Engineering a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells

Protein Engineering, Design and Selection

Volumn 25, Issue 10, 2012, Pages 561-569

  Kuo, Shu Ru ^a   Wong, Lucas ^b,c   Liu, Jen Sing ^a,b  

^a Cancer Research Institute   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c Division of Hematology/Oncology   (United States)

Author keywords

bispecific; CD123; CD3; leukemia; therapeutics

Indexed keywords

BISPECIFIC; CD123; CD3; LEUKEMIA; THERAPEUTICS;

BINDING ENERGY; CYTOLOGY; DISEASES; STEM CELLS; TUMORS;

ANTIBODIES;

CD123 CD3 BISPECIFIC SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY STRUCTURE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL KILLING; CONTROLLED STUDY; LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIGENS, CD3; CELL LINE; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-3 RECEPTOR ALPHA SUBUNIT; LEUKEMIA; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES; T-LYMPHOCYTES;

EID: 84866996937     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs040     Document Type: Article

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