Identification of N -glycans displaying mannose-6-phosphate and their site of attachment on therapeutic enzymes for lysosomal storage disorder treatment

Analytical Chemistry

Volumn 83, Issue 13, 2011, Pages 5344-5352

  Bones, Jonathan ^a,d   Mittermayr, Stefan ^a   McLoughlin, Niaobh ^a   Hilliard, Mark ^a   Wynne, Kieran ^a   Johnson, Gibbes R ^b   Grubb, Jeffrey H ^c   Sly, William S ^c   Rudd, Pauline M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY PURIFICATION; ALKALINE PHOSPHATASE; ANALYTICAL CHALLENGE; ANALYTICAL STRATEGY; ANION EXCHANGE; CHINESE HAMSTER OVARY CELLS; EXOGLYCOSIDASE; GLUCURONIDASE; GLYCANS; LASER INDUCED FLUORESCENCE DETECTION; LYSOSOMAL STORAGE DISORDER; MIXED OXIDE; MULTI-DIMENSIONAL APPROACH; SELECTIVE ENRICHMENT; SEMI-QUANTITATIVE; SIMPLE APPROACH; SITE-SPECIFIC; STRUCTURAL CHARACTERIZATION; THERAPEUTIC ENZYME; TIO;

AMINO ACIDS; BEARINGS (STRUCTURAL); CAPILLARY ELECTROPHORESIS; CHARACTERIZATION; OLIGOSACCHARIDES; PHOSPHATASES; TITANIUM DIOXIDE;

CATALYSTS;

MANNOSE 6 PHOSPHATE; MANNOSE PHOSPHATE; MANNOSE-6-PHOSPHATE; POLYSACCHARIDE;

AFFINITY CHROMATOGRAPHY; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; HAMSTER; ION EXCHANGE CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LYSOSOME STORAGE DISEASE; SPECTROFLUOROMETRY;

ANIMALS; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, ION EXCHANGE; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; LYSOSOMAL STORAGE DISEASES; MANNOSEPHOSPHATES; MODELS, MOLECULAR; POLYSACCHARIDES; SPECTROMETRY, FLUORESCENCE;

EID: 79960012424     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac2007784     Document Type: Article

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