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Volumn 2, Issue 1, 2011, Pages 309-316

Novel monoclonal antibodies for cancer treatment: The trifunctional an-tibody catumaxomab (Removab®)

Author keywords

Anti CD3; Anti EpCAM; Catumaxomab; Epithelial cell adhesion molecule (EpCAM); Malignant ascites; Targeted cancer immunotherapy; Trifunctional antibody

Indexed keywords

CATUMAXOMAB; CD16 ANTIGEN; CD3 ANTIGEN; DIURETIC AGENT; EPITHELIAL CELL ADHESION MOLECULE; FC RECEPTOR; FC RECEPTOR IIA;

EID: 83655196673     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.2.309     Document Type: Review
Times cited : (77)

References (37)
  • 1
    • 35548961447 scopus 로고    scopus 로고
    • A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects
    • Strome SE, Sausville EA, Mann D. A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects. Oncologist 2007;12:1084-95.
    • (2007) Oncologist , vol.12 , pp. 1084-1095
    • Strome, S.E.1    Sausville, E.A.2    Mann, D.3
  • 2
    • 62149138484 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy
    • Chames P, Baty D. Bispecific antibodies for cancer therapy. Curr Opin Drug Discov Devel 2009;12:276-83.
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 276-283
    • Chames, P.1    Baty, D.2
  • 3
    • 0021832361 scopus 로고
    • Hybrid antibodies can target sites for attack by T cells
    • Staerz UD, Kanagawa O, Bevan MJ. Hybrid antibodies can target sites for attack by T cells. Nature 1985;314:628-31.
    • (1985) Nature , vol.314 , pp. 628-631
    • Staerz, U.D.1    Kanagawa, O.2    Bevan, M.J.3
  • 4
    • 34547579096 scopus 로고    scopus 로고
    • Characterisation of the new Ep-CAM-specific antibody HO-3, implications for trifunctional an-tibody immunotherapy of cancer
    • Ruf P, Gires O, Jäger M, et al. Characterisation of the new Ep-CAM-specific antibody HO-3: implications for trifunctional an-tibody immunotherapy of cancer. Br J Cancer 2007;97:315-21.
    • (2007) Br J Cancer , vol.97 , pp. 315-321
    • Ruf, P.1    Gires, O.2    Jäger, M.3
  • 5
    • 0033178740 scopus 로고    scopus 로고
    • Simultaneous acti-vation of T-cells and accessory cells by a new class of intact bispecific antibody results in efficient tumour cell killing
    • Zeidler R, Reisbach G, Wollenberg B, et al. Simultaneous acti-vation of T-cells and accessory cells by a new class of intact bispecific antibody results in efficient tumour cell killing. J Immunol 1999;163:1246-52.
    • (1999) J Immunol , vol.163 , pp. 1246-1252
    • Zeidler, R.1    Reisbach, G.2    Wollenberg, B.3
  • 6
    • 0034051390 scopus 로고    scopus 로고
    • The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells
    • Zeidler R, Mysliwietz J, Csanady M, et al. The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br J Cancer 2000;83:261-6.
    • (2000) Br J Cancer , vol.83 , pp. 261-266
    • Zeidler, R.1    Mysliwietz, J.2    Csanady, M.3
  • 7
    • 0034978614 scopus 로고    scopus 로고
    • Lysis of prostate car-cinoma cells by trifunctional bispecific antibodies (αEp-CAM × αCD3)
    • Riesenberg R, Buchner A, Pohla H, et al. Lysis of prostate car-cinoma cells by trifunctional bispecific antibodies (αEp-CAM × αCD3). J Histochem Cytochem 2001;49:911-7.
    • (2001) J Histochem Cytochem , vol.49 , pp. 911-917
    • Riesenberg, R.1    Buchner, A.2    Pohla, H.3
  • 8
    • 16644394804 scopus 로고    scopus 로고
    • Opsonization with a trifunctional bispecific (αCD3 × αEpCAM) antibody results in efficient lysis in vitro and in vivo of EpCAM positive tumour cells by cytotoxic T lymphocytes
    • Schmitt M, Schmitt A, Reinhardt P, et al. Opsonization with a trifunctional bispecific (αCD3 × αEpCAM) antibody results in efficient lysis in vitro and in vivo of EpCAM positive tumour cells by cytotoxic T lymphocytes. Int J Oncol 2004;25:841-8.
    • (2004) Int J Oncol , vol.25 , pp. 841-848
    • Schmitt, M.1    Schmitt, A.2    Reinhardt, P.3
  • 9
    • 34447298354 scopus 로고    scopus 로고
    • Pattern and prognostic factors in patients with malignant ascites, a retrospective study
    • Ayantunde AA, Parsons SL. Pattern and prognostic factors in patients with malignant ascites: a retrospective study. Ann Oncol 2007;18:945-9.
    • (2007) Ann Oncol , vol.18 , pp. 945-949
    • Ayantunde, A.A.1    Parsons, S.L.2
  • 11
    • 33644765785 scopus 로고    scopus 로고
    • Malignant ascites, systematic review and guideline for treatment
    • Becker G, Galandi D, Blum HE. Malignant ascites: systematic review and guideline for treatment. Eur J Cancer 2006;42:589-97.
    • (2006) Eur J Cancer , vol.42 , pp. 589-597
    • Becker, G.1    Galandi, D.2    Blum, H.E.3
  • 12
    • 0030275353 scopus 로고    scopus 로고
    • Malignant ascites, demographics, therapeutic efficacy and predictors of survival
    • Mackey JR, Venner PM. Malignant ascites: demographics, therapeutic efficacy and predictors of survival. Can J Oncol 1996;6:474-80.
    • (1996) Can J Oncol , vol.6 , pp. 474-480
    • Mackey, J.R.1    Venner, P.M.2
  • 13
    • 0029901208 scopus 로고    scopus 로고
    • Malignant ascites, a 2-year review from a teaching hospital
    • Parsons SL, Lang MW, Steel RJC. Malignant ascites: a 2-year review from a teaching hospital. Eur J Surg Oncol 1996;22:237-9.
    • (1996) Eur J Surg Oncol , vol.22 , pp. 237-239
    • Parsons, S.L.1    Lang, M.W.2    Steel, R.J.C.3
  • 14
    • 2942577573 scopus 로고    scopus 로고
    • Malignant ascites, past, present, and future
    • Adam RA, Adam YG. Malignant ascites: past, present, and future. J Am Coll Surg 2004;198:999-1011.
    • (2004) J Am Coll Surg , vol.198 , pp. 999-1011
    • Adam, R.A.1    Adam, Y.G.2
  • 15
    • 0028834106 scopus 로고
    • Pathogenesis of ascites tumor growth, vascular permeability factor, vascular hyper-permeability, and ascites fluid accumulation
    • Nagy JA, Masse EM, Herzberg KT, et al. Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyper-permeability, and ascites fluid accumulation. Cancer Res 1995;55:360-8.
    • (1995) Cancer Res , vol.55 , pp. 360-368
    • Nagy, J.A.1    Masse, E.M.2    Herzberg, K.T.3
  • 16
    • 0028857418 scopus 로고
    • Pathogenesis of asci-tes tumor growth, angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining
    • Nagy JA, Morgan ES, Herzberg KT, et al. Pathogenesis of asci-tes tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining. Cancer Res 1995;55:376-85.
    • (1995) Cancer Res , vol.55 , pp. 376-385
    • Nagy, J.A.1    Morgan, E.S.2    Herzberg, K.T.3
  • 17
    • 34548445119 scopus 로고    scopus 로고
    • The pathogenesis of malignant ascites
    • Tamsma J. The pathogenesis of malignant ascites. Cancer Treat Res 2007;134:109-18.
    • (2007) Cancer Treat Res , vol.134 , pp. 109-118
    • Tamsma, J.1
  • 18
    • 0032764755 scopus 로고    scopus 로고
    • Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies, evaluation of five epithelial markers
    • Davidson B, Risberg B, Kristensen G, et al. Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies: evaluation of five epithelial markers. Virchows Archiv 1999;435:43-9.
    • (1999) Virchows Archiv , vol.435 , pp. 43-49
    • Davidson, B.1    Risberg, B.2    Kristensen, G.3
  • 19
    • 0026777532 scopus 로고
    • Immunocytochemical staining of serous effusions with the monoclonal antibody Ber-EP4
    • De Angelis M, Buley ID, Heryet A, et al. Immunocytochemical staining of serous effusions with the monoclonal antibody Ber-EP4. Cytopathology 1992;3:111-7.
    • (1992) Cytopathology , vol.3 , pp. 111-117
    • De Angelis, M.1    Buley, I.D.2    Heryet, A.3
  • 20
    • 0027430843 scopus 로고
    • Utility of BER-EP4 in the diagnosis of adenocarcinoma in effusions, an immunocyto-chemical study of 232 cases
    • Diaz-Arias AA, Loy TS, Bickel JT, et al. Utility of BER-EP4 in the diagnosis of adenocarcinoma in effusions: an immunocyto-chemical study of 232 cases. Diagn Cytopathol 1993;9:516-21.
    • (1993) Diagn Cytopathol , vol.9 , pp. 516-521
    • Diaz-Arias, A.A.1    Loy, T.S.2    Bickel, J.T.3
  • 21
    • 26444477424 scopus 로고    scopus 로고
    • Evaluation of a panel of molecular markers for the diagnosis of malignant serous ef-fusions
    • Passebosc-Faure K, Li G, Lambert C, et al. Evaluation of a panel of molecular markers for the diagnosis of malignant serous ef-fusions. Clin Cancer Res 2005;11:6862-7.
    • (2005) Clin Cancer Res , vol.11 , pp. 6862-6867
    • Passebosc-Faure, K.1    Li, G.2    Lambert, C.3
  • 22
    • 4344637470 scopus 로고    scopus 로고
    • Peritoneal inflammation - a microenvironment for epithelial ovarian cancer (EOC)
    • Freedman RS, Deavers M, Liu J, et al. Peritoneal inflammation - a microenvironment for epithelial ovarian cancer (EOC). J Transl Med 2004;2:23.
    • (2004) J Transl Med , vol.2 , pp. 23
    • Freedman, R.S.1    Deavers, M.2    Liu, J.3
  • 23
    • 0030037480 scopus 로고    scopus 로고
    • Normal human immune peritoneal cells, subpopulations and functional char-acteristics
    • Kubicka U, Olszewski WL, Tarnowski W, et al. Normal human immune peritoneal cells: subpopulations and functional char-acteristics. Scand J Immunol 1996;44:157-63.
    • (1996) Scand J Immunol , vol.44 , pp. 157-163
    • Kubicka, U.1    Olszewski, W.L.2    Tarnowski, W.3
  • 24
    • 34447132202 scopus 로고    scopus 로고
    • Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM × anti-CD3 antibody, a phase I/II study
    • Burges A, Wimberger P, Kümper C, et al. Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM × anti-CD3 antibody: a phase I/II study. Clin Cancer Res 2007;13:3899-905.
    • (2007) Clin Cancer Res , vol.13 , pp. 3899-3905
    • Burges, A.1    Wimberger, P.2    Kümper, C.3
  • 25
    • 77954676136 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer, results of a prospective randomized phase II/III trial
    • Heiss MM, Murawa P, Koralewski P, et al. The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized phase II/III trial. Int J Cancer. 2010;127:2209-21.
    • (2010) Int J Cancer , vol.127 , pp. 2209-2221
    • Heiss, M.M.1    Murawa, P.2    Koralewski, P.3
  • 26
    • 67549087235 scopus 로고    scopus 로고
    • Randomized, multi-center, two-dose level, open-label, phase IIa study with the in-traperitoneally infused trifunctional bispecific antibody ca-tumaxomab (anti-EpCAM × anti-CD3) to select the better dose level in platinum refractory epithelial ovarian cancer patients
    • Abstract 5556
    • Belau A, Pfisterer J, Wimberger P, et al. Randomized, multi-center, two-dose level, open-label, phase IIa study with the in-traperitoneally infused trifunctional bispecific antibody ca-tumaxomab (anti-EpCAM × anti-CD3) to select the better dose level in platinum refractory epithelial ovarian cancer patients. J Clin Oncol 2007;25(Suppl):Abstract5556.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Belau, A.1    Pfisterer, J.2    Wimberger, P.3
  • 27
    • 79952257330 scopus 로고    scopus 로고
    • Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer, an open-label, multicenter, phase I/II trial
    • Ströhlein MA, Lordick F, Rüttinger D, et al. Immunotherapy of peritoneal carcinomatosis with the antibody catumaxomab in colon, gastric, or pancreatic cancer: an open-label, multicenter, phase I/II trial. Onkologie 2011;34:101-8.
    • (2011) Onkologie , vol.34 , pp. 101-108
    • Ströhlein, M.A.1    Lordick, F.2    Rüttinger, D.3
  • 29
    • 3242679103 scopus 로고    scopus 로고
    • Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents, theory and practice
    • Parulekar WR, Eisenhauer EA. Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: theory and practice. J Natl Cancer Inst 2004;96:990-7.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 990-997
    • Parulekar, W.R.1    Eisenhauer, E.A.2
  • 30
    • 84881210724 scopus 로고    scopus 로고
    • [Internet] Removab Summary of Product Characteristics
    • [Internet] Removab Summary of Product Characteristics. http://www.emea.europa.eu/humandocs/PDFs/EPAR/removab/H-972-PI-en.pdf.
  • 32
    • 0027531868 scopus 로고
    • General aspects of cyto-kine-release syndrome, timing and incidence of symptoms
    • Jeyarajah DR, Thistlethwaite JR Jr. General aspects of cyto-kine-release syndrome: timing and incidence of symptoms. Transplant Proc 1993;25:16-20.
    • (1993) Transplant Proc , vol.25 , pp. 16-20
    • Jeyarajah, D.R.1    Thistlethwaite Jr., J.R.2
  • 33
    • 0033214207 scopus 로고    scopus 로고
    • Cytokine-release syn-drome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab IDEC-C2B8)
    • Winkler U, Jensen M, Manzke O, et al. Cytokine-release syn-drome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood 1999;94:2217-24.
    • (1999) Blood , vol.94 , pp. 2217-2224
    • Winkler, U.1    Jensen, M.2    Manzke, O.3
  • 34
    • 0038054750 scopus 로고    scopus 로고
    • Human antiglobulin response to foreign antibodies, therapeutic benefit?
    • DeNardo GL, Bradt BM, Mirick GR, et al. Human antiglobulin response to foreign antibodies: therapeutic benefit? Cancer Immunol Immunother 2003;52:309-16.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 309-316
    • DeNardo, G.L.1    Bradt, B.M.2    Mirick, G.R.3
  • 35
    • 0037056226 scopus 로고    scopus 로고
    • Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma
    • Marmé A, Strauss G, Bastert G, et al. Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma. Int J Cancer 2002;101:183-9.
    • (2002) Int J Cancer , vol.101 , pp. 183-189
    • Marmé, A.1    Strauss, G.2    Bastert, G.3
  • 36
    • 33748328199 scopus 로고    scopus 로고
    • Survival benefit associated with human anti-mouse antibody (HAMA) in pa-tients with B-cell malignancies
    • Azinovic I, DeNardo GL, Lamborn KR, et al. Survival benefit associated with human anti-mouse antibody (HAMA) in pa-tients with B-cell malignancies. Cancer Immunol Immunother 2006;55:1451-8.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1451-1458
    • Azinovic, I.1    DeNardo, G.L.2    Lamborn, K.R.3
  • 37
    • 79952255462 scopus 로고    scopus 로고
    • The trifunctional anti-body catumaxomab, correlation between immunological re-sponse and clinical outcome - new analysis of a pivotal phase II/III study
    • Abstract 2551
    • Ott MG, Lindhofer H, Linke RG, et al. The trifunctional anti-body catumaxomab: correlation between immunological re-sponse and clinical outcome - new analysis of a pivotal phase II/III study. J Clin Oncol 2010;28(Suppl):Abstract2551.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Ott, M.G.1    Lindhofer, H.2    Linke, R.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.