메뉴 건너뛰기




Volumn 22, Issue 24, 2002, Pages 10613-10620

An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain

Author keywords

Cholesterol side chain cleavage enzyme; Neurosteroid; P450scc; StAR; Steroidogenesis; Steroidogenic acute regulatory protein

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOSTEROID; MESSENGER RNA; NEUROSTEROID; SEX HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

EID: 0037115040     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-24-10613.2002     Document Type: Article
Times cited : (181)

References (51)
  • 1
    • 0035923595 scopus 로고    scopus 로고
    • The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?
    • Akwa Y, Ladurelle N, Covey DF, Baulieu EE (2001) The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms? Proc Natl Acad Sci USA 98:14033-14037.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14033-14037
    • Akwa, Y.1    Ladurelle, N.2    Covey, D.F.3    Baulieu, E.E.4
  • 4
    • 0029855881 scopus 로고    scopus 로고
    • The pathophysiology and genetics of congenital lipoid adrenal hyperplasia
    • Bose HS, Sugawara T, Strauss III JF, Miller WL (1996) The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med 335:1870-1878.
    • (1996) N Engl J Med , vol.335 , pp. 1870-1878
    • Bose, H.S.1    Sugawara, T.2    Strauss J.F. III3    Miller, W.L.4
  • 5
    • 0033594958 scopus 로고    scopus 로고
    • The active form of the steroidogenic acute regulatory protein, STAR, appears to be a molten globule
    • Bose HS, Whittal RM, Baldwin MA, Miller WL (1999) The active form of the steroidogenic acute regulatory protein, STAR, appears to be a molten globule. Proc Natl Acad Sci USA 96:7250-7255.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7250-7255
    • Bose, H.S.1    Whittal, R.M.2    Baldwin, M.A.3    Miller, W.L.4
  • 7
    • 0030848810 scopus 로고    scopus 로고
    • Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
    • Caron KM, Soo SC, Wetsel WC, Stocco DM, Clark BJ, Parker KL (1997) Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc Natl Acad Sci USA 94:11540-11545.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11540-11545
    • Caron, K.M.1    Soo, S.C.2    Wetsel, W.C.3    Stocco, D.M.4    Clark, B.J.5    Parker, K.L.6
  • 8
    • 0028104418 scopus 로고
    • The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    • Clark BJ, Wells J, King SR, Stocco DM (1994) The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 269:28314-28322.
    • (1994) J Biol Chem , vol.269 , pp. 28314-28322
    • Clark, B.J.1    Wells, J.2    King, S.R.3    Stocco, D.M.4
  • 9
    • 0033953033 scopus 로고    scopus 로고
    • Neurosteroids: Biosynthesis and function of these novel neuromodulators
    • Compagnone NA, Mellon SH (2000) Neurosteroids: Biosynthesis and function of these novel neuromodulators. Front Neuroendocrinol 21:1-56.
    • (2000) Front Neuroendocrinol , vol.21 , pp. 1-56
    • Compagnone, N.A.1    Mellon, S.H.2
  • 10
    • 0029012280 scopus 로고
    • Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis
    • Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH (1995) Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology 136:2689-2696.
    • (1995) Endocrinology , vol.136 , pp. 2689-2696
    • Compagnone, N.A.1    Bulfone, A.2    Rubenstein, J.L.3    Mellon, S.H.4
  • 12
    • 0025996448 scopus 로고
    • Regulation of steroid hormone biosynthesis. Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells
    • Epstein LF, Orme-Johnson NR (1991) Regulation of steroid hormone biosynthesis. Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells. J Biol Chem 266:19739-19745.
    • (1991) J Biol Chem , vol.266 , pp. 19739-19745
    • Epstein, L.F.1    Orme-Johnson, N.R.2
  • 13
    • 0030248197 scopus 로고    scopus 로고
    • Behavioral effects of 3α-androstanediol I: Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux
    • Frye CA, Van Keuren KR, Erskine MS (1996) Behavioral effects of 3α-androstanediol I: Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behav Brain Res 79:109-118.
    • (1996) Behav Brain Res , vol.79 , pp. 109-118
    • Frye, C.A.1    Van Keuren, K.R.2    Erskine, M.S.3
  • 14
    • 0031740349 scopus 로고    scopus 로고
    • Steroidogenic acute regulatory protein (STAR) transcripts constitutively expressed in the adult rat central nervous system: Colocalization of STAR, cytochrome P-450SCC (CYP XIA1), and 3β-hydroxysteroid dehydrogenase in the rat brain
    • Furukawa A, Miyatake A, Ohnishi T, Ichikawa Y (1998) Steroidogenic acute regulatory protein (STAR) transcripts constitutively expressed in the adult rat central nervous system: Colocalization of STAR, cytochrome P-450SCC (CYP XIA1), and 3β-hydroxysteroid dehydrogenase in the rat brain. J Neurochem 71:2231-2238.
    • (1998) J Neurochem , vol.71 , pp. 2231-2238
    • Furukawa, A.1    Miyatake, A.2    Ohnishi, T.3    Ichikawa, Y.4
  • 16
    • 0028842196 scopus 로고
    • GluR3 is the major AMPA glutamate receptor of oxytocinergic magnocellular neurons and is localized at synapses
    • Ginsberg SD, Price DL, Blackstone CD, Huganir RL, Martin LJ (1995) GluR3 is the major AMPA glutamate receptor of oxytocinergic magnocellular neurons and is localized at synapses. Neuroscience 65:563-575.
    • (1995) Neuroscience , vol.65 , pp. 563-575
    • Ginsberg, S.D.1    Price, D.L.2    Blackstone, C.D.3    Huganir, R.L.4    Martin, L.J.5
  • 18
    • 0033679883 scopus 로고    scopus 로고
    • Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein
    • Hales KH, Diemer T, Ginde S, Shankar BK, Roberts M, Bosmann HB, Hales DB (2000) Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein. Endocrinology 141:4000-4012.
    • (2000) Endocrinology , vol.141 , pp. 4000-4012
    • Hales, K.H.1    Diemer, T.2    Ginde, S.3    Shankar, B.K.4    Roberts, M.5    Bosmann, H.B.6    Hales, D.B.7
  • 20
    • 0025042560 scopus 로고
    • Studies of the immunohistochemical and biochemical localization of the cytochrome P-450scc-linked monooxygenase system in the adult rat brain
    • Iwahashi K, Ozaki HS, Tsubaki M, Ohnishi J, Takeuchi Y, Ichikawa Y (1990) Studies of the immunohistochemical and biochemical localization of the cytochrome P-450scc-linked monooxygenase system in the adult rat brain. Biochim Biophys Acta 1035:182-189.
    • (1990) Biochim Biophys Acta , vol.1035 , pp. 182-189
    • Iwahashi, K.1    Ozaki, H.S.2    Tsubaki, M.3    Ohnishi, J.4    Takeuchi, Y.5    Ichikawa, Y.6
  • 21
    • 0034913104 scopus 로고    scopus 로고
    • Neurosteroid synthesis by cytochrome p450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium -dependent synthesis
    • Kimoto T, Tsurugizawa T, Ohta Y, Makino J, Tamura H, Hojo Y, Takata N, Kawato S (2001) Neurosteroid synthesis by cytochrome p450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calcium -dependent synthesis. Endocrinology 142:3578-3589.
    • (2001) Endocrinology , vol.142 , pp. 3578-3589
    • Kimoto, T.1    Tsurugizawa, T.2    Ohta, Y.3    Makino, J.4    Tamura, H.5    Hojo, Y.6    Takata, N.7    Kawato, S.8
  • 22
    • 0028868949 scopus 로고
    • Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein
    • King SR, Ronen-Fuhrmann T, Timberg R, Clark BJ, Orly J, Stocco DM (1995) Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein. Endocrinology 136:5165-5176.
    • (1995) Endocrinology , vol.136 , pp. 5165-5176
    • King, S.R.1    Ronen-Fuhrmann, T.2    Timberg, R.3    Clark, B.J.4    Orly, J.5    Stocco, D.M.6
  • 24
    • 0020636067 scopus 로고
    • Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis. Discovery of a rapidly induced protein
    • Krueger RJ, Orme-Johnson NR (1983) Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis. Discovery of a rapidly induced protein. J Biol Chem 258:10159-10167.
    • (1983) J Biol Chem , vol.258 , pp. 10159-10167
    • Krueger, R.J.1    Orme-Johnson, N.R.2
  • 26
    • 0027770697 scopus 로고
    • The human peripheral benzodiazepine receptor gene: Cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia
    • Lin D, Chang YJ, Strauss III JF, Miller WL (1993) The human peripheral benzodiazepine receptor gene: Cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. Genomics 18:643-650.
    • (1993) Genomics , vol.18 , pp. 643-650
    • Lin, D.1    Chang, Y.J.2    Strauss J.F. III3    Miller, W.L.4
  • 28
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004-1007.
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 29
    • 0033605114 scopus 로고    scopus 로고
    • Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse Leydig tumor cells. Involvement of the steroidogenic acute regulatory (STAR) protein
    • Manna PR, Tena-Sempere M, Huhtaniemi IT (1999) Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse Leydig tumor cells. Involvement of the steroidogenic acute regulatory (STAR) protein. J Biol Chem 274:5909-5918.
    • (1999) J Biol Chem , vol.274 , pp. 5909-5918
    • Manna, P.R.1    Tena-Sempere, M.2    Huhtaniemi, I.T.3
  • 30
    • 0027381252 scopus 로고
    • Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain
    • Mellon SH, Deschepper CF (1993) Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res 629:283-292.
    • (1993) Brain Res , vol.629 , pp. 283-292
    • Mellon, S.H.1    Deschepper, C.F.2
  • 31
    • 0036133869 scopus 로고    scopus 로고
    • Neurosteroids: Biochemistry and clinical significance
    • Mellon SH, Griffin LD (2002) Neurosteroids: Biochemistry and clinical significance. Trends Endocrinol Metab 13:35-43.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 35-43
    • Mellon, S.H.1    Griffin, L.D.2
  • 33
    • 0026649978 scopus 로고
    • Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: Regulation by a mitochondrial diazepam binding inhibitor receptor
    • Papadopoulos V, Guarneri P, Kreuger KE, Guidotti A, Costa E (1992) Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: Regulation by a mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sci USA 89:5113-5117.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5113-5117
    • Papadopoulos, V.1    Guarneri, P.2    Kreuger, K.E.3    Guidotti, A.4    Costa, E.5
  • 35
    • 0037023245 scopus 로고    scopus 로고
    • Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats
    • Sakamoto H, Ukena K, Tsutsui K (2002) Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats. Neurosci Lett 322:111-115.
    • (2002) Neurosci Lett , vol.322 , pp. 111-115
    • Sakamoto, H.1    Ukena, K.2    Tsutsui, K.3
  • 37
    • 0034899563 scopus 로고    scopus 로고
    • Tracking the role of a star in the sky of the new millennium
    • Stocco DM (2001) Tracking the role of a star in the sky of the new millennium. Mol Endocrinol 15:1245-1254.
    • (2001) Mol Endocrinol , vol.15 , pp. 1245-1254
    • Stocco, D.M.1
  • 38
    • 0030047248 scopus 로고    scopus 로고
    • Regulation of the acute production of steroids in steroidogenic cells
    • Stocco DM, Clark BJ (1996) Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244.
    • (1996) Endocr Rev , vol.17 , pp. 221-244
    • Stocco, D.M.1    Clark, B.J.2
  • 39
    • 0025941096 scopus 로고
    • The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors
    • Stocco DM, Sodeman TC (1991) The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors. J Biol Chem 266:19731-19738.
    • (1991) J Biol Chem , vol.266 , pp. 19731-19738
    • Stocco, D.M.1    Sodeman, T.C.2
  • 41
    • 0028819993 scopus 로고
    • Structure of the human steroidogenic acute regulatory protein (STAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity
    • Sugawara T, Lin D, Holt JA, Martin KO, Javitt NB, Miller WL, Strauss III JF (1995b) Structure of the human steroidogenic acute regulatory protein (STAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity. Biochemistry 34:12506-12512.
    • (1995) Biochemistry , vol.34 , pp. 12506-12512
    • Sugawara, T.1    Lin, D.2    Holt, J.A.3    Martin, K.O.4    Javitt, N.B.5    Miller, W.L.6    Strauss J.F. III7
  • 42
    • 0028948819 scopus 로고
    • Ethanol inhibition of inducible nitric oxide synthase activity in C6 glioma cells
    • Syapin PJ (1995) Ethanol inhibition of inducible nitric oxide synthase activity in C6 glioma cells. Alcohol Clin Exp Res 19:262-267.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 262-267
    • Syapin, P.J.1
  • 43
    • 0035697669 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression in mesencephalic astrocyte cultures
    • Syapin PJ, Koss JS, Cutler CY (2001) Inducible nitric oxide synthase expression in mesencephalic astrocyte cultures. Proc West Pharmacol Soc 44:117-119.
    • (2001) Proc West Pharmacol Soc , vol.44 , pp. 117-119
    • Syapin, P.J.1    Koss, J.S.2    Cutler, C.Y.3
  • 44
    • 0034064138 scopus 로고    scopus 로고
    • Structure lipid transport mechanism of a StAR-related domain
    • Tsujishita Y, Hurley JH (2000) Structure lipid transport mechanism of a StAR-related domain. Nat Struct Biol 7:408-414.
    • (2000) Nat Struct Biol , vol.7 , pp. 408-414
    • Tsujishita, Y.1    Hurley, J.H.2
  • 45
    • 0034029877 scopus 로고    scopus 로고
    • Novel brain function: Biosynthesis and actions of neurosteroids in neurons
    • Tsutsui K, Ukena K, Usui M, Sakamoto H, Takase M (2000) Novel brain function: Biosynthesis and actions of neurosteroids in neurons. Neurosci Res 36:261-273.
    • (2000) Neurosci Res , vol.36 , pp. 261-273
    • Tsutsui, K.1    Ukena, K.2    Usui, M.3    Sakamoto, H.4    Takase, M.5
  • 46
    • 85011436398 scopus 로고    scopus 로고
    • Cytochrome P450 sidechain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats
    • Ukena K, Usui M, Kohchi C, Tsutsui K (1998) Cytochrome P450 sidechain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats. Endocrinology 139:137-147.
    • (1998) Endocrinology , vol.139 , pp. 137-147
    • Ukena, K.1    Usui, M.2    Kohchi, C.3    Tsutsui, K.4
  • 47
    • 85047676517 scopus 로고    scopus 로고
    • 4-isomerase in the rat Purkinje neuron during neonatal life
    • 4-isomerase in the rat Purkinje neuron during neonatal life. Endocrinology 140:805-813.
    • (1999) Endocrinology , vol.140 , pp. 805-813
    • Ukena, K.1    Kohchi, C.2    Tsutsui, K.3
  • 50
    • 0035103695 scopus 로고    scopus 로고
    • Steroidogenic factor-1 expression in marmoset rat hippocampus: Co-localization with StAR and aromatase
    • Wehrenberg U, Prange-Kiel J, Rune GM (2001) Steroidogenic factor-1 expression in marmoset rat hippocampus: Co-localization with StAR and aromatase. J Neurochem 76:1879-1886.
    • (2001) J Neurochem , vol.76 , pp. 1879-1886
    • Wehrenberg, U.1    Prange-Kiel, J.2    Rune, G.M.3
  • 51
    • 0033305132 scopus 로고    scopus 로고
    • Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain
    • Zwain IH, Yen SS (1999) Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 140:3843-3852.
    • (1999) Endocrinology , vol.140 , pp. 3843-3852
    • Zwain, I.H.1    Yen, S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.