Expression of Groucho/TLE proteins during pancreas development

BMC Developmental Biology

Volumn 8, Issue , 2008, Pages

  Hoffman, Brad G ^a   Zavaglia, Bogard ^a   Beach, Mike ^a   Helgason, Cheryl D ^a,b  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; INSULIN; NEUROGENIN 3; PANCREAS POLYPEPTIDE; PROTEIN ARX; PROTEIN EH1; PROTEIN GROUCHO; PROTEIN NKX2 2; PROTEIN NKX6 1; PROTEIN TLE; PROTEIN TLE1; PROTEIN TLE2; PROTEIN TLE3; PROTEIN TLE4; SOMATOSTATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; PROTEIN; REPRESSOR PROTEIN; TLE1 PROTEIN, MOUSE; TLE2 PROTEIN, MOUSE; TLE3 PROTEIN, MOUSE; TLE4 PROTEIN, MOUSE; TLE6 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL SPECIFICITY; CELL TYPE; EMBRYO; ENDOCRINE CELL; GENE; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GROUCHO GENE; IMMUNOFLUORESCENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PANCREAS DEVELOPMENT; PANCREAS ISLET BETA CELL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TLE1 GENE; TLE2 GENE; TLE3 GENE; TLE4 GENE; TLE5 GENE; TLE6 GENE; ANIMAL; BIOSYNTHESIS; CELL LINE; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE; PANCREAS; PHYSIOLOGY; PRENATAL DEVELOPMENT; RAT;

MAMMALIA;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; MICE, INBRED ICR; PANCREAS; PROTEINS; RATS; REPRESSOR PROTEINS;

EID: 52649149203     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-8-81     Document Type: Article

References (57)

1. Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Q Wei WK Miskimins R Miskimins, J Biol Chem 2005 280 16 16284 16294 10.1074/jbc.M500491200 15695521
2. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. T Sun Y Echelard R Lu DI Yuk S Kaing CD Stiles DH Rowitch, Curr Biol 2001 11 1413 1420 10.1016/S0960-9822(01)00441-9 11566099
3. Nkx2.2-repressor activity is sufficient to specify {alpha}-cells and a small number of {beta}-cells in the pancreatic islet. MJ Doyle ZL Loomis L Sussel, Development 2007 134 515 523 10.1242/dev.02763 17202186
4. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. P Collombat J Hecksher-Sorensen V Broccoli J Krull I Ponte T Mundiger J Smith P Gruss P Serup A Mansouri, Development 2005 132 2969 2980 10.1242/dev.01870 15930104
5. The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. T Iype DG Taylor SM Ziesmann JC Garmey H Watada RG Mirmira, Mol Endocrinol 2004 18 1363 1375 10.1210/me.2004-0006 15056733
6. Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. RG Mirmira H Watada MS German, J Biol Chem 2000 275 14743 14751 10.1074/jbc.275.19.14743 10799563
7. Transcriptional networks regulating neuronal identity in the developing spinal cord. SK Lee SL Pfaff, Nat Neurosci 2001 4 Suppl 1183 1191 10.1038/nn750 11687828
8. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. J Muhr E Andersson M Persson TM Jessell J Ericson, Cell 2001 104 861 873 10.1016/S0092-8674(01)00283- 5 11290324
9. Groucho/TLE family proteins and transcriptional repression. G Chen AJ Courey, Gene 2000 249 1 16 10.1016/S0378-1119(00)00161-X 10831834
10. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. G Jimenez Z Paroush D Ish-Horowicz, Genes Dev 1997 11 3072 3082 9367988 10.1101/gad.11.22.3072
11. Mammalian Groucho homologs: redundancy or specificity? M Gasperowicz F Otto, J Cell Biochem 2005 95 670 687 10.1002/jcb.20476 15861397
12. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. A Palaparti A Baratz S Stifani, J Biol Chem 1997 272 26604 26610 10.1074/jbc.272.42.26604 9334241
13. TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination. G Dehni Y Liu J Husain S Stifani, Mech Dev 1995 53 369 381 10.1016/0925-4773(95)00452-1 8645603
14. Combinatorial expression patterns of individual TLE proteins during cell determination and differentiation suggest non-redundant functions for mammalian homologs of Drosophila Groucho. J Yao Y Liu J Husain R Lo A Palaparti J Henderson S Stifani, Dev Growth Differ 1998 40 133 146 10.1046/j.1440-169X.1998. 00003.x 9572356
15. A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development. T Allen CG Lobe, Cell Mol Biol (Noisy-le-grand) 1999 45 687 708 10512199
16. TCF and Groucho-related genes influence pituitary growth and development. ML Brinkmeier MA Potok KB Cha T Gridley S Stifani J Meeldijk H Clevers SA Camper, Mol Endocrinol 2003 17 2152 2161 10.1210/me.2003-0225 12907761
17. Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation. Y Cai PD Brophy I Levitan S Stifani GR Dressler, Embo J 2003 22 5522 5529 14532124 10.1093/emboj/cdg536
18. Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis. SL Nutt D Eberhard M Horcher AG Rolink M Busslinger, Int Rev Immunol 2001 20 65 82 11342298
19. Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. WF Wang YG Wang AM Reginato S Plotkina T Gridley BR Olsen, Dev Dyn 2002 224 79 89 10.1002/dvdy.10089 11984876
20. Groucho corepressor proteins regulate otic vesicle outgrowth. B Bajoghli N Aghaallaei T Czerny, Dev Dyn 2005 233 760 771 10.1002/dvdy.20398 15861392
21. Six3 and Six6 activity is modulated by members of the groucho family. J Lopez-Rios K Tessmar F Loosli J Wittbrodt P Bovolenta, Development 2003 130 185 195 10.1242/dev.00185 12441302
22. The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. M Kobayashi K Nishikawa T Suzuki M Yamamoto, Dev Biol 2001 232 315 326 10.1006/dbio.2001.0185 11401394
23. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. H Brantjes J Roose M van De Wetering H Clevers, Nucleic Acids Res 2001 29 1410 1419 11266540 10.1093/nar/29.7.1410
24. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. JC Wang M Waltner-Law K Yamada H Osawa S Stifani DK Granner, J Biol Chem 2000 275 18418 18423 10.1074/jbc.M910211199 10748198
25. Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression. HN Nuthall J Husain KW McLarren S Stifani, Mol Cell Biol 2002 22 389 399 11756536 10.1128/MCB.22.2.389-399.2002
26. Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1. KW McLarren FM Theriault S Stifani, J Biol Chem 2001 276 1578 1584 10.1074/jbc.M007629200 11035023
27. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. D Grbavec R Lo Y Liu S Stifani, Eur J Biochem 1998 258 339 349 10.1046/j.1432-1327.1998.2580339.x 9874198
28. The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. J Yao E Lai S Stifani, Mol Cell Biol 2001 21 1962 1972 11238932 10.1128/MCB.21.6.1962-1972.2001
29. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. M Sander S Paydar J Ericson J Briscoe E Berber M German TM Jessell JL Rubenstein, Genes Dev 2000 14 2134 2139 10970877 10.1101/gad.820400
30. Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. A Vallstedt J Muhr A Pattyn A Pierani M Mendelsohn M Sander TM Jessell J Ericson, Neuron 2001 31 743 755 10.1016/S0896-6273(01)00412-3 11567614
31. A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. AS Siddiqui J Khattra AD Delaney Y Zhao C Astell J Asano R Babakaiff S Barber J Beland S Bohacec M Brown-John S Chand D Charest AM Charters R Cullum N Dhalla R Featherstone DS Gerhard B Hoffman RA Holt J Hou BY Kuo LL Lee S Lee D Leung K Ma C Matsuo M Mayo H McDonald AL Prabhu, Proc Natl Acad Sci USA 2005 102 18485 18490 16352711 10.1073/pnas.0509455102
32. Identification of transcripts with enriched expression in the developing and adult pancreas. BG Hoffman B Zavaglia J Witzsche T Ruiz de Algara M Beach PA Hoodless SJ Jones MA Marra CD Helgason, Genome Biol 2008 9 R99 18554416 10.1186/gb-2008-9-6-r99
33. Notch gene expression during pancreatic organogenesis. E Lammert J Brown DA Melton, Mech Dev 2000 94 199 203 10.1016/S0925-4773(00)00317-8 10842072
34. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. H Li S Arber TM Jessell H Edlund, Nat Genet 1999 23 67 70 10471501
35. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. M Sander L Sussel J Conners D Scheel J Kalamaras F Dela Cruz V Schwitzgebel A Hayes-Jordan M German, Development 2000 127 5533 5540 11076772
36. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. SB Nelson AE Schaffer M Sander, Development 2007 134 2491 2500 10.1242/dev.002691 17537793
37. Pancreatic duodenal homeobox-1, PDX-1, a major reulator of beta cell identity and function. C McKinnon K Docherty, Diabetologia 2001 44 1203 1214 10.1007/s001250100628 11692168
38. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. G Gu J Dubauskaite D Melton, Development 2002 129 2447 2457 11973276
39. mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. J Jensen P Serup C Karlsen TF Nielsen OD Madsen, J Biol Chem 1996 271 18749 18758 10.1074/jbc.271.31.18749 8702531
40. Control of endodermal endocrine development by Hes-1. J Jensen EE Pedersen P Galante J Hald RS Heller M Ishibashi R Kageyama F Guillemot P Serup OD Madsen, Nat Genet 2000 24 36 44 10.1038/72814 10615124
41. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. J Jensen RS Heller T Funder-Nielsen EE Pedersen C Lindsell G Weinmaster OD Madsen P Serup, Diabetes 2000 49 163 176 10.2337/diabetes.49.2.163 10868931
42. Notch signalling controls pancreatic cell differentiation. A Apelqvist H Li L Sommer P Beatus D Anderson T Honjo M Hrabe de Angelis U Lendahl H Edlund, Nature 1999 400 877 881 10.1038/23716 10476967
43. Notch signaling controls multiple steps of pancreatic differentiation. LC Murtaugh BZ Stanger KM Kwan DA Melton, Proc Natl Acad Sci USA 2003 100 14920 14925 14657333 10.1073/pnas.2436557100
44. Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. P Collombat J Hecksher-Sorensen J Krull J Berger D Riedel PL Herrera P Serup A Mansouri, J Clin Invest 2007 117 961 970 17404619 10.1172/JCI29115
45. Aristaless-related homeobox gene, the gene responsible for West syndrome and related disorders, is a Groucho/transducin-like enhancer of split dependent transcriptional repressor. O McKenzie I Ponte M Mangelsdorf M Finnis G Colasante C Shoubridge S Stifani J Gecz V Broccoli, Neuroscience 2007 146 236 247 10.1016/j.neuroscience.2007.01.038 17331656
46. Disrupted development of the cerebral hemispheres in transgenic mice expressing the mammalian Groucho homologue transducin-like-enhancer of split 1 in postmitotic neurons. J Yao Y Liu R Lo I Tretjakoff A Peterson S Stifani, Mech Dev 2000 93 105 115 10.1016/S0925-4773(00)00278-1 10781944
47. Gene regulatory factors in pancreatic development. J Jensen, Dev Dyn 2004 229 176 200 10.1002/dvdy.10460 14699589
48. A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. HN Nuthall K Joachim A Palaparti S Stifani, J Biol Chem 2002 277 51049 51057 10.1074/jbc.M111660200 12397081
49. Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. N Marcal H Patel Z Dong S Belanger-Jasmin B Hoffman CD Helgason J Dang S Stifani, Mol Cell Biol 2005 25 10916 10929 16314515 10.1128/MCB.25.24.10916- 10929.2005
50. Opposing actions of Arx and Pax4 in endocrine pancreas development. P Collombat A Mansouri J Hecksher-Sorensen P Serup J Krull G Gradwohl P Gruss, Genes Dev 2003 17 2591 2603 14561778 10.1101/gad.269003
51. Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. A Pattyn A Vallstedt JM Dias M Sander J Ericson, Development 2003 130 4149 4159 10.1242/dev.00641 12874134
52. NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. KD Henseleit SB Nelson K Kuhlbrodt JC Hennings J Ericson M Sander, Development 2005 132 3139 3149 10.1242/dev.01875 15944193
53. Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells. L Marzban G Soukhatcheva CB Verchere, Endocrinology 2005 146 1808 1817 10.1210/en.2004-1175 15618358
54. DiscoverySpace: an interactive data analysis application. N Robertson M Oveisi-Fordorei SD Zuyderduyn RJ Varhol C Fjell M Marra S Jones A Siddiqui, Genome Biol 2007 8 R6 17210078 10.1186/gb-2007-8-1-r6
55. Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing P Green, Genome Res 1998 8 186 194 9521922
56. A new mathematical model for relative quantification in real-time RT-PCR. MW Pfaffl, Nucleic Acids Res 2001 29 e45 11328886 10.1093/nar/29.9.e45
57. A multipotent progenitor domain guides pancreatic organogenesis. Q Zhou AC Law J Rajagopal WJ Anderson PA Gray DA Melton, Dev Cell 2007 13 103 114 10.1016/j.devcel.2007.06.001 17609113