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Volumn 324, Issue 1, 2014, Pages 75-83

Regulation of MDA-MB-231 cell proliferation by GSK-3β involves epigenetic modifications under high glucose conditions

Author keywords

Breast cancer; DNA methylation; GSK 3 ; Histone H3 phosphorylation; Hyperglycemia

Indexed keywords

CYCLIN D1; DNA; DNA METHYLTRANSFERASE 1; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE H3; MATRILYSIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 12; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SNAIL; VIMENTIN;

EID: 84899485973     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.03.019     Document Type: Article
Times cited : (28)

References (60)
  • 1
    • 77954036677 scopus 로고    scopus 로고
    • Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells
    • Abiola M., Favier M., Christodoulou-Vafeiadou E., Pichard A.L., Martelly I., Guillet-Deniau I. Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells. PLoS One 2009, 4:e8509.
    • (2009) PLoS One , vol.4
    • Abiola, M.1    Favier, M.2    Christodoulou-Vafeiadou, E.3    Pichard, A.L.4    Martelly, I.5    Guillet-Deniau, I.6
  • 2
    • 79953171491 scopus 로고    scopus 로고
    • DNA methylation in metabolic disorders
    • Barres R., Zierath J.R. DNA methylation in metabolic disorders. Am. J. Clin. Nutr. 2011, 93:897S-900S.
    • (2011) Am. J. Clin. Nutr. , vol.93
    • Barres, R.1    Zierath, J.R.2
  • 3
    • 61349132129 scopus 로고    scopus 로고
    • Role of Wnt signaling in the development of type 2 diabetes
    • Bordonaro M. Role of Wnt signaling in the development of type 2 diabetes. Vitam. Horm. 2009, 80:563-581.
    • (2009) Vitam. Horm. , vol.80 , pp. 563-581
    • Bordonaro, M.1
  • 5
    • 33746239119 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells
    • Cao Q., Lu X., Feng Y.J. Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells. Cell Res. 2006, 16:671-677.
    • (2006) Cell Res. , vol.16 , pp. 671-677
    • Cao, Q.1    Lu, X.2    Feng, Y.J.3
  • 6
    • 44849134456 scopus 로고    scopus 로고
    • Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner
    • Caspi M., Zilberberg A., Eldar-Finkelman H., Rosin-Arbesfeld R. Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner. Oncogene 2008, 27:3546-3555.
    • (2008) Oncogene , vol.27 , pp. 3546-3555
    • Caspi, M.1    Zilberberg, A.2    Eldar-Finkelman, H.3    Rosin-Arbesfeld, R.4
  • 7
    • 84872498754 scopus 로고    scopus 로고
    • DNA methylation is associated with transcription of Snail and Slug genes
    • Chen Y., Wang K., Qian C.N., Leach R. DNA methylation is associated with transcription of Snail and Slug genes. Biochem. Biophys. Res. Commun. 2013, 430:1083-1090.
    • (2013) Biochem. Biophys. Res. Commun. , vol.430 , pp. 1083-1090
    • Chen, Y.1    Wang, K.2    Qian, C.N.3    Leach, R.4
  • 8
    • 21344450516 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation
    • Choi H.S., Choi B.Y., Cho Y.Y., Mizuno H., Kang B.S., Bode A.M., Dong Z. Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation. Cancer Res. 2005, 65:5818-5827.
    • (2005) Cancer Res. , vol.65 , pp. 5818-5827
    • Choi, H.S.1    Choi, B.Y.2    Cho, Y.Y.3    Mizuno, H.4    Kang, B.S.5    Bode, A.M.6    Dong, Z.7
  • 9
    • 79960144827 scopus 로고    scopus 로고
    • Epigenetics: a new bridge between nutrition and health
    • Choi S.W., Friso S. Epigenetics: a new bridge between nutrition and health. Adv. Nutr. 2010, 1:8-16.
    • (2010) Adv. Nutr. , vol.1 , pp. 8-16
    • Choi, S.W.1    Friso, S.2
  • 10
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987, 162:156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 11
    • 71849084548 scopus 로고    scopus 로고
    • GSK-3beta and control of glucose metabolism and insulin action in human skeletal muscle
    • Ciaraldi T.P., Carter L., Mudaliar S., Henry R.R. GSK-3beta and control of glucose metabolism and insulin action in human skeletal muscle. Mol. Cell Endocrinol. 2010, 315:153-158.
    • (2010) Mol. Cell Endocrinol. , vol.315 , pp. 153-158
    • Ciaraldi, T.P.1    Carter, L.2    Mudaliar, S.3    Henry, R.R.4
  • 12
    • 33846901599 scopus 로고    scopus 로고
    • Snail in the frame of malignant tumor recurrence
    • De Craene B., Berx G. Snail in the frame of malignant tumor recurrence. Breast Cancer Res. 2006, 8:105.
    • (2006) Breast Cancer Res. , vol.8 , pp. 105
    • De Craene, B.1    Berx, G.2
  • 13
    • 33744969113 scopus 로고    scopus 로고
    • The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation
    • Dong Z., Bode A.M. The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation. Mol. Carcinog. 2006, 45:416-421.
    • (2006) Mol. Carcinog. , vol.45 , pp. 416-421
    • Dong, Z.1    Bode, A.M.2
  • 14
    • 0019026208 scopus 로고
    • Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase
    • Embi N., Rylatt D.B., Cohen P. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur. J. Biochem. 1980, 107:519-527.
    • (1980) Eur. J. Biochem. , vol.107 , pp. 519-527
    • Embi, N.1    Rylatt, D.B.2    Cohen, P.3
  • 15
    • 20344399386 scopus 로고    scopus 로고
    • Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells
    • Erdal E., Ozturk N., Cagatay T., Eksioglu-Demiralp E., Ozturk M. Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. Int. J. Cancer 2005, 115:903-910.
    • (2005) Int. J. Cancer , vol.115 , pp. 903-910
    • Erdal, E.1    Ozturk, N.2    Cagatay, T.3    Eksioglu-Demiralp, E.4    Ozturk, M.5
  • 16
    • 1542319832 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
    • Etoh T., Kanai Y., Ushijima S., Nakagawa T., Nakanishi Y., Sasako M., Kitano S., Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol. 2004, 164:689-699.
    • (2004) Am. J. Pathol. , vol.164 , pp. 689-699
    • Etoh, T.1    Kanai, Y.2    Ushijima, S.3    Nakagawa, T.4    Nakanishi, Y.5    Sasako, M.6    Kitano, S.7    Hirohashi, S.8
  • 17
    • 58049198236 scopus 로고    scopus 로고
    • Talk is cheap-cross-talk in establishment, maintenance, and readout of chromatin modifications
    • Fischle W. Talk is cheap-cross-talk in establishment, maintenance, and readout of chromatin modifications. Genes Dev. 2008, 22:3375-3382.
    • (2008) Genes Dev. , vol.22 , pp. 3375-3382
    • Fischle, W.1
  • 18
    • 84882417694 scopus 로고    scopus 로고
    • The 'golden age' of DNA methylation in neurodegenerative diseases
    • Fuso A. The 'golden age' of DNA methylation in neurodegenerative diseases. Clin. Chem. Lab. Med. 2012, 1-12.
    • (2012) Clin. Chem. Lab. Med. , pp. 1-12
    • Fuso, A.1
  • 20
    • 84879963666 scopus 로고    scopus 로고
    • High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells
    • Gupta C., Tikoo K. High glucose and insulin differentially modulates proliferation in MCF-7 and MDA-MB-231 cells. J. Mol. Endocrinol. 2013, 51:119-129.
    • (2013) J. Mol. Endocrinol. , vol.51 , pp. 119-129
    • Gupta, C.1    Tikoo, K.2
  • 21
    • 0035962664 scopus 로고    scopus 로고
    • Histone H3 phosphorylation and cell division
    • Hans F., Dimitrov S. Histone H3 phosphorylation and cell division. Oncogene 2001, 20:3021-3027.
    • (2001) Oncogene , vol.20 , pp. 3021-3027
    • Hans, F.1    Dimitrov, S.2
  • 22
    • 78751644241 scopus 로고    scopus 로고
    • Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes
    • Henriksen E.J. Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes. Curr. Diabetes Rev. 2010, 6:285-293.
    • (2010) Curr. Diabetes Rev. , vol.6 , pp. 285-293
    • Henriksen, E.J.1
  • 23
    • 0033047813 scopus 로고    scopus 로고
    • Methylation profiling of CpG islands in human breast cancer cells
    • Huang T.H., Perry M.R., Laux D.E. Methylation profiling of CpG islands in human breast cancer cells. Hum. Mol. Genet. 1999, 8:459-470.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 459-470
    • Huang, T.H.1    Perry, M.R.2    Laux, D.E.3
  • 24
    • 84867191630 scopus 로고    scopus 로고
    • The involvement of the Wnt signaling pathway and TCF7L2 in diabetes mellitus: the current understanding, dispute, and perspective
    • Ip W., Chiang Y.T., Jin T. The involvement of the Wnt signaling pathway and TCF7L2 in diabetes mellitus: the current understanding, dispute, and perspective. Cell. Biosci. 2012, 2:28.
    • (2012) Cell. Biosci. , vol.2 , pp. 28
    • Ip, W.1    Chiang, Y.T.2    Jin, T.3
  • 27
    • 55049106032 scopus 로고    scopus 로고
    • The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
    • Jin T., Liu L. The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol. Endocrinol. 2008, 22:2383-2392.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 2383-2392
    • Jin, T.1    Liu, L.2
  • 28
    • 0029898837 scopus 로고    scopus 로고
    • DNA methylation errors and cancer
    • Jones P.A. DNA methylation errors and cancer. Cancer Res. 1996, 56:2463-2467.
    • (1996) Cancer Res. , vol.56 , pp. 2463-2467
    • Jones, P.A.1
  • 30
    • 34250703744 scopus 로고    scopus 로고
    • Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo
    • Kokkinos M.I., Wafai R., Wong M.K., Newgreen D.F., Thompson E.W., Waltham M. Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo. Cells Tissues Organs 2007, 185:191-203.
    • (2007) Cells Tissues Organs , vol.185 , pp. 191-203
    • Kokkinos, M.I.1    Wafai, R.2    Wong, M.K.3    Newgreen, D.F.4    Thompson, E.W.5    Waltham, M.6
  • 31
    • 70449701913 scopus 로고    scopus 로고
    • Epigenetic cross-talk between DNA methylation and histone modifications in human cancers
    • Kondo Y. Epigenetic cross-talk between DNA methylation and histone modifications in human cancers. Yonsei Med. J. 2009, 50:455-463.
    • (2009) Yonsei Med. J. , vol.50 , pp. 455-463
    • Kondo, Y.1
  • 32
    • 23344447873 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance
    • Kulikov R., Boehme K.A., Blattner C. Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Mol. Cell Biol. 2005, 25:7170-7180.
    • (2005) Mol. Cell Biol. , vol.25 , pp. 7170-7180
    • Kulikov, R.1    Boehme, K.A.2    Blattner, C.3
  • 33
    • 57349143530 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy
    • Luo J. Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett. 2009, 273:194-200.
    • (2009) Cancer Lett. , vol.273 , pp. 194-200
    • Luo, J.1
  • 34
    • 77953484480 scopus 로고    scopus 로고
    • Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
    • Mendez M.G., Kojima S., Goldman R.D. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J. 2010, 24:1838-1851.
    • (2010) FASEB J. , vol.24 , pp. 1838-1851
    • Mendez, M.G.1    Kojima, S.2    Goldman, R.D.3
  • 35
    • 33846809037 scopus 로고    scopus 로고
    • DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains
    • Monier K., Mouradian S., Sullivan K.F. DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains. J. Cell Sci. 2007, 120:101-114.
    • (2007) J. Cell Sci. , vol.120 , pp. 101-114
    • Monier, K.1    Mouradian, S.2    Sullivan, K.F.3
  • 36
    • 0036302960 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle
    • Nikoulina S.E., Ciaraldi T.P., Mudaliar S., Carter L., Johnson K., Henry R.R. Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle. Diabetes 2002, 51:2190-2198.
    • (2002) Diabetes , vol.51 , pp. 2190-2198
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Carter, L.4    Johnson, K.5    Henry, R.R.6
  • 37
    • 16844374033 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells
    • Ougolkov A.V., Fernandez-Zapico M.E., Savoy D.N., Urrutia R.A., Billadeau D.D. Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res. 2005, 65:2076-2081.
    • (2005) Cancer Res. , vol.65 , pp. 2076-2081
    • Ougolkov, A.V.1    Fernandez-Zapico, M.E.2    Savoy, D.N.3    Urrutia, R.A.4    Billadeau, D.D.5
  • 38
    • 77952552967 scopus 로고    scopus 로고
    • Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans
    • Pasco M.Y., Catoire H., Parker J.A., Brais B., Rouleau G.A., Neri C. Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans. Neurobiol. Dis. 2010, 38:425-433.
    • (2010) Neurobiol. Dis. , vol.38 , pp. 425-433
    • Pasco, M.Y.1    Catoire, H.2    Parker, J.A.3    Brais, B.4    Rouleau, G.A.5    Neri, C.6
  • 39
    • 33745627069 scopus 로고    scopus 로고
    • DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
    • Peng D.F., Kanai Y., Sawada M., Ushijima S., Hiraoka N., Kitazawa S., Hirohashi S. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis 2006, 27:1160-1168.
    • (2006) Carcinogenesis , vol.27 , pp. 1160-1168
    • Peng, D.F.1    Kanai, Y.2    Sawada, M.3    Ushijima, S.4    Hiraoka, N.5    Kitazawa, S.6    Hirohashi, S.7
  • 40
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson K.D. DNA methylation and human disease. Nat. Rev. Genet. 2005, 6:597-610.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 41
    • 79954631857 scopus 로고    scopus 로고
    • Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells
    • Schisano B., Tripathi G., McGee K., McTernan P.G., Ceriello A. Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. Diabetologia 2011, 54:1219-1226.
    • (2011) Diabetologia , vol.54 , pp. 1219-1226
    • Schisano, B.1    Tripathi, G.2    McGee, K.3    McTernan, P.G.4    Ceriello, A.5
  • 43
    • 84878441665 scopus 로고    scopus 로고
    • Genomic insights into cancer-associated aberrant CpG island hypermethylation
    • Sproul D., Meehan R.R. Genomic insights into cancer-associated aberrant CpG island hypermethylation. Brief. Funct. Genomics 2013.
    • (2013) Brief. Funct. Genomics
    • Sproul, D.1    Meehan, R.R.2
  • 45
    • 0035320566 scopus 로고    scopus 로고
    • The role of DNA methyltransferase 1 in growth control
    • Szyf M. The role of DNA methyltransferase 1 in growth control. Front. Biosci. 2001, 6:D599-D609.
    • (2001) Front. Biosci. , vol.6
    • Szyf, M.1
  • 47
    • 33847091642 scopus 로고    scopus 로고
    • Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    • Tikoo K., Tripathi D.N., Kabra D.G., Sharma V., Gaikwad A.B. Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53. FEBS Lett. 2007, 581:1071-1078.
    • (2007) FEBS Lett. , vol.581 , pp. 1071-1078
    • Tikoo, K.1    Tripathi, D.N.2    Kabra, D.G.3    Sharma, V.4    Gaikwad, A.B.5
  • 49
    • 40949148556 scopus 로고    scopus 로고
    • GSK-3-specific inhibitor-supplemented hESC medium prevents the epithelial-mesenchymal transition process and the up-regulation of matrix metalloproteinases in hESCs cultured in feeder-free conditions
    • Ullmann U., Gilles C., De Rycke M., Van de Velde H., Sermon K., Liebaers I. GSK-3-specific inhibitor-supplemented hESC medium prevents the epithelial-mesenchymal transition process and the up-regulation of matrix metalloproteinases in hESCs cultured in feeder-free conditions. Mol. Hum. Reprod. 2008, 14:169-179.
    • (2008) Mol. Hum. Reprod. , vol.14 , pp. 169-179
    • Ullmann, U.1    Gilles, C.2    De Rycke, M.3    Van de Velde, H.4    Sermon, K.5    Liebaers, I.6
  • 51
    • 85029450496 scopus 로고    scopus 로고
    • Breast Cancer Statistics, Available at: (accessed 25 April 2013).
    • G. Wishart, Breast Cancer Statistics, 2012, Available at: (accessed 25 April 2013). http://www.gordonwishart.com/news/breast-cancer-statistics-2012/.
    • (2012)
    • Wishart, G.1
  • 54
    • 77649129121 scopus 로고    scopus 로고
    • GSK3: a multifaceted kinase in Wnt signaling
    • Wu D., Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem. Sci. 2010, 35:161-168.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 161-168
    • Wu, D.1    Pan, W.2
  • 58
    • 80054070144 scopus 로고    scopus 로고
    • Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells
    • Zhang Y., Chen F.Q., Sun Y.H., Zhou S.Y., Li T.Y., Chen R. Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells. J. Exp. Clin. Cancer Res. 2011, 30:98.
    • (2011) J. Exp. Clin. Cancer Res. , vol.30 , pp. 98
    • Zhang, Y.1    Chen, F.Q.2    Sun, Y.H.3    Zhou, S.Y.4    Li, T.Y.5    Chen, R.6
  • 59
    • 0035694469 scopus 로고    scopus 로고
    • Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases
    • Barlev N.A., Liu L., Chehab N.H., Mansfield K., Harris K.G., Halazonetis T.D., Berger S.L. Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases. Mol. Cell 2001, 8:1243-1254.
    • (2001) Mol. Cell , vol.8 , pp. 1243-1254
    • Barlev, N.A.1    Liu, L.2    Chehab, N.H.3    Mansfield, K.4    Harris, K.G.5    Halazonetis, T.D.6    Berger, S.L.7
  • 60
    • 56749169365 scopus 로고    scopus 로고
    • P53 induces distinct epigenetic states at its direct target promoters
    • Vrba L., Junk D.J., Novak P., Futscher B.W. p53 induces distinct epigenetic states at its direct target promoters. BMC Genomics 2008, 9:486.
    • (2008) BMC Genomics , vol.9 , pp. 486
    • Vrba, L.1    Junk, D.J.2    Novak, P.3    Futscher, B.W.4


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