Evaluation of insulin and ascorbic acid effects on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of STZ-Induced diabetic rats

Cellular and Molecular Neurobiology

Volumn 29, Issue 1, 2009, Pages 133-140

  Jafari Anarkooli, Iraj ^a,b   Sankian, Mojtaba ^a   Vahedi, Fatemeh ^c   Bonakdaran, Shokoofeh ^a   Varasteh, Abdol Reza ^a   Haghir, Hossein ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c RAZI VACCINE AND SERUM RESEARCH INSTITUTE   (Iran)

Author keywords

Apoptosis; Ascorbic acid; Bax; Bcl 2; Bcl xL; Diabetes; Hippocampus; Insulin; Rat Caspase 3

Indexed keywords

ASCORBIC ACID; CASPASE 3; INSULIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FLUOROMETRY; HIPPOCAMPUS; INCUBATION TIME; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SYNTHESIS; RAT; STREPTOZOCIN DIABETES; THERAPY EFFECT; TISSUE SECTION; TREATMENT OUTCOME; TREATMENT RESPONSE; WISTAR RAT;

ANIMALS; ASCORBIC ACID; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOOD GLUCOSE; BODY WEIGHT; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; FROZEN SECTIONS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; INSULIN; MALE; RATS; RATS, WISTAR; STREPTOZOCIN;

ANIMALIA; RATTUS;

EID: 58849130984     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-008-9305-y     Document Type: Article

References (40)

1. YH Ahn YH Kim SH Hong JY Koh 1998 Depletion of intracellular zinc induces protein synthesis-dependent neuronal apoptosis in mouse cortical culture Exp Neurol 154 47 56 10.1006/exnr.1998.6931
2. DA Allen MM Yaqoob SM Harwood 2005 Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications J Nutr Biochem 16 705 713 10.1016/j.jnutbio.2005.06.007
3. M Aragno R Mastrocola E Brignardello M Catalano G Robino R Manti M Parola O Danni G Boccuzzi 2002 Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats Endocrinology 143 3250 3258 10.1210/en.2002-220182
4. A Ashkenazi VM Dixit 1998 Death receptors: signaling and modulation Science 281 1305 1308 10.1126/science.281.5381.1305
5. O Bar-Am O Weinreb T Amit MB Youdim 2005 Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine FASEB J 19 1899 1901
6. BA Barres IK Hart HS Coles JF Burne JT Voyvodic WD Richardson MC Raff 1992 Cell death and control of cell survival in the oligodendrocyte lineage Cell 70 31 46 10.1016/0092-8674(92)90531-G
7. A Basu S Haldar 1998 The relationship between Bcl-2, Bax and p53: consequences for cell cycle progression and cell death Mol Hum Reprod 4 1099 1109 10.1093/molehr/4.12.1099
8. GJ Biessels A Kamal IJ Urban BM Spruijt DW Erkelens WH Gispen 1998 Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment Brain Res 800 125 135 10.1016/S0006-8993(98) 00510-1
9. M Brownlee A Cerami H Vlassara 1988 Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications N Engl J Med 318 1315 1321
10. MJ Chong MR Murray EC Gosink HR Russell A Srinivasan M Kapsetaki SJ Korsmeyer PJ McKinnon 2000 Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system Proc Natl Acad Sci USA 97 889 894 10.1073/pnas.97.2.889
11. MC Desco M Asensi R Marquez J Martinez-Valls M Vento FV Pallardo J Sastre J Vina 2002 Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol Diabetes 51 1118 1124 10.2337/diabetes.51.4. 1118
12. PC Endresen T Loennechen H Kildalsen J Aarbakke 1996 Apoptosis and transmethylation metabolites in HL-60 cells J Pharmacol Exp Ther 278 1318 1324
13. DA Greene MJ Stevens I Obrosova EL Feldman 1999 Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy Eur J Pharmacol 375 217 223 10.1016/S0014-2999(99)00356-8
14. JM Han BJ Chang TZ Li NH Choe FS Quan BJ Jang IH Cho HN Hong JH Lee 2007 Protective effects of ascorbic acid against lead-induced apoptotic neurodegeneration in the developing rat hippocampus in vivo Brain Res 1185 68 74 10.1016/j.brainres.2007.09.044
15. AI Jafari M Sankian S Ahmadpour H Haghir S Bonakdaran A Varasteh 2007 The study of effects of insulin and ascorbic acid on Bcl-2 family expression in hippocampus of streptozotocin (STZ)-induced diabetic rats J Zanjan Univ Med Sci 60 1 16
16. PC Kam NI Ferch 2000 Apoptosis: mechanisms and clinical implications Anaesthesia 55 1081 1093 10.1046/j.1365-2044.2000.01554.x
17. O Khookhor Q Bolin Y Oshida Y Sato 2007 Effect of Mongolian plants on in vivo insulin action in diabetic rats Diabetes Res Clin Pract 75 135 140 10.1016/j.diabres.2006.06.027
18. G Kroemer 1997 The proto-oncogene Bcl-2 and its role in regulating apoptosis Nat Med 3 614 620 10.1038/nm0697-614
19. D Kumar J Zimpelmann S Robertson KD Burns 2004 Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney Nephron Exp Nephrol 96 e77 e88 10.1159/000076749
20. ZG Li W Zhang AA Sima 2002 C-peptide prevents hippocampal apoptosis in type 1 diabetes Int J Exp Diabetes Res 3 241 245 10.1080/15604280214936
21. ZG Li W Zhang G Grunberger AA Sima 2002 Hippocampal neuronal apoptosis in type 1 diabetes Brain Res 946 221 231 10.1016/S0006-8993(02)02887-1
22. ZG Li W Zhang AA Sima 2003 C-peptide enhances insulin-mediated cell growth and protection against high glucose-induced apoptosis in SH-SY5Y cells Diabetes Metab Res Rev 19 375 385 10.1002/dmrr.389
23. SA Lipton 1996 Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species Brain Pathol 6 507 517
24. N Orike G Middleton E Borthwick V Buchman T Cowen AM Davies 2001 Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons J Cell Biol 154 995 1005 10.1083/jcb.200101068
25. P Piotrowski K Wierzbicka M Smialek 2001 Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants Folia Neuropathol 39 147 154
26. F Podesta G Romeo WH Liu S Krajewski JC Reed C Gerhardinger M Lorenzi 2000 Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro Am J Pathol 156 1025 1032
27. S Raha GE McEachern AT Myint BH Robinson 2000 Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase Free Radic Biol Med 29 170 180 10.1016/S0891-5849(00)00338-5
28. LP Reagan AM Magarinos BS McEwen 1999 Neurological changes induced by stress in streptozotocin diabetic rats Ann N Y Acad Sci 893 126 137 10.1111/j.1749-6632.1999.tb07822.x
29. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Diabetes Care 26:S5-S20
30. JW Russell KA Sullivan AJ Windebank DN Herrmann EL Feldman 1999 Neurons undergo apoptosis in animal and cell culture models of diabetes Neurobiol Dis 6 347 363 10.1006/nbdi.1999.0254
31. A Rytter CM Cardoso P Johansson T Cronberg MJ Hansson G Mattiasson E Elmer T Wieloch 2005 The temperature dependence and involvement of mitochondria permeability transition and caspase activation in damage to organotypic hippocampal slices following in vitro ischemia J Neurochem 95 1108 1117 10.1111/j.1471-4159.2005.03420.x
32. A Saraste K Pulkki 2000 Morphologic and biochemical hallmarks of apoptosis Cardiovasc Res 45 528 537 10.1016/S0008-6363(99)00384-3
33. J Schlegel I Peters S Orrenius DK Miller NA Thornberry TT Yamin DW Nicholson 1996 CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis J Biol Chem 271 1841 1844
34. AM Sharifi SH Mousavi M Farhadi B Larijani 2007 Study of high glucose-induced apoptosis in PC12 cells: role of bax protein J Pharmacol Sci 104 258 262 10.1254/jphs.FP0070258
35. AA Sima V Nathaniel V Bril TA McEwen DA Greene 1988 Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demonstration of axo-glial dysjunction in human diabetic neuropathy J Clin Invest 81 349 364 10.1172/JCI113327
36. S Srinivasan MJ Stevens H Sheng KE Hall JW Wiley 1998 Serum from patients with type 2 diabetes with neuropathy induces complement-independent, calcium-dependent apoptosis in cultured neuronal cells J Clin Invest 102 1454 1462 10.1172/JCI2793
37. NA Thornberry Y Lazebnik 1998 Caspases: enemies within Science 281 1312 1316 10.1126/science.281.5381.1312
38. AM Vincent M Brownlee JW Russell 2002 Oxidative stress and programmed cell death in diabetic neuropathy Ann N Y Acad Sci 959 368 383
39. X Wang NG Zelenski J Yang J Sakai MS Brown JL Goldstein 1996 Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis Embo J 15 1012 1020
40. U Wenzel A Nickel S Kuntz H Daniel 2004 Ascorbic acid suppresses drug-induced apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions Carcinogenesis 25 703 712 10.1093/carcin/bgh079