Orally administrated ascorbic acid suppresses neuronal damage and modifies expression of SVCT2 and GLUT1 in the brain of diabetic rats with cerebral ischemia-reperfusion

Nutrients

Volumn 6, Issue 4, 2014, Pages 1554-1577

  Iwata, Naohiro ^a   Okazaki, Mari ^a   Xuan, Meiyan ^a   Kamiuchi, Shinya ^a   Matsuzaki, Hirokazu ^a   Hibino, Yasuhide ^a  

^a JOSAI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Ascorbic acid; Cytokine; Diabetes mellitus; Glucose transporter 1 (GLUT1); Middle cerebral artery occlusion and reperfusion; Oxidative stress; Proinflammatory; Rat; Sodium dependent vitamin C transporter 2 (SVCT2); Streptozotocin

Indexed keywords

ASCORBIC ACID; CASPASE 3; GLUCOSE TRANSPORTER 1; INTERLEUKIN 1BETA; OXYGEN; PEPTIDES AND PROTEINS; SODIUM DEPENDENT VITAMIN C TRANSPORTER 2; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CASP3 PROTEIN, RAT; SLC23A2 PROTEIN, RAT; SLC2A1 PROTEIN, RAT; SODIUM ASCORBIC ACID COTRANSPORTER; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIAPOPTOTIC ACTIIVTY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; EDEMA; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LASER DOPPLER FLOWMETRY; MALE; MOUSE; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SCORING SYSTEM; WEIGHT REDUCTION; ANIMAL; BRAIN; DIABETES MELLITUS, EXPERIMENTAL; DIET SUPPLEMENTATION; DRUG EFFECTS; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVE CELL; ORAL DRUG ADMINISTRATION; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; ASCORBIC ACID; BRAIN; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; ENDOTHELIAL CELLS; GLUCOSE TRANSPORTER TYPE 1; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERLEUKIN-1BETA; MALE; NEURONS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-COUPLED VITAMIN C TRANSPORTERS; STREPTOZOCIN; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84898928588     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6041554     Document Type: Article

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