The AGC kinase SGK1 regulates T H 1 and T H 2 differentiation downstream of the mTORC2 complex

Nature Immunology

Volumn 15, Issue 5, 2014, Pages 457-464

  Heikamp, Emily B ^a   Patel, Chirag H ^a   Collins, Sam ^b   Waickman, Adam ^a   Oh, Min Hee ^b   Sun, Im Hong ^a   Illei, Peter ^b   Sharma, Archna ^c   Naray Fejes Toth, Aniko ^d   Fejes Toth, Geza ^d   Misra Sen, Jyoti ^c   Horton, Maureen R ^b   Powell, Jonathan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; ANIMALS; ASTHMA; CELL DIFFERENTIATION; CELLS, CULTURED; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; GENE EXPRESSION REGULATION; IMMEDIATE-EARLY PROTEINS; INTERFERON-GAMMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; POXVIRIDAE INFECTIONS; PROTEIN-SERINE-THREONINE KINASES; T CELL TRANSCRIPTION FACTOR 1; TH1 CELLS; TH2 CELLS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR BURDEN; UBIQUITIN-PROTEIN LIGASES; VACCINIA VIRUS;

EID: 84899094151     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2867     Document Type: Article

References (41)

1. Pearce L.R. Komander D. &Alessi D.R. The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell. Biol. 11 9-22 (2010
2. Biondi R.M. Kieloch A. Currie R.A. Deak M. &Alessi D.R. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK but not PKB. EMBO J. 20 4380-4390 (2001
3. Garcia-Martinez J.M. &Alessi D.R. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- And glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416 375-385 (2008
4. Yan L. Mieulet V. &Lamb R.F. mTORC2 is the hydrophobic motif kinase for SGK1. Biochem. J. 416 e19-e21 (2008
5. Debonneville C. et al. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression. EMBO J. 20 7052-7059 (2001
6. Ichimura T. et al. 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. J. Biol. Chem. 280 13187-13194 (2005
7. Di Pietro N. et al. Serum- And glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1. Mol. Endocrinol. 24 370-380 (2010
8. Brunet A. et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21 952-965 (2001
9. Sakoda H. et al. Differing roles of Akt and serum- And glucocorticoid-regulated kinase in glucose metabolism DNA synthesis and oncogenic activity. J. Biol. Chem. 278 25802-25807 (2003
10. Wiemuth D. et al. Interaction of serum- And glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One 5 e12163 (2010
11. Fejes-Toth G. Frindt G. Naray-Fejes-Toth A. &Palmer L.G. Epithelial Na+ channel activation and processing in mice lacking SGK1. Am. J. Physiol. Renal Physiol. 294 F1298-F1305 (2008
12. Wu C. et al. Induction of pathogenic T17 cells by inducible salt-sensing kinase SGK1. Nature 496 513-517 (2013
13. Kleinewietfeld M. et al. Sodium chloride drives autoimmune disease by the induction of pathogenic T17 cells. Nature 496 518-522 (2013
14. Zoncu R. Efeyan A. &Sabatini D.M. mTOR: From growth signal integration to cancer diabetes and ageing. Nat. Rev. Mol. Cell. Biol. 12 21-35 (2011
15. Powell J.D. Pollizzi K.N. Heikamp E.B. &Horton M.R. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 30 39-68 (2012
16. Delgoffe G.M. et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30 832-844 (2009
17. Zhang S. et al. Constitutive reductions in mTOR alter cell size immune cell development and antibody production. Blood 117 1228-1238 (2011
18. Delgoffe G.M. et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12 295-303 (2011
19. Lee K. et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32 743-753 (2010
20. Murray J.T. et al. Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem. J. 384 477-488 (2004
21. Lu M. Wang J. Ives H.E. &Pearce D. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J. Biol. Chem. 286 30647-30654 (2011
22. Feldman M.E. et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7 e38 (2009
23. Sarbassov D.D. Guertin D.A. Ali S.M. &Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 1098-1101 (2005
24. Guertin D.A. et al. Ablation in mice of the mTORC components raptor rictor or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha but not S6K1. Dev. Cell 11 859-871 (2006
25. Jacinto E. et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127 125-137 (2006
26. Oliver P.M. et al. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity 25 929-940 (2006
27. Fang D. et al. Dysregulation of T lymphocyte function in itchy mice: A role for Itch in TH2 differentiation. Nat. Immunol. 3 281-287 (2002
28. Li B. Tournier C. Davis R.J. &Flavell R.A. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J. 18 420-432 (1999
29. Huang T.J. et al. Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-?. J. Immunol. 166 207-217 (2001
30. Liu C. et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108 837-847 (2002
31. Yu Q. Sharma A. &Sen J.M. TCF1 and β-catenin regulate T cell development and function. Immunol. Res. 47 45-55 (2010
32. Yu Q. et al. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-?. Nat. Immunol. 10 992-999 (2009
33. Roose J. et al. Synergy between tumor suppressor APC and the β-catenin-Tcf4 target Tcf1. Science 285 1923-1926 (1999
34. Quezada S.A. et al. Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J. Exp. Med. 207 637-650 (2010
35. Suissa S. Ernst P. Benayoun S. Baltzan M. &Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. N. Engl. J. Med. 343 332-336 (2000
36. Fanta C.H. Asthma. N. Engl. J. Med. 360 1002-1014 (2009
37. Littenberg B. &Gluck E.H. A controlled trial of methylprednisolone in the emergency treatment of acute asthma. N. Engl. J. Med. 314 150-152 (1986
38. Sherk A.B. et al. Development of a small-molecule serum- And glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 68 7475-7483 (2008
39. Ackermann T.F. et al. EMD638683 a novel SGK inhibitor with antihypertensive potency. Cell Physiol. Biochem. 28 137-146 (2011
40. Kumar A. et al. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Mol. Cell Biol. 28 61-70 (2008
41. Daan de Boer J. et al. Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice. Am. J. Respir. Cell. Mol. Biol. 48 382-389 (2013