Vimentin and epithelial-mesenchymal transition in human breast cancer - Observations in vitro and in vivo

Cells Tissues Organs

Volumn 185, Issue 1-3, 2007, Pages 191-203

  Kokkinos, Maria I ^a,d   Wafai, Razan ^a   Wong, Meng Kang ^a   Newgreen, Donald F ^b   Thompson, Erik W ^a,c   Waltham, Mark ^a,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c Victorian Breast Cancer Research Consortium   (Australia)

^d ST VINCENT S HOSPITAL   (Australia)

Author keywords

Breast cancer; Epithelial mesenchymal transition; PMC42; Prognosis; Vimentin; Xenograft

Indexed keywords

KERATIN; UVOMORULIN; VIMENTIN;

BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL JUNCTION; CELL TRANSFORMATION; CONFERENCE PAPER; DISEASE MARKER; EMBRYO DEVELOPMENT; EPITHELIUM CELL; FOCAL ADHESION; GENE OVEREXPRESSION; HEMIDESMOSOME; HUMAN; INTERMEDIATE FILAMENT; MESENCHYME CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; EPITHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MESODERM; MICE; MICE, SCID; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS; VIMENTIN;

EID: 34250703744     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000101320     Document Type: Conference Paper

References (67)

1. Ackland, M.L., D.F. Newgreen, M. Fridman, M.C. Waltham, A. Arvanitis, J. Minichiello, J.T. Price, E.W. Thompson (2003) Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells. Lab Invest 83 : 435-448.
2. Addis, B.J., B. Corrin (1985) Pulmonary blastoma, carcinosarcoma and spindle-cell carcinoma: an immunohistochemical study of keratin intermediate filaments. J Pathol 147 : 291-301.
3. Badwaik, N.K., J.J. Rasweiler, 4th, F. Muradali (1998) Co-expression of cytokeratins and vimentin by highly invasive trophoblast in the white-winged vampire bat, Diaemus youngi, and the black mastiff bat, Molossus ater, with observations on intermediate filament proteins in the decidua and intraplacental trophoblast. J Reprod Fertil 114 : 307-325.
4. Bakin, A.V., A.K. Tomlinson, N.A. Bhowmick, H.L. Moses, C.L. Arteaga (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275 : 36803-36810.
5. Capetanaki, Y., S. Smith, J.P. Heath (1989) Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation. J Cell Biol 109 : 1653-1664.
6. Carter, V., B.K. Shenton, B. Jaques, D. Turner, D. Talbot, A. Gupta, C.E. Chapman, C.J. Matthews, G. Cavanagh (2005) Vimentin antibodies: a non-HLA antibody as a potential risk factor in renal transplantation. Transplant Proc 37 : 654-657.
7. Condeelis, J., J.E. Segall (2003) Intravital imaging of cell movement in tumours. Nat Rev Cancer 3 : 921-930.
8. Devkota, B., M. Sasaki, M. Matsui, C. Amaya Montoya, Y.I. Miyake (2006) Alterations in the immunohistochemical localization patterns of alpha-smooth muscle actin (SMA) and vimentin in the postnatally developing bovine cryptorchid testis. J Reprod Dev 52: 329-334.
9. Duband, J.L., F. Monier, M. Delannet, D. Newgreen (1995) Epithelium-mesenchyme transition during neural crest development. Acta Anat (Basel) 154: 63-78.
10. Dumitrescu, R.G., I. Cotarla (2005) Understanding breast cancer risk - where do we stand in 2005? J Cell Mol Med 9 : 208-221.
11. Eckes, B., E. Colucci-Guyon, H. Smola, S. Nodder, C. Babinet, T. Krieg, P. Martin (2000) Impaired wound healing in embryonic and adult mice lacking vimentin. J Cell Sci 113(Pt 13) : 2455-2462.
12. Ehmann, U.K., J.T. DeVries, M.S. Chen, A.A. Adamos, R.C. Guzman, M.B. Omary (2003) An in vitro model of epithelial cell growth stimulation in the rodent mammary gland. Cell Prolif 36 : 177-190.
13. Eriksson, J.E., T. He, A.V. Trejo-Skalli, A.S. Harmala-Brasken, J. Hellman, Y.H. Chou, R.D. Goldman (2004) Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments. J Cell Sci 117 : 919-932.
14. Evans, R.M. (1998) Vimentin: the conundrum of the intermediate filament gene family. Bioessays 20 : 79-86.
15. Fitchett, J.E., E.D. Hay (1989) Medial edge epithelium transforms to mesenchyme after embryonic palatal shelves fuse. Dev Biol 131 : 455-474.
16. Franke, W.W., C. Grund, C. Kuhn, B.W. Jackson, K. Illmensee (1982) Formation of cytoskeletal elements during mouse embryogenesis. III. Primary mesenchymal cells and the first appearance of vimentin filaments. Differentiation 23 : 43-59.
17. Galou, M., E. Colucci-Guyon, D. Ensergueix, J.L. Ridet, M. Gimenez y Ribotta, A. Privat, C. Babinet, P. Dupouey (1996) Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout mice. J Cell Biol 133 : 853-863.
18. Galou, M., J. Gao, J. Humbert, M. Mericskay, Z. Li, D. Paulin, P. Vicart (1997) The importance of intermediate filaments in the adaptation of tissues to mechanical stress: evidence from gene knockout studies. Biol Cell 89 : 85-97.
19. Gavrilovic, J., G. Moens, J.P. Thiery, J. Jouanneau (1990) Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line. Cell Regul 1 : 1003-1014.
20. Gilles, C., E.W. Thompson (1996) The epithelial to mesenchymal transition and metastatic progression in carcinoma. Breast J 2 : 83-96.
21. Gilles, C., M. Polette, J. Zahm, J. Tournier, L. Volders, J. Foidart, P. Birembaut (1999) Vimentin contributes to human mammary epithelial cell migration. J Cell Sci 112 : 4615-4625.
22. Gilles, C., M. Polette, M. Mestdagt, B. Nawrocki-Raby, P. Ruggeri, P. Birembaut, J.M. Foidart (2003) Transactivation of vimentin by betacatenin in human breast cancer cells. Cancer Res 63 : 2658-2664.
23. Gilles, C., D. Newgreen, H. Sato, E.W. Thompson (2004) Matrix metalloproteases and epithelial-to mesenchymal transition: implications for carcinoma metastasis; in Savagner, P. (ed): Rise and Fall of Epithelial Phenotype. Georgetown, Landes Bioscience Publishers, pp 297-315. www.eurekah.com.
24. Giunciuglio, D., M. Culty, G. Fassina, L. Masiello, A. Melchiori, G. Paglialunga, G. Arand, F. Ciardiello, F. Basolo, E.W. Thompson, et al. (1995) Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes. Int J Cancer 63 : 815-822.
25. Grunert, S., M. Jechlinger, H. Beug (2003) Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4 : 657-665.
26. Haigh, T., C. Chen, C.J. Jones, J.D. Aplin (1999) Studies of mesenchymal cells from 1st trimester human placenta: expression of cytokeratin outside the trophoblast lineage. Placenta 20 : 615-625.
27. Heatley, M.K., P. Ewings, W. Odling Smee, P. Maxwell, P.G. Toner (2002) Vimentin expression does not assist in predicting survival in ductal carcinoma of the breast. Pathology 34 : 230-232.
28. Helfand, B.T., L. Chang, R.D. Goldman (2004) Intermediate filaments are dynamic and motile elements of cellular architecture. J Cell Sci 117 : 133-141.
29. Hendrix, M.J., E.A. Seftor, R.E. Seftor, K.T. Trevor (1997) Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior. Am J Pathol 150 : 483-495.
30. Holwell, T.A., S.C. Schweitzer, R.M. Evans (1997) Tetracycline regulated expression of vimentin in fibroblasts derived from vimentin null mice. J Cell Sci 110(Pt 16) : 1947-1956.
31. Huber, M.A., N. Azoitei, B. Baumann, S. Grunert, A. Sommer, H. Pehamberger, N. Kraut, H. Beug, T. Wirth (2004) NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114 : 569-581.
32. Kaufmann, O., T. Deidesheimer, M. Muehlenberg, P. Deicke, M. Dietel (1996) Immunohistochemical differentiation of metastatic breast carcinomas from metastatic adenocarcinomas of other common primary sites. Histopathology 29 : 233-240.
33. Korsching, E., J. Packeisen, C. Liedtke, D. Hungermann, P. Wulfing, P.J. van Diest, B. Brandt, W. Boecker, H. Buerger (2005) The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? J Pathol 206 : 451-457.
34. Lafleur, M.A., A.F. Drew, E.L. de Sousa, T. Blick, M. Bills, E.C. Walker, E.D. Williams, M. Waltham, E.W. Thompson (2005) Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: A major induction of stromal MMP-13. Int J Cancer 114 : 544-554.
35. Larsson, A., U. Wilhelmsson, M. Pekna, M. Pekny (2004) Increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of old GFAP(-/-)Vim(-/-) mice. Neurochem Res 29 : 2069-2073.
36. Lee, J.M., S. Dedhar, R. Kalluri, E.W. Thompson (2006) The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172 : 973-981.
37. Lochter, A., Z. Werb, M.J. Bissell (1999) Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant. Matrix Biol 18 : 455-467.
38. Michalczyk, A., R.W. Brown, J.P. Collins, M.L. Ackland (2001) Lactation affects expression of intermediate filaments in human breast epithelium. Differentiation 67 : 41-49.
39. Miettinen, P.J., R. Ebner, A.R. Lopez, R. Derynck (1994) TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 127 : 2021-2036.
40. Moisan, E., D. Girard (2006) Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis. J Leukoc Biol 79 : 489-498.
41. Nagaraja, G.M., M. Othman, B.P. Fox, R. Alsaber, C.M. Pellegrino, Y. Zeng, R. Khanna, P. Tamburini, A. Swaroop, R.P. Kandpal (2006) Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics. Oncogene 25: 2328-2338.
42. Nieman, M.T., R.S. Prudoff, K.R. Johnson, M.J. Wheelock (1999) N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 147 : 631-644.
43. Page, M. (1989) Changing patterns of cytokeratins and vimentin in the early chick embryo. Development 105 : 97-107.
44. Perou, C.M., T. Sorlie, M.B. Eisen, M. van de Rijn, S.S. Jeffrey, C.A. Rees, J.R. Pollack, D.T. Ross, H. Johnsen, L.A. Akslen, O. Fluge, A. Pergamenschikov, C. Williams, S.X. Zhu, P.E. Lonning, A.L. Borresen-Dale, P.O. Brown, D. Botstein (2000) Molecular portraits of human breast tumours. Nature 406 : 747-752.
45. Petersen, O.W., H. Lind Nielsen, T. Gudjonsson, R. Villadsen, L. Ronnov-Jessen, M.J. Bissell (2001) The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res 3 : 213-217.
46. Rae, J.M., M.D. Johnson, J.O. Scheys, K.E. Cordero, J.M. Larios, M.E. Lippman (2005) GREB 1 is a critical regulator of hormone dependent breast cancer growth. Breast Cancer Res Treat 92 : 141-149.
47. Rakha, E.A., D.A. El-Rehim, C. Paish, A.R. Green, A.H. Lee, J.F. Robertson, R.W. Blamey, D. Macmillan, I.O. Ellis (2006) Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance. Eur J Cancer 42: 3149-3156.
48. Rastaldi, M.P., F. Ferrario, L. Giardino, G. Dell'Antonio, C. Grillo, P. Grillo, F. Strutz, G.A. Muller, G. Colasanti, G. D'Amico (2002) Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 62 : 137-146.
49. Reis-Filho, J.S. (2005) Re: Korsching et al. The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? J Pathol 2005; 206: 451-457.
50. J Pathol 207 : 367-369; author reply 370-361.
51. Runembert, I., S. Couette, P. Federici, E. Colucci-Guyon, C. Babinet, P. Briand, G. Friedlander, F. Terzi (2004) Recovery of Na-glucose cotransport activity after renal ischemia is impaired in mice lacking vimentin. Am J Physiol Renal Physiol 287 : F960-F968.
52. Sarria, A.J., S.R. Panini, R.M. Evans (1992) A functional role for vimentin intermediate filaments in the metabolism of lipoproteinderived cholesterol in human SW-13 cells. J Biol Chem 267 : 19455-19463.
53. Schietke, R., D. Brohl, T. Wedig, N. Mucke, H. Herrmann, T.M. Magin (2006) Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis. Eur J Cell Biol 85 : 1-10.
54. Seshadri, R., W.A. Raymond, A.S. Leong, D.J. Horsfall, K. McCaul (1996) Vimentin expression is not associated with poor prognosis in breast cancer. Int J Cancer 67 : 353-356.
55. Sternlicht, M.D., A. Lochter, C.J. Sympson, B. Huey, J.P. Rougier, J.W. Gray, D. Pinkel, M.J. Bissell, Z. Werb (1999) The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98 : 137-146.
56. Strizzi, L., C. Bianco, N. Normanno, M. Seno, C. Wechselberger, B. Wallace-Jones, N.I. Khan, M. Hirota, Y. Sun, M. Sanicola, D.S. Salomon (2004) Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice. J Cell Physiol 201 : 266-276.
57. Thiery, J.P., J.P. Sleeman (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7 : 131-142.
58. Thompson, E.W., S. Paik, N. Brunner, C.L. Sommers, G. Zugmaier, R. Clarke, T.B. Shima, J. Torri, S. Donahue, M.E. Lippman, et al. (1992) Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol 150 : 534-544.
59. Thompson, E.W., J. Torri, M. Sabol, C.L. Sommers, S. Byers, E.M. Valverius, G.R. Martin, M.E. Lippman, M.R. Stampfer, R.B. Dickson (1994) Oncogene-induced basement membrane invasiveness in human mammary epithelial cells. Clin Exp Metastasis 12 : 181-194.
60. Thompson, E.W., D.F. Newgreen, D. Tarin (2005) Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 65 : 5991-5995; discussion 5995.
61. Vincent-Salomon, A., J.P. Thiery (2003) Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res 5 : 101-106.
62. Walter, I., S. Schonkypl (2006) Extracellular matrix components and matrix degrading enzymes in the feline placenta during gestation. Placenta 27 : 291-306.
63. Ward, K.R., K.X. Zhang, A.M. Somasiri, C.D. Roskelley, J.W. Schrader (2004) Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis. Oncogene 23 : 1187-1196.
64. Willipinski-Stapelfeldt, B., S. Riethdorf, V. Assmann, U. Woelfle, T. Rau, G. Sauter, J. Heukeshoven, K. Pantel (2005) Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clin Cancer Res 11 : 8006-8014.
65. Willis, B.C., J.M. Liebler, K. Luby-Phelps, A.G. Nicholson, E.D. Crandall, R.M. du Bois, Z. Borok (2005) Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 166 : 1321-1332.
66. Yang, J., Y. Liu (2001) Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159 : 1465-1475.
67. Zajchowski, D.A., M.F. Bartholdi, Y. Gong, L. Webster, H.L. Liu, A. Munishkin, C. Beauheim, S. Harvey, S.P. Ethier, P.H. Johnson (2001) Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Res 61 : 5168-5178.