메뉴 건너뛰기




Volumn 36, Issue 11, 2013, Pages 674-684

Towards a 'systems'-level understanding of the nervous system and its disorders

Author keywords

Cytokine; Enterotype; Hypothalamic neurogenesis; Immune surveillance; Immunoglobulin superfamily; Inflammatory reflex; Leptin; Microbiome; Microvesicle; Neural stem cell; Niche; Tolerance

Indexed keywords

AGOUTI RELATED PROTEIN; BEZAFIBRATE; CELL ADHESION MOLECULE; CHEMOKINE; CIGLITAZONE; COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR 2; CYTOKINE; EXENDIN 4; GHRELIN; HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN SENSITIZING AGENT; LEPTIN; LIRAGLUTIDE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROPROTECTIVE AGENT; NEUROTRANSMITTER; PIOGLITAZONE; PROOPIOMELANOCORTIN; PROTEIN; PROTOGENIN; SIRTUIN; TOLL LIKE RECEPTOR 3; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84886945841     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2013.07.003     Document Type: Review
Times cited : (39)

References (117)
  • 1
    • 78650031168 scopus 로고    scopus 로고
    • Neurodegeneration and the neuroimmune system
    • El Khoury J. Neurodegeneration and the neuroimmune system. Nat. Med. 2010, 16:1369-1370.
    • (2010) Nat. Med. , vol.16 , pp. 1369-1370
    • El Khoury, J.1
  • 2
    • 80055068784 scopus 로고    scopus 로고
    • Immune and neuroimmune alterations in mood disorders and schizophrenia
    • Drexhage R.C., et al. Immune and neuroimmune alterations in mood disorders and schizophrenia. Int. Rev. Neurobiol. 2011, 101:169-201.
    • (2011) Int. Rev. Neurobiol. , vol.101 , pp. 169-201
    • Drexhage, R.C.1
  • 3
    • 78751566697 scopus 로고    scopus 로고
    • Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
    • Kapogiannis D., Mattson M.P. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol. 2011, 10:187-198.
    • (2011) Lancet Neurol. , vol.10 , pp. 187-198
    • Kapogiannis, D.1    Mattson, M.P.2
  • 4
    • 78650589408 scopus 로고    scopus 로고
    • Energy metabolism in adult neural stem cell fate
    • Rafalski V.A., Brunet A. Energy metabolism in adult neural stem cell fate. Prog. Neurobiol. 2011, 93:182-203.
    • (2011) Prog. Neurobiol. , vol.93 , pp. 182-203
    • Rafalski, V.A.1    Brunet, A.2
  • 5
    • 84857058397 scopus 로고    scopus 로고
    • Metabolic syndrome as a risk factor for neurological disorders
    • Farooqui A.A., et al. Metabolic syndrome as a risk factor for neurological disorders. Cell. Mol. Life Sci. 2012, 69:741-762.
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 741-762
    • Farooqui, A.A.1
  • 6
    • 79960645242 scopus 로고    scopus 로고
    • Gut feelings: the emerging biology of gut-brain communication
    • Mayer E.A. Gut feelings: the emerging biology of gut-brain communication. Nat. Rev. Neurosci. 2011, 12:453-466.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 453-466
    • Mayer, E.A.1
  • 7
    • 79952497372 scopus 로고    scopus 로고
    • Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease
    • Ochoa-Reparaz J., et al. Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. Ann. Neurol. 2011, 69:240-247.
    • (2011) Ann. Neurol. , vol.69 , pp. 240-247
    • Ochoa-Reparaz, J.1
  • 8
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    • Cryan J.F., Dinan T.G. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 2012, 13:701-712.
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 9
    • 34249849030 scopus 로고    scopus 로고
    • Regulation of CNS synapses by neuronal MHC class I
    • Goddard C.A., et al. Regulation of CNS synapses by neuronal MHC class I. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:6828-6833.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 6828-6833
    • Goddard, C.A.1
  • 10
    • 70449758396 scopus 로고    scopus 로고
    • Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity
    • Datwani A., et al. Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity. Neuron 2009, 64:463-470.
    • (2009) Neuron , vol.64 , pp. 463-470
    • Datwani, A.1
  • 11
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S., et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-219.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1
  • 12
    • 58949099391 scopus 로고    scopus 로고
    • Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
    • Baranzini S.E., et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum. Mol. Genet. 2009, 18:767-778.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 767-778
    • Baranzini, S.E.1
  • 13
    • 73249122274 scopus 로고    scopus 로고
    • Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
    • Rioux J.D., et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:18680-18685.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 18680-18685
    • Rioux, J.D.1
  • 14
    • 78149241644 scopus 로고    scopus 로고
    • Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset
    • Khankhanian P., et al. Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset. BMC Genomics 2010, 11:626.
    • (2010) BMC Genomics , vol.11 , pp. 626
    • Khankhanian, P.1
  • 15
    • 80054850284 scopus 로고    scopus 로고
    • SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients
    • McElroy J.P., et al. SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. Genes Immun. 2011, 12:523-530.
    • (2011) Genes Immun. , vol.12 , pp. 523-530
    • McElroy, J.P.1
  • 16
    • 73149105743 scopus 로고    scopus 로고
    • + regulatory T cells via a TGF-beta-dependent mechanism
    • + regulatory T cells via a TGF-beta-dependent mechanism. J. Leukoc. Biol. 2009, 86:1275-1283.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1275-1283
    • Bhowmick, S.1
  • 17
    • 31044450303 scopus 로고    scopus 로고
    • Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow
    • Katayama Y., et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 2006, 124:407-421.
    • (2006) Cell , vol.124 , pp. 407-421
    • Katayama, Y.1
  • 18
    • 39749164920 scopus 로고    scopus 로고
    • Haematopoietic stem cell release is regulated by circadian oscillations
    • Mendez-Ferrer S., et al. Haematopoietic stem cell release is regulated by circadian oscillations. Nature 2008, 452:442-447.
    • (2008) Nature , vol.452 , pp. 442-447
    • Mendez-Ferrer, S.1
  • 19
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • Mendez-Ferrer S., et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010, 466:829-834.
    • (2010) Nature , vol.466 , pp. 829-834
    • Mendez-Ferrer, S.1
  • 20
    • 84555189736 scopus 로고    scopus 로고
    • The bone marrow at the crossroads of blood and immunity
    • Mercier F.E., et al. The bone marrow at the crossroads of blood and immunity. Nat. Rev. Immunol. 2011, 12:49-60.
    • (2011) Nat. Rev. Immunol. , vol.12 , pp. 49-60
    • Mercier, F.E.1
  • 21
    • 80054035544 scopus 로고    scopus 로고
    • Diabetes impairs hematopoietic stem cell mobilization by altering niche function
    • Ferraro F., et al. Diabetes impairs hematopoietic stem cell mobilization by altering niche function. Sci. Transl. Med. 2011, 3:104ra101.
    • (2011) Sci. Transl. Med. , vol.3
    • Ferraro, F.1
  • 22
    • 80053593864 scopus 로고    scopus 로고
    • Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit
    • Rosas-Ballina M., et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 2011, 334:98-101.
    • (2011) Science , vol.334 , pp. 98-101
    • Rosas-Ballina, M.1
  • 23
    • 80053604734 scopus 로고    scopus 로고
    • Functional innervation of hepatic iNKT cells is immunosuppressive following stroke
    • Wong C.H., et al. Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science 2011, 334:101-105.
    • (2011) Science , vol.334 , pp. 101-105
    • Wong, C.H.1
  • 24
    • 84863857952 scopus 로고    scopus 로고
    • Central nervous system: a modified immune surveillance circuit?
    • Romo-Gonzalez T., et al. Central nervous system: a modified immune surveillance circuit?. Brain Behav. Immun. 2012, 26:823-829.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 823-829
    • Romo-Gonzalez, T.1
  • 25
    • 79955101574 scopus 로고    scopus 로고
    • Inflammatory and immunological parameters in adults with Down syndrome
    • Trotta M.B., et al. Inflammatory and immunological parameters in adults with Down syndrome. Immun. Ageing 2011, 8:4.
    • (2011) Immun. Ageing , vol.8 , pp. 4
    • Trotta, M.B.1
  • 26
    • 84870498631 scopus 로고    scopus 로고
    • B cell exchange across the blood-brain barrier in multiple sclerosis
    • von Budingen H.C., et al. B cell exchange across the blood-brain barrier in multiple sclerosis. J. Clin. Invest. 2012, 122:4533-4543.
    • (2012) J. Clin. Invest. , vol.122 , pp. 4533-4543
    • von Budingen, H.C.1
  • 27
    • 84858158701 scopus 로고    scopus 로고
    • Sodium channels and microglial function
    • Black J.A., Waxman S.G. Sodium channels and microglial function. Exp. Neurol. 2012, 234:302-315.
    • (2012) Exp. Neurol. , vol.234 , pp. 302-315
    • Black, J.A.1    Waxman, S.G.2
  • 28
    • 84865469861 scopus 로고    scopus 로고
    • T cells become licensed in the lung to enter the central nervous system
    • Odoardi F., et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012, 488:675-679.
    • (2012) Nature , vol.488 , pp. 675-679
    • Odoardi, F.1
  • 29
    • 33847337984 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury
    • Zhao P., et al. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J. Neurosci. 2007, 27:2357-2368.
    • (2007) J. Neurosci. , vol.27 , pp. 2357-2368
    • Zhao, P.1
  • 30
    • 34548096949 scopus 로고    scopus 로고
    • Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21
    • Zhao P., et al. Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. J. Neurosci. 2007, 27:8893-8902.
    • (2007) J. Neurosci. , vol.27 , pp. 8893-8902
    • Zhao, P.1
  • 31
    • 84859454582 scopus 로고    scopus 로고
    • Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    • Derecki N.C., et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 2012, 484:105-109.
    • (2012) Nature , vol.484 , pp. 105-109
    • Derecki, N.C.1
  • 32
    • 84872057940 scopus 로고    scopus 로고
    • TREM2 variants in Alzheimer's disease
    • Guerreiro R., et al. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 2012, 368:117-127.
    • (2012) N. Engl. J. Med. , vol.368 , pp. 117-127
    • Guerreiro, R.1
  • 33
    • 84872088087 scopus 로고    scopus 로고
    • Variant of TREM2 associated with the risk of Alzheimer's disease
    • Jonsson T., et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N. Engl. J. Med. 2012, 368:107-116.
    • (2012) N. Engl. J. Med. , vol.368 , pp. 107-116
    • Jonsson, T.1
  • 34
    • 45849118673 scopus 로고    scopus 로고
    • Alarm or curse? The pain of neuroinflammation
    • Saab C.Y., et al. Alarm or curse? The pain of neuroinflammation. Brain Res. Rev. 2008, 58:226-235.
    • (2008) Brain Res. Rev. , vol.58 , pp. 226-235
    • Saab, C.Y.1
  • 35
    • 78651473243 scopus 로고    scopus 로고
    • Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages
    • London A., et al. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J. Exp. Med. 2011, 208:23-39.
    • (2011) J. Exp. Med. , vol.208 , pp. 23-39
    • London, A.1
  • 36
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • Shechter R., et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med. 2009, 6:e1000113.
    • (2009) PLoS Med. , vol.6
    • Shechter, R.1
  • 37
    • 59349121859 scopus 로고    scopus 로고
    • IFN-gamma and IL-4 differentially shape metabolic responses and neuroprotective phenotype of astrocytes
    • Garg S.K., et al. IFN-gamma and IL-4 differentially shape metabolic responses and neuroprotective phenotype of astrocytes. J. Neurochem. 2009, 108:1155-1166.
    • (2009) J. Neurochem. , vol.108 , pp. 1155-1166
    • Garg, S.K.1
  • 38
    • 44849104439 scopus 로고    scopus 로고
    • Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype
    • Garg S.K., et al. Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype. J. Immunol. 2008, 180:3866-3873.
    • (2008) J. Immunol. , vol.180 , pp. 3866-3873
    • Garg, S.K.1
  • 39
    • 84870534288 scopus 로고    scopus 로고
    • Mutant huntingtin impairs immune cell migration in Huntington disease
    • Kwan W., et al. Mutant huntingtin impairs immune cell migration in Huntington disease. J. Clin. Invest. 2012, 122:4737-4747.
    • (2012) J. Clin. Invest. , vol.122 , pp. 4737-4747
    • Kwan, W.1
  • 40
    • 80053082182 scopus 로고    scopus 로고
    • Decreased AIRE expression and global thymic hypofunction in Down syndrome
    • Lima F.A., et al. Decreased AIRE expression and global thymic hypofunction in Down syndrome. J. Immunol. 2011, 187:3422-3430.
    • (2011) J. Immunol. , vol.187 , pp. 3422-3430
    • Lima, F.A.1
  • 41
    • 33744968445 scopus 로고    scopus 로고
    • Breaking ignorance: the case of the brain
    • Wekerle H. Breaking ignorance: the case of the brain. Curr. Top. Microbiol. Immunol. 2006, 305:25-50.
    • (2006) Curr. Top. Microbiol. Immunol. , vol.305 , pp. 25-50
    • Wekerle, H.1
  • 42
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh P.J., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 43
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
    • Turnbaugh P.J., et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci. Transl. Med. 2009, 1:6ra14.
    • (2009) Sci. Transl. Med. , vol.1
    • Turnbaugh, P.J.1
  • 44
    • 84865294186 scopus 로고    scopus 로고
    • The outliers become a stampede as immunometabolism reaches a tipping point
    • Nikolajczyk B.S., et al. The outliers become a stampede as immunometabolism reaches a tipping point. Immunol. Rev. 2012, 249:253-275.
    • (2012) Immunol. Rev. , vol.249 , pp. 253-275
    • Nikolajczyk, B.S.1
  • 45
    • 81355164058 scopus 로고    scopus 로고
    • Regulation of energy balance and body weight by the brain: a distributed system prone to disruption
    • Faulconbridge L.F., Hayes M.R. Regulation of energy balance and body weight by the brain: a distributed system prone to disruption. Psychiatr. Clin. North Am. 2011, 34:733-745.
    • (2011) Psychiatr. Clin. North Am. , vol.34 , pp. 733-745
    • Faulconbridge, L.F.1    Hayes, M.R.2
  • 46
    • 79960428264 scopus 로고    scopus 로고
    • Neurobiology of food anticipatory circadian rhythms
    • Mistlberger R.E. Neurobiology of food anticipatory circadian rhythms. Physiol. Behav. 2011, 104:535-545.
    • (2011) Physiol. Behav. , vol.104 , pp. 535-545
    • Mistlberger, R.E.1
  • 47
    • 16244388931 scopus 로고    scopus 로고
    • Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
    • Lam T.K., et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat. Med. 2005, 11:320-327.
    • (2005) Nat. Med. , vol.11 , pp. 320-327
    • Lam, T.K.1
  • 48
    • 17844379953 scopus 로고    scopus 로고
    • Hypothalamic sensing of fatty acids
    • Lam T.K., et al. Hypothalamic sensing of fatty acids. Nat. Neurosci. 2005, 8:579-584.
    • (2005) Nat. Neurosci. , vol.8 , pp. 579-584
    • Lam, T.K.1
  • 49
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai A., et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005, 434:1026-1031.
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1
  • 50
    • 31544465941 scopus 로고    scopus 로고
    • Molecular disruption of hypothalamic nutrient sensing induces obesity
    • He W., et al. Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat. Neurosci. 2006, 9:227-233.
    • (2006) Nat. Neurosci. , vol.9 , pp. 227-233
    • He, W.1
  • 51
    • 33646590947 scopus 로고    scopus 로고
    • Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    • Kitamura T., et al. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat. Med. 2006, 12:534-540.
    • (2006) Nat. Med. , vol.12 , pp. 534-540
    • Kitamura, T.1
  • 52
    • 44949163013 scopus 로고    scopus 로고
    • Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
    • Buettner C., et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat. Med. 2008, 14:667-675.
    • (2008) Nat. Med. , vol.14 , pp. 667-675
    • Buettner, C.1
  • 53
    • 77951162087 scopus 로고    scopus 로고
    • Hypothalamic sensing of circulating lactate regulates glucose production
    • Kokorovic A., et al. Hypothalamic sensing of circulating lactate regulates glucose production. J. Cell. Mol. Med. 2009, 13:4403-4408.
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 4403-4408
    • Kokorovic, A.1
  • 54
    • 77957550128 scopus 로고    scopus 로고
    • Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production
    • Ross R.A., et al. Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E633-E639.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299
    • Ross, R.A.1
  • 55
    • 80755168947 scopus 로고    scopus 로고
    • Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats
    • Knight C.M., et al. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes 2011, 60:2691-2700.
    • (2011) Diabetes , vol.60 , pp. 2691-2700
    • Knight, C.M.1
  • 56
    • 48749105887 scopus 로고    scopus 로고
    • Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
    • Ono H., et al. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J. Clin. Invest. 2008, 118:2959-2968.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2959-2968
    • Ono, H.1
  • 57
    • 77449144768 scopus 로고    scopus 로고
    • Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
    • Lin H.V., et al. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 2010, 59:337-346.
    • (2010) Diabetes , vol.59 , pp. 337-346
    • Lin, H.V.1
  • 58
    • 78650191226 scopus 로고    scopus 로고
    • 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    • Xu Y., et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat. Neurosci. 2010, 13:1457-1459.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1457-1459
    • Xu, Y.1
  • 59
    • 77950264425 scopus 로고    scopus 로고
    • Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    • Hill J.W., et al. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010, 11:286-297.
    • (2010) Cell Metab. , vol.11 , pp. 286-297
    • Hill, J.W.1
  • 60
    • 34249911241 scopus 로고    scopus 로고
    • Hypothalamic resistin induces hepatic insulin resistance
    • Muse E.D., et al. Hypothalamic resistin induces hepatic insulin resistance. J. Clin. Invest. 2007, 117:1670-1678.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1670-1678
    • Muse, E.D.1
  • 61
    • 84873131782 scopus 로고    scopus 로고
    • Hypothalamic control of energy balance: insights into the role of synaptic plasticity
    • Dietrich M.O., Horvath T.L. Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Trends Neurosci. 2013, 36:65-73.
    • (2013) Trends Neurosci. , vol.36 , pp. 65-73
    • Dietrich, M.O.1    Horvath, T.L.2
  • 62
    • 84863051235 scopus 로고    scopus 로고
    • Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits
    • Bouret S.G., et al. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J. Neurosci. 2012, 32:1244-1252.
    • (2012) J. Neurosci. , vol.32 , pp. 1244-1252
    • Bouret, S.G.1
  • 63
    • 84870624154 scopus 로고    scopus 로고
    • Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
    • Varela L., Horvath T.L. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep. 2012, 13:1079-1086.
    • (2012) EMBO Rep. , vol.13 , pp. 1079-1086
    • Varela, L.1    Horvath, T.L.2
  • 64
    • 80054927541 scopus 로고    scopus 로고
    • Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring
    • Steculorum S.M., Bouret S.G. Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Endocrinology 2011, 152:4171-4179.
    • (2011) Endocrinology , vol.152 , pp. 4171-4179
    • Steculorum, S.M.1    Bouret, S.G.2
  • 65
    • 84872073192 scopus 로고    scopus 로고
    • Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice
    • Bouyer K., Simerly R.B. Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice. J. Neurosci. 2013, 33:840-851.
    • (2013) J. Neurosci. , vol.33 , pp. 840-851
    • Bouyer, K.1    Simerly, R.B.2
  • 66
    • 1842529267 scopus 로고    scopus 로고
    • Rapid rewiring of arcuate nucleus feeding circuits by leptin
    • Pinto S., et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 2004, 304:110-115.
    • (2004) Science , vol.304 , pp. 110-115
    • Pinto, S.1
  • 67
    • 80052922112 scopus 로고    scopus 로고
    • Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
    • Yang Y., et al. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 2011, 146:992-1003.
    • (2011) Cell , vol.146 , pp. 992-1003
    • Yang, Y.1
  • 68
    • 27344441682 scopus 로고    scopus 로고
    • Neurogenesis in the hypothalamus of adult mice: potential role in energy balance
    • Kokoeva M.V., et al. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 2005, 310:679-683.
    • (2005) Science , vol.310 , pp. 679-683
    • Kokoeva, M.V.1
  • 69
    • 49649118850 scopus 로고    scopus 로고
    • Leptin increases adult hippocampal neurogenesis in vivo and in vitro
    • Garza J.C., et al. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J. Biol. Chem. 2008, 283:18238-18247.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18238-18247
    • Garza, J.C.1
  • 70
    • 67650459465 scopus 로고    scopus 로고
    • Ghrelin regulates hippocampal neurogenesis in adult mice
    • Moon M., et al. Ghrelin regulates hippocampal neurogenesis in adult mice. Endocr. J. 2009, 56:525-531.
    • (2009) Endocr. J. , vol.56 , pp. 525-531
    • Moon, M.1
  • 71
    • 84855426656 scopus 로고    scopus 로고
    • Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice
    • McNay D.E., et al. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J. Clin. Invest. 2012, 122:142-152.
    • (2012) J. Clin. Invest. , vol.122 , pp. 142-152
    • McNay, D.E.1
  • 72
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley M.A., et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003, 37:649-661.
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1
  • 73
    • 77956173468 scopus 로고    scopus 로고
    • Neurodevelopmental actions of leptin
    • Bouret S.G. Neurodevelopmental actions of leptin. Brain Res. 2010, 1350:2-9.
    • (2010) Brain Res. , vol.1350 , pp. 2-9
    • Bouret, S.G.1
  • 74
    • 84871721552 scopus 로고    scopus 로고
    • MTOR: on target for novel therapeutic strategies in the nervous system
    • Maiese K., et al. mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol. Med. 2013, 19:51-60.
    • (2013) Trends Mol. Med. , vol.19 , pp. 51-60
    • Maiese, K.1
  • 75
    • 84864395390 scopus 로고    scopus 로고
    • Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease
    • O'Neill C., et al. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. Biochem. Soc. Trans. 2012, 40:721-727.
    • (2012) Biochem. Soc. Trans. , vol.40 , pp. 721-727
    • O'Neill, C.1
  • 76
    • 80055112213 scopus 로고    scopus 로고
    • Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases
    • Amato S., Man H.Y. Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases. Cell Cycle 2011, 10:3452-3460.
    • (2011) Cell Cycle , vol.10 , pp. 3452-3460
    • Amato, S.1    Man, H.Y.2
  • 77
    • 84865274411 scopus 로고    scopus 로고
    • The neurobiology of sirtuins and their role in neurodegeneration
    • Donmez G. The neurobiology of sirtuins and their role in neurodegeneration. Trends Pharmacol. Sci. 2012, 33:494-501.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 494-501
    • Donmez, G.1
  • 78
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • Thaler J.P., et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 2012, 122:153-162.
    • (2012) J. Clin. Invest. , vol.122 , pp. 153-162
    • Thaler, J.P.1
  • 79
    • 74949114118 scopus 로고    scopus 로고
    • De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
    • Pierce A.A., Xu A.W. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J. Neurosci. 2010, 30:723-730.
    • (2010) J. Neurosci. , vol.30 , pp. 723-730
    • Pierce, A.A.1    Xu, A.W.2
  • 80
    • 82255169467 scopus 로고    scopus 로고
    • Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice
    • Czupryn A., et al. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science 2011, 334:1133-1137.
    • (2011) Science , vol.334 , pp. 1133-1137
    • Czupryn, A.1
  • 81
    • 77956264569 scopus 로고    scopus 로고
    • Leptin as a metabolic link to multiple sclerosis
    • Matarese G., et al. Leptin as a metabolic link to multiple sclerosis. Nat. Rev. Neurol. 2010, 6:455-461.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 455-461
    • Matarese, G.1
  • 82
    • 78650667165 scopus 로고    scopus 로고
    • + T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway
    • + T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway. J. Immunol. 2010, 185:7474-7479.
    • (2010) J. Immunol. , vol.185 , pp. 7474-7479
    • Galgani, M.1
  • 83
    • 79960956148 scopus 로고    scopus 로고
    • Biomarker-based dissection of neurodegenerative diseases
    • Olsson B., et al. Biomarker-based dissection of neurodegenerative diseases. Prog. Neurobiol. 2011, 95:520-534.
    • (2011) Prog. Neurobiol. , vol.95 , pp. 520-534
    • Olsson, B.1
  • 84
    • 84859842601 scopus 로고    scopus 로고
    • Regional susceptibilities to mitochondrial dysfunctions in the CNS
    • Pinto M., et al. Regional susceptibilities to mitochondrial dysfunctions in the CNS. Biol. Chem. 2012, 393:275-281.
    • (2012) Biol. Chem. , vol.393 , pp. 275-281
    • Pinto, M.1
  • 85
    • 77956938588 scopus 로고    scopus 로고
    • Behavioral and pharmacologic therapies for obesity
    • Vetter M.L., et al. Behavioral and pharmacologic therapies for obesity. Nat. Rev. Endocrinol. 2010, 6:578-588.
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 578-588
    • Vetter, M.L.1
  • 86
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: an integrative view
    • Clemente J.C., et al. The impact of the gut microbiota on human health: an integrative view. Cell 2012, 148:1258-1270.
    • (2012) Cell , vol.148 , pp. 1258-1270
    • Clemente, J.C.1
  • 87
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round J.L., et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011, 332:974-977.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1
  • 88
    • 79952601424 scopus 로고    scopus 로고
    • Normal gut microbiota modulates brain development and behavior
    • Heijtz R.D., et al. Normal gut microbiota modulates brain development and behavior. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:3047-3052.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 3047-3052
    • Heijtz, R.D.1
  • 89
    • 84878241830 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    • Clarke G., et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol. Psychiatry 2012, 18:666-673.
    • (2012) Mol. Psychiatry , vol.18 , pp. 666-673
    • Clarke, G.1
  • 90
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    • Bravo J.A., et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:16050-16055.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 16050-16055
    • Bravo, J.A.1
  • 91
    • 77956057409 scopus 로고    scopus 로고
    • Pyrosequencing study of fecal microflora of autistic and control children
    • Finegold S.M., et al. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe 2010, 16:444-453.
    • (2010) Anaerobe , vol.16 , pp. 444-453
    • Finegold, S.M.1
  • 92
    • 67449116625 scopus 로고    scopus 로고
    • Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    • Pollinger B., et al. Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J. Exp. Med. 2009, 206:1303-1316.
    • (2009) J. Exp. Med. , vol.206 , pp. 1303-1316
    • Pollinger, B.1
  • 93
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer K., et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011, 479:538-541.
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1
  • 94
    • 77955913743 scopus 로고    scopus 로고
    • A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
    • Ochoa-Reparaz J., et al. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol. 2010, 3:487-495.
    • (2010) Mucosal Immunol. , vol.3 , pp. 487-495
    • Ochoa-Reparaz, J.1
  • 95
    • 77958119730 scopus 로고    scopus 로고
    • Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression
    • Ochoa-Reparaz J., et al. Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J. Immunol. 2010, 185:4101-4108.
    • (2010) J. Immunol. , vol.185 , pp. 4101-4108
    • Ochoa-Reparaz, J.1
  • 96
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
    • O'Mahony S.M., et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol. Psychiatry 2009, 65:263-267.
    • (2009) Biol. Psychiatry , vol.65 , pp. 263-267
    • O'Mahony, S.M.1
  • 97
    • 79551681952 scopus 로고    scopus 로고
    • Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation
    • Bailey M.T., et al. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav. Immun. 2011, 25:397-407.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 397-407
    • Bailey, M.T.1
  • 98
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • Wu G.D., et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334:105-108.
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1
  • 99
    • 84859648364 scopus 로고    scopus 로고
    • Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters
    • Davey K.J., et al. Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters. Psychopharmacology (Berl.) 2012, 221:155-169.
    • (2012) Psychopharmacology (Berl.) , vol.221 , pp. 155-169
    • Davey, K.J.1
  • 100
    • 84858784781 scopus 로고    scopus 로고
    • Merging systems biology with pharmacodynamics
    • Iyengar R., et al. Merging systems biology with pharmacodynamics. Sci. Transl. Med. 2012, 4:126ps127.
    • (2012) Sci. Transl. Med. , vol.4
    • Iyengar, R.1
  • 101
    • 80054986458 scopus 로고    scopus 로고
    • Perivascular instruction of cell genesis and fate in the adult brain
    • Goldman S.A., Chen Z. Perivascular instruction of cell genesis and fate in the adult brain. Nat. Neurosci. 2011, 14:1382-1389.
    • (2011) Nat. Neurosci. , vol.14 , pp. 1382-1389
    • Goldman, S.A.1    Chen, Z.2
  • 102
    • 52949116088 scopus 로고    scopus 로고
    • Mobilized hematopoietic stem cell yield depends on species-specific circadian timing
    • Lucas D., et al. Mobilized hematopoietic stem cell yield depends on species-specific circadian timing. Cell Stem Cell 2008, 3:364-366.
    • (2008) Cell Stem Cell , vol.3 , pp. 364-366
    • Lucas, D.1
  • 103
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 2008, 10:1470-1476.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1470-1476
    • Skog, J.1
  • 104
    • 66449084646 scopus 로고    scopus 로고
    • Signaling by gasotransmitters
    • Mustafa A.K., et al. Signaling by gasotransmitters. Sci. Signal. 2009, 2:re2.
    • (2009) Sci. Signal. , vol.2
    • Mustafa, A.K.1
  • 105
    • 79952751974 scopus 로고    scopus 로고
    • Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis
    • Moriyama M., et al. Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. J. Neurosci. 2011, 31:3981-3989.
    • (2011) J. Neurosci. , vol.31 , pp. 3981-3989
    • Moriyama, M.1
  • 106
    • 36849076770 scopus 로고    scopus 로고
    • The classical complement cascade mediates CNS synapse elimination
    • Stevens B., et al. The classical complement cascade mediates CNS synapse elimination. Cell 2007, 131:1164-1178.
    • (2007) Cell , vol.131 , pp. 1164-1178
    • Stevens, B.1
  • 107
    • 79955764824 scopus 로고    scopus 로고
    • The Down syndrome critical region regulates retinogeniculate refinement
    • Blank M., et al. The Down syndrome critical region regulates retinogeniculate refinement. J. Neurosci. 2011, 31:5764-5776.
    • (2011) J. Neurosci. , vol.31 , pp. 5764-5776
    • Blank, M.1
  • 108
    • 77949872011 scopus 로고    scopus 로고
    • Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation
    • Wong Y.H., et al. Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation. J. Neurosci. 2010, 30:4428-4439.
    • (2010) J. Neurosci. , vol.30 , pp. 4428-4439
    • Wong, Y.H.1
  • 109
    • 79960856255 scopus 로고    scopus 로고
    • Comprehensive gene expression analysis of human embryonic stem cells during differentiation into neural cells
    • Fathi A., et al. Comprehensive gene expression analysis of human embryonic stem cells during differentiation into neural cells. PLoS ONE 2011, 6:e22856.
    • (2011) PLoS ONE , vol.6
    • Fathi, A.1
  • 110
    • 77957255968 scopus 로고    scopus 로고
    • Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis
    • Okun E., et al. Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:15625-15630.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 15625-15630
    • Okun, E.1
  • 111
    • 70349838218 scopus 로고    scopus 로고
    • Cytokines and CNS development
    • Deverman B.E., Patterson P.H. Cytokines and CNS development. Neuron 2009, 64:61-78.
    • (2009) Neuron , vol.64 , pp. 61-78
    • Deverman, B.E.1    Patterson, P.H.2
  • 112
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • Boulanger L.M. Immune proteins in brain development and synaptic plasticity. Neuron 2009, 64:93-109.
    • (2009) Neuron , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 113
    • 84860122734 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system
    • Montgomery S.L., Bowers W.J. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. J. Neuroimmune Pharmacol. 2012, 7:42-59.
    • (2012) J. Neuroimmune Pharmacol. , vol.7 , pp. 42-59
    • Montgomery, S.L.1    Bowers, W.J.2
  • 114
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: a nutrient and energy sensor that maintains energy homeostasis
    • Hardie D.G., et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 2012, 13:251-262.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1
  • 115
    • 84872501218 scopus 로고    scopus 로고
    • Insulin in the brain: sources, localization and functions
    • Ghasemi R., et al. Insulin in the brain: sources, localization and functions. Mol. Neurobiol. 2013, 47:145-171.
    • (2013) Mol. Neurobiol. , vol.47 , pp. 145-171
    • Ghasemi, R.1
  • 116
    • 84858750516 scopus 로고    scopus 로고
    • Metabolic actions of hypothalamic SIRT1
    • Coppari R. Metabolic actions of hypothalamic SIRT1. Trends Endocrinol. Metab. 2012, 23:179-185.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 179-185
    • Coppari, R.1
  • 117
    • 80054123174 scopus 로고    scopus 로고
    • Protective effects and mechanisms of sirtuins in the nervous system
    • Zhang F., et al. Protective effects and mechanisms of sirtuins in the nervous system. Prog. Neurobiol. 2011, 95:373-395.
    • (2011) Prog. Neurobiol. , vol.95 , pp. 373-395
    • Zhang, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.