus 로고
    • Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines
    • Charrad RS, Gadhoum Z, Qi J et al. Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood 99, 290-299 (2002).
    • (2002) Blood , vol.99 , pp. 290-299
    • Charrad, R.S.1    Gadhoum, Z.2    Qi, J.3
  • 30
    • 3042775143 scopus 로고    scopus 로고
    • The effect of anti-CD44 monoclonal antibodies on differentiation and proliferation of human acute myeloid leukemia cells
    • Gadhoum Z, Delaunay J, Maquarre E et al. The effect of anti-CD44 monoclonal antibodies on differentiation and proliferation of human acute myeloid leukemia cells. Leuk. Lymphoma 45, 1501-1510 (2004).
    • (2004) Leuk. Lymphoma , vol.45 , pp. 1501-1510
    • Gadhoum, Z.1    Delaunay, J.2    Maquarre, E.3
  • 31
    • 62549090127 scopus 로고    scopus 로고
    • CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancer xenografts
    • Marangoni E, Lecomte N, Durant L et al. CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancer xenografts. Br. J. Cancer 100, 918-922 (2009).
    • (2009) Br. J. Cancer , vol.100 , pp. 918-922
    • Marangoni, E.1    Lecomte, N.2    Durant, L.3
  • 32
    • 84857063740 scopus 로고    scopus 로고
    • CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome
    • Idowu MO, Kmieciak M, Dumur C et al. CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome. Hum. Pathol. 43, 364-373 (2012).
    • (2012) Hum. Pathol. , vol.43 , pp. 364-373
    • Idowu, M.O.1    Kmieciak, M.2    Dumur, C.3
  • 33
    • 80054879984 scopus 로고    scopus 로고
    • Breast cancer stem cell markers CD44 CD24 and ALDH1: Expression distribution within intrinsic molecular subtype
    • Ricardo S, Vieira AF, Gerhard R et al. Breast cancer stem cell markers CD44, CD24 and ALDH1: Expression distribution within intrinsic molecular subtype. J. Clin. Pathol. 64, 937-946 (2011).
    • (2011) J. Clin. Pathol. , vol.64 , pp. 937-946
    • Ricardo, S.1    Vieira, A.F.2    Gerhard, R.3
  • 34
    • 0025347505 scopus 로고
    • Homotypic cell aggregation induced by anti-CD44(Pgp-1) monoclonal antibodies and related to CD44(Pgp-1) expression
    • Belitsos PC, Hildreth JE, August JT. Homotypic cell aggregation induced by anti-CD44(Pgp-1) monoclonal antibodies and related to CD44(Pgp-1) expression. J. Immunol. 144, 1661-1670 (1990).
    • (1990) J. Immunol. , vol.144 , pp. 1661-1670
    • Belitsos, P.C.1    Hildreth, J.E.2    August, J.T.3
  • 35
    • 84898899502 scopus 로고    scopus 로고
    • Anti-CD44 antibody treatment inhibits pancreatic cancer metastasis and postradiotherapy recurrence
    • Abstract
    • Tang W, Hao X, He F, Li L, Xu L. Anti-CD44 antibody treatment inhibits pancreatic cancer metastasis and postradiotherapy recurrence. Cancer Res. 71(8 Suppl. 1), Abstract 565 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.8 , pp. 565
    • Tang, W.1    Hao, X.2    He, F.3    Li, L.4    Xu, L.5
  • 36
    • 84855829724 scopus 로고    scopus 로고
    • Antitumor effect against human cancer xenografts by a fully human monoclonal anibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells
    • Masuko K, Okazaki S, Satoh M et al. antitumor effect against human cancer xenografts by a fully human monoclonal anibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells. PLoS ONE 7, e29728 (2012).
    • (2012) PLoS ONE , vol.7
    • Masuko, K.1    Okazaki, S.2    Satoh, M.3
  • 37
    • 80053174609 scopus 로고    scopus 로고
    • CD44 isoforms are heterogenously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers
    • Olsson E, Honeth G, Bendahl PO et al. CD44 isoforms are heterogenously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. BMC Cancer 11, 418 (2011).
    • (2011) BMC Cancer , vol.11 , Issue.418
    • Olsson, E.1    Honeth, G.2    Bendahl, P.O.3
  • 38
    • 84899515010 scopus 로고    scopus 로고
    • Targeting CD44 in head and neck squamous cell carcinoma (HNSCC) with a new humanized antibody RO5429083
    • Abstract
    • Perez A, Neskey DM, Wen J et al. Targeting CD44 in head and neck squamous cell carcinoma (HNSCC) with a new humanized antibody RO5429083. Cancer Res. 72(8 Suppl. 1), Abstract 2521 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.8 , pp. 2521
    • Perez, A.1    Neskey, D.M.2    Wen, J.3
  • 39
    • 84865713442 scopus 로고    scopus 로고
    • Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist
    • Weigand S, Herting F, Maisel D et al. Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist. Cancer Res. 72, 4329-4339 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 4329-4339
    • Weigand, S.1    Herting, F.2    Maisel, D.3
  • 40
    • 70349436013 scopus 로고    scopus 로고
    • Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma
    • Hama T, Yuza Y, Saito Y et al. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist 14, 900-908 (2009).
    • (2009) Oncologist , vol.14 , pp. 900-908
    • Hama, T.1    Yuza, Y.2    Saito, Y.3
  • 41
    • 84876037294 scopus 로고    scopus 로고
    • Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
    • Zhang S, Wu CC, Fecteau JF et al. Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44. Proc. Natl Acad. Sci. USA 110, 6127-6132 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 6127-6132
    • Zhang, S.1    Wu, C.C.2    Fecteau, J.F.3
  • 42
    • 84881015517 scopus 로고    scopus 로고
    • CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia
    • Fedorchenko O, Stiefelhagen M, Peer-Zada AA et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood 121, 4126-4136 (2013).
    • (2013) Blood , vol.121 , pp. 4126-4136
    • Fedorchenko, O.1    Stiefelhagen, M.2    Peer-Zada, A.A.3
  • 43
    • 80051589767 scopus 로고    scopus 로고
    • Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia
    • Kikushige Y, Ishikawa F, Miyamoto T et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell 20, 246-259 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 246-259
    • Kikushige, Y.1    Ishikawa, F.2    Miyamoto, T.3
  • 46
    • 84859158880 scopus 로고    scopus 로고
    • The cd47-sirpα pathway in cancer immune evasion and potential therapeutic implications
    • Chao MP, Weissman IL, Majeti R. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr. Opin. Immunol. 24, 225-232 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 225-232
    • Chao, M.P.1    Weissman, I.L.2    Majeti, R.3
  • 47
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal S, Jamieson CH, Pang WW et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271-285 (2009).
    • (2009) Cell , vol.138 , pp. 271-285
    • Jaiswal, S.1    Jamieson, C.H.2    Pang, W.W.3
  • 48
    • 84860174226 scopus 로고    scopus 로고
    • The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    • Willingham SB, Volkmer JP, Gentles AJ et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc. Natl Acad. Sci. USA 109, 6662-6667 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 6662-6667
    • Willingham, S.B.1    Volkmer, J.P.2    Gentles, A.J.3
  • 49
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 138, 286-299 (2009).
    • (2009) Cell , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3
  • 50
    • 69549114870 scopus 로고    scopus 로고
    • Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    • Chan KS, Espinosa I, Chaoa A et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc. Natl Acad. Sci. USA 106, 14016-14021 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14016-14021
    • Chan, K.S.1    Espinosa, I.2    Chaoa, A.3
  • 51
    • 80855128780 scopus 로고    scopus 로고
    • Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy
    • Chao MP, Tang C, Pachynski RK et al. Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood 118, 4890-4901 (2011).
    • (2011) Blood , vol.118 , pp. 4890-4901
    • Chao, M.P.1    Tang, C.2    Pachynski, R.K.3
  • 52
    • 79951845617 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
    • Chao MP, Alizadeh AA, Tang C et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res. 71, 1374-1384 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1374-1384
    • Chao, M.P.1    Alizadeh, A.A.2    Tang, C.3
  • 53
    • 84871182464 scopus 로고    scopus 로고
    • Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
    • Kim D, Wang J, Willingham SB et al. Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia 26, 2538-2545 (2012).
    • (2012) Leukemia , vol.26 , pp. 2538-2545
    • Kim, D.1    Wang, J.2    Willingham, S.B.3
  • 54
    • 84860135764 scopus 로고    scopus 로고
    • Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma
    • Edris B, Weiskopf K, Volkmer AK et al. Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc. Natl Acad. Sci. USA 109, 6656-6661 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 6656-6661
    • Edris, B.1    Weiskopf, K.2    Volkmer, A.K.3
  • 55
    • 84899500513 scopus 로고    scopus 로고
    • Development of anti-CD47 therapy for pediatric brain tumors
    • Abstract 5281
    • Gholamin S, Mitra SS, Richard CE et al. Development of anti-CD47 therapy for pediatric brain tumors. Cancer Res. 73(8 Suppl. 1), Abstract 5281 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.8
    • Gholamin, S.1    Mitra, S.S.2    Richard, C.E.3
  • 56
    • 84879733796 scopus 로고    scopus 로고
    • Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response
    • Tseng D, Volkmer JP, Willingham SB et al. Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Proc. Natl Acad. Sci. USA 110, 11103-11108 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 11103-11108
    • Tseng, D.1    Volkmer, J.P.2    Willingham, S.B.3
  • 57
    • 13344250476 scopus 로고    scopus 로고
    • Monoclonal antibody 7G3 recognizes the N-Terminal domain of the human interleukin-3 (IL-3) receptor α-chain and functions as a specific IL-3 receptor antagonist
    • Sun Q, Woodcock JM, Rapoport A et al. Monoclonal antibody 7G3 recognizes the N-Terminal domain of the human interleukin-3 (IL-3) receptor α-chain and functions as a specific IL-3 receptor antagonist. Blood 87, 83-92 (1996).
    • (1996) Blood , vol.87 , pp. 83-92
    • Sun, Q.1    Woodcock, J.M.2    Rapoport, A.3
  • 58
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia 14, 1777-1784 (2000).
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3
  • 59
    • 0037108559 scopus 로고    scopus 로고
    • Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis
    • Testa U, Riccioni R, Militi S et al. Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis. Blood 100, 2980-2988 (2002).
    • (2002) Blood , vol.100 , pp. 2980-2988
    • Testa, U.1    Riccioni, R.2    Militi, S.3
  • 60
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibodymediated targeting of CD123, IL-3 receptor α chain, eliminates human acute myeloid leukemic stem cells
    • Jin L, Lee EM, Ramshaw HS et al. Monoclonal antibodymediated targeting of CD123, IL-3 receptor α chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cells 5, 31-42 (2009).
    • (2009) Cell Stem Cells , vol.5 , pp. 31-42
    • Jin, L.1    Lee, E.M.2    Ramshaw, H.S.3
  • 61
    • 82855177875 scopus 로고    scopus 로고
    • High levels of cd34+cd38low/-cd123+ blasts are predictive of an adverse outcome in acute myeloid leukemias: A groupe ouest-est des leucemies aigues et maladies du sang (goelams) study
    • Vergez F, Green AS, Tamburini J et al. High levels of CD34+CD38low/-CD123+ blasts are predictive of an adverse outcome in acute myeloid leukemias: A Groupe Ouest-Est des Leucemies Aigues et Maladies du Sang (GOELAMS) study. Haematologica 96, 1792-1798 (2011).
    • (2011) Haematologica , vol.96 , pp. 1792-1798
    • Vergez, F.1    Green, A.S.2    Tamburini, J.3
  • 62
    • 80052622425 scopus 로고    scopus 로고
    • Auger electron radioimmunotherapeutic agent specific for the CD123+/ CD131-phenotype of the leukemia stem cell population
    • Leyton JV, Hu M, Gao C et al. Auger electron radioimmunotherapeutic agent specific for the CD123+/ CD131-phenotype of the leukemia stem cell population. J. Nucl. Med. 52, 1465-1473 (2011).
    • (2011) J. Nucl. Med. , vol.52 , pp. 1465-1473
    • Leyton, J.V.1    Hu, M.2    Gao, C.3
  • 63
    • 84862024025 scopus 로고    scopus 로고
    • A phase i study of anti-cd123 monoclonal antibody (mab) csl360 targeting leukemia stem cells (lsc) in aml
    • Suppl.), Abstract e13012
    • Roberts AW, He S, Ritchie D et al. A Phase I study of anti-CD123 monoclonal antibody (mAb) CSL360 targeting leukemia stem cells (LSC) in AML. J. Clin. Oncol. 28(15 Suppl.), Abstract e13012 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.15
    • Roberts, A.W.1    He, S.2    Ritchie, D.3
  • 65
    • 84866996937 scopus 로고    scopus 로고
    • Engineering a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells
    • Kuo SR, Wong L, Liu JS. Engineering a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein Eng. Des. Sel. 25, 561-570 (2012).
    • (2012) Protein Eng. Des. Sel. , vol.25 , pp. 561-570
    • Kuo, S.R.1    Wong, L.2    Liu, J.S.3
  • 66
    • 77955782190 scopus 로고    scopus 로고
    • A recombinant trispecific single-chain Fv derivate directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting
    • Kügler M, Stein C, Kellner C et al. A recombinant trispecific single-chain Fv derivate directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting. Br. J. Haematol. 150, 574-586 (2010).
    • (2010) Br. J. Haematol. , vol.150 , pp. 574-586
    • Kügler, M.1    Stein, C.2    Kellner, C.3
  • 67
    • 59749103834 scopus 로고    scopus 로고
    • Nuclear signalling by tumour-Associated antigen EpCAM
    • Maetzel D, Denzel S, Mack B et al. Nuclear signalling by tumour-Associated antigen EpCAM. Nat. Cell Biol. 11, 162-171 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 162-171
    • Maetzel, D.1    Denzel, S.2    Mack, B.3
  • 68
    • 84860367617 scopus 로고    scopus 로고
    • EpCAM and its potential role in tumor-initiating cells
    • Imrich S, Hachmeister M, Gires O. EpCAM and its potential role in tumor-initiating cells. Cell Adh. Migr. 6, 30-38 (2012).
    • (2012) Cell Adh. Migr. , vol.6 , pp. 30-38
    • Imrich, S.1    Hachmeister, M.2    Gires, O.3
  • 70
    • 28744445538 scopus 로고    scopus 로고
    • MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
    • Brischwein K, Schlereth B, Guller B et al. MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors. Mol. Immunol. 43, 1129-1143 (2006).
    • (2006) Mol. Immunol. , vol.43 , pp. 1129-1143
    • Brischwein, K.1    Schlereth, B.2    Guller, B.3
  • 71
    • 64649103924 scopus 로고    scopus 로고
    • Mode of cytotoxic action of T-cell engaging BiTE antibody MT110
    • Haas C, Krinner E, Brischwein K et al. Mode of cytotoxic action of T-cell engaging BiTE antibody MT110. Immunobiology 214, 441-453 (2009).
    • (2009) Immunobiology , vol.214 , pp. 441-453
    • Haas, C.1    Krinner, E.2    Brischwein, K.3
  • 72
    • 84899518680 scopus 로고    scopus 로고
    • Functional importance of EpCAM for the activity of tumor-initiating cancer cells and their eradication by EpCAM/CD3-bispecific antibody MT110. Cancer Res. 71(8 Suppl. 1
    • Münz M, Herrmann I, Friedrich M et al. Functional importance of EpCAM for the activity of tumor-initiating cancer cells and their eradication by EpCAM/CD3-bispecific antibody MT110. Cancer Res. 71(8 Suppl. 1), Abstract 1790 (2011).
    • (2011) Abstract , vol.1790
    • Münz, M.1    Herrmann, I.2    Friedrich, M.3
  • 73
    • 78149460436 scopus 로고    scopus 로고
    • Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells
    • Herrmann I, Baeuerle PA, Friedrich M et al. Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells. PLoS ONE 5, e13474 (2010).
    • (2010) PLoS ONE , vol.5
    • Herrmann, I.1    Baeuerle, P.A.2    Friedrich, M.3
  • 74
    • 84856007019 scopus 로고    scopus 로고
    • EpCAM/ cd3-bispecific t-cell engaging antibody mt110 eliminates primary human pancreatic cancer stem cells
    • Cioffi M, Dorado J, Baeuerle PA, Heeschen C. EpCAM/ CD3-bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin. Cancer Res. 18, 465-474 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 465-474
    • Cioffi, M.1    Dorado, J.2    Baeuerle, P.A.3    Heeschen, C.4
  • 76
    • 84867733430 scopus 로고    scopus 로고
    • A phase i study of epcam/cd3-bispecific antibody (mt110) in patients with advanced solid tumors
    • Suppl.), Abstract 2504 2012
    • Fiedler WM, Wolf M, Kebenko M et al. (2012) A Phase I study of EpCAM/CD3-bispecific antibody (MT110) in patients with advanced solid tumors. J. Clin. Oncol. 30(15 Suppl.), Abstract 2504 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.15
    • Fiedler, W.M.1    Wolf, M.2    Kebenko, M.3
  • 77
    • 77953665930 scopus 로고    scopus 로고
    • Structural and functional characterization of the trifunctional antibody catumaxomab
    • Chelius D, Ruf P, Gruber P et al. Structural and functional characterization of the trifunctional antibody catumaxomab. Mabs 2, 309-319 (2010).
    • (2010) Mabs , vol.2 , pp. 309-319
    • Chelius, D.1    Ruf, P.2    Gruber, P.3
  • 78
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
    • Seimetz D, Lindhofer H, Bokemeyer C. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat. Rev. 36, 458-467 (2010).
    • (2010) Cancer Treat. Rev. , vol.36 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 79
    • 84856034032 scopus 로고    scopus 로고
    • Trifunctional antibodies induce efficient antitumour activity with immune cells from head and neck squamous cell carcinoma patients after radio-chemotherapy treatment
    • Schroeder P, Lindemann C, Dettmar K et al. Trifunctional antibodies induce efficient antitumour activity with immune cells from head and neck squamous cell carcinoma patients after radio-chemotherapy treatment. Clin. Transl. Oncol. 13, 889-898 (2011).
    • (2011) Clin. Transl. Oncol. , vol.13 , pp. 889-898
    • Schroeder, P.1    Lindemann, C.2    Dettmar, K.3
  • 80
    • 84893134949 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab amplifies and shapes tumor-specific immunity when applied to gastric cancer patients in the adjuvant setting
    • doi:10.4161/ hv.26065 Epub ahead of print
    • Atanackovic D, Reinhard H, Meyer S et al. The trifunctional antibody catumaxomab amplifies and shapes tumor-specific immunity when applied to gastric cancer patients in the adjuvant setting. Hum. Vaccin. Immunother. doi:10.4161/ hv.26065 (2013) (Epub ahead of print).
    • (2013) Hum. Vaccin. Immunother.
    • Atanackovic, D.1    Reinhard, H.2    Meyer, S.3
  • 81
    • 63649133396 scopus 로고    scopus 로고
    • Treatment of malignant pleural effusions with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x anti-CD3): Results of a Phase 1/2 study
    • Sebastian M, Kiewe P, Schuette W et al. Treatment of malignant pleural effusions with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x anti-CD3): Results of a Phase 1/2 study. J. Immunother. 32, 195-202 (2009).
    • (2009) J. Immunother. , vol.32 , pp. 195-202
    • Sebastian, M.1    Kiewe, P.2    Schuette, W.3
  • 82
    • 77954676136 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized Phase II/III trial
    • Heiss MM, Murawa P, Koralewski P et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized Phase II/III trial. Int. J. Cancer 127, 2209-2221 (2010).
    • (2010) Int. J. Cancer , vol.127 , pp. 2209-2221
    • Heiss, M.M.1    Murawa, P.2    Koralewski, P.3
  • 83
    • 79952257330 scopus 로고    scopus 로고
    • Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: An open-label, multicenter, Phase I/II trial
    • Ströhlein MA, Lordick F, Rüttinger D et al. Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: An open-label, multicenter, Phase I/II trial. Onkologie 34, 101-108 (2011).
    • (2011) Onkologie , vol.34 , pp. 101-108
    • Ströhlein, M.A.1    Lordick, F.2    Rüttinger, D.3
  • 84
    • 84855401998 scopus 로고    scopus 로고
    • Immunomonitoring results of a Phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3)
    • Jäger M, Schoberth A, Ruf P et al. Immunomonitoring results of a Phase II/III study of malignant ascites patients treated with the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3). Cancer Res. 72, 24-32 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 24-32
    • Jäger, M.1    Schoberth, A.2    Ruf, P.3
  • 85
    • 83655196673 scopus 로고    scopus 로고
    • Novel monoclonal antibodies for cancer treatment: The trifunctional antibody catumaxomab (removab)
    • Seimetz D. Novel monoclonal antibodies for cancer treatment: The trifunctional antibody catumaxomab (removab). J. Cancer 2, 309-316 (2011).
    • (2011) J. Cancer , vol.2 , pp. 309-316
    • Seimetz, D.1
  • 86
    • 80051809050 scopus 로고    scopus 로고
    • Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: Results from the CALGB 9581
    • Niedzwiecki D, Bertagnolli MM, Warren RS et al. Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: Results from the CALGB 9581. J. Clin. Oncol. 29, 3146-3152 (2011).
    • (2011) J. Clin. Oncol , pp. 3146-3152
    • Niedzwiecki, D.1    Bertagnolli, M.M.2    Warren, R.S.3
  • 87
    • 77951881160 scopus 로고    scopus 로고
    • An open-label, randomized phase ii study of adecatumumab, a fully human anti-epcam antibody, as monotherapy in patients with metastatic breast cancer
    • Schmidt M, Scheulen ME, Dittrich C et al. An open-label, randomized Phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer. Ann. Oncol. 21, 275-282 (2010).
    • (2010) Ann. Oncol. , vol.21 , pp. 275-282
    • Schmidt, M.1    Scheulen, M.E.2    Dittrich, C.3
  • 88
    • 0031453534 scopus 로고    scopus 로고
    • AC133, a novel marker for human hematopoietic stem and progenitor cells
    • Yin AH, Miraglia S, Zanjani ED et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90, 5002-5012 (1997).
    • (1997) Blood , vol.90 , pp. 5002-5012
    • Yin, A.H.1    Miraglia, S.2    Zanjani, E.D.3
  • 89
    • 84872902302 scopus 로고    scopus 로고
    • CD133 as a biomarker for putative cancer stem cells in solid tumours: Limitations, problems and challenges
    • Grosse-Gehling P, Fargeas CA, Dittfeld C et al. CD133 as a biomarker for putative cancer stem cells in solid tumours: Limitations, problems and challenges. J. Pathol. 229, 355-378 (2013).
    • (2013) J. Pathol. , vol.229 , pp. 355-378
    • Grosse-Gehling, P.1    Fargeas, C.A.2    Dittfeld, C.3
  • 90
    • 49749144107 scopus 로고    scopus 로고
    • The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
    • Bidlingmaier S, Zhu X, Liu B. The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J. Mol. Med. 86, 1025-1032 (2008).
    • (2008) J. Mol. Med. , vol.86 , pp. 1025-1032
    • Bidlingmaier, S.1    Zhu, X.2    Liu, B.3
  • 91
    • 0037036423 scopus 로고    scopus 로고
    • AC133-2, a novel isoform of himan AC133 stem cell antigen
    • Yu Y, Flint A, Dvorin EL, Bischoff J. AC133-2, a novel isoform of himan AC133 stem cell antigen. J. Biol. Chem. 277, 20711-20716 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 20711-20716
    • Yu, Y.1    Flint, A.2    Dvorin, E.L.3    Bischoff, J.4
  • 92
    • 76549120193 scopus 로고    scopus 로고
    • The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation
    • Kemper K, Sprick MR, de Bree M et al. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res. 70, 719-729 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 719-729
    • Kemper, K.1    Sprick, M.R.2    De Bree, M.3
  • 93
    • 80054003177 scopus 로고    scopus 로고
    • Targeting tumorinitiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenograft model of human head and neck cancer
    • Waldron NN, Kaufman DS, Oh S et al. Targeting tumorinitiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenograft model of human head and neck cancer. Mol. Cancer Ther. 10, 1829-1839 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1829-1839
    • Waldron, N.N.1    Kaufman, D.S.2    Oh, S.3
  • 94
    • 84883244302 scopus 로고    scopus 로고
    • Cytokine-induced killer (CIK) cells bound with antiCD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo
    • Huang J, Li C, Wang Y et al. Cytokine-induced killer (CIK) cells bound with antiCD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin. Immunol. 149, 156-168 (2013).
    • (2013) Clin. Immunol. , vol.149 , pp. 156-168
    • Huang, J.1    Li, C.2    Wang, Y.3
  • 95
    • 84855398829 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology
    • Gao J, Chang YS, Jallal B, Viner J. Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology. Cancer Res. 72, 3-12 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 3-12
    • Gao, J.1    Chang, Y.S.2    Jallal, B.3    Viner, J.4
  • 96
    • 79955805214 scopus 로고    scopus 로고
    • Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma
    • Moreau P, Cavallo F, Leleu X et al. Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma. Leukemia 25, 872-874 (2011).
    • (2011) Leukemia , vol.25 , pp. 872-874
    • Moreau, P.1    Cavallo, F.2    Leleu, X.3
  • 97
    • 84859163193 scopus 로고    scopus 로고
    • The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors
    • Scagliotti GV, Novello S. The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors. Cancer Treat. Rev. 38, 292-302 (2012).
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 292-302
    • Scagliotti, G.V.1    Novello, S.2
  • 98
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectal cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • Dallas NA, Xia L, Gan F et al. Chemoresistant colorectal cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 69, 1951-1957 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Gan, F.3
  • 99
    • 79960438373 scopus 로고    scopus 로고
    • Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
    • Hart LS, Dollof NG, Dicker DT et al. Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab. Cell Cycle 10, 2331-2338 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 2331-2338
    • Hart, L.S.1    Dollof, N.G.2    Dicker, D.T.3
  • 100
    • 58749086023 scopus 로고    scopus 로고
    • A humanized anti-IGF-1R monoclonal antibody (AVE1642) enhances bortezomib-induced apoptosis in myeloma lacking CD45
    • Descamps G, Gomez-Bougie P, Venot C et al. A humanized anti-IGF-1R monoclonal antibody (AVE1642) enhances bortezomib-induced apoptosis in myeloma lacking CD45. Br. J. Cancer 100, 366-369 (2009).
    • (2009) Br. J. Cancer , vol.100 , pp. 366-369
    • Descamps, G.1    Gomez-Bougie, P.2    Venot, C.3
  • 101
    • 84865858012 scopus 로고    scopus 로고
    • Targeting Notch signaling for cancer therapeutic intervention
    • Shao H, Huang Q, Liu ZJ. Targeting Notch signaling for cancer therapeutic intervention. Adv. Pharmacol. 65, 191-234 (2012).
    • (2012) Adv. Pharmacol. , vol.65 , pp. 191-234
    • Shao, H.1    Huang, Q.2    Liu, Z.J.3
  • 103
    • 82655164839 scopus 로고    scopus 로고
    • Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
    • Kuhnert F, Kirshner JR, Thurston G. Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc. Cell 3, 20 (2011).
    • (2011) Vasc. Cell , vol.3 , Issue.20
    • Kuhnert, F.1    Kirshner, J.R.2    Thurston, G.3
  • 104
    • 67849124654 scopus 로고    scopus 로고
    • DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency
    • Hoey T, Yen WC, Axelrod F et al. DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell 5, 168-177 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 168-177
    • Hoey, T.1    Yen, W.C.2    Axelrod, F.3
  • 105
    • 84866920000 scopus 로고    scopus 로고
    • Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells
    • Yen WC, Fischer MM, Hynes M et al. Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells. Clin. Cancer Res. 18, 5374-5386 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 5374-5386
    • Yen, W.C.1    Fischer, M.M.2    Hynes, M.3
  • 106
    • 84899543869 scopus 로고    scopus 로고
    • Anti-DLL4 treatment inhibits melanoma tumor growth, recurrence, metastases, and reduces frequency of cancer stem cells in a clinically relevant tumor model in NOD/SCID mice
    • Abstract 2834
    • Beviglia L, Yeung P, Fischer M et al. Anti-DLL4 treatment inhibits melanoma tumor growth, recurrence, metastases, and reduces frequency of cancer stem cells in a clinically relevant tumor model in NOD/SCID mice. Cancer Res. 71(8 Suppl. 1), Abstract 2834 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.8
    • Beviglia, L.1    Yeung, P.2    Fischer, M.3
  • 107
    • 84899540790 scopus 로고    scopus 로고
    • Anti-DLL (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts
    • Abstract 3725
    • Yen WC, Fischer MM, Shah J et al. Anti-DLL (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts. Cancer Res. 73(8 Suppl. 1), Abstract 3725 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.8
    • Yen, W.C.1    Fischer, M.M.2    Shah, J.3
  • 108
    • 84899549792 scopus 로고    scopus 로고
    • Anti-DLL4 reduces tumor growth and tumorigenicity in B-RAF V600E melanomas including those with acquired resistance to B-RAF inhibitors
    • Abstract LB-196
    • Breviglia L, Yeung P, Fischer M et al. Anti-DLL4 reduces tumor growth and tumorigenicity in B-RAF V600E melanomas including those with acquired resistance to B-RAF inhibitors, Cancer Res. 72(8 Suppl. 1), Abstract LB-196 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.8
    • Breviglia, L.1    Yeung, P.2    Fischer, M.3
  • 109
    • 84899531219 scopus 로고    scopus 로고
    • Targeting cancer stem cells by an anti-DLL4 antibody inhibits epithelial-To-mesenchymal transition, delays tumor recurrence and overcomes drug resistance in breast and pancreatic cancer
    • Abstract 3357
    • Yen WC, Fischer M, Lewicki J, Gurney A, Hoey T. Targeting cancer stem cells by an anti-DLL4 antibody inhibits epithelial-To-mesenchymal transition, delays tumor recurrence and overcomes drug resistance in breast and pancreatic cancer. Cancer Res. 72(8 Suppl. 1), Abstract 3357 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.8
    • Yen, W.C.1    Fischer, M.2    Lewicki, J.3    Gurney, A.4    Hoey, T.5
  • 113
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos NJ et al. Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis. Nature 444, 1032-1037 (2006).
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 115
    • 84891850788 scopus 로고    scopus 로고
    • Phase I study of REGN421 (R)/SAR153192 a fully-human delta-like ligand 4 (Dll4) monoclonal antibody (mAb) in patients with advanced solid tumors
    • Suppl.) Abstract 2502
    • Jimeno A, LoRusso P, Strother RM et al. Phase I study of REGN421 (R)/SAR153192, a fully-human delta-like ligand 4 (Dll4) monoclonal antibody (mAb), in patients with advanced solid tumors. J. Clin. Oncol. 31(15 Suppl.), Abstract 2502 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.15
    • Jimeno, A.1    LoRusso, P.2    Strother, R.M.3
  • 116
    • 84899505855 scopus 로고    scopus 로고
    • Anti-notch1 antibody (omp-52m51) impedes tumor growth and cancer stem cell frequency (csc) in a chemo-refractory breast cancer xenograft model with an activating notch1 mutation and screening for activated notch1 across multiple solid tumor types
    • Abstract 3728
    • Cancilla B, Cain J, Wang M et al. Anti-Notch1 antibody (OMP-52M51) impedes tumor growth and cancer stem cell frequency (CSC) in a chemo-refractory breast cancer xenograft model with an activating Notch1 mutation and screening for activated Notch1 across multiple solid tumor types. Cancer Res. 73(8 Suppl. 1), Abstract 3728 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.8
    • Cancilla, B.1    Cain, J.2    Wang, M.3
  • 119
    • 84873998813 scopus 로고    scopus 로고
    • Frizzled homolog proteins, microRNAs and Wnt signaling in cancer
    • Ueno K, Hirata H, Hinoda Y, Dahiya R. Frizzled homolog proteins, microRNAs and Wnt signaling in cancer. Int. J. Cancer 132, 1731-1740 (2013).
    • (2013) Int. J. Cancer , vol.132 , pp. 1731-1740
    • Ueno, K.1    Hirata, H.2    Hinoda, Y.3    Dahiya, R.4
  • 120
    • 84878077268 scopus 로고    scopus 로고
    • Targeting cancer stem cells by a novel anti-frizzled antibody inhibits pancreatic tumor growth and induces differentiation
    • Abstract 973 2011
    • Yen WC, Fischer M, Lewicki J, Gurney A, Hoey T. (2011) Targeting cancer stem cells by a novel anti-frizzled antibody inhibits pancreatic tumor growth and induces differentiation. Cancer Res. 71(8 Suppl. 1), Abstract 973 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.8
    • Yen, W.C.1    Fischer, M.2    Lewicki, J.3    Gurney, A.4    Hoey, T.5
  • 121
    • 84899584781 scopus 로고    scopus 로고
    • Development of a novel Wnt pathway antagonist antibody, OMP-18R5, that reduces tumor initiating cell frequency in breast cancer
    • Abstract 3356
    • Lewicki J, Axelrod F, Beviglia L et al. Development of a novel Wnt pathway antagonist antibody, OMP-18R5, that reduces tumor initiating cell frequency in breast cancer. Cancer Res. 72(8 Suppl. 1), Abstract 3356 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.8
    • Lewicki, J.1    Axelrod, F.2    Beviglia, L.3
  • 123
    • 84899575925 scopus 로고    scopus 로고
    • First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5; anti-Frizzled) targeting WNT pathway in a Phase I study for patients with advanced solid tumors
    • Suppl.), Abstract 2540
    • Smith DC, Rosen LS, Chugh R et al. First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5; anti-Frizzled) targeting WNT pathway in a Phase I study for patients with advanced solid tumors. J. Clin. Oncol. 31(15 Suppl.), Abstract 2540 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.15
    • Smith, D.C.1    Rosen, L.S.2    Chugh, R.3
  • 124
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 125
    • 84874857331 scopus 로고    scopus 로고
    • HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Inplications for efficacy of adjuvant trastuzumab
    • Ithimakin S, Day KC, Malik F et al. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Inplications for efficacy of adjuvant trastuzumab. Cancer Res. 73, 1635-1646 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 1635-1646
    • Ithimakin, S.1    Day, K.C.2    Malik, F.3
  • 126
    • 79957622341 scopus 로고    scopus 로고
    • Emerging concepts in clinical targeting of cancer stem cells
    • Rasheed ZA, Kowalski J, Smith BD, Matsui W. Emerging concepts in clinical targeting of cancer stem cells. Stem Cells 29, 883-887 (2011).
    • (2011) Stem Cells , vol.29 , pp. 883-887
    • Rasheed, Z.A.1    Kowalski, J.2    Smith, B.D.3    Matsui, W.4
  • 127
    • 84865494894 scopus 로고    scopus 로고
    • Stem cells in breast tumours: Are they ready for the clinic?
    • Ablett MP, Singh JK, Clarke RB. Stem cells in breast tumours: Are they ready for the clinic? Eur. J. Cancer 48, 2104-2116 (2012).
    • (2012) Eur. J. Cancer , vol.48 , pp. 2104-2116
    • Ablett, M.P.1    Singh, J.K.2    Clarke, R.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.