Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 10, 2002, Pages 1181-1188

  Murphy, Stephanie J ^a   Littleton Kearney, Marguerite T ^a   Hurn, Patricia D ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Experimental stroke; Hormone replacement therapy; Progesterone

Indexed keywords

CARBON 14; IODOPHENAZONE; PROGESTERONE; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; IMAGE ANALYSIS; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RAT; REPERFUSION INJURY; STAINING;

EID: 0036791875     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000037990.07114.07     Document Type: Article

References (57)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-166
2. Alkayed NJ, Murphy SJ, Traystman RJ, Hurn PD (2000) Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 31:161-168
3. Asbury ET, Fritts ME, Horton JE, Isaac WL (1998) Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat. Behav Brain Res 97:99-106
4. Betz AL, Coester HC (1990a) Effects of steroids on edema and sodium uptake of the brain during focal ischemia in rats. Stroke 21:1199-1204
5. Betz AL, Coester HC (1990b) Effect of steroid therapy on ischaemic brain oedema and blood to brain sodium transport. Acta Neurochir Suppl (Wein) 51:256-258
6. Bramlett HM, Dietrich WD (2001) Neuropathological protection after traumatic brain injury in intact female rats versus males or ovariectomized females. J Neurotrauma 18:891-900
7. Butcher RL, Collins WE, Fugo NW (1974) Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17β throughout the 4-day estrous cycle of the rat. Endocrinology 94:1704-1708
8. Cervantes M, Gonzalez-Vidal MD, Ruelas R, Escobar A, Morali G (2002) Neuroprotective effects of progesterone on damage elicited by acute global cerebral ischemia in neurons of the caudate nucleus. Arch Med Res 33:6-14
9. Chen J, Chopp M, Li Y (1999) Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 171:24-30
10. Galani R, Hoffman SW, Stein DG (2001) Effects of the duration of progesterone treatment on the resolution of cerebral edema induced by cortical contusions in rats. Restor Neurol Neurosci 18:161-166
11. Gillum LA, Mamidipudi SK, Johnston SC (2000) Ischemic stroke risk with oral contraceptives: a meta-analysis. JAMA 284:72-78
12. Gonzalez-Vidal MD, Cervera-Gaviria M, Ruelas R, Escobar A, Morali G, Cervantes M (1998) Progesterone: protective effects on cat hippocampal neuronal damage due to acute global cerebral ischemia. Arch Med Res 29:117-124
13. Grattan DR, Rocca MS, Strauss KI, Sagrillo CA, Selmanoff M, McCarthy MM (1996) GABAergic neuronal activity and mRNA levels for both forms of glutamic acid decarboxylase (GAD65 and GAD67) are reduced in he diagonal band of Broca during the afternoon of proestrus. Brain Res 733:46-55
14. Green PS, Simpkins JW (2000) Neuroprotective effects of estrogens: potential mechanisms of action. Int J Dev Neurosci 18:347-358
15. Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Rosner B, Speizer FE, Hennekens CH (1996) Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 335:453-461
16. Grodstein F, Manson JE, Colditz GA, Willett WC, Speizer FE, Stampfer MJ (2000) A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 133:933-941
17. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E (1998) Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. JAMA 280:605-613
18. Hurn PD, Littleton-Kearney MT, Kirsch JR, Dharmarajan AM, Traystman RJ (1995) Postischemic cerebral blood flow recovery in the female: effect of 17β-estradiol. J Cereb Blood Flow Metab 15:666-672
19. Hurn PD, Alkayed NJ, Toung TJK, Traystman RJ, Crain BJ, Nelson RJ, Korach KS (1998) Female vs male: injury in experimental stroke. In: Pharmacology of cerebral ischemia (Krieglstein J, ed), Stuttgart, Germany: Medpharm Scientific Publishing, pp 379-386
20. Jiang CW, Sarrel PM, Lindsay DC, Poole-Wilson PA, Collins P (1992) Progesterone induces endothelium-independent relaxation of rabbit coronary artery in vitro. Eur J Pharmacol 211:163-167
21. Jiang N, Chopp M, Stein D, Feit H (1996) Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res 735:101-107
22. a receptor binding in female rat brain. J Steroid Biochem Molec Biol 38:141-147
23. Jussofie A, Korner I, Schell C, Hiemke C (1995) Time course of the effects of steroid hormone deprivation elicited by ovariectomy or ovariectomy plus adrenalectomy on the affinity and density of GABA binding sites in distinct rat brain areas. Exp Clin Endocrinol Diabetes 103:196-204
24. Kagstrom E, Smith ML, Siesjo BK (1983) Local cerebral blood flow in the recovery period following complete cerebral ischemia in the rat. J Cereb Blood Flow Metab 3:170-182
25. Karas RH, van Eickels M, Lydon JP, Roddy S, Kwoun M, Aronovitz M, Baur WE, Conneely O, O'Malley BW, Mendelsohn ME (2001) A complex role for the progesterone receptor in the response to vascular injury. J Clin Invest 108:611-618
26. Kumon Y, Kim SC, Tompkins P, Stevens A, Sakaki S, Loftus CM (2000) Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J Neurosurg 92:848-852
27. Lee WS, Harder JA, Yoshizumi M, Lee ME, Haber E (1997) Progesterone inhibits arterial smooth muscle cell proliferation. Nat Med 3:1005-1008
28. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
29. Lu CP, Cho E, Marx GF, Gibson J (1996) Cerebral hemodynamic response to female sex hormones in the rat. Microvasc Res 51:393-395
30. a receptor: mechanism of action and physiological significance. Prog Neurobiol 38:379-395
31. McCarthy MM (1995) Frank A. Beach Award. Functional significance of steroid modulation of GABAergic neurotransmission: analysis at the behavioral, cellular, and molecular levels. Horm Behav 29:131-140
32. Moffatt CA, Rissman EF, Shupnik MA, Blaustein JD (1998) Induction of progestin receptors by estradiol in the forebrain of estrogen receptor-alpha gene-disrupted mice. J Neurosci 18:9556-9563
33. Moran MH, Smith SS (1998) Progesterone withdrawal. Part I: proconvulsant effects. Brain Res 807:84-90
34. Murphy SJ, Traystman RJ, Hurn PD (2000) Progesterone exacerbates striatal stroke injury in progesterone-deficient female animals. Stroke 31:1173-1178
35. Nequin LG, Alvarez J, Schwartz NB (1979) Measurement of serum steroid and gonadotropin levels and uterine and ovarian variables throughout 4 day and 5 day estrous cycles in the rat. Biol Reprod 20:659-670
36. Roof RL, Hall ED (2000) Gender differences in acute CNS trauma and stroke: Neuroprotective effects of estrogen and progesterone. J Neurotrauma 17:367-388
37. Roof RL, Duvdevani R, Braswell L, Stein DG (1994) Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats. Exp Neurol 129:64-69
38. Roof RL, Duvdevani R, Heyburn JW, Stein DG (1996) Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp Neurol 138:246-251
39. Roof RL, Hoffman SW, Stein DG (1997) Progesterone protects against lipid peroxidation following traumatic brain injury in rats. Mol Chem Neuropathol 31:1-11
40. Rusa R, Alkayed NJ, Crain BJ, Traystman RJ, Kimes AS, London ED, Klaus JA, Hurn PD (1999) 17β-estradiol reduces stroke injury in estrogen-deficient female animals. Stroke 30:1665-1670
41. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL (1997) Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 87:724-730
42. Smith SS (1991) Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells. Neuroscience 42:309-320
43. Smith SS (1994) Female sex steroid hormones: from receptors to networks to performance-actions on the sensorimotor system. Prog Neurobiol 44:55-86
44. Smith SS, Waterhouse BD, Chapin JK, Woodward DJ (1987) Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action. Brain Res 400:353-359
45. Smith SS, Gong QH, Hsu FC, Markowitz RS, ffrench-Mullen JM, Li X (1998) GABA(A) receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392:926-930
46. Stein DG (2001) Brain damage, sex hormones and recovery: a new role for progesterone and estrogen? TRENDS Neurosci 24:386-391
47. Stein DF, Roof RL, Fulop ZL (1999) Brain damage, sex hormones and recovery. In: Cognitive neurorehabilitation: a comprehensive approach (Stuss DT, Winocur G, Roberson IH, eds), Cambridge, U.K.: Cambridge University Press, pp 73-93
48. Sutter-Dub MT, Leclercq R, Sutter BC, Jacquot R (1974) Plasma glucose, progesterone and immunoreactive insulin levels in the lactating rat. Horm Metab Res 6:297-300
49. Tischkau SA, Ramirez VD (1993) A specific membrane binding protein for progesterone in rat brain: sex differences and induction by estrogen. Proc Natl Acad Sci U S A 90:1285-1289
50. Toung TJ, Traystman RJ, Hurn PD (1998) Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 29:1666-1670
51. Vink R, Nimmo AJ, Cernak I (2001) An overview of new and novel pharmacotherapies for use in traumatic brain injury. Clin Exp Pharmacol Physiol 28:919-921
52. Weiland NG (1992) Glutamic acid decarboxylase messenger ribonucleic acid is regulated by estradiol and progesterone in the hippocampus. Endocrinology 131:2697-2702
53. a receptor are regulated by progesterone in subfields of the hippocampus. Molec Brain Res 32:271-278
54. Wenger NK, Speroff L, Packard B (1993) Cardiovascular health and disease in women. N Engl J Med 329:247-256
55. Wiest WG (1970) Progesterone and 20α-hydroxypregn-4-en-3-one in plasma, ovaries and uteri during pregnancy in the rat. Endocrinology 87:43-48
56. World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception (1998) Cardiovascular disease and the use of oral and injectable progestogen-only contraceptives and combined injectable contraceptives: results of an international, multicenter, case-control study. Contraception 57:315-324
57. Wright DW, Bauer ME, Hoffman SW, Stein DG (2001) Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. J Neurotrauma 18:901-999