메뉴 건너뛰기




Volumn 108, Issue 3, 2009, Pages 563-577

The Na+-dependent L-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids

Author keywords

Brain cortex; Flavonoid; Neuron; Sodium vitamin C co transporters 2; Stem cells

Indexed keywords

ASCORBIC ACID; COTRANSPORTER; MEMBRANE PROTEIN; PHLORETIN; QUERCETIN; SODIUM DEPENDENT ASCORBIC ACID TRANSPORTER 1; SODIUM DEPENDENT ASCORBIC ACID TRANSPORTER 2; UNCLASSIFIED DRUG;

EID: 58149349823     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05788.x     Document Type: Article
Times cited : (50)

References (39)
  • 1
    • 0033567885 scopus 로고    scopus 로고
    • Stromal cell oxidation: A mechanism by which tumors obtain vitamin C
    • Agus D. B., Vera J. C. Golde D. W. (1999) Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res. 59, 4555 4558.
    • (1999) Cancer Res. , vol.59 , pp. 4555-4558
    • Agus, D.B.1    Vera, J.C.2    Golde, D.W.3
  • 2
    • 19944426551 scopus 로고    scopus 로고
    • Vitamin C uptake and recycling among normal and tumoral cells from the central nervous system
    • Astuya A., Caprile T., Castro M. et al. (2005) Vitamin C uptake and recycling among normal and tumoral cells from the central nervous system. J. Neurosci. Res. 79, 146 156.
    • (2005) J. Neurosci. Res. , vol.79 , pp. 146-156
    • Astuya, A.1    Caprile, T.2    Castro, M.3
  • 3
    • 0034658572 scopus 로고    scopus 로고
    • The vitamin C transporter SVCT2 is expressed by astrocytes in culture but not in situ
    • Berger U. V. Hediger M. A. (2000) The vitamin C transporter SVCT2 is expressed by astrocytes in culture but not in situ. Neuroreport 11, 1395 1399.
    • (2000) Neuroreport , vol.11 , pp. 1395-1399
    • Berger, U.V.1    Hediger, M.A.2
  • 4
    • 33845626164 scopus 로고    scopus 로고
    • Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SV neo: Effect of steroids, flavonoids and NSAIDs
    • Biondi C., Pavan B., Dalpiaz A., Medici S., Lunghi L. Vesce F. (2007) Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SV neo: effect of steroids, flavonoids and NSAIDs. Mol. Hum. Reprod. 13, 77 83.
    • (2007) Mol. Hum. Reprod. , vol.13 , pp. 77-83
    • Biondi, C.1    Pavan, B.2    Dalpiaz, A.3    Medici, S.4    Lunghi, L.5    Vesce, F.6
  • 6
    • 34447313639 scopus 로고    scopus 로고
    • Intracellular ascorbic acid inhibits transport of glucose by neurons, but not by astrocytes
    • Castro M. A., Pozo M., Cortés C., García M. A., Concha I. I. Nualart F. (2007) Intracellular ascorbic acid inhibits transport of glucose by neurons, but not by astrocytes. J. Neurochem. 102, 773 782.
    • (2007) J. Neurochem. , vol.102 , pp. 773-782
    • Castro, M.A.1    Pozo, M.2    Cortés, C.3    García, M.A.4    Concha, I.I.5    Nualart, F.6
  • 7
    • 84989085650 scopus 로고
    • Effects of acute ascorbic acid deficiency on the plasma lipids and postheparine lipolytic activity in guinea pigs
    • Chauhan V., Chauhan A. Sarkar A. (1987) Effects of acute ascorbic acid deficiency on the plasma lipids and postheparine lipolytic activity in guinea pigs. Ann. NY Acad. Sci. 498, 464 469.
    • (1987) Ann. NY Acad. Sci. , vol.498 , pp. 464-469
    • Chauhan, V.1    Chauhan, A.2    Sarkar, A.3
  • 8
    • 0032705918 scopus 로고    scopus 로고
    • Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2
    • Daruwala R., Song J., Koh W. S., Rumsey S. C. Levine M. (1999) Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. FEBS Lett. 460, 480 484.
    • (1999) FEBS Lett. , vol.460 , pp. 480-484
    • Daruwala, R.1    Song, J.2    Koh, W.S.3    Rumsey, S.C.4    Levine, M.5
  • 9
    • 34249004934 scopus 로고    scopus 로고
    • Cell-cycle control and cortical development
    • Dehay C. Kennedy H. (2007) Cell-cycle control and cortical development. Nat. Rev. 8, 438 450.
    • (2007) Nat. Rev. , vol.8 , pp. 438-450
    • Dehay, C.1    Kennedy, H.2
  • 10
    • 1342329720 scopus 로고    scopus 로고
    • Neurotrophin effects on neuroblastoma cells: Correlation with trk and p75NTR expression and influence of Trk receptor bodies
    • Evangelopoulos M. E., Weis J. Kruttgen A. J. (2004) Neurotrophin effects on neuroblastoma cells: correlation with trk and p75NTR expression and influence of Trk receptor bodies. Neurooncology 66, 101 110.
    • (2004) Neurooncology , vol.66 , pp. 101-110
    • Evangelopoulos, M.E.1    Weis, J.2    Kruttgen, A.J.3
  • 11
    • 0032497816 scopus 로고    scopus 로고
    • Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters
    • Faaland C. A., Race J. E., Ricken G., Warner F. J., Williams W. J. Holtzman E. J. (1998) Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. Biochim. Biophys. Acta 1442, 353 360.
    • (1998) Biochim. Biophys. Acta , vol.1442 , pp. 353-360
    • Faaland, C.A.1    Race, J.E.2    Ricken, G.3    Warner, F.J.4    Williams, W.J.5    Holtzman, E.J.6
  • 12
    • 0035140305 scopus 로고    scopus 로고
    • Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier
    • García M. A., Carrasco M., Godoy A., Reinicke K., Montecinos V. P., Aguayo L., Tapia J. C., Vera J. C. Nualart F. (2001) Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier. J. Cell. Biochem. 80, 491 503.
    • (2001) J. Cell. Biochem. , vol.80 , pp. 491-503
    • García, M.A.1    Carrasco, M.2    Godoy, A.3    Reinicke, K.4    Montecinos, V.P.5    Aguayo, L.6    Tapia, J.C.7    Vera, J.C.8    Nualart, F.9
  • 14
    • 33846847224 scopus 로고    scopus 로고
    • Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations
    • Godoy A., Ormazabal V., Moraga-Cid G. et al. (2007) Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations. J. Biol. Chem. 282, 615 624.
    • (2007) J. Biol. Chem. , vol.282 , pp. 615-624
    • Godoy, A.1    Ormazabal, V.2    Moraga-Cid, G.3
  • 15
    • 0033593017 scopus 로고    scopus 로고
    • The human erythrocyte sugar transporter presents two sugar import sites
    • Hamill S., Cloherty E. K. Carruthers A. (1999) The human erythrocyte sugar transporter presents two sugar import sites. Biochemistry 38, 16974 16983.
    • (1999) Biochemistry , vol.38 , pp. 16974-16983
    • Hamill, S.1    Cloherty, E.K.2    Carruthers, A.3
  • 16
    • 0031012411 scopus 로고    scopus 로고
    • Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    • Jaiswal N., Haynesworth S. E., Caplan A. I. Bruder S. P. (1997) Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. 64, 295 312.
    • (1997) J. Cell. Biochem. , vol.64 , pp. 295-312
    • Jaiswal, N.1    Haynesworth, S.E.2    Caplan, A.I.3    Bruder, S.P.4
  • 17
    • 0031753792 scopus 로고    scopus 로고
    • Characterization of the phosphoinositide-linked dopamine receptor in a mouse hippocampal-neuroblastoma hybrid cell line
    • Jin L. Q., Cai G., Wang H. Y., Smith C. Friedman E. J. (1998) Characterization of the phosphoinositide-linked dopamine receptor in a mouse hippocampal-neuroblastoma hybrid cell line. Neurochemistry 71, 1935 1943.
    • (1998) Neurochemistry , vol.71 , pp. 1935-1943
    • Jin, L.Q.1    Cai, G.2    Wang, H.Y.3    Smith, C.4    Friedman, E.J.5
  • 18
    • 0023086554 scopus 로고
    • Requirement for vitamin C based on metabolic studies
    • Kallner A. (1987) Requirement for vitamin C based on metabolic studies. Ann. NY Acad. Sci. 498, 418 423.
    • (1987) Ann. NY Acad. Sci. , vol.498 , pp. 418-423
    • Kallner, A.1
  • 19
    • 0034722124 scopus 로고    scopus 로고
    • Sodium-ascorbate cotransport controls intracellular ascorbate concentration in primary astrocyte cultures expressing the SVCT2 transporter
    • Korkok J., Yan R., Siushansian R., Dixon S. J. Wilson J. X. (2000) Sodium-ascorbate cotransport controls intracellular ascorbate concentration in primary astrocyte cultures expressing the SVCT2 transporter. Brain Res. 881, 144 151.
    • (2000) Brain Res. , vol.881 , pp. 144-151
    • Korkok, J.1    Yan, R.2    Siushansian, R.3    Dixon, S.J.4    Wilson, J.X.5
  • 21
    • 0038167080 scopus 로고    scopus 로고
    • Ascorbate-induced differentiation of embryonic cortical precursors into neurons and astrocytes
    • Lee J. Y., Chang M. Y., Park C. H., Kim H. Y., Kim J. H., Son H., Lee Y. S. Lee S. H. (2003) Ascorbate-induced differentiation of embryonic cortical precursors into neurons and astrocytes. J. Neurosci. Res. 73, 156 165.
    • (2003) J. Neurosci. Res. , vol.73 , pp. 156-165
    • Lee, J.Y.1    Chang, M.Y.2    Park, C.H.3    Kim, H.Y.4    Kim, J.H.5    Son, H.6    Lee, Y.S.7    Lee, S.H.8
  • 22
    • 33746383473 scopus 로고    scopus 로고
    • Ascorbate transport and recycling by SH-SY5Y neuroblastoma cells: Response to glutamate toxicity
    • May J. M., Li L., Hayslett K. Qu Z. C. (2006) Ascorbate transport and recycling by SH-SY5Y neuroblastoma cells: response to glutamate toxicity. Neurochem. Res. 31, 785 794.
    • (2006) Neurochem. Res. , vol.31 , pp. 785-794
    • May, J.M.1    Li, L.2    Hayslett, K.3    Qu, Z.C.4
  • 23
    • 33645302927 scopus 로고    scopus 로고
    • Immunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brain
    • Mun G. H., Kim M. J., Lee J. H. et al. (2006) Immunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brain. J. Neurosci. Res. 83, 919 928.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 919-928
    • Mun, G.H.1    Kim, M.J.2    Lee, J.H.3
  • 24
    • 0033119017 scopus 로고    scopus 로고
    • Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain
    • Nualart F., Godoy A. Reinicke K. (1999) Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain. Brain Res. 824, 97 104.
    • (1999) Brain Res. , vol.824 , pp. 97-104
    • Nualart, F.1    Godoy, A.2    Reinicke, K.3
  • 25
  • 26
    • 0842299586 scopus 로고    scopus 로고
    • Cerebellar granule cell precursors can differentiate into astroglial cells
    • Okano-Uchida T., Himi T., Komiya Y. Ichizaki Y. (2004) Cerebellar granule cell precursors can differentiate into astroglial cells. Proc. Natl Acad. Sci. USA 101, 1211 1216.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1211-1216
    • Okano-Uchida, T.1    Himi, T.2    Komiya, Y.3    Ichizaki, Y.4
  • 27
    • 34147223962 scopus 로고    scopus 로고
    • Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity
    • Qiu S., Li L., Weeber E. J. May J. M. (2007) Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. J. Neurosci. Res. 85, 1046 1056.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 1046-1056
    • Qiu, S.1    Li, L.2    Weeber, E.J.3    May, J.M.4
  • 29
    • 0034194081 scopus 로고    scopus 로고
    • Ascorbate regulation and its neuroprotective role in the brain
    • Rice M. E. (2000) Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci. 23, 209 216.
    • (2000) Trends Neurosci. , vol.23 , pp. 209-216
    • Rice, M.E.1
  • 30
    • 0030839797 scopus 로고    scopus 로고
    • Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid
    • Rumsey S. C., Kwon O., Xu G. W., Burant C. F., Simpson I. Levine M. (1997) Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J. Biol. Chem. 272, 18982 18989.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18982-18989
    • Rumsey, S.C.1    Kwon, O.2    Xu, G.W.3    Burant, C.F.4    Simpson, I.5    Levine, M.6
  • 31
    • 0037013196 scopus 로고    scopus 로고
    • Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose
    • Song J., Kwon O., Chen S., Daruwala R., Eck P., Park J. B. Levine M. (2002) Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose. J. Biol. Chem. 277, 15252 15260.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15252-15260
    • Song, J.1    Kwon, O.2    Chen, S.3    Daruwala, R.4    Eck, P.5    Park, J.B.6    Levine, M.7
  • 32
    • 85047699109 scopus 로고    scopus 로고
    • Ascorbic acid transporter Slc23a1 is essential for the vitamin C transport into the brain and for perinatal survival
    • Sotiriou S., Gispert S., Cheng J. et al. (2002) Ascorbic acid transporter Slc23a1 is essential for the vitamin C transport into the brain and for perinatal survival. Nat. Med. 8, 514 517.
    • (2002) Nat. Med. , vol.8 , pp. 514-517
    • Sotiriou, S.1    Gispert, S.2    Cheng, J.3
  • 33
    • 0015831449 scopus 로고
    • Ascorbic acid homeostasis in the central nervous system
    • Spector R. Lorenzo A. V. (1973) Ascorbic acid homeostasis in the central nervous system. Am. J. Physiol. 225, 757 763.
    • (1973) Am. J. Physiol. , vol.225 , pp. 757-763
    • Spector, R.1    Lorenzo, A.V.2
  • 34
    • 0030983467 scopus 로고    scopus 로고
    • Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells
    • Spielholz C., Golde D. W., Houghton A. N., Nualart F. Vera J. C. (1997) Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res. 57, 2529 2537.
    • (1997) Cancer Res. , vol.57 , pp. 2529-2537
    • Spielholz, C.1    Golde, D.W.2    Houghton, A.N.3    Nualart, F.4    Vera, J.C.5
  • 36
    • 0027302594 scopus 로고
    • Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
    • Vera J. C., Rivas C. I., Fischbarg J. Golde D. (1993) Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature 364, 79 82.
    • (1993) Nature , vol.364 , pp. 79-82
    • Vera, J.C.1    Rivas, C.I.2    Fischbarg, J.3    Golde, D.4
  • 39
    • 0035172717 scopus 로고    scopus 로고
    • Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors
    • Yan J., Studer L. McKay R. D. G. (2001) Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors. J. Neurochem. 76, 307 311.
    • (2001) J. Neurochem. , vol.76 , pp. 307-311
    • Yan, J.1    Studer, L.2    McKay, R.D.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.