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Volumn 33, Issue 5, 2014, Pages 1327-1334

Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells

Author keywords

Apigenin; Flavonoid; Hydrogen peroxide; MC3T3 E1 cells; Osteoblastic cells; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ALKALINE PHOSPHATASE; ANTIOXIDANT; APIGENIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE SIALOPROTEIN; CATALASE; COLLAGEN; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE 1; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; OSTEOCALCIN; OSTEOGENIC PROTEIN 1; OSTEOPONTIN; OSTEOPROTEGERIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR OSTERIX; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE;

EID: 84899526289     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1666     Document Type: Article
Times cited : (79)

References (54)
  • 1
    • 84857966186 scopus 로고    scopus 로고
    • Reactive oxygen species: A double-edged sword in reproduction
    • Da Silva FM, Marques A and Chaveiro A: Reactive oxygen species: a double-edged sword in reproduction. Open Vet Sci J 127-133, 2010.
    • (2010) Open Vet Sci J , pp. 127-133
    • Da Silva, F.M.1    Marques, A.2    Chaveiro, A.3
  • 4
    • 33846546145 scopus 로고    scopus 로고
    • Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis
    • Ozgocmen S, Kaya H, Fadillioglu E, Aydogan R and Yilmaz Z: Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem 295: 45-52, 2007.
    • (2007) Mol Cell Biochem , vol.295 , pp. 45-52
    • Ozgocmen, S.1    Kaya, H.2    Fadillioglu, E.3    Aydogan, R.4    Yilmaz, Z.5
  • 5
    • 46349109742 scopus 로고    scopus 로고
    • 2 while making cholesterol
    • 2 while making cholesterol. Endocrinology 149: 3264-3266, 2008.
    • (2008) Endocrinology , vol.149 , pp. 3264-3266
    • Manolagas, S.C.1
  • 6
    • 32144434247 scopus 로고    scopus 로고
    • 2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines
    • 2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines. Cell Biol Toxicol 22: 39-46, 2006.
    • (2006) Cell Biol Toxicol , vol.22 , pp. 39-46
    • Lee, D.H.1    Lim, B.S.2    Lee, Y.K.3    Yang, H.C.4
  • 7
    • 0035882483 scopus 로고    scopus 로고
    • Oxidative stress modulates osteoblastic differentiation of vascular and bone cells
    • Mody N, Parhami F, Sarafian TA and Demer LL: Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31: 509-519, 2001.
    • (2001) Free Radic Biol Med , vol.31 , pp. 509-519
    • Mody, N.1    Parhami, F.2    Sarafian, T.A.3    Demer, L.L.4
  • 8
    • 0033567436 scopus 로고    scopus 로고
    • Involvement nitric oxide and biopterin in proinflammatory cytokine-induced apoptotic cell death in mouse osteoblastic cell line MC3T3-E1
    • Mogi M, Kinpara K, Kondo A and Togari A: Involvement nitric oxide and biopterin in proinflammatory cytokine-induced apoptotic cell death in mouse osteoblastic cell line MC3T3-E1. Biochem Pharmacol 58: 649-654, 1999.
    • (1999) Biochem Pharmacol , vol.58 , pp. 649-654
    • Mogi, M.1    Kinpara, K.2    Kondo, A.3    Togari, A.4
  • 9
    • 67649336391 scopus 로고    scopus 로고
    • Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells
    • Choi EM, Kim GH and Lee YS: Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells. Toxicol In Vitro 23: 862-867, 2009.
    • (2009) Toxicol in Vitro , vol.23 , pp. 862-867
    • Choi, E.M.1    Kim, G.H.2    Lee, Y.S.3
  • 10
    • 84861672298 scopus 로고    scopus 로고
    • Alpha-lipoic acid protects against hydrogen peroxide-induced oxidative stress in MC3T3-E1 osteoblast-like cells
    • Xiao Y, Cui J, Shi Y and Le G: Alpha-lipoic acid protects against hydrogen peroxide-induced oxidative stress in MC3T3-E1 osteoblast-like cells. J Funct Foods 4: 642-649, 2012.
    • (2012) J Funct Foods , vol.4 , pp. 642-649
    • Xiao, Y.1    Cui, J.2    Shi, Y.3    Le, G.4
  • 11
    • 33746632989 scopus 로고    scopus 로고
    • Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: The effects glutamate and protection by purines
    • Fatokun AA, Stone TW and Smith RA: Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: the effects glutamate and protection by purines. Bone 39: 542-551, 2006.
    • (2006) Bone , vol.39 , pp. 542-551
    • Fatokun, A.A.1    Stone, T.W.2    Smith, R.A.3
  • 12
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts end osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone
    • Weinstein RS, Jilka RL, Parfitt AM and Manolagas SC: Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts end osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274-282, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 274-282
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 13
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medical significance of the flavonoids
    • Havsteen BH: The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96: 67-202, 2002.
    • (2002) Pharmacol Ther , vol.96 , pp. 67-202
    • Havsteen, B.H.1
  • 15
    • 84860797409 scopus 로고    scopus 로고
    • Apigenin induces apoptosis via tumor necrosis factor receptor and-Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin
    • Chan LP, Chou TH, Ding HY, Chen PR, Chiang FY, Kuo PL and Liang CH: Apigenin induces apoptosis via tumor necrosis factor receptor and-Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. Biochim Biophys Acta 1820: 1081-1091, 2012.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 1081-1091
    • Chan, L.P.1    Chou, T.H.2    Ding, H.Y.3    Chen, P.R.4    Chiang, F.Y.5    Kuo, P.L.6    Liang, C.H.7
  • 16
    • 84863197873 scopus 로고    scopus 로고
    • Apigenin induces apoptosis and blocks growth medroxyprogesterone acetate-dependent BT-474 xenograft tumors
    • Mafuvadze B, Liang Y, Besch-Williford C, Zhang X and Hyder SM: Apigenin induces apoptosis and blocks growth medroxyprogesterone acetate-dependent BT-474 xenograft tumors. Horm Cancer 3: 160-171, 2012.
    • (2012) Horm Cancer , vol.3 , pp. 160-171
    • Mafuvadze, B.1    Liang, Y.2    Besch-Williford, C.3    Zhang, X.4    Hyder, S.M.5
  • 17
    • 38449107785 scopus 로고    scopus 로고
    • Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation
    • Nicholas C, Batra S, Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge DC, Grotewold E and Doseff AI: Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. J Immunol 179: 7121-7127, 2007.
    • (2007) J Immunol , vol.179 , pp. 7121-7127
    • Nicholas, C.1    Batra, S.2    Vargo, M.A.3    Voss, O.H.4    Gavrilin, M.A.5    Wewers, M.D.6    Guttridge, D.C.7    Grotewold, E.8    Doseff, A.I.9
  • 18
    • 0021259185 scopus 로고
    • Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations
    • Landolfi R, Mower RL and Steiner M: Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem Pharmacol 33: 1525-1530, 1984.
    • (1984) Biochem Pharmacol , vol.33 , pp. 1525-1530
    • Landolfi, R.1    Mower, R.L.2    Steiner, M.3
  • 20
    • 33947417220 scopus 로고    scopus 로고
    • Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-α-induced production interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells
    • Choi EM: Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-α-induced production interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells. Pharmazie 62: 216-220, 2007.
    • (2007) Pharmazie , vol.62 , pp. 216-220
    • Choi, E.M.1
  • 21
    • 0034781797 scopus 로고    scopus 로고
    • Localization of zinc after in vitro mineralization in osteoblastic cells
    • Kanno S, Anuradha CD and Hirano S: Localization of zinc after in vitro mineralization in osteoblastic cells. Biol Trace Elem Res 83: 39-47, 2001.
    • (2001) Biol Trace Elem Res , vol.83 , pp. 39-47
    • Kanno, S.1    Anuradha, C.D.2    Hirano, S.3
  • 22
    • 77952023804 scopus 로고    scopus 로고
    • Prooxidative effects of green tea polyphenol (-)-epigallocatechin-3- gallate on the HIT-T15 pancreatic beta cell line
    • Suh KS, Chon S, Oh S, Kim SW, Kim JW, Kim YS and Woo JT: Prooxidative effects of green tea polyphenol (-)-epigallocatechin-3-gallate on the HIT-T15 pancreatic beta cell line. Cell Biol Toxicol 26: 189-199, 2010.
    • (2010) Cell Biol Toxicol , vol.26 , pp. 189-199
    • Suh, K.S.1    Chon, S.2    Oh, S.3    Kim, S.W.4    Kim, J.W.5    Kim, Y.S.6    Woo, J.T.7
  • 23
    • 84873111292 scopus 로고    scopus 로고
    • The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells
    • Kim HS, Suh KS, Ko A, Sul D, Choi D, Lee SK and Jung WW: The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells. Int J Mol Med 31: 243-251, 2013.
    • (2013) Int J Mol Med , vol.31 , pp. 243-251
    • Kim, H.S.1    Suh, K.S.2    Ko, A.3    Sul, D.4    Choi, D.5    Lee, S.K.6    Jung, W.W.7
  • 24
    • 33646130142 scopus 로고    scopus 로고
    • Visualization of mitochondrial membrane potential and reactive oxygen species via double staining
    • Szilágyi G, Simon L, Koska P, Telek G and Nagy Z: Visualization of mitochondrial membrane potential and reactive oxygen species via double staining. Neurosci Lett 399: 206-209, 2006.
    • (2006) Neurosci Lett , vol.399 , pp. 206-209
    • Szilágyi, G.1    Simon, L.2    Koska, P.3    Telek, G.4    Nagy, Z.5
  • 25
    • 34248233130 scopus 로고    scopus 로고
    • Loss of mitochondrial membrane potential is inhibited by bombesin in etoposide-induced apoptosis in PC-3 prostate carcinoma cells
    • Salido M, Gonzalez JL and Vilches J: Loss of mitochondrial membrane potential is inhibited by bombesin in etoposide-induced apoptosis in PC-3 prostate carcinoma cells. Mol Cancer Ther 6: 1292-1299, 2007.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1292-1299
    • Salido, M.1    Gonzalez, J.L.2    Vilches, J.3
  • 26
    • 0020678843 scopus 로고
    • In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
    • Sudo H, Kodama HA, Amagai Y, Yamamoto S and Kasai S: In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96: 191-198, 1983.
    • (1983) J Cell Biol , vol.96 , pp. 191-198
    • Sudo, H.1    Kodama, H.A.2    Amagai, Y.3    Yamamoto, S.4    Kasai, S.5
  • 27
    • 0025845372 scopus 로고
    • Initiation and progression of mineralization of bone nodules formed in vitro: The role of alkaline phosphatase and organic phosphate
    • Bellows CG, Aubin JE and Heersche JN: Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate. Bone Miner 14: 27-40, 1991.
    • (1991) Bone Miner , vol.14 , pp. 27-40
    • Bellows, C.G.1    Aubin, J.E.2    Heersche, J.N.3
  • 28
    • 0035434018 scopus 로고    scopus 로고
    • Temporal and spatial mRNA expression of bone sialoprotein and type I collagen during rodent tooth movement
    • Domon S, Shimokawa H, Yamaguchi S and Soma K: Temporal and spatial mRNA expression of bone sialoprotein and type I collagen during rodent tooth movement. Eur J Orthod 23: 339-348, 2001.
    • (2001) Eur J Orthod , vol.23 , pp. 339-348
    • Domon, S.1    Shimokawa, H.2    Yamaguchi, S.3    Soma, K.4
  • 30
    • 0035206443 scopus 로고    scopus 로고
    • Minireview: The OPG/RANKL/RANK system
    • Khosla S: Minireview: the OPG/RANKL/RANK system. Endocrinology 142: 5050-5055, 2001.
    • (2001) Endocrinology , vol.142 , pp. 5050-5055
    • Khosla, S.1
  • 31
    • 84857963574 scopus 로고    scopus 로고
    • Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: The marrow ablation model under PTH challenge
    • Wade-Gueye NM, Boudiffa M, Vanden-Bossche A, Laroche N, Aubin JE, Vico L, Lafage-Proust MH and Malaval L: Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge. Bone 50: 1064-1073, 2012.
    • (2012) Bone , vol.50 , pp. 1064-1073
    • Wade-Gueye, N.M.1    Boudiffa, M.2    Vanden-Bossche, A.3    Laroche, N.4    Aubin, J.E.5    Vico, L.6    Lafage-Proust, M.H.7    Malaval, L.8
  • 32
    • 13944264312 scopus 로고    scopus 로고
    • Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma
    • Cao Y, Zhou Z, de Crombrugghe B, Nakashima K, Guan H, Duan X, Jia SF and Kleinerman ES: Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res 65: 1124-1128, 2005.
    • (2005) Cancer Res , vol.65 , pp. 1124-1128
    • Cao, Y.1    Zhou, Z.2    De Crombrugghe, B.3    Nakashima, K.4    Guan, H.5    Duan, X.6    Jia, S.F.7    Kleinerman, E.S.8
  • 34
    • 0026068646 scopus 로고
    • Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1
    • Takuwa Y, Ohse C, Wang EA, Wozney JM and Yamashita K: Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun 174: 96-101, 1991.
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 96-101
    • Takuwa, Y.1    Ohse, C.2    Wang, E.A.3    Wozney, J.M.4    Yamashita, K.5
  • 35
    • 0030748086 scopus 로고    scopus 로고
    • Interleukin-1β enhances and tumor necrosis factor-α inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteoblastic cells
    • Nakase T, Takaoka K, Masuhara K, Shimizu K, Yoshikawa H and Ochi T: Interleukin-1β enhances and tumor necrosis factor-α inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteoblastic cells. Bone 21: 17-21, 1997.
    • (1997) Bone , vol.21 , pp. 17-21
    • Nakase, T.1    Takaoka, K.2    Masuhara, K.3    Shimizu, K.4    Yoshikawa, H.5    Ochi, T.6
  • 36
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 37
    • 0028963084 scopus 로고
    • Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao R and Cooper GM: Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267: 2003-2006, 1995.
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2
  • 38
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke TF, Kaplan DR and Cantley LC: PI3K: downstream AKTion blocks apoptosis. Cell 88: 435-437, 1997.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 39
    • 84876699998 scopus 로고    scopus 로고
    • Deoxyactein isolated from cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity
    • Choi EM: Deoxyactein isolated from cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. J Appl Toxicol 33: 488-494, 2013.
    • (2013) J Appl Toxicol , vol.33 , pp. 488-494
    • Choi, E.M.1
  • 40
    • 84864300045 scopus 로고    scopus 로고
    • Protective effect of apocynin on antimycin A-induced cell damage in osteoblastic MC3T3-E1 cells
    • Choi EM and Lee YS: Protective effect of apocynin on antimycin A-induced cell damage in osteoblastic MC3T3-E1 cells. J Appl Toxicol 32: 714-721, 2012.
    • (2012) J Appl Toxicol , vol.32 , pp. 714-721
    • Choi, E.M.1    Lee, Y.S.2
  • 41
    • 80855123883 scopus 로고    scopus 로고
    • Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity
    • Choi EM: Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. Inflamm Res 60:1005-1012, 2011.
    • (2011) Inflamm Res , vol.60 , pp. 1005-1012
    • Choi, E.M.1
  • 42
    • 0037414760 scopus 로고    scopus 로고
    • The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2
    • Kim HJ, Kim JH, Bae SC, Choi JY, Kim HJ and Ryoo HM: The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278: 319-326, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 319-326
    • Kim, H.J.1    Kim, J.H.2    Bae, S.C.3    Choi, J.Y.4    Kim, H.J.5    Ryoo, H.M.6
  • 43
    • 0037184027 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1 / Runx2
    • Xiao G, Jiang D, Gopalakrishnan R and Franceschi RT: Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1 / Runx2. J Biol Chem 277: 36181-36187, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 36181-36187
    • Xiao, G.1    Jiang, D.2    Gopalakrishnan, R.3    Franceschi, R.T.4
  • 44
    • 84863064486 scopus 로고    scopus 로고
    • Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells
    • Lee YS and Choi EM: Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells. J Oral Pathol Med 41: 171-177, 2012.
    • (2012) J Oral Pathol Med , vol.41 , pp. 171-177
    • Lee, Y.S.1    Choi, E.M.2
  • 46
  • 47
    • 0029739428 scopus 로고    scopus 로고
    • Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-κB
    • Schmidt KN, Amstad P, Cerutti P and Baeuerle PA: Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-κB. Adv Exp Med Biol 387: 63-68, 1996.
    • (1996) Adv Exp Med Biol , vol.387 , pp. 63-68
    • Schmidt, K.N.1    Amstad, P.2    Cerutti, P.3    Baeuerle, P.A.4
  • 48
    • 84870687642 scopus 로고    scopus 로고
    • Aluminum induces osteoblast apoptosis through the oxidative stress-mediated JNK signaling pathway
    • Li X, Han Y, Guan Y, Zhang L, Bai C and Li Y: Aluminum induces osteoblast apoptosis through the oxidative stress-mediated JNK signaling pathway. Biol Trace Elem Res 150: 502-508, 2012.
    • (2012) Biol Trace Elem Res , vol.150 , pp. 502-508
    • Li, X.1    Han, Y.2    Guan, Y.3    Zhang, L.4    Bai, C.5    Li, Y.6
  • 49
    • 0036667555 scopus 로고    scopus 로고
    • Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
    • Zelko IN, Mariani TJ and Folz RJ: Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 33: 337-349, 2002.
    • (2002) Free Radic Biol Med , vol.33 , pp. 337-349
    • Zelko, I.N.1    Mariani, T.J.2    Folz, R.J.3
  • 51
    • 80051906217 scopus 로고    scopus 로고
    • Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves
    • Sun L, Zhang J, Lu X, Zhang L and Zhang Y: Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves. Food Chem Toxicol 49: 2689-2696, 2011.
    • (2011) Food Chem Toxicol , vol.49 , pp. 2689-2696
    • Sun, L.1    Zhang, J.2    Lu, X.3    Zhang, L.4    Zhang, Y.5
  • 53
    • 84883296314 scopus 로고    scopus 로고
    • Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers
    • Bao YY, Zhou SH, Fan J and Wang QY: Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. Future Oncol 9: 1353-1364, 2013.
    • (2013) Future Oncol , vol.9 , pp. 1353-1364
    • Bao, Y.Y.1    Zhou, S.H.2    Fan, J.3    Wang, Q.Y.4
  • 54
    • 84885073826 scopus 로고    scopus 로고
    • Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
    • Maggioni D, Garavello W, Rigolio R, Pignataro L, Gaini R and Nicolini G: Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis. Int J Oncol 43: 1675-1682, 2013.
    • (2013) Int J Oncol , vol.43 , pp. 1675-1682
    • Maggioni, D.1    Garavello, W.2    Rigolio, R.3    Pignataro, L.4    Gaini, R.5    Nicolini, G.6


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