메뉴 건너뛰기




Volumn 63, Issue 5, 2014, Pages 1804-1816

Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CELL DIFFERENTIATION; CO-REPRESSOR PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCAGON; GLUCAGON-SECRETING CELLS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN-SECRETING CELLS; MICE; TRANSCRIPTION FACTORS;

EID: 84899049495     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0867     Document Type: Article
Times cited : (19)

References (46)
  • 1
    • 37249066122 scopus 로고    scopus 로고
    • Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells
    • DOI 10.1002/dvdy.21366
    • Spence JR, Wells JM. Translational embryology: using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn 2007;236:3218-3227 (Pubitemid 350276381)
    • (2007) Developmental Dynamics , vol.236 , Issue.12 , pp. 3218-3227
    • Spence, J.R.1    Wells, J.M.2
  • 4
    • 84865157730 scopus 로고    scopus 로고
    • Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine
    • Nostro MC, Keller G. Generation of beta cells from human pluripotent stem cells: potential for regenerative medicine. Semin Cell Dev Biol 2012;23:701-710
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 701-710
    • Nostro, M.C.1    Keller, G.2
  • 5
    • 84856504995 scopus 로고    scopus 로고
    • Groucho: A corepressor with instructive roles in development
    • Turki-Judeh W, Courey AJ. Groucho: a corepressor with instructive roles in development. Curr Top Dev Biol 2012;98:65-96
    • (2012) Curr Top Dev Biol , vol.98 , pp. 65-96
    • Turki-Judeh, W.1    Courey, A.J.2
  • 6
    • 34547128888 scopus 로고    scopus 로고
    • The 'Marx' of Groucho on development and disease
    • DOI 10.1016/j.tcb.2007.07.002, PII S0962892407001341
    • Buscarlet M, Stifani S. The 'Marx' of Groucho on development and disease. Trends Cell Biol 2007;17:353-361 (Pubitemid 47102197)
    • (2007) Trends in Cell Biology , vol.17 , Issue.7 , pp. 353-361
    • Buscarlet, M.1    Stifani, S.2
  • 7
    • 24744435397 scopus 로고    scopus 로고
    • Mammalian Groucho homologs: Redundancy or specificity?
    • DOI 10.1002/jcb.20476
    • Gasperowicz M, Otto F. Mammalian Groucho homologs: redundancy or specificity? J Cell Biochem 2005;95:670-687 (Pubitemid 41420155)
    • (2005) Journal of Cellular Biochemistry , vol.95 , Issue.4 , pp. 670-687
    • Gasperowicz, M.1    Otto, F.2
  • 8
    • 84858841326 scopus 로고    scopus 로고
    • The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation
    • Metzger DE, Gasperowicz M, Otto F, Cross JC, Gradwohl G, Zaret KS. The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation. Development 2012;139:1447-1456
    • (2012) Development , vol.139 , pp. 1447-1456
    • Metzger, D.E.1    Gasperowicz, M.2    Otto, F.3    Cross, J.C.4    Gradwohl, G.5    Zaret, K.S.6
  • 10
    • 33847360050 scopus 로고    scopus 로고
    • Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet
    • DOI 10.1242/dev.02763
    • Doyle MJ, Loomis ZL, Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development 2007;134:515-523 (Pubitemid 46332488)
    • (2007) Development , vol.134 , Issue.3 , pp. 515-523
    • Doyle, M.J.1    Loomis, Z.L.2    Sussel, L.3
  • 11
    • 80455173402 scopus 로고    scopus 로고
    • Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming
    • Papizan JB, Singer RA, Tschen SI, et al. Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev 2011;25:2291-2305
    • (2011) Genes Dev , vol.25 , pp. 2291-2305
    • Papizan, J.B.1    Singer, R.A.2    Tschen, S.I.3
  • 12
    • 79954563768 scopus 로고    scopus 로고
    • Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx
    • Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell 2011;20:419-429
    • (2011) Dev Cell , vol.20 , pp. 419-429
    • Dhawan, S.1    Georgia, S.2    Tschen, S.I.3    Fan, G.4    Bhushan, A.5
  • 14
    • 0035937415 scopus 로고    scopus 로고
    • Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    • DOI 10.1016/S0092-8674(01)00283-5
    • Muhr J, Andersson E, Persson M, Jessell TM, Ericson J. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 2001;104:861-873 (Pubitemid 32289279)
    • (2001) Cell , vol.104 , Issue.6 , pp. 861-873
    • Muhr, J.1    Andersson, E.2    Persson, M.3    Jessell, T.M.4    Ericson, J.5
  • 15
    • 84873514082 scopus 로고    scopus 로고
    • Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic beta cell identity
    • Schaffer AE, Taylor BL, Benthuysen JR, et al. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic beta cell identity. PLoS Genet 2013;9:e1003274
    • (2013) PLoS Genet , vol.9
    • Schaffer, A.E.1    Taylor, B.L.2    Benthuysen, J.R.3
  • 16
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel F, Népote V, Avril I, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010;464:1149-1154
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Népote, V.2    Avril, I.3
  • 17
    • 84860410786 scopus 로고    scopus 로고
    • Context-specific α- to-β-cell reprogramming by forced Pdx1 expression
    • Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV. Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev 2011;25:1680-1685
    • (2011) Genes Dev , vol.25 , pp. 1680-1685
    • Yang, Y.P.1    Thorel, F.2    Boyer, D.F.3    Herrera, P.L.4    Wright, C.V.5
  • 18
    • 77149159725 scopus 로고    scopus 로고
    • Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation
    • Santisteban P, Recacha P, Metzger DE, Zaret KS. Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation. Dev Dyn 2010;239:980-986
    • (2010) Dev Dyn , vol.239 , pp. 980-986
    • Santisteban, P.1    Recacha, P.2    Metzger, D.E.3    Zaret, K.S.4
  • 19
    • 0037097981 scopus 로고    scopus 로고
    • Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
    • DOI 10.1101/gad.985002
    • Lee CS, Perreault N, Brestelli JE, Kaestner KH. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev 2002;16:1488-1497 (Pubitemid 34686330)
    • (2002) Genes and Development , vol.16 , Issue.12 , pp. 1488-1497
    • Lee, C.S.1    Perreault, N.2    Brestelli, J.E.3    Kaestner, K.H.4
  • 21
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 2000;127:2317-2322 (Pubitemid 30386571)
    • (2000) Development , vol.127 , Issue.11 , pp. 2317-2322
    • Herrera, P.L.1
  • 22
    • 1642474003 scopus 로고    scopus 로고
    • Global expression analysis of gene regulatory pathways during endocrine pancreatic development
    • DOI 10.1242/dev.00921
    • Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 2004;131:165-179 (Pubitemid 38111424)
    • (2004) Development , vol.131 , Issue.1 , pp. 165-179
    • Gu, G.1    Wells, J.M.2    Dombkowski, D.3    Preffer, F.4    Aronow, B.5    Melton, D.A.6
  • 24
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997;15:871-875
    • (1997) Nat Biotechnol , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 26
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • Johansson KA, Dursun U, Jordan N, et al. Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 2007;12:457-465
    • (2007) Dev Cell , vol.12 , pp. 457-465
    • Johansson, K.A.1    Dursun, U.2    Jordan, N.3
  • 27
    • 76749108047 scopus 로고    scopus 로고
    • Rfx6 directs islet formation and insulin production in mice and humans
    • Smith SB, Qu HQ, Taleb N, et al. Rfx6 directs islet formation and insulin production in mice and humans. Nature 2010;463:775-780
    • (2010) Nature , vol.463 , pp. 775-780
    • Smith, S.B.1    Qu, H.Q.2    Taleb, N.3
  • 28
    • 72449156523 scopus 로고    scopus 로고
    • Single pancreatic beta cells co-express multiple islet hormone genes in mice
    • Katsuta H, Akashi T, Katsuta R, et al. Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia 2010;53:128-138
    • (2010) Diabetologia , vol.53 , pp. 128-138
    • Katsuta, H.1    Akashi, T.2    Katsuta, R.3
  • 29
    • 0028926254 scopus 로고
    • Morphological and functional characterization of beta TC-6 cells - An insulin-secreting cell line derived from transgenic mice
    • Poitout V, Stout LE, Armstrong MB, Walseth TF, Sorenson RL, Robertson RP. Morphological and functional characterization of beta TC-6 cells - an insulin-secreting cell line derived from transgenic mice. Diabetes 1995;44:306-313
    • (1995) Diabetes , vol.44 , pp. 306-313
    • Poitout, V.1    Stout, L.E.2    Armstrong, M.B.3    Walseth, T.F.4    Sorenson, R.L.5    Robertson, R.P.6
  • 30
    • 0025269469 scopus 로고
    • Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression
    • Hamaguchi K, Leiter EH. Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes 1990;39:415-425 (Pubitemid 20111421)
    • (1990) Diabetes , vol.39 , Issue.4 , pp. 415-425
    • Hamaguchi, K.1    Leiter, E.H.2
  • 31
    • 35349013604 scopus 로고    scopus 로고
    • Repression by Groucho/TLE/Grg Proteins: Genomic Site Recruitment Generates Compacted Chromatin In Vitro and Impairs Activator Binding In Vivo
    • DOI 10.1016/j.molcel.2007.10.002, PII S1097276507006417
    • Sekiya T, Zaret KS. Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell 2007;28:291-303 (Pubitemid 47600002)
    • (2007) Molecular Cell , vol.28 , Issue.2 , pp. 291-303
    • Sekiya, T.1    Zaret, K.S.2
  • 32
    • 34247853278 scopus 로고    scopus 로고
    • The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6
    • DOI 10.1042/BJ20070053
    • Gauthier BR, Gosmain Y, Mamin A, Philippe J. The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6. Biochem J 2007;403:593-601 (Pubitemid 46706988)
    • (2007) Biochemical Journal , vol.403 , Issue.3 , pp. 593-601
    • Gauthier, B.R.1    Gosmain, Y.2    Mamin, A.3    Philippe, J.4
  • 35
    • 0036139165 scopus 로고    scopus 로고
    • Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements
    • DOI 10.1210/me.16.1.170
    • Gauthier BR, Schwitzgebel VM, Zaiko M, Mamin A, Ritz-Laser B, Philippe J. Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements. Mol Endocrinol 2002;16:170-183 (Pubitemid 34044506)
    • (2002) Molecular Endocrinology , vol.16 , Issue.1 , pp. 170-183
    • Gauthier, B.R.1    Schwitzgebel, V.M.2    Zaiko, M.3    Mamin, A.4    Ritz-Laser, B.5    Philippe, J.6
  • 36
    • 0033557490 scopus 로고    scopus 로고
    • Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
    • Kaestner KH, Katz J, Liu Y, Drucker DJ, Schütz G. Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev 1999;13:495-504 (Pubitemid 29108764)
    • (1999) Genes and Development , vol.13 , Issue.4 , pp. 495-504
    • Kaestner, K.H.1    Katz, J.2    Liu, Y.3    Drucker, D.J.4    Schutz, G.5
  • 37
    • 80054682732 scopus 로고    scopus 로고
    • Transcriptomes of the major human pancreatic cell types
    • Dorrell C, Schug J, Lin CF, et al. Transcriptomes of the major human pancreatic cell types. Diabetologia 2011;54:2832-2844
    • (2011) Diabetologia , vol.54 , pp. 2832-2844
    • Dorrell, C.1    Schug, J.2    Lin, C.F.3
  • 39
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627-632
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 40
    • 78649522751 scopus 로고    scopus 로고
    • NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming
    • Gefen-Halevi S, Rachmut IH, Molakandov K, et al. NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming. Cell Reprogram 2010;12:655-664
    • (2010) Cell Reprogram , vol.12 , pp. 655-664
    • Gefen-Halevi, S.1    Rachmut, I.H.2    Molakandov, K.3
  • 41
    • 80054756679 scopus 로고    scopus 로고
    • Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate
    • Mauda-Havakuk M, Litichever N, Chernichovski E, et al. Ectopic PDX-1 expression directly reprograms human keratinocytes along pancreatic insulin-producing cells fate. PLoS One 2011;6:e26298
    • (2011) PLoS One , vol.6
    • Mauda-Havakuk, M.1    Litichever, N.2    Chernichovski, E.3
  • 43
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    • Collombat P, Xu X, Ravassard P, et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009;138:449-462
    • (2009) Cell , vol.138 , pp. 449-462
    • Collombat, P.1    Xu, X.2    Ravassard, P.3
  • 44
    • 84878983251 scopus 로고    scopus 로고
    • Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss
    • Wilcox CL, Terry NA, Walp ER, Lee RA, May CL. Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss. PLoS One 2013;8:e66214
    • (2013) PLoS One , vol.8
    • Wilcox, C.L.1    Terry, N.A.2    Walp, E.R.3    Lee, R.A.4    May, C.L.5
  • 45
    • 34250854205 scopus 로고    scopus 로고
    • The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    • DOI 10.1210/er.2006-0026
    • Dunning BE, Gerich JE. The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications. Endocr Rev 2007;28:253-283 (Pubitemid 46984828)
    • (2007) Endocrine Reviews , vol.28 , Issue.3 , pp. 253-283
    • Dunning, B.E.1    Gerich, J.E.2
  • 46
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
    • Morris AP, Voight BF, Teslovich TM, et al.; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012;44:981-990
    • (2012) Nat Genet , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.