메뉴 건너뛰기




Volumn 8, Issue 1 APR, 2014, Pages

The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats

Author keywords

Allopregnanolone; Cognition; Midbrain ventral tegmental area; Progesterone; Reproduction

Indexed keywords

CORTICOSTERONE; ESTRADIOL; NEUROSTEROID; PREGNANE X RECEPTOR; PROGESTERONE; STEROID HORMONE;

EID: 84899134619     PISSN: 16625137     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnsys.2014.00060     Document Type: Article
Times cited : (13)

References (84)
  • 1
    • 84871896555 scopus 로고    scopus 로고
    • Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    • doi: 10. 1371/journal. pone. 0053376
    • Acosta, S. A., Tajiri, N., Shinozuka, K., Ishikawa, H., Grimmig, B., Diamond, D., et al. (2013). Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model. PLoS ONE 8: e53376. doi: 10. 1371/journal. pone. 0053376.
    • (2013) PLoS ONE , vol.8
    • Acosta, S.A.1    Tajiri, N.2    Shinozuka, K.3    Ishikawa, H.4    Grimmig, B.5    Diamond, D.6
  • 2
    • 36749048035 scopus 로고    scopus 로고
    • Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice
    • doi: 10. 1073/pnas. 0709419104
    • Agís-Balboa, R. C., Pinna, G., Pibiri, F., Kadriu, B., Costa, E., and Guidotti, A. (2007). Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc. Natl. Acad. Sci. U. S. A. 104, 18736-18741. doi: 10. 1073/pnas. 0709419104.
    • (2007) Proc. Natl. Acad. Sci. U.S. A , vol.104 , pp. 18736-18741
    • Agís-Balboa, R.C.1    Pinna, G.2    Pibiri, F.3    Kadriu, B.4    Costa, E.5    Guidotti, A.6
  • 3
    • 79957616944 scopus 로고    scopus 로고
    • Extended paced mating tests induces conditioned place preference without affecting sexual arousal
    • doi: 10. 1016/j. yhbeh. 2010. 08. 016
    • Arzate, D. M., Portillo, W., Rodríguez, C., Corona, R., and Paredes, R. G. (2011). Extended paced mating tests induces conditioned place preference without affecting sexual arousal. Horm. Behav. 59, 674-680. doi: 10. 1016/j. yhbeh. 2010. 08. 016.
    • (2011) Horm. Behav , vol.59 , pp. 674-680
    • Arzate, D.M.1    Portillo, W.2    Rodríguez, C.3    Corona, R.4    Paredes, R.G.5
  • 4
    • 1342309158 scopus 로고    scopus 로고
    • Aromatase expression by reactive astroglia is neuroprotective
    • doi: 10. 1196/annals. 1286. 028
    • Azcoitia, I., Sierra, A., Veiga, S., and Garcia-Segura, L. M. (2003). Aromatase expression by reactive astroglia is neuroprotective. Ann. N. Y. Acad. Sci. 1007, 298-305. doi: 10. 1196/annals. 1286. 028.
    • (2003) Ann. N.Y. Acad. Sci , vol.1007 , pp. 298-305
    • Azcoitia, I.1    Sierra, A.2    Veiga, S.3    Garcia-Segura, L.M.4
  • 5
    • 84885457276 scopus 로고    scopus 로고
    • Multifunctional aspects of allopregnanolone in stress and related disorders
    • doi: 10. 1016/j. pnpbp. 2013. 09. 005
    • Bali, A., and Jaggi, A. S. (2014). Multifunctional aspects of allopregnanolone in stress and related disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 48, 64-78. doi: 10. 1016/j. pnpbp. 2013. 09. 005.
    • (2014) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.48 , pp. 64-78
    • Bali, A.1    Jaggi, A.S.2
  • 6
    • 0035225989 scopus 로고    scopus 로고
    • Stress and neuroactive steroids
    • doi: 10. 1016/S0074-7742(01)46065-X
    • Barbaccia, M. L., Serra, M., Purdy, R. H., and Biggio, G. (2001). Stress and neuroactive steroids. Int. Rev. Neurobiol. 246, 243-272. doi: 10. 1016/S0074-7742(01)46065-X.
    • (2001) Int. Rev. Neurobiol , vol.246 , pp. 243-272
    • Barbaccia, M.L.1    Serra, M.2    Purdy, R.H.3    Biggio, G.4
  • 7
    • 4944230477 scopus 로고    scopus 로고
    • Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
    • doi: 10. 1124/mol. 66. 3
    • Bauer, B., Hartz, A. M., Fricker, G., and Miller, D. S. (2004). Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol. Pharmacol. 66, 413-419. doi: 10. 1124/mol. 66. 3.
    • (2004) Mol. Pharmacol , vol.66 , pp. 413-419
    • Bauer, B.1    Hartz, A.M.2    Fricker, G.3    Miller, D.S.4
  • 8
    • 33748950454 scopus 로고    scopus 로고
    • In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
    • doi: 10. 1124/mol. 106. 023796
    • Bauer, B., Yang, X., Hartz, A. M., Olson, E. R., Zhao, R., Kalvass, J. C., et al. (2006). In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol. Pharmacol. 70, 1212-1219. doi: 10. 1124/mol. 106. 023796.
    • (2006) Mol. Pharmacol , vol.70 , pp. 1212-1219
    • Bauer, B.1    Yang, X.2    Hartz, A.M.3    Olson, E.R.4    Zhao, R.5    Kalvass, J.C.6
  • 9
    • 37249001769 scopus 로고    scopus 로고
    • Hormone-replacement therapy, dementia and stroke
    • doi: 10. 2217/17455057. 3. 6. 699
    • Billeci, A., Caso, V., Paciaroni, M., Palmerini, F., and Agnelli, G. (2007). Hormone-replacement therapy, dementia and stroke. Womens Health 3, 699-710. doi: 10. 2217/17455057. 3. 6. 699.
    • (2007) Womens Health , vol.3 , pp. 699-710
    • Billeci, A.1    Caso, V.2    Paciaroni, M.3    Palmerini, F.4    Agnelli, G.5
  • 10
    • 0033902005 scopus 로고    scopus 로고
    • Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat
    • doi: 10. 1007/s002130000471
    • Bitran, D., Foley, M., Audette, D., Leslie, N., and Frye, C. A. (2000). Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat. Psychopharmacology 151, 64-71. doi: 10. 1007/s002130000471.
    • (2000) Psychopharmacology , vol.151 , pp. 64-71
    • Bitran, D.1    Foley, M.2    Audette, D.3    Leslie, N.4    Frye, C.A.5
  • 11
    • 84875420499 scopus 로고    scopus 로고
    • Neurosteroids as regenerative agents in the brain: Therapeutic implications
    • doi: 10. 1038/nrendo. 2013. 31
    • Brinton, R. D. (2013). Neurosteroids as regenerative agents in the brain: therapeutic implications. Nat. Rev. Endocrinol. 9, 241-250. doi: 10. 1038/nrendo. 2013. 31.
    • (2013) Nat. Rev. Endocrinol , vol.9 , pp. 241-250
    • Brinton, R.D.1
  • 12
    • 84892836127 scopus 로고    scopus 로고
    • Allopregnanolone in the brain: Protecting pregnancy and birth outcomes
    • doi: 10. 1016/j. pneurobio. 2013. 08. 005
    • Brunton, P. J., Russell, J. A., and Hirst, J. J. (2014). Allopregnanolone in the brain: Protecting pregnancy and birth outcomes. Prog. Neurobiol. 113, 106-136. doi: 10. 1016/j. pneurobio. 2013. 08. 005.
    • (2014) Prog. Neurobiol , vol.113 , pp. 106-136
    • Brunton, P.J.1    Russell, J.A.2    Hirst, J.J.3
  • 13
    • 70349732917 scopus 로고    scopus 로고
    • Hormonal and testing conditions for the induction of conditioned place preference by paced mating
    • doi: 10. 1016/j. yhbeh. 2009. 07. 007
    • Camacho, F. J., García-Horsman, P., and Paredes, R. G. (2009). Hormonal and testing conditions for the induction of conditioned place preference by paced mating. Horm. Behav. 56, 410-415. doi: 10. 1016/j. yhbeh. 2009. 07. 007.
    • (2009) Horm. Behav , vol.56 , pp. 410-415
    • Camacho, F.J.1    García-Horsman, P.2    Paredes, R.G.3
  • 14
    • 84855697856 scopus 로고    scopus 로고
    • Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: Protective effects of LXR activation
    • doi: 10. 1194/jlr. M021188
    • Cermenati, G., Abbiati, F., Cermenati, S., Brioschi, E., Volonterio, A., Cavaletti, G., et al. (2012). Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation. J. Lipid Res. 53, 300-310. doi: 10. 1194/jlr. M021188.
    • (2012) J. Lipid Res , vol.53 , pp. 300-310
    • Cermenati, G.1    Abbiati, F.2    Cermenati, S.3    Brioschi, E.4    Volonterio, A.5    Cavaletti, G.6
  • 15
    • 77956578447 scopus 로고    scopus 로고
    • Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy
    • doi: 10. 1523/JNEUROSCI. 1898-10. 2010
    • Cermenati, G., Giatti, S., Cavaletti, G., Bianchi, R., Maschi, O., Pesaresi, M., et al. (2010). Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy. J. Neurosci. 30, 11896-11901. doi: 10. 1523/JNEUROSCI. 1898-10. 2010.
    • (2010) J. Neurosci , vol.30 , pp. 11896-11901
    • Cermenati, G.1    Giatti, S.2    Cavaletti, G.3    Bianchi, R.4    Maschi, O.5    Pesaresi, M.6
  • 16
    • 0032724682 scopus 로고    scopus 로고
    • Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat
    • doi: 10. 1016/S0022-510X(99)00247-6
    • Chen, J., Chopp, M., and Li, Y. (1999). Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J. Neurol. Sci. 171, 24-30. doi: 10. 1016/S0022-510X(99)00247-6.
    • (1999) J. Neurol. Sci , vol.171 , pp. 24-30
    • Chen, J.1    Chopp, M.2    Li, Y.3
  • 17
    • 0016803079 scopus 로고
    • Subcellular distribution and properties of progesterone (delta4-steroid) 5a-reductase in rat medial basal hypothalamus
    • Cheng, Y. J., and Karavolas, H. J. (1975). Subcellular distribution and properties of progesterone (delta4-steroid) 5a-reductase in rat medial basal hypothalamus. J. Biol. Chem. 250, 7997-8003.
    • (1975) J. Biol. Chem , vol.250 , pp. 7997-8003
    • Cheng, Y.J.1    Karavolas, H.J.2
  • 18
    • 0036592202 scopus 로고    scopus 로고
    • The nuclear receptor PXR: A master regulator of "homeland" defense
    • doi: 10. 1615/CritRevEukaryotGeneExpr. v12. i1. 30
    • Dussault, I., and Forman, B. M. (2002). The nuclear receptor PXR: a master regulator of "homeland" defense. Crit. Rev. Eukaryot. Gene Expr. 12, 53-64. doi: 10. 1615/CritRevEukaryotGeneExpr. v12. i1. 30.
    • (2002) Crit. Rev. Eukaryot. Gene Expr , vol.12 , pp. 53-64
    • Dussault, I.1    Forman, B.M.2
  • 19
    • 35248825937 scopus 로고    scopus 로고
    • Sexual experience of male rats influences anxiety-like behavior and androgen levels
    • doi: 10. 1016/j. physbeh. 2007. 04. 018
    • Edinger, K. L., and Frye, C. A. (2007). Sexual experience of male rats influences anxiety-like behavior and androgen levels. Physiol. Behav. 92, 443-453. doi: 10. 1016/j. physbeh. 2007. 04. 018.
    • (2007) Physiol. Behav , vol.92 , pp. 443-453
    • Edinger, K.L.1    Frye, C.A.2
  • 20
    • 0021995410 scopus 로고
    • Effects of paced coital stimulation on estrus duration in intact cycling rats and ovariectomized and ovariectomized-adrenalectomized hormone-primed rats
    • doi: 10. 1037/0735-7044. 99. 1. 151
    • Erskine, M. S. (1985). Effects of paced coital stimulation on estrus duration in intact cycling rats and ovariectomized and ovariectomized-adrenalectomized hormone-primed rats. Behav. Neurosci. 99, 151-161. doi: 10. 1037/0735-7044. 99. 1. 151.
    • (1985) Behav. Neurosci , vol.99 , pp. 151-161
    • Erskine, M.S.1
  • 21
    • 0038210248 scopus 로고    scopus 로고
    • Nuclear receptors and the control of metabolism
    • doi: 10. 1146/annurev. physiol. 65. 092101. 142528
    • Francis, G. A., Fayard, E., Picard, F., and Auwerx, J. (2002). Nuclear receptors and the control of metabolism. Annu. Rev. Physiol. 65, 261-311. doi: 10. 1146/annurev. physiol. 65. 092101. 142528.
    • (2002) Annu. Rev. Physiol , vol.65 , pp. 261-311
    • Francis, G.A.1    Fayard, E.2    Picard, F.3    Auwerx, J.4
  • 22
    • 0034855948 scopus 로고    scopus 로고
    • The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents
    • doi: 10. 1006/hbeh. 2001. 1674
    • Frye, C. A. (2001a). The role of neurosteroids and nongenomic effects of progestins in the ventral tegmental area in mediating sexual receptivity of rodents. Horm. Behav. 40, 226-233. doi: 10. 1006/hbeh. 2001. 1674.
    • (2001) Horm. Behav , vol.40 , pp. 226-233
    • Frye, C.A.1
  • 23
    • 0035663215 scopus 로고    scopus 로고
    • The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents
    • doi: 10. 1016/S0165-0173(01)00119-9
    • Frye, C. A. (2001b). The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents. Brain Res. Brain Res. Rev. 37, 201-222. doi: 10. 1016/S0165-0173(01)00119-9.
    • (2001) Brain Res. Brain Res. Rev , vol.37 , pp. 201-222
    • Frye, C.A.1
  • 24
    • 71249129127 scopus 로고    scopus 로고
    • Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions
    • doi: 10. 1016/j. psyneuen. 2009. 07. 005
    • Frye, C. A. (2009). Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions. Psychoneuroendocrinology 34, S143-S161. doi: 10. 1016/j. psyneuen. 2009. 07. 005.
    • (2009) Psychoneuroendocrinology , vol.34
    • Frye, C.A.1
  • 25
    • 80054765623 scopus 로고    scopus 로고
    • Novel substrates for, and sources of, progestogens for reproduction
    • doi: 10. 1111/j. 1365-2826. 2011. 02180. x
    • Frye, C. A. (2011). Novel substrates for, and sources of, progestogens for reproduction. J. Neuroendocrinol. 23, 961-973. doi: 10. 1111/j. 1365-2826. 2011. 02180. x.
    • (2011) J. Neuroendocrinol , vol.23 , pp. 961-973
    • Frye, C.A.1
  • 26
    • 0032718657 scopus 로고    scopus 로고
    • Mating stimuli influence endogenous variations in the neurosteroids 3α, 5α-THP and 3α-Diol
    • doi: 10. 1046/j. 1365-2826. 1999. 00379. x
    • Frye, C. A., and Bayon, L. E. (1999). Mating stimuli influence endogenous variations in the neurosteroids 3α, 5α-THP and 3α-Diol. J. Neuroendocrinol. 11, 839-847. doi: 10. 1046/j. 1365-2826. 1999. 00379. x.
    • (1999) J. Neuroendocrinol , vol.11 , pp. 839-847
    • Frye, C.A.1    Bayon, L.E.2
  • 27
    • 34547674690 scopus 로고    scopus 로고
    • Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
    • doi: 10. 1016/j. nlm. 2007. 04. 003
    • Frye, C. A., Duffy, C. K., and Walf, A. A. (2007). Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiol. Learn. Mem. 88, 208-216. doi: 10. 1016/j. nlm. 2007. 04. 003.
    • (2007) Neurobiol. Learn. Mem , vol.88 , pp. 208-216
    • Frye, C.A.1    Duffy, C.K.2    Walf, A.A.3
  • 28
    • 54149103046 scopus 로고    scopus 로고
    • Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
    • doi: 10. 1016/j. yhbeh. 2008. 07. 013
    • Frye, C. A., Koonce, C. J., Edinger, K. L., Osborne, D. M., and Walf, A. A. (2008b). Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice. Horm. Behav. 54, 726-734. doi: 10. 1016/j. yhbeh. 2008. 07. 013.
    • (2008) Horm. Behav , vol.54 , pp. 726-734
    • Frye, C.A.1    Koonce, C.J.2    Edinger, K.L.3    Osborne, D.M.4    Walf, A.A.5
  • 29
    • 84906940614 scopus 로고    scopus 로고
    • Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol-and 3α, 5α-THP-facilitated lordosis of female rats
    • doi: 10. 1007/s00213-013-3406-0. [Epub ahead of print]
    • Frye, C. A., Koonce, C. J., and Walf, A. A. (2014). Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol-and 3α, 5α-THP-facilitated lordosis of female rats. Psychopharmacology. doi: 10. 1007/s00213-013-3406-0. [Epub ahead of print].
    • (2014) Psychopharmacology
    • Frye, C.A.1    Koonce, C.J.2    Walf, A.A.3
  • 30
    • 84930278626 scopus 로고    scopus 로고
    • Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats
    • (in press), doi: 10. 1007/s00213-014-3569-3
    • Frye, C. A., Koonce, C. J., and Walf, A. A. (in press). Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats. Psychopharmacology. doi: 10. 1007/s00213-014-3569-3.
    • Psychopharmacology
    • Frye, C.A.1    Koonce, C.J.2    Walf, A.A.3
  • 31
    • 84879838900 scopus 로고    scopus 로고
    • Motivated behaviors and levels of 3α, 5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats
    • doi: 10. 1111/jsm. 12173
    • Frye, C. A., Koonce, C. J., Walf, A. A., and Rusconi, J. C. (2013). Motivated behaviors and levels of 3α, 5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats. J. Sex. Med. 10, 1692-1706. doi: 10. 1111/jsm. 12173.
    • (2013) J. Sex. Med , vol.10 , pp. 1692-1706
    • Frye, C.A.1    Koonce, C.J.2    Walf, A.A.3    Rusconi, J.C.4
  • 32
    • 84857501507 scopus 로고    scopus 로고
    • Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats
    • doi: 10. 3275/7334
    • Frye, C. A., and Paris, J. J. (2011). Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats. J. Endocrinol. Invest. 34, e188-e199. doi: 10. 3275/7334.
    • (2011) J. Endocrinol. Invest , vol.34
    • Frye, C.A.1    Paris, J.J.2
  • 33
    • 48749115502 scopus 로고    scopus 로고
    • Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3α, 5α-THP formation in the midbrain ventral tegmental area
    • doi: 10. 1016/j. bbr. 2008. 06. 005
    • Frye, C. A., Paris, J. J., and Rhodes, M. E. (2008a). Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3α, 5α-THP formation in the midbrain ventral tegmental area. Behav. Brain Res. 193, 269-276. doi: 10. 1016/j. bbr. 2008. 06. 005.
    • (2008) Behav. Brain Res , vol.193 , pp. 269-276
    • Frye, C.A.1    Paris, J.J.2    Rhodes, M.E.3
  • 34
    • 65949084002 scopus 로고    scopus 로고
    • Increasing 3α, 5α-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats
    • doi: 10. 1530/REP-08-0250
    • Frye, C. A., Paris, J. J., and Rhodes, M. E. (2009). Increasing 3α, 5α-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats. Reproduction 137, 119-128. doi: 10. 1530/REP-08-0250.
    • (2009) Reproduction , vol.137 , pp. 119-128
    • Frye, C.A.1    Paris, J.J.2    Rhodes, M.E.3
  • 35
    • 84861933636 scopus 로고    scopus 로고
    • Effects and mechanisms of 3α, 5α,-THP on emotion, motivation, and reward functions involving pregnane xenobiotic receptor
    • doi: 10. 3389/fnins. 2011. 00136
    • Frye, C. A., Paris, J. J., Walf, A. A., and Rusconi, J. C. (2012). Effects and mechanisms of 3α, 5α,-THP on emotion, motivation, and reward functions involving pregnane xenobiotic receptor. Front. Neurosci. 195: 136. doi: 10. 3389/fnins. 2011. 00136.
    • (2012) Front. Neurosci , vol.195 , pp. 136
    • Frye, C.A.1    Paris, J.J.2    Walf, A.A.3    Rusconi, J.C.4
  • 36
    • 33750920149 scopus 로고    scopus 로고
    • Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats
    • doi: 10. 1159/000096051
    • Frye, C. A., and Rhodes, M. E. (2006). Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats. Neuroendocrinology 83, 336-347. doi: 10. 1159/000096051.
    • (2006) Neuroendocrinology , vol.83 , pp. 336-347
    • Frye, C.A.1    Rhodes, M.E.2
  • 37
    • 33644514957 scopus 로고    scopus 로고
    • 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors
    • doi: 10. 1016/j. neuroscience. 2005. 06. 015
    • Frye, C. A., Rhodes, M. E., Petralia, S. M., Walf, A. A., Sumida, K., and Edinger, K. L. (2006). 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience 138, 1007-1014. doi: 10. 1016/j. neuroscience. 2005. 06. 015.
    • (2006) Neuroscience , vol.138 , pp. 1007-1014
    • Frye, C.A.1    Rhodes, M.E.2    Petralia, S.M.3    Walf, A.A.4    Sumida, K.5    Edinger, K.L.6
  • 38
    • 44549084222 scopus 로고    scopus 로고
    • Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways
    • doi: 10. 1016/j. steroids. 2008. 01. 020
    • Frye, C. A., and Walf, A. A. (2008). Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways. Steroids 73, 906-913. doi: 10. 1016/j. steroids. 2008. 01. 020.
    • (2008) Steroids , vol.73 , pp. 906-913
    • Frye, C.A.1    Walf, A.A.2
  • 39
    • 0031740349 scopus 로고    scopus 로고
    • Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: Colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3β-hydroxysteroid dehydrogenase in the rat brain
    • doi: 10. 1046/j. 1471-4159. 1998. 71062231. x
    • Furukawa, A., Miyatake, A., Ohnishi, T., and Ichikawa, Y. (1998). Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3β-hydroxysteroid dehydrogenase in the rat brain. J. Neurochem. 71, 2231-2238. doi: 10. 1046/j. 1471-4159. 1998. 71062231. x.
    • (1998) J. Neurochem , vol.71 , pp. 2231-2238
    • Furukawa, A.1    Miyatake, A.2    Ohnishi, T.3    Ichikawa, Y.4
  • 40
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • doi: 10. 1074/jbc. M010173200
    • Geick, A., Eichelbaum, M., and Burk, O. (2001). Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276, 14581-14587. doi: 10. 1074/jbc. M010173200.
    • (2001) J. Biol. Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 42
    • 34248561199 scopus 로고    scopus 로고
    • The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology
    • doi: 10. 1016/j. ctrv. 2007. 02. 003
    • Harmsen, S., Meijerman, I., Beijnen, J. H., and Schellens, J. H. (2007). The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. Cancer Treat. Rev. 33, 369-380. doi: 10. 1016/j. ctrv. 2007. 02. 003.
    • (2007) Cancer Treat. Rev , vol.33 , pp. 369-380
    • Harmsen, S.1    Meijerman, I.2    Beijnen, J.H.3    Schellens, J.H.4
  • 43
    • 1942474435 scopus 로고    scopus 로고
    • Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury
    • He, J., Hoffman, S. W., and Stein, D. G. (2004). Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury. Restor. Neurol. Neurosci. 22, 19-31.
    • (2004) Restor. Neurol. Neurosci , vol.22 , pp. 19-31
    • He, J.1    Hoffman, S.W.2    Stein, D.G.3
  • 44
    • 0037115040 scopus 로고    scopus 로고
    • An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain
    • King, S. R., Manna, P. R., Ishii, T., Syapin, P. J., Ginsberg, S. D., Wilson, K., et al. (2002). An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J. Neurosci. 22, 10613-10620.
    • (2002) J. Neurosci , vol.22 , pp. 10613-10620
    • King, S.R.1    Manna, P.R.2    Ishii, T.3    Syapin, P.J.4    Ginsberg, S.D.5    Wilson, K.6
  • 45
    • 41149146739 scopus 로고    scopus 로고
    • Reproduction-induced neuroplasticity: Natural behavioural and neuronal alterations associated with the production and care of offspring
    • doi: 10. 1111/j. 1365-2826. 2008. 01667. x
    • Kinsley, C. H., and Lambert, K. G. (2008). Reproduction-induced neuroplasticity: natural behavioural and neuronal alterations associated with the production and care of offspring. J. Neuroendocrinol. 20, 515-525. doi: 10. 1111/j. 1365-2826. 2008. 01667. x.
    • (2008) J. Neuroendocrinol , vol.20 , pp. 515-525
    • Kinsley, C.H.1    Lambert, K.G.2
  • 46
    • 0036799870 scopus 로고    scopus 로고
    • The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
    • doi: 10. 1210/er. 2001-0038
    • Kliewer, S. A., Goodwin, B., and Willson, T. M. (2002). The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr. Rev. 23, 687-702. doi: 10. 1210/er. 2001-0038.
    • (2002) Endocr. Rev , vol.23 , pp. 687-702
    • Kliewer, S.A.1    Goodwin, B.2    Willson, T.M.3
  • 47
    • 18844427516 scopus 로고    scopus 로고
    • Pup exposure differentially enhances foraging ability in primiparous and nulliparous rats
    • doi: 10. 1016/j. physbeh. 2005. 03. 012
    • Lambert, K. G., Berry, A. E., Griffins, G., Amory-Meyers, E., Madonia-Lomas, L., Love, G., et al. (2005). Pup exposure differentially enhances foraging ability in primiparous and nulliparous rats. Physiol. Behav. 84, 799-806. doi: 10. 1016/j. physbeh. 2005. 03. 012.
    • (2005) Physiol. Behav , vol.84 , pp. 799-806
    • Lambert, K.G.1    Berry, A.E.2    Griffins, G.3    Amory-Meyers, E.4    Madonia-Lomas, L.5    Love, G.6
  • 48
    • 0030992888 scopus 로고    scopus 로고
    • Regional distribution of cytosolic and particulate 5a-dihydroprogesterone 3a-hydroxysteroid oxidoreductases in female rat brain
    • doi: 10. 1016/S0960-0760(96)00195-1
    • Li, X., Bertics, P. J., and Karavolas, H. J. (1997). Regional distribution of cytosolic and particulate 5a-dihydroprogesterone 3a-hydroxysteroid oxidoreductases in female rat brain. J. Steroid Biochem. Mol. Biol. 60, 311-318. doi: 10. 1016/S0960-0760(96)00195-1.
    • (1997) J. Steroid Biochem. Mol. Biol , vol.60 , pp. 311-318
    • Li, X.1    Bertics, P.J.2    Karavolas, H.J.3
  • 49
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)
    • doi: 10. 1006/meth. 2001. 1262
    • Livak, K. J., and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T). Methods 25, 402-408. doi: 10. 1006/meth. 2001. 1262.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 50
    • 49649102377 scopus 로고    scopus 로고
    • The pregnane X receptor: From bench to bedside
    • doi: 10. 1517/17425255. 4. 7. 895
    • Ma, X., Idle, J. R., and Gonzalez, F. J. (2008). The pregnane X receptor: from bench to bedside. Expert Opin. Drug Metab. Toxicol. 4, 895-908. doi: 10. 1517/17425255. 4. 7. 895.
    • (2008) Expert Opin. Drug Metab. Toxicol , vol.4 , pp. 895-908
    • Ma, X.1    Idle, J.R.2    Gonzalez, F.J.3
  • 51
    • 72449205923 scopus 로고    scopus 로고
    • Changes in anxiety and cognition due to reproductive experience: A review of data from rodent and human mothers
    • doi: 10. 1016/j. neubiorev. 2009. 08. 011
    • Macbeth, A. H., and Luine, V. N. (2010). Changes in anxiety and cognition due to reproductive experience: a review of data from rodent and human mothers. Neurosci. Biobehav. Rev. 34, 452-467. doi: 10. 1016/j. neubiorev. 2009. 08. 011.
    • (2010) Neurosci. Biobehav. Rev , vol.34 , pp. 452-467
    • Macbeth, A.H.1    Luine, V.N.2
  • 52
    • 84861405815 scopus 로고    scopus 로고
    • Hormone therapy, dementia, and cognition: The Women's Health Initiative 10 years on
    • doi: 10. 3109/13697137. 2012. 660613
    • Maki, P. M., and Henderson, V. W. (2012). Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on. Climacteric 15, 256-262. doi: 10. 3109/13697137. 2012. 660613.
    • (2012) Climacteric , vol.15 , pp. 256-262
    • Maki, P.M.1    Henderson, V.W.2
  • 53
    • 0027381252 scopus 로고
    • Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain
    • doi: 10. 1016/0006-8993(93)91332-M
    • Mellon, S. H., and Deschepper, C. F. (1993). Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 629, 283-292. doi: 10. 1016/0006-8993(93)91332-M.
    • (1993) Brain Res , vol.629 , pp. 283-292
    • Mellon, S.H.1    Deschepper, C.F.2
  • 54
    • 40749148475 scopus 로고    scopus 로고
    • Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease
    • doi: 10. 1016/j. brainresrev. 2007. 05. 012
    • Mellon, S. H., Gong, W., and Schonemann, M. D. (2008). Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res. Rev. 57, 410-420. doi: 10. 1016/j. brainresrev. 2007. 05. 012.
    • (2008) Brain Res. Rev , vol.57 , pp. 410-420
    • Mellon, S.H.1    Gong, W.2    Schonemann, M.D.3
  • 55
    • 84860448923 scopus 로고    scopus 로고
    • LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals
    • doi: 10. 1016/j. neuint. 2012. 02. 025
    • Mitro, N., Cermenati, G., Giatti, S., Abbiati, F., Pesaresi, M., Calabrese, D., et al. (2012). LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochem. Int. 60, 616-621. doi: 10. 1016/j. neuint. 2012. 02. 025.
    • (2012) Neurochem. Int , vol.60 , pp. 616-621
    • Mitro, N.1    Cermenati, G.2    Giatti, S.3    Abbiati, F.4    Pesaresi, M.5    Calabrese, D.6
  • 56
    • 0036791875 scopus 로고    scopus 로고
    • Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats
    • doi: 10. 1097/00004647-200210000-00005
    • Murphy, S. J., Littleton-Kearney, M. T., and Hurn, P. D. (2002). Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats. J. Cereb. Blood Flow Metab. 22, 1181-1188. doi: 10. 1097/00004647-200210000-00005.
    • (2002) J. Cereb. Blood Flow Metab , vol.22 , pp. 1181-1188
    • Murphy, S.J.1    Littleton-Kearney, M.T.2    Hurn, P.D.3
  • 57
    • 63849146957 scopus 로고    scopus 로고
    • Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: Functional similarities between pig and human PXR. J
    • doi: 10. 1124/jpet. 108. 149690
    • Ott, M., Fricker, G., and Bauer, B. (2009). Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J. Pharmacol. Exp. Ther. 329, 141-149. doi: 10. 1124/jpet. 108. 149690.
    • (2009) Pharmacol. Exp. Ther , vol.329 , pp. 141-149
    • Ott, M.1    Fricker, G.2    Bauer, B.3
  • 58
    • 33746035655 scopus 로고    scopus 로고
    • Translocator protein (18kDa): New nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
    • doi: 10. 1016/j. tips. 2006. 06. 005
    • Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J. J., Lindemann, P., et al. (2006). Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol. Sci. 27, 402-409. doi: 10. 1016/j. tips. 2006. 06. 005.
    • (2006) Trends Pharmacol. Sci , vol.27 , pp. 402-409
    • Papadopoulos, V.1    Baraldi, M.2    Guilarte, T.R.3    Knudsen, T.B.4    Lacapère, J.J.5    Lindemann, P.6
  • 59
    • 47249128235 scopus 로고    scopus 로고
    • Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks
    • doi: 10. 1530/REP-07-0512
    • Paris, J. J., and Frye, C. A. (2008). Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks. Reproduction 136, 105-115. doi: 10. 1530/REP-07-0512.
    • (2008) Reproduction , vol.136 , pp. 105-115
    • Paris, J.J.1    Frye, C.A.2
  • 61
    • 15044355642 scopus 로고    scopus 로고
    • In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters
    • doi: 10. 1007/s00213-004-2001-9
    • Petralia, S. M., and Frye, C. A. (2005). In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters. Psychopharmacology 178, 174-182. doi: 10. 1007/s00213-004-2001-9.
    • (2005) Psychopharmacology , vol.178 , pp. 174-182
    • Petralia, S.M.1    Frye, C.A.2
  • 62
    • 23944478886 scopus 로고    scopus 로고
    • Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus
    • doi: 10. 1111/j. 1365-2826. 2005. 01342. x
    • Petralia, S. M., Jahagirdar, V., and Frye, C. A. (2005). Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus. J. Neuroendocrinol. 17, 545-552. doi: 10. 1111/j. 1365-2826. 2005. 01342. x.
    • (2005) J. Neuroendocrinol , vol.17 , pp. 545-552
    • Petralia, S.M.1    Jahagirdar, V.2    Frye, C.A.3
  • 63
    • 51749097102 scopus 로고    scopus 로고
    • Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice
    • doi: 10. 1007/s11064-008-9718-5
    • Pinna, G., Agis-Balboa, R. C., Pibiri, F., Nelson, M., Guidotti, A., and Costa, E. (2008). Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem. Res. 33, 1990-2007. doi: 10. 1007/s11064-008-9718-5.
    • (2008) Neurochem. Res , vol.33 , pp. 1990-2007
    • Pinna, G.1    Agis-Balboa, R.C.2    Pibiri, F.3    Nelson, M.4    Guidotti, A.5    Costa, E.6
  • 64
    • 84055191662 scopus 로고    scopus 로고
    • Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder
    • doi: 10. 1111/j. 1365-2826. 2011. 02234. x
    • Pinna, G., and Rasmusson, A. M. (2012). Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. J. Neuroendocrinol. 24, 102-116. doi: 10. 1111/j. 1365-2826. 2011. 02234. x.
    • (2012) J. Neuroendocrinol , vol.24 , pp. 102-116
    • Pinna, G.1    Rasmusson, A.M.2
  • 65
    • 0025882098 scopus 로고
    • Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain
    • doi: 10. 1073/pnas. 88. 10. 4553
    • Purdy, R. H., Morrow, A. L., Moore, P. H. Jr., and Paul, S. M. (1991). Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc. Natl. Acad. Sci. U. S. A. 88, 4553-4557. doi: 10. 1073/pnas. 88. 10. 4553.
    • (1991) Proc. Natl. Acad. Sci. U.S. A , vol.88 , pp. 4553-4557
    • Purdy, R.H.1    Morrow, A.L.2    Moore Jr., P.H.3    Paul, S.M.4
  • 66
    • 37549037886 scopus 로고    scopus 로고
    • Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse
    • doi: 10. 1523/JNEUROSCI. 4823-07. 2007
    • Repa, J. J., Li, H., Frank-Cannon, T. C., Valasek, M. A., Turley, S. D., Tansey, M. G., and Dietschy, J. M. (2007). Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J. Neurosci. 27, 14470-14480. doi: 10. 1523/JNEUROSCI. 4823-07. 2007.
    • (2007) J. Neurosci , vol.27 , pp. 14470-14480
    • Repa, J.J.1    Li, H.2    Frank-Cannon, T.C.3    Valasek, M.A.4    Turley, S.D.5    Tansey, M.G.6    Dietschy, J.M.7
  • 67
    • 0026690043 scopus 로고
    • Progesterone treatment attenuates brain edema following contusion injury in male and female rats
    • Roof, R. L., Duvdevani, R., and Stein, D. G. (1992). Progesterone treatment attenuates brain edema following contusion injury in male and female rats. Restor. Neurol. Neurosci. 4, 425-427.
    • (1992) Restor. Neurol. Neurosci , vol.4 , pp. 425-427
    • Roof, R.L.1    Duvdevani, R.2    Stein, D.G.3
  • 68
    • 0027522598 scopus 로고
    • Gender influences outcome of brain injury: Progesterone plays a protective role
    • doi: 10. 1016/0006-8993(93)91526-X
    • Roof, R. L., Duvdevani, R., and Stein, D. G. (1993). Gender influences outcome of brain injury: progesterone plays a protective role. Brain Res. 607, 333-336. doi: 10. 1016/0006-8993(93)91526-X.
    • (1993) Brain Res , vol.607 , pp. 333-336
    • Roof, R.L.1    Duvdevani, R.2    Stein, D.G.3
  • 69
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • doi: 10. 1001/jama. 288. 3. 321
    • Rossouw, J. E., Anderson, G. L., Prentice, R. L., LaCroix, A. Z., Kooperberg, C., Stefanick, M. L., et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 288, 321-333. doi: 10. 1001/jama. 288. 3. 321.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3    LaCroix, A.Z.4    Kooperberg, C.5    Stefanick, M.L.6
  • 70
    • 0035035186 scopus 로고    scopus 로고
    • Memory retention is modulated by acute estradiol and progesterone replacement
    • doi: 10. 1037/0735-7044. 115. 2. 384
    • Sandstrom, N. J., and Williams, C. L. (2001). Memory retention is modulated by acute estradiol and progesterone replacement. Behav. Neurosci. 115, 384-393. doi: 10. 1037/0735-7044. 115. 2. 384.
    • (2001) Behav. Neurosci , vol.115 , pp. 384-393
    • Sandstrom, N.J.1    Williams, C.L.2
  • 71
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • doi: 10. 1038/nprot. 2008. 73
    • Schmittgen, T. D., and Livak, K. J. (2008). Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3, 1101-1108. doi: 10. 1038/nprot. 2008. 73.
    • (2008) Nat. Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 72
    • 33750609871 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in relation to the use of combined postmenopausal hormone therapy: Detection bias and resolution of discrepant findings in two Women's Health Initiative studies
    • doi: 10. 1080/13697130601012061
    • Shapiro, S. (2006). Risk of cardiovascular disease in relation to the use of combined postmenopausal hormone therapy: detection bias and resolution of discrepant findings in two Women's Health Initiative studies. Climacteric 9, 416-420. doi: 10. 1080/13697130601012061.
    • (2006) Climacteric , vol.9 , pp. 416-420
    • Shapiro, S.1
  • 73
    • 0038386058 scopus 로고    scopus 로고
    • Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study: A randomized controlled trial
    • doi: 10. 1001/jama. 289. 20. 2651
    • Shumaker, S. A., Legault, C., Rapp, S. R., Thal, L., Wallace, R. B., Ockene, J. K., et al. (2003). Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 289, 2651-2662. doi: 10. 1001/jama. 289. 20. 2651.
    • (2003) JAMA , vol.289 , pp. 2651-2662
    • Shumaker, S.A.1    Legault, C.2    Rapp, S.R.3    Thal, L.4    Wallace, R.B.5    Ockene, J.K.6
  • 74
    • 84860829707 scopus 로고    scopus 로고
    • Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex
    • doi: 10. 1073/pnas. 1205189109
    • Tan, X. J., Dai, Y. B., Wu, W. F., Warner, M., and Gustafsson, J. Å. (2012). Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex. Proc. Natl. Acad. Sci. U. S. A. 109, 7493-7498. doi: 10. 1073/pnas. 1205189109.
    • (2012) Proc. Natl. Acad. Sci. U.S. A , vol.109 , pp. 7493-7498
    • Tan, X.J.1    Dai, Y.B.2    Wu, W.F.3    Warner, M.4    Gustafsson, J.A.5
  • 75
    • 3042701662 scopus 로고    scopus 로고
    • Estrogen and progesterone improve scopolamine-induced impairment of spatial memory
    • Tanabe, F., Miyasaka, N., Kubota, T., and Aso, T. (2004). Estrogen and progesterone improve scopolamine-induced impairment of spatial memory. J. Med. Dent. Sci. 51, 89-98.
    • (2004) J. Med. Dent. Sci , vol.51 , pp. 89-98
    • Tanabe, F.1    Miyasaka, N.2    Kubota, T.3    Aso, T.4
  • 76
    • 40749126815 scopus 로고    scopus 로고
    • Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice
    • doi: 10. 1161/ATVBAHA. 107. 160465
    • Tang, W., Ma, Y., Jia, L., Ioannou, Y. A., Davies, J. P., and Yu, L. (2008). Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice. Arterioscler. Thromb. Vasc. Biol. 28, 448-454. doi: 10. 1161/ATVBAHA. 107. 160465.
    • (2008) Arterioscler. Thromb. Vasc. Biol , vol.28 , pp. 448-454
    • Tang, W.1    Ma, Y.2    Jia, L.3    Ioannou, Y.A.4    Davies, J.P.5    Yu, L.6
  • 77
    • 84872677234 scopus 로고    scopus 로고
    • Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
    • doi: 10. 1038/nchembio. 1156
    • Theofilopoulos, S., Wang, Y., Kitambi, S. S., Sacchetti, P., Sousa, K. M., Bodin, K., et al. (2013). Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat. Chem. Biol. 9, 126-133. doi: 10. 1038/nchembio. 1156.
    • (2013) Nat. Chem. Biol , vol.9 , pp. 126-133
    • Theofilopoulos, S.1    Wang, Y.2    Kitambi, S.S.3    Sacchetti, P.4    Sousa, K.M.5    Bodin, K.6
  • 78
    • 4944246436 scopus 로고    scopus 로고
    • Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats
    • doi: 10. 1097/01. WCB. 0000135594. 13576. D2
    • Toung, T. J., Chen, T. Y., Littleton-Kearney, M. T., Hurn, P. D., and Murphy, S. J. (2004). Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats. J. Cereb. Blood Flow Metab. 24, 1160-1166. doi: 10. 1097/01. WCB. 0000135594. 13576. D2.
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , pp. 1160-1166
    • Toung, T.J.1    Chen, T.Y.2    Littleton-Kearney, M.T.3    Hurn, P.D.4    Murphy, S.J.5
  • 79
    • 84868584216 scopus 로고    scopus 로고
    • RU486 blocks effects of allopregnanolone on the response to restraint stress
    • doi: 10. 1016/j. pbb. 2012. 09. 024
    • Uphouse, L., Adams, S., Miryala, C. S., Hassell, J., and Hiegel, C. (2013). RU486 blocks effects of allopregnanolone on the response to restraint stress. Pharmacol. Biochem. Behav. 103, 568-572. doi: 10. 1016/j. pbb. 2012. 09. 024.
    • (2013) Pharmacol. Biochem. Behav , vol.103 , pp. 568-572
    • Uphouse, L.1    Adams, S.2    Miryala, C.S.3    Hassell, J.4    Hiegel, C.5
  • 80
    • 11444265087 scopus 로고    scopus 로고
    • Mild restraint reduces the time hormonally primed rats spend with sexually active males
    • doi: 10. 1016/j. bbr. 2004. 08. 001
    • Uphouse, L., Selvamani, A., Lincoln, C., Morales, L., and Comeaux, D. (2005). Mild restraint reduces the time hormonally primed rats spend with sexually active males. Behav. Brain Res. 157, 343-350. doi: 10. 1016/j. bbr. 2004. 08. 001.
    • (2005) Behav. Brain Res , vol.157 , pp. 343-350
    • Uphouse, L.1    Selvamani, A.2    Lincoln, C.3    Morales, L.4    Comeaux, D.5
  • 81
    • 33646840883 scopus 로고    scopus 로고
    • Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats
    • doi: 10. 1016/j. nlm. 2006. 01. 004
    • Walf, A. A., Rhodes, M. E., and Frye, C. A. (2006). Ovarian steroids enhance object recognition in naturally cycling and ovariectomized, hormone-primed rats. Neurobiol. Learn. Mem. 86, 35-46. doi: 10. 1016/j. nlm. 2006. 01. 004.
    • (2006) Neurobiol. Learn. Mem , vol.86 , pp. 35-46
    • Walf, A.A.1    Rhodes, M.E.2    Frye, C.A.3
  • 82
    • 85047684678 scopus 로고    scopus 로고
    • Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system
    • doi: 10. 1210/mend. 16. 6. 0835
    • Whitney, K. D., Watson, M. A., Collins, J. L., Benson, W. G., Stone, T. M., Numerick, M. J., et al. (2002). Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol. Endocrinol. 16, 1378-1385. doi: 10. 1210/mend. 16. 6. 0835.
    • (2002) Mol. Endocrinol , vol.16 , pp. 1378-1385
    • Whitney, K.D.1    Watson, M.A.2    Collins, J.L.3    Benson, W.G.4    Stone, T.M.5    Numerick, M.J.6
  • 83
    • 12344299301 scopus 로고    scopus 로고
    • Melatonin attenuates lipopolysaccharide-induced down-regulation of pregnane X receptor and its target gene CYP3A in mouse liver
    • doi: 10. 1111/j. 1600-079X. 2004. 00171. x
    • Xu, D. X., Wei, W., Sun, M. F., Wei, L. Z., and Wang, J. P. (2005). Melatonin attenuates lipopolysaccharide-induced down-regulation of pregnane X receptor and its target gene CYP3A in mouse liver. J. Pineal Res. 38, 27-34. doi: 10. 1111/j. 1600-079X. 2004. 00171. x.
    • (2005) J. Pineal Res , vol.38 , pp. 27-34
    • Xu, D.X.1    Wei, W.2    Sun, M.F.3    Wei, L.Z.4    Wang, J.P.5
  • 84
    • 61549104490 scopus 로고    scopus 로고
    • PXR: A xenobiotic receptor of diverse function implicated in pharmacogenetics
    • doi: 10. 2217/14622416. 9. 11. 1695
    • Zhang, B., Xie, W., and Krasowski, M. D. (2008). PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics 9, 1695-1709. doi: 10. 2217/14622416. 9. 11. 1695.
    • (2008) Pharmacogenomics , vol.9 , pp. 1695-1709
    • Zhang, B.1    Xie, W.2    Krasowski, M.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.