Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: Correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism

Epigenetics

Volumn 9, Issue 4, 2014, Pages 621-633

  Coppedè, Fabio ^a,b   Migheli, Francesca ^a,b   Lopomo, Angela ^a,c   Failli, Alessandra ^a,b   Legitimo, Annalisa ^a   Consolini, Rita ^a   Fontanini, Gabriella ^a   Sensi, Elisa ^a   Servadio, Adele ^a   Seccia, Massimo ^a   Zocco, Giuseppe ^a   Chiarugi, Massimo ^a   Spisni, Roberto ^a   Migliore, Lucia ^a,b  

^a UNIVERSITY OF PISA   (Italy)

^b ISTITUTO TOSCANO TUMORI   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

APC; CDKN2A; Colorectal Cancer; DNA methylation; Epigenetics; Folate metabolism; hMLH1; MGMT; Polymorphisms; RASSF1A

Indexed keywords

5, 10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); B RAF KINASE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CARBON METABOLISM; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; DNA POLYMORPHISM; DNMT3B GENE; FEMALE; FOLATE METABOLISM; GENE; GENE MUTATION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; MTR GENE; MTRR GENE; PROMOTER REGION; RFC1 GENE; TYMS GENE; VERY ELDERLY; BLOOD; CASE CONTROL STUDY; COLON; COLORECTAL TUMOR; GENETIC POLYMORPHISM; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; PATHOLOGY; RECTUM;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COLON; COLORECTAL NEOPLASMS; DNA METHYLATION; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; INTESTINAL MUCOSA; MALE; METABOLIC NETWORKS AND PATHWAYS; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RECTUM; VITAMIN B 12;

EID: 84899066134     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.27956     Document Type: Article

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