-
1
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
2
-
-
10344259136
-
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter
-
Andrejeva J., Childs K.S., Young D.F., Carlos T.S., Stock N., Goodbourn S., Randall R.E. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl. Acad. Sci. USA 2004, 101:17264-17269.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 17264-17269
-
-
Andrejeva, J.1
Childs, K.S.2
Young, D.F.3
Carlos, T.S.4
Stock, N.5
Goodbourn, S.6
Randall, R.E.7
-
3
-
-
33749529385
-
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation
-
Bibeau-Poirier A., Gravel S.P., Clément J.F., Rolland S., Rodier G., Coulombe P., Hiscott J., Grandvaux N., Meloche S., Servant M.J. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. J.Immunol. 2006, 177:5059-5067.
-
(2006)
J.Immunol.
, vol.177
, pp. 5059-5067
-
-
Bibeau-Poirier, A.1
Gravel, S.P.2
Clément, J.F.3
Rolland, S.4
Rodier, G.5
Coulombe, P.6
Hiscott, J.7
Grandvaux, N.8
Meloche, S.9
Servant, M.J.10
-
4
-
-
41949092999
-
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
-
Clément J.F., Bibeau-Poirier A., Gravel S.P., Grandvaux N., Bonneil E., Thibault P., Meloche S., Servant M.J. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J.Virol. 2008, 82:3984-3996.
-
(2008)
J.Virol.
, vol.82
, pp. 3984-3996
-
-
Clément, J.F.1
Bibeau-Poirier, A.2
Gravel, S.P.3
Grandvaux, N.4
Bonneil, E.5
Thibault, P.6
Meloche, S.7
Servant, M.J.8
-
5
-
-
25444495693
-
The yin and yang of type I interferon activity in bacterial infection
-
Decker T., Müller M., Stockinger S. The yin and yang of type I interferon activity in bacterial infection. Nat. Rev. Immunol. 2005, 5:675-687.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 675-687
-
-
Decker, T.1
Müller, M.2
Stockinger, S.3
-
6
-
-
84862812890
-
RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex
-
e15
-
Deng Y.Z., Yao F., Li J.J., Mao Z.F., Hu P.T., Long L.Y., Li G., Ji X.D., Shi S., Guan D.X., et al. RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology 2012, 142:812-823. e15.
-
(2012)
Gastroenterology
, vol.142
, pp. 812-823
-
-
Deng, Y.Z.1
Yao, F.2
Li, J.J.3
Mao, Z.F.4
Hu, P.T.5
Long, L.Y.6
Li, G.7
Ji, X.D.8
Shi, S.9
Guan, D.X.10
-
7
-
-
0038393016
-
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
-
Fitzgerald K.A., McWhirter S.M., Faia K.L., Rowe D.C., Latz E., Golenbock D.T., Coyle A.J., Liao S.M., Maniatis T. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 2003, 4:491-496.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
McWhirter, S.M.2
Faia, K.L.3
Rowe, D.C.4
Latz, E.5
Golenbock, D.T.6
Coyle, A.J.7
Liao, S.M.8
Maniatis, T.9
-
8
-
-
0036222620
-
Human Toll-like receptor 4 recognizes host-specific LPS modifications
-
Hajjar A.M., Ernst R.K., Tsai J.H., Wilson C.B., Miller S.I. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat. Immunol. 2002, 3:354-359.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 354-359
-
-
Hajjar, A.M.1
Ernst, R.K.2
Tsai, J.H.3
Wilson, C.B.4
Miller, S.I.5
-
9
-
-
28644433321
-
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
-
Huang J., Liu T., Xu L.G., Chen D., Zhai Z., Shu H.B. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J. 2005, 24:4018-4028.
-
(2005)
EMBO J.
, vol.24
, pp. 4018-4028
-
-
Huang, J.1
Liu, T.2
Xu, L.G.3
Chen, D.4
Zhai, Z.5
Shu, H.B.6
-
10
-
-
0035047145
-
Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways
-
Iwamura T., Yoneyama M., Yamaguchi K., Suhara W., Mori W., Shiota K., Okabe Y., Namiki H., Fujita T. Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 2001, 6:375-388.
-
(2001)
Genes Cells
, vol.6
, pp. 375-388
-
-
Iwamura, T.1
Yoneyama, M.2
Yamaguchi, K.3
Suhara, W.4
Mori, W.5
Shiota, K.6
Okabe, Y.7
Namiki, H.8
Fujita, T.9
-
11
-
-
0038476601
-
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
-
Karaghiosoff M., Steinborn R., Kovarik P., Kriegshäuser G., Baccarini M., Donabauer B., Reichart U., Kolbe T., Bogdan C., Leanderson T., et al. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat. Immunol. 2003, 4:471-477.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 471-477
-
-
Karaghiosoff, M.1
Steinborn, R.2
Kovarik, P.3
Kriegshäuser, G.4
Baccarini, M.5
Donabauer, B.6
Reichart, U.7
Kolbe, T.8
Bogdan, C.9
Leanderson, T.10
-
12
-
-
0037022639
-
Interferon regulatory factor-3 is an invivo target of DNA-PK
-
Karpova A.Y., Trost M., Murray J.M., Cantley L.C., Howley P.M. Interferon regulatory factor-3 is an invivo target of DNA-PK. Proc. Natl. Acad. Sci. USA 2002, 99:2818-2823.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2818-2823
-
-
Karpova, A.Y.1
Trost, M.2
Murray, J.M.3
Cantley, L.C.4
Howley, P.M.5
-
13
-
-
70350484946
-
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
-
Kovalenko A., Kim J.C., Kang T.B., Rajput A., Bogdanov K., Dittrich-Breiholz O., Kracht M., Brenner O., Wallach D. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J.Exp. Med. 2009, 206:2161-2177.
-
(2009)
J.Exp. Med.
, vol.206
, pp. 2161-2177
-
-
Kovalenko, A.1
Kim, J.C.2
Kang, T.B.3
Rajput, A.4
Bogdanov, K.5
Dittrich-Breiholz, O.6
Kracht, M.7
Brenner, O.8
Wallach, D.9
-
14
-
-
54449099430
-
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression
-
Kubota T., Matsuoka M., Chang T.H., Tailor P., Sasaki T., Tashiro M., Kato A., Ozato K. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J.Biol. Chem. 2008, 283:25660-25670.
-
(2008)
J.Biol. Chem.
, vol.283
, pp. 25660-25670
-
-
Kubota, T.1
Matsuoka, M.2
Chang, T.H.3
Tailor, P.4
Sasaki, T.5
Tashiro, M.6
Kato, A.7
Ozato, K.8
-
15
-
-
37349111560
-
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling
-
Li S., Wang L., Berman M.A., Zhang Y., Dorf M.E. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol. Cell 2006, 24:497-509.
-
(2006)
Mol. Cell
, vol.24
, pp. 497-509
-
-
Li, S.1
Wang, L.2
Berman, M.A.3
Zhang, Y.4
Dorf, M.E.5
-
16
-
-
84863262889
-
EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex
-
Li G., Ji X.D., Gao H., Zhao J.S., Xu J.F., Sun Z.J., Deng Y.Z., Shi S., Feng Y.X., Zhu Y.Q., et al. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nat Commun 2012, 3:667.
-
(2012)
Nat Commun
, vol.3
, pp. 667
-
-
Li, G.1
Ji, X.D.2
Gao, H.3
Zhao, J.S.4
Xu, J.F.5
Sun, Z.J.6
Deng, Y.Z.7
Shi, S.8
Feng, Y.X.9
Zhu, Y.Q.10
-
17
-
-
0031893220
-
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
-
Lin R., Heylbroeck C., Pitha P.M., Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 1998, 18:2986-2996.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2986-2996
-
-
Lin, R.1
Heylbroeck, C.2
Pitha, P.M.3
Hiscott, J.4
-
18
-
-
1642297150
-
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation
-
Mori M., Yoneyama M., Ito T., Takahashi K., Inagaki F., Fujita T. Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J.Biol. Chem. 2004, 279:9698-9702.
-
(2004)
J.Biol. Chem.
, vol.279
, pp. 9698-9702
-
-
Mori, M.1
Yoneyama, M.2
Ito, T.3
Takahashi, K.4
Inagaki, F.5
Fujita, T.6
-
19
-
-
0242574745
-
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
-
Qin B.Y., Liu C., Lam S.S., Srinath H., Delston R., Correia J.J., Derynck R., Lin K. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat. Struct. Biol. 2003, 10:913-921.
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 913-921
-
-
Qin, B.Y.1
Liu, C.2
Lam, S.S.3
Srinath, H.4
Delston, R.5
Correia, J.J.6
Derynck, R.7
Lin, K.8
-
20
-
-
77951645463
-
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells
-
Qiu Y., Mao T., Zhang Y., Shao M., You J., Ding Q., Chen Y., Wu D., Xie D., Lin X., et al. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci. Signal. 2010, 3:ra7.
-
(2010)
Sci. Signal.
, vol.3
-
-
Qiu, Y.1
Mao, T.2
Zhang, Y.3
Shao, M.4
You, J.5
Ding, Q.6
Chen, Y.7
Wu, D.8
Xie, D.9
Lin, X.10
-
21
-
-
33744499683
-
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1
-
Saitoh T., Tun-Kyi A., Ryo A., Yamamoto M., Finn G., Fujita T., Akira S., Yamamoto N., Lu K.P., Yamaoka S. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat. Immunol. 2006, 7:598-605.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 598-605
-
-
Saitoh, T.1
Tun-Kyi, A.2
Ryo, A.3
Yamamoto, M.4
Finn, G.5
Fujita, T.6
Akira, S.7
Yamamoto, N.8
Lu, K.P.9
Yamaoka, S.10
-
22
-
-
0038434274
-
Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock
-
Sakaguchi S., Negishi H., Asagiri M., Nakajima C., Mizutani T., Takaoka A., Honda K., Taniguchi T. Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. Biochem. Biophys. Res. Commun. 2003, 306:860-866.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 860-866
-
-
Sakaguchi, S.1
Negishi, H.2
Asagiri, M.3
Nakajima, C.4
Mizutani, T.5
Takaoka, A.6
Honda, K.7
Taniguchi, T.8
-
23
-
-
79956141306
-
Interferon regulatory factors in human lupus pathogenesis
-
Salloum R., Niewold T.B. Interferon regulatory factors in human lupus pathogenesis. Transl. Res. 2011, 157:326-331.
-
(2011)
Transl. Res.
, vol.157
, pp. 326-331
-
-
Salloum, R.1
Niewold, T.B.2
-
24
-
-
0038660668
-
Identification of the minimal phosphoacceptor site required for invivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
-
Servant M.J., Grandvaux N., tenOever B.R., Duguay D., Lin R., Hiscott J. Identification of the minimal phosphoacceptor site required for invivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J.Biol. Chem. 2003, 278:9441-9447.
-
(2003)
J.Biol. Chem.
, vol.278
, pp. 9441-9447
-
-
Servant, M.J.1
Grandvaux, N.2
Tenoever, B.R.3
Duguay, D.4
Lin, R.5
Hiscott, J.6
-
25
-
-
0038363463
-
Triggering the interferon antiviral response through an IKK-related pathway
-
Sharma S., tenOever B.R., Grandvaux N., Zhou G.P., Lin R., Hiscott J. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003, 300:1148-1151.
-
(2003)
Science
, vol.300
, pp. 1148-1151
-
-
Sharma, S.1
Tenoever, B.R.2
Grandvaux, N.3
Zhou, G.P.4
Lin, R.5
Hiscott, J.6
-
26
-
-
84863271200
-
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway
-
Shi S., Deng Y.Z., Zhao J.S., Ji X.D., Shi J., Feng Y.X., Li G., Li J.J., Zhu D., Koeffler H.P., et al. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J.Biol. Chem. 2012, 287:7845-7858.
-
(2012)
J.Biol. Chem.
, vol.287
, pp. 7845-7858
-
-
Shi, S.1
Deng, Y.Z.2
Zhao, J.S.3
Ji, X.D.4
Shi, J.5
Feng, Y.X.6
Li, G.7
Li, J.J.8
Zhu, D.9
Koeffler, H.P.10
-
27
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140:805-820.
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
28
-
-
17644402442
-
Type I interferons (alpha/beta) in immunity and autoimmunity
-
Theofilopoulos A.N., Baccala R., Beutler B., Kono D.H. Type I interferons (alpha/beta) in immunity and autoimmunity. Annu. Rev. Immunol. 2005, 23:307-336.
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 307-336
-
-
Theofilopoulos, A.N.1
Baccala, R.2
Beutler, B.3
Kono, D.H.4
-
29
-
-
68949206434
-
Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach
-
Witt J., Barisic S., Schumann E., Allgöwer F., Sawodny O., Sauter T., Kulms D. Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach. BMC Syst. Biol. 2009, 3:71.
-
(2009)
BMC Syst. Biol.
, vol.3
, pp. 71
-
-
Witt, J.1
Barisic, S.2
Schumann, E.3
Allgöwer, F.4
Sawodny, O.5
Sauter, T.6
Kulms, D.7
-
30
-
-
0035930630
-
Protein phosphatase 2A interacts with and directly dephosphorylates RelA
-
Yang J., Fan G.H., Wadzinski B.E., Sakurai H., Richmond A. Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J.Biol. Chem. 2001, 276:47828-47833.
-
(2001)
J.Biol. Chem.
, vol.276
, pp. 47828-47833
-
-
Yang, J.1
Fan, G.H.2
Wadzinski, B.E.3
Sakurai, H.4
Richmond, A.5
-
31
-
-
77952566304
-
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
-
Yang P., An H., Liu X., Wen M., Zheng Y., Rui Y., Cao X. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat. Immunol. 2010, 11:487-494.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 487-494
-
-
Yang, P.1
An, H.2
Liu, X.3
Wen, M.4
Zheng, Y.5
Rui, Y.6
Cao, X.7
-
32
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., Fujita T. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004, 5:730-737.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
Shinobu, N.4
Imaizumi, T.5
Miyagishi, M.6
Taira, K.7
Akira, S.8
Fujita, T.9
-
33
-
-
78650130030
-
The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3
-
Yu Y., Hayward G.S. The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3. Immunity 2010, 33:863-877.
-
(2010)
Immunity
, vol.33
, pp. 863-877
-
-
Yu, Y.1
Hayward, G.S.2
-
34
-
-
55549146091
-
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
-
Zhang M., Tian Y., Wang R.P., Gao D., Zhang Y., Diao F.C., Chen D.Y., Zhai Z.H., Shu H.B. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Res. 2008, 18:1096-1104.
-
(2008)
Cell Res.
, vol.18
, pp. 1096-1104
-
-
Zhang, M.1
Tian, Y.2
Wang, R.P.3
Gao, D.4
Zhang, Y.5
Diao, F.C.6
Chen, D.Y.7
Zhai, Z.H.8
Shu, H.B.9
-
35
-
-
64149123275
-
The TAK1-JNK cascade is required for IRF3 function in theinnate immune response
-
Zhang B., Li M., Chen L., Yang K., Shan Y., Zhu L., Sun S., Li L., Wang C. The TAK1-JNK cascade is required for IRF3 function in theinnate immune response. Cell Res. 2009, 19:412-428.
-
(2009)
Cell Res.
, vol.19
, pp. 412-428
-
-
Zhang, B.1
Li, M.2
Chen, L.3
Yang, K.4
Shan, Y.5
Zhu, L.6
Sun, S.7
Li, L.8
Wang, C.9
-
36
-
-
53349168904
-
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
-
Zhong B., Yang Y., Li S., Wang Y.Y., Li Y., Diao F., Lei C., He X., Zhang L., Tien P., Shu H.B. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008, 29:538-550.
-
(2008)
Immunity
, vol.29
, pp. 538-550
-
-
Zhong, B.1
Yang, Y.2
Li, S.3
Wang, Y.Y.4
Li, Y.5
Diao, F.6
Lei, C.7
He, X.8
Zhang, L.9
Tien, P.10
Shu, H.B.11
|