Designing inhibitors of cytochrome c/cardiolipin peroxidase complexes: Mitochondria-targeted imidazole-substituted fatty acids

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 221-230

  Jiang, Jianfei ^a   Bakan, Ahmet ^b   Kapralov, Alexandr A ^a   Ishara Silva, K ^a   Huang, Zhentai ^a   Amoscato, Andrew A ^a   Peterson, James ^a   Krishna Garapati, Venkata ^c   Saxena, Sunil ^a   Bayir, Hülya ^a,b   Atkinson, Jeffrey ^c   Bahar, Ivet ^b   Kagan, Valerian E ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c BROCK UNIVERSITY   (Canada)

Author keywords

All atom molecular dynamics simulation; Cardiolipin peroxidation; Cytochrome c; Electron paramagnetic resonance; Free radicals; Imidazole substituted stearic acid; Mitochondria targeting; Peroxidase inhibitors; Reactive intermediates

Indexed keywords

CARDIOLIPIN; CASPASE 3; CASPASE 7; CYTOCHROME C; IMIDAZOLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STEARIC ACID DERIVATIVE; 1,1',2,2'-TETRAOLEOYLCARDIOLIPIN; 1,2-OLEOYLPHOSPHATIDYLCHOLINE; ENZYME INHIBITOR; IMIDAZOLE; ORGANOPHOSPHORUS COMPOUND; PEROXIDASE; PHOSPHATIDYLCHOLINE; RICINOLEIC ACID;

ABSORPTION SPECTROSCOPY; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; EMBRYO; ENZYME ACTIVITY; ENZYME METABOLISM; FREQUENCY MODULATION; IN VITRO STUDY; IONIZING RADIATION; MITOCHONDRION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION MONITORING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EMBRYONIC STEM CELL; ENZYMOLOGY; GAMMA RADIATION; HEART MITOCHONDRION; HORSE; METABOLISM; RADIATION RESPONSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; APOPTOSIS; CARDIOLIPINS; CYTOCHROMES C; DRUG DESIGN; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; GAMMA RAYS; HORSES; IMIDAZOLES; MICE; MITOCHONDRIA, HEART; MOLECULAR DYNAMICS SIMULATION; ORGANOPHOSPHORUS COMPOUNDS; PEROXIDASE; PHOSPHATIDYLCHOLINES; RICINOLEIC ACIDS; STEARIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898831522     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.02.029     Document Type: Article

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