Interaction of serum- and Glucocorticoid regulated Kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Wiemuth, Dominik ^a   Lott, J Shaun ^b   Ly, Kevin ^a   Ke, Ying ^a   Teesdale Spittle, Paul ^c   Snyder, Peter M ^d   McDonald, Fiona J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 2; EPITHELIAL SODIUM CHANNEL; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UBIQUITIN PROTEIN LIGASE NEDD4; ESCRT PROTEIN; IMMEDIATE EARLY PROTEIN; NEDD4 UBIQUITIN PROTEIN LIGASES; PEPTIDE FRAGMENT; PROTEIN SERINE THREONINE KINASE; SERUM GLUCOCORTICOID REGULATED KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; TRYPTOPHAN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; IN VITRO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; WILD TYPE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME ACTIVATION; METABOLISM; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENZYME ACTIVATION; EPITHELIAL SODIUM CHANNEL; IMMEDIATE-EARLY PROTEINS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; TRYPTOPHAN; UBIQUITIN-PROTEIN LIGASES;

EID: 77957907781     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012163     Document Type: Article

References (34)

1. Garty H, Palmer LG (1997) Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77: 359-396.
2. Snyder PM, Steines JC, Olson DR (2004) Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference. J Biol Chem 279: 5042-5046.
3. + channel trafficking. Endocrinology 146: 5079-5085.
4. Hughey RP, Bruns JB, Kinlough CL, Harkleroad KL, Tong Q, et al. (2004) Epithelial sodium channels are activated by furin-dependent proteolysis. J Biol Chem 279: 18111-18114.
5. + channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. J Biol Chem 282: 6153-6160.
6. Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, et al. (1999) Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci USA 96: 2514-2519.
7. Snyder PM, Olson DR, Kabra R, Zhou R, Steines JC (2004) cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2. J Biol Chem 279: 45753-45758.
8. Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, et al. (2001) SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol 280: F303-F313.
9. Náray-Fejes-Tóth A, Canessa C, Cleaveland ES, Aldrich G, Fejes-Tóth G (1999) sgk is an aldosterone-induced kinase in the renal collecting duct. J Biol Chem 274: 16973-16978.
10. + channel regulation. Am J Physiol Renal Physiol 281: F469-F477.
11. McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, et al. (2002) Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. Am J Physiol Renal Physiol 283: F431-436.
12. Goulet CC, Volk KA, Adams CM, Prince LS, Stokes JB, et al. (1998) Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. J Biol Chem 273: 30012-30017.
13. Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, et al. (2008) Saltsensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol 295: F462-F470.
14. + channel by human Nedd4. J Biol Chem 276: 28321-28326.
15. Lott JS, Coddington-Lawson SJ, Teesdale-Spittle PH, McDonald FJ (2002) A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel. Biochem J 361: 481-488.
16. Asher C, Sinha I, Garty H (2003) Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance. Biochim Biophys Acta 1612: 59-64.
17. Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, et al. (2002) The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. Faseb J 16: U510-U531.
18. + channel. J Biol Chem 278: 20019-20028.
19. + channel. J Biol Chem 277: 5-8.
20. + channel cell surface expression. EMBO J 20: 7052-7059.
21. Snyder PM (2009) Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2. Sci Signal 2: pe41.
22. Liang X, Peters KW, Butterworth MB, Frizzell RA (2006) 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem 281: 16323-16332.
23. Zhou R, Snyder PM (2005) Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. J Biol Chem 280: 4518-4523.
24. Rauh R, Dinudom A, Fotia AB, Paulides M, Kumar S, et al. (2006) Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoidinducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflugers Arch 452: 290-299.
25. Asher C, Chigaev A, Garty H (2001) Characterization of interactions between Nedd4 and b and cENaC using surface plasmon resonance. Biochem Biophys Res Comm 286: 1228-1231.
26. Kobayashi T, Cohen P (1999) Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339 (Pt 2): 319-328.
27. Sheppard DN, Carson MR, Ostedgaard LS, Denning GM, Welsh MJ (1994) Expression of cystic fibrosis transmembrane conductance regulator in a model epithelium. Am J Physiol Lung Cell Mol Physiol 266: L405-L413.
28. Jennings MD, Blankley RT, Baron M, Golovanov AP, Avis JM (2007) Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex. J Biol Chem 282: 29032-29042.
29. Kobayashi T, Deak M, Morrice N, Cohen P (1999) Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoidinduced protein kinase. Biochem J 344: 189-197.
30. Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, et al. (2004) Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. Obes Res 12: 862-870.
31. Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, et al. (2003) Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A. Cardiovasc Res 57: 1079-1084.
32. +-channel subunits. Biochem J 345: 503-509.
33. Gill S, Hippel P (1989) Calculation of protein extinction coefficients from amino acid sequence data. Anal Biochem 182: 319-326.
34. Jönsson U, Fägerstam L, Ivarsson B, Johnsson B, Karlsson R, et al. (1991) Realtime biospecific interaction analysis using surface plasmon resonance and a sensor chip technology. Biotechniques 11: 620-627.