Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors

Biotechnology and Applied Biochemistry

Volumn 61, Issue 2, 2014, Pages 184-192

  Madhavarao, Chikkathur N ^a   Agarabi, Cyrus D ^a   Wong, Lily ^a   Müller Loennies, Sven ^b   Braulke, Thomas ^c   Khan, Mansoor ^a   Anderson, Howard ^a   Johnson, Gibbes R ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b RESEARCH CENTER BORSTEL   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

bioreactors; capillary electrophoresis; enzyme replacement therapies; enzymes; lysosomal storage diseases; mannose 6 phosphate

Indexed keywords

BIOCONVERSION; BIOREACTORS; CAPILLARY ELECTROPHORESIS; DISEASE CONTROL; KINETIC PARAMETERS; PHOSPHORYLATION; VOLATILE FATTY ACIDS;

BIOTECHNOLOGY PRODUCTS; CATALYTIC PROPERTIES; ENZYME REPLACEMENT THERAPY; MANNOSE 6 PHOSPHATES; MANUFACTURING PROCESS CHANGES; PRODUCTION CULTURE; SINGLE-CHAIN ANTIBODIES; STEADY-STATE ANALYSIS;

ENZYMES;

BETA GLUCURONIDASE; BUTYRIC ACID; MANNOSE 6 PHOSPHATE; RECOMBINANT ENZYME; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; BUTYRIC ACID DERIVATIVE; MANNOSE PHOSPHATE; MANNOSE-6-PHOSPHATE; POLYSACCHARIDE;

ARTICLE; BIOREACTOR; CAPILLARY ELECTROPHORESIS; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REACTOR OPERATION; STEADY STATE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CHO CELL LINE; CRICETULUS; ENZYMOLOGY; HAMSTER; HUMAN; LYSOSOMAL STORAGE DISEASES; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; BIOREACTORS; BUTYRATES; CHO CELLS; CRICETINAE; CRICETULUS; GLUCURONIDASE; HUMANS; LYSOSOMAL STORAGE DISEASES; MANNOSEPHOSPHATES; PHOSPHORYLATION; POLYSACCHARIDES;

EID: 84899409679     PISSN: 08854513     EISSN: 14708744     Source Type: Journal    
DOI: 10.1002/bab.1151     Document Type: Article

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