Kras Gene Mutation and RASSF1A, FHIT and MGMT Gene Promoter Hypermethylation: Indicators of Tumor Staging and Metastasis in Adenocarcinomatous Sporadic Colorectal Cancer in Indian Population

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Sinha, Rupal ^a,b   Hussain, Showket ^b   Mehrotra, Ravi ^b   Kumar, R Suresh ^b   Kumar, Kapil ^a   Pande, Pankaj ^a   Doval, Dinesh Chandra ^a   Basir, Seemi Farhat ^c   Bharadwaj, Mausumi ^b  

^a RAJIV GANDHI CANCER INSTITUTE AND RESEARCH CENTRE   (India)

^b INSTITUTE OF CYTOLOGY AND PREVENTIVE ONCOLOGY   (India)

^c JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CANCER INVASION; CANCER STAGING; CLINICAL FEATURE; CLINICAL INDICATOR; CODON; COLORECTAL CANCER; CONTROLLED STUDY; DEMOGRAPHY; DNA METHYLATION; DNA MODIFICATION; DNA POLYMORPHISM; DRINKING BEHAVIOR; EATING HABIT; FEMALE; FHIT GENE; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CORRELATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INDIAN; KRAS GENE; LIFESTYLE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MGMT GENE; PATHOLOGY; POPULATION RESEARCH; RASSF1A GENE; SMOKING; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ADENOCARCINOMA; ADULT; AGED; COLORECTAL NEOPLASMS; DIET; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA MUTATIONAL ANALYSIS; DNA REPAIR ENZYMES; FEMALE; HUMANS; INDIA; LIFE STYLE; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; NEOPLASM STAGING; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84875730328     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060142     Document Type: Article

References (54)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
2. Notani PN, (2001) Global variation in cancer incidence and mortality. Current Science 81: 465-474.
3. Jemal A, Bray F, (2011) Center MM, Ferlay J, Ward E, et al (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
4. Lao VV, Grady WM, (2011) Epigenetics and colorectal cancer. Nat Rev Gastroenterol Hepatol 8: 686-700.
5. Brink M, Weijenberg MP, De Goeij AF, Schouten LJ, Koedijk FD, et al. (2004) Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis 25: 1619-1628.
6. Brink M, de Goeij AF, Weijenberg MP, Roemen GM, Lentjes MH, et al. (2003) K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis 24: 703-710.
7. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 95: 6870-6875.
8. Abouzeid HE, Kassem AM, Abdel Wahab AH, El-mezayen HA, Sharad H, et al. (2011) Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors. Tumour Biol 32: 845-852.
9. Dammann R, Schagdarsurengin U, Strunnikova M, Rastetter M, Seidel C, et al. (2003) Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol Histopathol 18: 665-677.
10. van der Weyden L, Adams DJ, (2007) The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim Biophys Acta 1776: 58-85.
11. Dhillon VS, Shahid M, Husain SA, (2004) CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. Mol Cancer 3: 33.
12. Yin DT, Wang L, Sun J, Yin F, Yan Q, et al. (2010) Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma. Int J Clin Exp Pathol 3: 482-491.
13. Sidhu S, Deep JS, Sobti RC, Sharma VL, Thakur H, (2010) Methylation pattern of MGMT gene in relation to age, smoking, drinking and dietary habits as epigenetic biomarker in prostate cancer patients. Genetic Engineering and Biotechnology Journal GEBJ-8: 1-11.
14. Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, et al. (2011) MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes Control 22: 301-309.
15. Li Z, Fang ZY, Ding Y, Yao WT, Yang Y, et al. (2012) Amplifications of NCOA3 gene in colorectal cancers in a Chinese population. World J Gastroenterol 18: 855-860.
16. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, et al. (2010) Cancer Staging Handbook: From the AJCC Cancer Staging Manual.: Springer Publishing Company. 173-206 p.
17. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama 284: 3043-3045.
18. Sambrook J, Fritsh EF, Maniatis T, (1989) Molecular Cloninig: A laboratory manual. Cold Spring Harbor, NY- Cold Spring Harbor Laboratory Press. 9: 16-9.
19. Wang S, An T, Wang J, Zhao J, Wang Z, et al. (2010) Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer. Clin Cancer Res 16: 1324-1330.
20. Maruyama R, Toyooka S, Toyooka KO, Virmani AK, Zochbauer-Muller S, et al. (2002) Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. Clin Cancer Res 8: 514-519.
21. Kaplan EL, Meier P, (1958) Non Parametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481.
22. Hibi K, Nakao A, (2006) Highly-methylated colorectal cancers show poorly-differentiated phenotype. Anticancer Res 26: 4263-4266.
23. Matsubara N, (2012) Epigenetic regulation and colorectal cancer. Dis Colon Rectum 55: 96-104.
24. Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, et al. (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122: 327-334.
25. Sameer AS, Chowdhri NA, Abdullah S, Shah ZA, Siddiqi MA, (2009) Mutation pattern of K-ras gene in colorectal cancer patients of Kashmir: a report. Indian J Cancer 46: 219-225.
26. Hinoda Y, (2011) [KRAS mutation test]. Rinsho Byori 59: 598-601.
27. van Engeland M, Weijenberg MP, Roemen GM, Brink M, de Bruine AP, et al. (2003) Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res 63: 3133-3137.
28. Brink M, Weijenberg MP, de Goeij AF, Roemen GM, Lentjes MH, et al. (2005) Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Br J Cancer 92: 1310-1320.
29. Stefani ED, Deneo-Pellegrini H, Ronco AL, Correa P, Boffetta P, et al. (2011) Dietary patterns and risk of colorectal cancer: a factor analysis in uruguay. Asian Pac J Cancer Prev 12: 753-759.
30. Kampman E, Voskuil DW, van Kraats AA, Balder HF, van Muijen GN, et al. (2000) Animal products and K-ras codon 12 and 13 mutations in colon carcinomas. Carcinogenesis 21: 307-309.
31. Martinez ME, Maltzman T, Marshall JR, Einspahr J, Reid ME, et al. (1999) Risk factors for Ki-ras protooncogene mutation in sporadic colorectal adenomas. Cancer Res 59: 5181-5185.
32. Paterson J, Baxter G, Lawrence J, Duthie G, (2006) Is there a role for dietary salicylates in health? Proc Nutr Soc 65: 93-96.
33. Magalhaes B, Peleteiro B, Lunet N, (2012) Dietary patterns and colorectal cancer: systematic review and meta-analysis. Eur J Cancer Prev 21: 15-23.
34. Hughes R, Cross AJ, Pollock JR, Bingham S, (2001) Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation. Carcinogenesis 22: 199-202.
35. Shin A, Hong CW, Sohn DK, Chang Kim B, Han KS, et al. (2011) Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. Am J Epidemiol 174: 552-562.
36. Giovannucci E, Martinez ME, (1996) Tobacco, colorectal cancer, and adenomas: a review of the evidence. J Natl Cancer Inst 88: 1717-1730.
37. Seitz HK, Simanowski UA, Garzon FT, Rideout JM, Peters TJ, et al. (1990) Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology 98: 406-413.
38. Homann N, Tillonen J, Salaspuro M, (2000) Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency. Int J Cancer 86: 169-173.
39. Kune GA, Vitetta L, (1992) Alcohol consumption and the etiology of colorectal cancer: a review of the scientific evidence from 1957 to 1991. Nutr Cancer 18: 97-111.
40. Cho YA, Kim J, (2011) Association between alcohol consumption and colorectal carcinogenesis: an ecological study in Korea. Asian Pac J Cancer Prev 12: 761-764.
41. Lee S, Hwang KS, Lee HJ, Kim JS, Kang GH, (2004) Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. Lab Invest 84: 884-893.
42. Sakamoto N, Terai T, Ajioka Y, Abe S, Kobayasi O, et al. (2004) Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors. Oncogene 23: 8900-8907.
43. van Engeland M, Roemen GM, Brink M, Pachen MM, Weijenberg MP, et al. (2002) K-ras mutations and RASSF1A promoter methylation in colorectal cancer. Oncogene 21: 3792-3795.
44. Dong SM, Lee EJ, Jeon ES, Park CK, Kim KM, (2005) Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod Pathol 18: 170-178.
45. Roa SJ, Garcia MP, Melo AA, Tapia EO, Villaseca HM, et al. (2008) [Gene methylation patterns in digestive tumors]. Rev Med Chil 136: 451-458.
46. Sultana SA, Kiranmayee S, Bammidi VK, Shaik AP, Jamil K, (2011) Introduction to the role of Fragile Histidine Triad (fhit) gene in cancer: A review of literature with special emphasis on cervical carcinoma. International Journal of Cancer Research 7: 99-113.
47. Lee SH, (2005) Aberrant FHIT transcripts in human colorectal cancers. Res Commun Mol Pathol Pharmacol 117-118: 153-165.
48. Hao XP, Willis JE, Pretlow TG, Rao JS, MacLennan GT, et al. (2000) Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions. Cancer Res 60: 18-21.
49. Neyaz MK, Hussain S, Hassan MI, Das BC, Husain SA, et al. (2010) Novel missense mutation in FHIT gene: interpreting the effect in HPV-mediated cervical cancer in Indian women. Mol Cell Biochem 335: 53-58.
50. Xu XL, Yu J, Zhang HY, Sun MH, Gu J, et al. (2004) Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 10: 3441-3454.
51. Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, et al. (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343: 1350-1354.
52. Kato K, Iida S, Uetake H, Takagi Y, Yamashita T, et al. (2008) Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer. Int J Cancer 122: 603-608.
53. Cejas P, Lopez-Gomez M, Aguayo C, Madero R, de Castro Carpeno J, et al. (2009) KRAS mutations in primary colorectal cancer tumors and related metastases: a potential role in prediction of lung metastasis. PLoS One 4: e8199.
54. Mannan A, Hahn-Stromberg V, (2009) K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma. Apmis 120: 459-468.