Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

British Journal of Pharmacology

Volumn 166, Issue 6, 2012, Pages 1872-1887

  Jiang, Bo ^a   Xiong, Zhe ^a   Yang, Jun ^a   Wang, Wei ^a   Wang, Yue ^a   Hu, Zhuang Li ^a,b,c   Wang, Fang ^a,b,c   Chen, Jian Guo ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province   (China)

Author keywords

5 HT; Brain derived neurotrophic factor; Chronic mild stress; Depression; Ginsenoside Rg1; Hippocampal neurogenesis

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; GINSENOSIDE RG 1; IMIPRAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN DEVELOPMENT; CHRONIC STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DOWN REGULATION; DRUG EFFECT; FORCED SWIMMING TEST; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOCOMOTION; MALE; MONOAMINERGIC SYSTEM; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; GINSENOSIDES; HINDLIMB SUSPENSION; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; NEUROGENESIS; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; SUCROSE; SWIMMING;

EID: 84863198809     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01902.x     Document Type: Article

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