Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous: System: Colocalization of StAR, cytochrome P-450(SCC) (CYP XIA1), and 3β-hydroxysteroid dehydrogenase in the rat brain

Journal of Neurochemistry

Volumn 71, Issue 6, 1998, Pages 2231-2238

  Furukawa, Aizo ^a   Miyatake, Akira ^a   Ohnishi, Taira ^a   Ichikawa, Yoshiyuki ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Brain; Cholesterol side chain cleavage enzyme; In situ hybridization; Neurosteroid; Ribonuclease protection assay; Steroidogenic acute regulatory protein

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL; CYTOCHROME P450; NEUROSTEROID; REGULATOR PROTEIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; CHOLESTEROL TRANSPORT; IN SITU HYBRIDIZATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEQUENCE ANALYSIS; STEROIDOGENESIS; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

EID: 0031740349     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71062231.x     Document Type: Article

References (37)

1. Baulieu E. E. (1991) Neurosteroids: a new function in the brain. Biol. Cell 71, 3-10.
2. Baulieu E. E. (1997) Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog. Horm. Res. 52, 1-32.
3. Bowlby M. R. (1993) Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. Mol. Pharmacol. 43, 813-819.
4. SCC and 3β-hydroxysteroid dehydrogenase/isomerase, enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. J. Biol. Chem. 272, 7899-7907.
5. Clark B. J., Wells J., King S. R., and Stocco D. M. (1994) The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J. Biol. Chem. 269, 28314-28322.
6. Corpechot C., Robel P., Axelson M., Sjovall J., and Baulieu E. E. (1981) Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc. Natl. Acad. Sci. USA 78, 4704-4707.
7. Flood J. F., Morley J. E., and Roberts E. (1992) Memory enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc. Natl. Acad. Sci. USA 89, 1567-1571.
8. 4-isomerase (3β-HSD), is expressed in rat brain. Mol. Brain Res. 30, 287-300.
9. Harrison N. L., Majewska M. D., Harrington J. W., and Barker J. L. (1987) Structure-activity relationships for steroid interaction with the gamma-aminobutyric acid A receptor complex. J. Pharmacol. Exp. Ther. 241, 346-353.
10. Hu Z. Y., Bourreau E., Jung Testas I., Robel P., and Baulieu E. E. (1987) Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc. Natl. Acad. Sci. USA 84, 8215-8219.
11. SCC-linked monooxygenase system in the adult rat brain. Biochim. Biophys. Acta 1035, 182-189.
12. Jung-Testas I., Hu Z. Y., Baulieu E. E., and Robel P. (1989a) Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125, 2083-2091.
13. Jung-Testas I., Hu Z. Y., Baulieu E. E., and Robel P. (1989b) Steroid synthesis in rat brain cell cultures. J. Steroid Biochem. 34, 511-519.
14. Karaboyas G. C. and Koritz S. B. (1965) Identity of the site of action of cAMP and ACTH in corticosteroidogenesis in rat adrenal and beef adrenal cortex slices. Biochemistry 4, 462-468.
15. Kavaliers M., Wiebe J. P., and Galea L. A. (1994) Male preference for the odors of estrous female mice is enhanced by the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP). Brain Res. 646, 140-144.
16. King S. R., Ronen Fuhrmann T., Timberg R., Clark B. J., Orly J., and Stocco D. M. (1995) Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein. Endocrinology 136, 5165-5176.
17. SCC. Evidence for an intramitochondrial cholesterol translocator. J. Biol. Chem. 262, 9181-9188.
18. Lee H. K., Ahn R. S., Kwon H. B., and Soh J. (1997) Nucleotide sequence of rat steroidogenic acute regulatory protein complementary DNA. Biochem. Biophys. Res. Commun. 230, 528-532.
19. Le Goascogne C., Robel P., Gouezou M., Sananes N., Baulieu E. E., and Waterman M. (1987) Neurosteroids: cytochrome P-450scc in rat brain. Science 237, 1212-1215.
20. Majewska M. D. and Schwartz R. D. (1987) Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? Brain Res. 404, 355-360.
21. Majewska M. D., Harrison N. L., and Schwartz R. D. (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232, 1004-1007.
22. Mellon S. H. and Deschepper C. F. (1993) Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 629, 283-292.
23. Mizutani T., Sonoda Y., Minegishi T., Wakabayashi K., and Miyamoto K. (1997) Molecular cloning, characterization and cellular distribution of rat steroidogenic acute regulatory protein (StAR) in the ovary. Life Sci. 61, 1497-1506.
24. Oonk R. B., Krasnow J. S., Beattie W. G., and Richards J. S. (1989) Cyclic AMP-dependent and -independent regulation of cholesterol side-chain cleavage cytochrome P-450 (P-450scc) in rat ovarian granulosa cells and corpora lutea: cDNA and deduced amino acid sequence of rat P-450scc. J. Biol. Chem. 264, 21934-21942.
25. Privalle C. T., McNamara B. C., Dhariwal M. S., and Jefcoate C. R. (1987) ACTH control of cholesterol side-chain cleavage at adrenal mitochondrial cytochrome P-450scc. Regulation of intramitochondrial cholesterol transfer. Mol. Cell. Endocrinol. 53, 87-101.
26. A receptors. Neuron 4, 759-765.
27. Sanne J. L. and Krueger K. E. (1995) Expression of cytochrome P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase in the rat central nervous system: a study by polymerase chain reaction and in situ hybridization. J. Neurochem. 65, 528-536.
28. 4-isomerase (3β-HSD) family. The exclusive 3β-HSD gene expressed in the skin. J. Biol. Chem. 268, 19659-19668.
29. Smith S. S. (1991) Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells. Neuroscience 42, 309-320.
30. Stone D. and Hechter O. (1954) Studies on ACTH action in perfused bovine adrenals: site of action of ACTH in corticosteroidogenesis. Arch. Biochem. Biophys. 51, 457-469.
31. Stromstedt M. and Waterman M. R. (1995) Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain. Mol. Brain Res. 34, 75-88.
32. Sugawara T., Holt J. A., Driscoll D., Strauss J. F. III, Lin D., Miller W. L., Patterson D., Clancy K. P., Hart I. M., Clark B. J., and Stocco D. M. (1995) Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Proc. Natl. Acad. Sci. USA 92, 4778-4782.
33. Tsutsui K. and Yamazaki T. (1995) Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain. Brain Res. 678, 1-9.
34. A receptor complex by steroids in slices of rat cuneate nucleus. Br. J. Pharmacol. 96, 409-417.
35. Ukena K., Usui M., Kohchi C., and Tsutsui K. (1998) Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neuronal change in rats. Endocrinology 139, 137-147.
36. Usui M., Yamazaki T., Kominami S., and Tsutsui K. (1995) Avian neurosteroids. II. Localization of a cytochrome P450scc-like substance in the quail brain. Brain Res. 678, 10-20.
37. Wu F. S., Gibbs T. T., and Farb D. H. (1991) Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol. Pharmacol. 40, 333-336.