메뉴 건너뛰기




Volumn 8, Issue 1, 2013, Pages

Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: Phytochemicals converge on radiation induced Rel signaling

Author keywords

Breast cancer; Curcumin; EF24; Genistein; Hypoxia; Neem leaf extract; NF B; Phytochemicals; Radio sensitization; Raspberry extract; Resveratrol

Indexed keywords

CURCUMIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN KINASE B; RESVERATROL;

EID: 84874406810     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-8-46     Document Type: Article
Times cited : (28)

References (75)
  • 1
    • 26444466467 scopus 로고    scopus 로고
    • Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    • 10.1016/j.radonc.2005.06.038, 16098619
    • Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, Becker A, Adam M, Molls M, Dunst J. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005, 77:18-24. 10.1016/j.radonc.2005.06.038, 16098619.
    • (2005) Radiother Oncol , vol.77 , pp. 18-24
    • Nordsmark, M.1    Bentzen, S.M.2    Rudat, V.3    Brizel, D.4    Lartigau, E.5    Stadler, P.6    Becker, A.7    Adam, M.8    Molls, M.9    Dunst, J.10
  • 2
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • 10.1200/JCO.20.3.680, 11821448
    • Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 2002, 20:680-687. 10.1200/JCO.20.3.680, 11821448.
    • (2002) J Clin Oncol , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 3
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks of human cancer
    • 10.1002/jcb.22214, 19479945
    • Ruan K, Song G, Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem 2009, 107:1053-1062. 10.1002/jcb.22214, 19479945.
    • (2009) J Cell Biochem , vol.107 , pp. 1053-1062
    • Ruan, K.1    Song, G.2    Ouyang, G.3
  • 4
    • 0023932431 scopus 로고
    • Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
    • 10.1016/0360-3016(88)90002-8, 3360652
    • Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, Broder GJ. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 1988, 14:831-838. 10.1016/0360-3016(88)90002-8, 3360652.
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 831-838
    • Gatenby, R.A.1    Kessler, H.B.2    Rosenblum, J.S.3    Coia, L.R.4    Moldofsky, P.J.5    Hartz, W.H.6    Broder, G.J.7
  • 5
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996, 56:4509-4515.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 6
    • 0030742027 scopus 로고    scopus 로고
    • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
    • 10.1016/S0360-3016(97)00101-6, 9226314
    • Brizel DM, Sibley GS, Prosnitz LR, Scher RL, Dewhirst MW. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1997, 38:285-289. 10.1016/S0360-3016(97)00101-6, 9226314.
    • (1997) Int J Radiat Oncol Biol Phys , vol.38 , pp. 285-289
    • Brizel, D.M.1    Sibley, G.S.2    Prosnitz, L.R.3    Scher, R.L.4    Dewhirst, M.W.5
  • 7
    • 0027261178 scopus 로고
    • Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone
    • 10.1016/0360-3016(93)90280-9, 8330993
    • Okunieff P, Hoeckel M, Dunphy EP, Schlenger K, Knoop C, Vaupel P. Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 1993, 26:631-636. 10.1016/0360-3016(93)90280-9, 8330993.
    • (1993) Int J Radiat Oncol Biol Phys , vol.26 , pp. 631-636
    • Okunieff, P.1    Hoeckel, M.2    Dunphy, E.P.3    Schlenger, K.4    Knoop, C.5    Vaupel, P.6
  • 8
    • 39749110780 scopus 로고    scopus 로고
    • Hypoxia and breast cancer: prognostic and therapeutic implications
    • 10.1007/s00018-007-7390-6, 17957335
    • Lundgren K, Holm C, Landberg G. Hypoxia and breast cancer: prognostic and therapeutic implications. Cell Mol Life Sci 2007, 64:3233-3247. 10.1007/s00018-007-7390-6, 17957335.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 3233-3247
    • Lundgren, K.1    Holm, C.2    Landberg, G.3
  • 9
    • 0025807618 scopus 로고
    • Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
    • Vaupel P, Schlenger K, Knoop C, Hockel M. Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 1991, 51:3316-3322.
    • (1991) Cancer Res , vol.51 , pp. 3316-3322
    • Vaupel, P.1    Schlenger, K.2    Knoop, C.3    Hockel, M.4
  • 10
    • 0031970946 scopus 로고    scopus 로고
    • Tumor oxygenation correlates with molecular growth determinants in breast cancer
    • 10.1023/A:1005921513083, 9596481
    • Hohenberger P, Felgner C, Haensch W, Schlag PM. Tumor oxygenation correlates with molecular growth determinants in breast cancer. Breast Cancer Res Treat 1998, 48:97-106. 10.1023/A:1005921513083, 9596481.
    • (1998) Breast Cancer Res Treat , vol.48 , pp. 97-106
    • Hohenberger, P.1    Felgner, C.2    Haensch, W.3    Schlag, P.M.4
  • 11
    • 34748860952 scopus 로고    scopus 로고
    • Hypoxic radiosensitization: adored and ignored
    • 10.1200/JCO.2007.12.7878, 17827455
    • Overgaard J. Hypoxic radiosensitization: adored and ignored. J Clin Oncol 2007, 25:4066-4074. 10.1200/JCO.2007.12.7878, 17827455.
    • (2007) J Clin Oncol , vol.25 , pp. 4066-4074
    • Overgaard, J.1
  • 12
    • 69449107156 scopus 로고    scopus 로고
    • NF-kappaB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells
    • 10.1158/1541-7786.MCR-08-0548, 19671685
    • Bendinelli P, Matteucci E, Maroni P, Desiderio MA. NF-kappaB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells. Mol Cancer Res 2009, 7:1328-1341. 10.1158/1541-7786.MCR-08-0548, 19671685.
    • (2009) Mol Cancer Res , vol.7 , pp. 1328-1341
    • Bendinelli, P.1    Matteucci, E.2    Maroni, P.3    Desiderio, M.A.4
  • 13
    • 79961174606 scopus 로고    scopus 로고
    • Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B
    • 10.1093/carcin/bgr101, 21642357
    • Tafani M, Schito L, Pellegrini L, Villanova L, Marfe G, Anwar T, Rosa R, Indelicato M, Fini M, Pucci B, Russo MA. Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B. Carcinogenesis 2011, 32:1167-1175. 10.1093/carcin/bgr101, 21642357.
    • (2011) Carcinogenesis , vol.32 , pp. 1167-1175
    • Tafani, M.1    Schito, L.2    Pellegrini, L.3    Villanova, L.4    Marfe, G.5    Anwar, T.6    Rosa, R.7    Indelicato, M.8    Fini, M.9    Pucci, B.10    Russo, M.A.11
  • 14
    • 0032977359 scopus 로고    scopus 로고
    • A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-kappaB in vivo
    • 10.2307/3580209, 10360790
    • Zhou D, Brown SA, Yu T, Chen G, Barve S, Kang BC, Thompson JS. A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-kappaB in vivo. Radiat Res 1999, 151:703-709. 10.2307/3580209, 10360790.
    • (1999) Radiat Res , vol.151 , pp. 703-709
    • Zhou, D.1    Brown, S.A.2    Yu, T.3    Chen, G.4    Barve, S.5    Kang, B.C.6    Thompson, J.S.7
  • 15
    • 45349091414 scopus 로고    scopus 로고
    • Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells
    • Aravindan N, Madhusoodhanan R, Ahmad S, Johnson D, Herman TS. Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol Ther 2008, 7:569-576.
    • (2008) Cancer Biol Ther , vol.7 , pp. 569-576
    • Aravindan, N.1    Madhusoodhanan, R.2    Ahmad, S.3    Johnson, D.4    Herman, T.S.5
  • 16
    • 68149164689 scopus 로고    scopus 로고
    • NFkappaB activity and transcriptional responses in human breast adenocarcinoma cells after single and fractionated irradiation
    • 10.4161/cbt.8.9.8105, 19276662
    • Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Aravindan N. NFkappaB activity and transcriptional responses in human breast adenocarcinoma cells after single and fractionated irradiation. Cancer Biol Ther 2009, 8:765-773. 10.4161/cbt.8.9.8105, 19276662.
    • (2009) Cancer Biol Ther , vol.8 , pp. 765-773
    • Madhusoodhanan, R.1    Natarajan, M.2    Veeraraghavan, J.3    Herman, T.S.4    Aravindan, N.5
  • 17
    • 70149091730 scopus 로고    scopus 로고
    • NFkappaB signaling related molecular alterations in human neuroblastoma cells after fractionated irradiation
    • 10.1269/jrr.08110, 19436149
    • Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Jamgade A, Singh N, Aravindan N. NFkappaB signaling related molecular alterations in human neuroblastoma cells after fractionated irradiation. J Radiat Res 2009, 50:311-324. 10.1269/jrr.08110, 19436149.
    • (2009) J Radiat Res , vol.50 , pp. 311-324
    • Madhusoodhanan, R.1    Natarajan, M.2    Veeraraghavan, J.3    Herman, T.S.4    Jamgade, A.5    Singh, N.6    Aravindan, N.7
  • 18
    • 0000784043 scopus 로고
    • Hormonal Control Regulation of Gene Transcription
    • North Holland, Amsterdam: Elsevier/ North Holland Biomedical Press Amsterdam, Cohen P, Foulkes JG
    • Baeuerle PA, Baltimore D. Hormonal Control Regulation of Gene Transcription. Molecular Aspects of Cellular Regulation 1991, 409-432. North Holland, Amsterdam: Elsevier/ North Holland Biomedical Press Amsterdam, Cohen P, Foulkes JG.
    • (1991) Molecular Aspects of Cellular Regulation , pp. 409-432
    • Baeuerle, P.A.1    Baltimore, D.2
  • 19
    • 0024475227 scopus 로고
    • NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control
    • 10.1016/0092-8674(89)90833-7, 2665943
    • Lenardo MJ, Baltimore D. NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989, 58:227-229. 10.1016/0092-8674(89)90833-7, 2665943.
    • (1989) Cell , vol.58 , pp. 227-229
    • Lenardo, M.J.1    Baltimore, D.2
  • 20
    • 0026331456 scopus 로고
    • B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50
    • 10.1016/0092-8674(91)90285-7, 1760839
    • Neri A, Chang CC, Lombardi L, Salina M, Corradini P, Maiolo AT, Chaganti RS, Dalla-Favera R. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Cell 1991, 67:1075-1087. 10.1016/0092-8674(91)90285-7, 1760839.
    • (1991) Cell , vol.67 , pp. 1075-1087
    • Neri, A.1    Chang, C.C.2    Lombardi, L.3    Salina, M.4    Corradini, P.5    Maiolo, A.T.6    Chaganti, R.S.7    Dalla-Favera, R.8
  • 22
    • 0029087935 scopus 로고
    • Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells
    • Tozawa K, Sakurada S, Kohri K, Okamoto T. Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells. Cancer Res 1995, 55:4162-4167.
    • (1995) Cancer Res , vol.55 , pp. 4162-4167
    • Tozawa, K.1    Sakurada, S.2    Kohri, K.3    Okamoto, T.4
  • 23
    • 36248973110 scopus 로고    scopus 로고
    • NF-kappa B-mediated adaptive resistance to ionizing radiation
    • 10.1016/j.freeradbiomed.2007.09.022, 2266095, 17967430
    • Ahmed KM, Li JJ. NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radic Biol Med 2008, 44:1-13. 10.1016/j.freeradbiomed.2007.09.022, 2266095, 17967430.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1-13
    • Ahmed, K.M.1    Li, J.J.2
  • 24
    • 0036178613 scopus 로고    scopus 로고
    • NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure
    • McBride WH, Pajonk F, Chiang CS, Sun JR. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure. Mil Med 2002, 167:66-67.
    • (2002) Mil Med , vol.167 , pp. 66-67
    • McBride, W.H.1    Pajonk, F.2    Chiang, C.S.3    Sun, J.R.4
  • 25
    • 51349098241 scopus 로고    scopus 로고
    • Induced telomerase activity in primary aortic endothelial cells by low-LET gamma-radiation is mediated through NF-kappaB activation
    • 10.1259/bjr/57867919, 18541630
    • Natarajan M, Mohan S, Konopinski R, Otto RA, Herman TS. Induced telomerase activity in primary aortic endothelial cells by low-LET gamma-radiation is mediated through NF-kappaB activation. Br J Radiol 2008, 81:711-720. 10.1259/bjr/57867919, 18541630.
    • (2008) Br J Radiol , vol.81 , pp. 711-720
    • Natarajan, M.1    Mohan, S.2    Konopinski, R.3    Otto, R.A.4    Herman, T.S.5
  • 26
    • 33847027318 scopus 로고    scopus 로고
    • Activation of p38MAPK by repetitive low-grade oxidative stress leads to pro-survival effects
    • 10.1016/j.bbamcr.2006.11.012, 17196679
    • Sen P, Chakraborty PK, Raha S. Activation of p38MAPK by repetitive low-grade oxidative stress leads to pro-survival effects. Biochim Biophys Acta 2007, 1773:367-374. 10.1016/j.bbamcr.2006.11.012, 17196679.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 367-374
    • Sen, P.1    Chakraborty, P.K.2    Raha, S.3
  • 28
    • 78650237844 scopus 로고    scopus 로고
    • Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells
    • Veeraraghavan J, Natarajan M, Herman TS, Aravindan N. Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells. Anticancer Res 2010, 30:4007-4015.
    • (2010) Anticancer Res , vol.30 , pp. 4007-4015
    • Veeraraghavan, J.1    Natarajan, M.2    Herman, T.S.3    Aravindan, N.4
  • 29
    • 79951946518 scopus 로고    scopus 로고
    • Curcumin regulates low-linear energy transfer gamma-radiation-induced NFkappaB-dependent telomerase activity in human neuroblastoma cells
    • 10.1016/j.ijrobp.2010.10.058, 3071590, 21236599
    • Aravindan N, Veeraraghavan J, Madhusoodhanan R, Herman TS, Natarajan M. Curcumin regulates low-linear energy transfer gamma-radiation-induced NFkappaB-dependent telomerase activity in human neuroblastoma cells. Int J Radiat Oncol Biol Phys 2011, 79:1206-1215. 10.1016/j.ijrobp.2010.10.058, 3071590, 21236599.
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 1206-1215
    • Aravindan, N.1    Veeraraghavan, J.2    Madhusoodhanan, R.3    Herman, T.S.4    Natarajan, M.5
  • 30
    • 79851491514 scopus 로고    scopus 로고
    • Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway
    • Veeraraghavan J, Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N. Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway. Anticancer Res 2011, 31:161-170.
    • (2011) Anticancer Res , vol.31 , pp. 161-170
    • Veeraraghavan, J.1    Aravindan, S.2    Natarajan, M.3    Awasthi, V.4    Herman, T.S.5    Aravindan, N.6
  • 31
    • 80052965034 scopus 로고    scopus 로고
    • Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells
    • 10.1097/MPA.0b013e31821f677d, 21697760
    • Veeraraghavan J, Natarajan M, Lagisetty P, Awasthi V, Herman TS, Aravindan N. Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells. Pancreas 2011, 40:1107-1119. 10.1097/MPA.0b013e31821f677d, 21697760.
    • (2011) Pancreas , vol.40 , pp. 1107-1119
    • Veeraraghavan, J.1    Natarajan, M.2    Lagisetty, P.3    Awasthi, V.4    Herman, T.S.5    Aravindan, N.6
  • 32
    • 84864021447 scopus 로고    scopus 로고
    • EF24 suppresses maturation and inflammatory response in dendritic cells
    • 10.1093/intimm/dxr121, 22378503
    • Vilekar P, Awasthi S, Natarajan A, Anant S, Awasthi V. EF24 suppresses maturation and inflammatory response in dendritic cells. Int Immunol 2012, 24:455-464. 10.1093/intimm/dxr121, 22378503.
    • (2012) Int Immunol , vol.24 , pp. 455-464
    • Vilekar, P.1    Awasthi, S.2    Natarajan, A.3    Anant, S.4    Awasthi, V.5
  • 33
    • 79958696614 scopus 로고    scopus 로고
    • Radiation-triggered tumor necrosis factor (TNF) alpha-NFkappaB cross-signaling favors survival advantage in human neuroblastoma cells
    • 10.1074/jbc.M110.193755, 3122217, 21527635
    • Veeraraghavan J, Natarajan M, Aravindan S, Herman TS, Aravindan N. Radiation-triggered tumor necrosis factor (TNF) alpha-NFkappaB cross-signaling favors survival advantage in human neuroblastoma cells. J Biol Chem 2011, 286:21588-21600. 10.1074/jbc.M110.193755, 3122217, 21527635.
    • (2011) J Biol Chem , vol.286 , pp. 21588-21600
    • Veeraraghavan, J.1    Natarajan, M.2    Aravindan, S.3    Herman, T.S.4    Aravindan, N.5
  • 34
    • 78650171560 scopus 로고    scopus 로고
    • Low-dose gamma-radiation-induced oxidative stress response in mouse brain and gut: regulation by NFkappaB-MnSOD cross-signaling
    • 10.1016/j.mrgentox.2010.10.006, 21056117
    • Veeraraghavan J, Natarajan M, Herman TS, Aravindan N. Low-dose gamma-radiation-induced oxidative stress response in mouse brain and gut: regulation by NFkappaB-MnSOD cross-signaling. Mutat Res 2011, 718:44-55. 10.1016/j.mrgentox.2010.10.006, 21056117.
    • (2011) Mutat Res , vol.718 , pp. 44-55
    • Veeraraghavan, J.1    Natarajan, M.2    Herman, T.S.3    Aravindan, N.4
  • 35
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • 10.1038/nrc2344, 18273037
    • Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008, 8:180-192. 10.1038/nrc2344, 18273037.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 36
    • 79955785090 scopus 로고    scopus 로고
    • Hypoxia induces RANK and RANKL expression by activating HIF-1alpha in breast cancer cells
    • 10.1016/j.bbrc.2011.04.035, 21514280
    • Tang ZN, Zhang F, Tang P, Qi XW, Jiang J. Hypoxia induces RANK and RANKL expression by activating HIF-1alpha in breast cancer cells. Biochem Biophys Res Commun 2011, 408:411-416. 10.1016/j.bbrc.2011.04.035, 21514280.
    • (2011) Biochem Biophys Res Commun , vol.408 , pp. 411-416
    • Tang, Z.N.1    Zhang, F.2    Tang, P.3    Qi, X.W.4    Jiang, J.5
  • 37
    • 0031838786 scopus 로고    scopus 로고
    • Response of tumour cells to hypoxia: role of p53 and NFkB
    • 10.1136/mp.51.2.55, 395611, 9713587
    • Royds JA, Dower SK, Qwarnstrom EE, Lewis CE. Response of tumour cells to hypoxia: role of p53 and NFkB. Mol Pathol 1998, 51:55-61. 10.1136/mp.51.2.55, 395611, 9713587.
    • (1998) Mol Pathol , vol.51 , pp. 55-61
    • Royds, J.A.1    Dower, S.K.2    Qwarnstrom, E.E.3    Lewis, C.E.4
  • 38
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues
    • Koong AC, Chen EY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res 1994, 54:1425-1430.
    • (1994) Cancer Res , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 39
    • 39949083227 scopus 로고    scopus 로고
    • Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells
    • 10.1007/s11010-007-9678-0, 18066712
    • Aravindan N, Madhusoodhanan R, Natarajan M, Herman TS. Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells. Mol Cell Biochem 2008, 310:167-179. 10.1007/s11010-007-9678-0, 18066712.
    • (2008) Mol Cell Biochem , vol.310 , pp. 167-179
    • Aravindan, N.1    Madhusoodhanan, R.2    Natarajan, M.3    Herman, T.S.4
  • 41
    • 0033023541 scopus 로고    scopus 로고
    • Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol
    • 10.1038/sj.bjp.0702357, 1565862, 10188978
    • Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol 1999, 126:673-680. 10.1038/sj.bjp.0702357, 1565862, 10188978.
    • (1999) Br J Pharmacol , vol.126 , pp. 673-680
    • Tsai, S.H.1    Lin-Shiau, S.Y.2    Lin, J.K.3
  • 42
    • 0034234254 scopus 로고    scopus 로고
    • Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase
    • Holmes-McNary M, Baldwin AS. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 2000, 60:3477-3483.
    • (2000) Cancer Res , vol.60 , pp. 3477-3483
    • Holmes-McNary, M.1    Baldwin, A.S.2
  • 43
    • 0034660659 scopus 로고    scopus 로고
    • Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation
    • Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 2000, 164:6509-6519.
    • (2000) J Immunol , vol.164 , pp. 6509-6519
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 44
    • 0029960272 scopus 로고    scopus 로고
    • A review of the clinical effects of phytoestrogens
    • Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstet Gynecol 1996, 87:897-904.
    • (1996) Obstet Gynecol , vol.87 , pp. 897-904
    • Knight, D.C.1    Eden, J.A.2
  • 45
    • 0024333326 scopus 로고
    • Cohort study of diet, lifestyle, and prostate cancer in Adventist men
    • 10.1002/1097-0142(19890801)64:3<598::AID-CNCR2820640306>3.0.CO;2-6, 2743254
    • Mills PK, Beeson WL, Phillips RL, Fraser GE. Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 1989, 64:598-604. 10.1002/1097-0142(19890801)64:3<598::AID-CNCR2820640306>3.0.CO;2-6, 2743254.
    • (1989) Cancer , vol.64 , pp. 598-604
    • Mills, P.K.1    Beeson, W.L.2    Phillips, R.L.3    Fraser, G.E.4
  • 46
    • 64649088510 scopus 로고    scopus 로고
    • Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents
    • 10.1016/j.canlet.2009.01.009, 3350786, 19231069
    • Ali S, Varghese L, Pereira L, Tulunay-Ugur OE, Kucuk O, Carey TE, Wolf GT, Sarkar FH. Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents. Cancer Lett 2009, 278:201-209. 10.1016/j.canlet.2009.01.009, 3350786, 19231069.
    • (2009) Cancer Lett , vol.278 , pp. 201-209
    • Ali, S.1    Varghese, L.2    Pereira, L.3    Tulunay-Ugur, O.E.4    Kucuk, O.5    Carey, T.E.6    Wolf, G.T.7    Sarkar, F.H.8
  • 47
    • 69449108087 scopus 로고    scopus 로고
    • Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells
    • 10.1016/j.lfs.2009.07.005, 19632246
    • Alonso V, Perez-Martinez FC, Calahorra FJ, Esbrit P. Phytoestrogen modulation of bone-related cytokines and its impact on cell viability in human prostate cancer cells. Life Sci 2009, 85:421-430. 10.1016/j.lfs.2009.07.005, 19632246.
    • (2009) Life Sci , vol.85 , pp. 421-430
    • Alonso, V.1    Perez-Martinez, F.C.2    Calahorra, F.J.3    Esbrit, P.4
  • 48
    • 48749117943 scopus 로고    scopus 로고
    • Multi-targeted therapy of cancer by genistein
    • 10.1016/j.canlet.2008.03.052, 2575691, 18492603
    • Banerjee S, Li Y, Wang Z, Sarkar FH. Multi-targeted therapy of cancer by genistein. Cancer Lett 2008, 269:226-242. 10.1016/j.canlet.2008.03.052, 2575691, 18492603.
    • (2008) Cancer Lett , vol.269 , pp. 226-242
    • Banerjee, S.1    Li, Y.2    Wang, Z.3    Sarkar, F.H.4
  • 49
    • 0041760908 scopus 로고    scopus 로고
    • Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha
    • 10.1016/S0006-2952(03)00415-5, 12963487
    • Baxa DM, Yoshimura FK. Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha. Biochem Pharmacol 2003, 66:1009-1018. 10.1016/S0006-2952(03)00415-5, 12963487.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1009-1018
    • Baxa, D.M.1    Yoshimura, F.K.2
  • 50
    • 34247137556 scopus 로고    scopus 로고
    • Vanden Berghe W: A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein
    • Dijsselbloem N, Goriely S, Albarani V, Gerlo S, Francoz S, Marine JC, Goldman M, Haegeman G. Vanden Berghe W: A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein. J Immunol 2007, 178:5048-5057.
    • (2007) J Immunol , vol.178 , pp. 5048-5057
    • Dijsselbloem, N.1    Goriely, S.2    Albarani, V.3    Gerlo, S.4    Francoz, S.5    Marine, J.C.6    Goldman, M.7    Haegeman, G.8
  • 51
    • 65649109390 scopus 로고    scopus 로고
    • Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines
    • 10.1002/cncr.24250, 19288574
    • Gadgeel SM, Ali S, Philip PA, Wozniak A, Sarkar FH. Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines. Cancer 2009, 115:2165-2176. 10.1002/cncr.24250, 19288574.
    • (2009) Cancer , vol.115 , pp. 2165-2176
    • Gadgeel, S.M.1    Ali, S.2    Philip, P.A.3    Wozniak, A.4    Sarkar, F.H.5
  • 52
    • 0041589149 scopus 로고    scopus 로고
    • Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells
    • 10.1038/sj.onc.1206583, 12879015
    • Gong L, Li Y, Nedeljkovic-Kurepa A, Sarkar FH. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 2003, 22:4702-4709. 10.1038/sj.onc.1206583, 12879015.
    • (2003) Oncogene , vol.22 , pp. 4702-4709
    • Gong, L.1    Li, Y.2    Nedeljkovic-Kurepa, A.3    Sarkar, F.H.4
  • 53
    • 68349144682 scopus 로고    scopus 로고
    • Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts
    • 10.1016/j.neuroscience.2009.06.037, 3103945, 19540315
    • Karmakar S, Roy Choudhury S, Banik NL, Ray SK. Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts. Neuroscience 2009, 163:286-295. 10.1016/j.neuroscience.2009.06.037, 3103945, 19540315.
    • (2009) Neuroscience , vol.163 , pp. 286-295
    • Karmakar, S.1    Roy Choudhury, S.2    Banik, N.L.3    Ray, S.K.4
  • 54
    • 51749113325 scopus 로고    scopus 로고
    • Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway
    • 10.1016/j.tiv.2008.08.001, 18761399
    • Li Z, Li J, Mo B, Hu C, Liu H, Qi H, Wang X, Xu J. Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway. Toxicol In Vitro 2008, 22:1749-1753. 10.1016/j.tiv.2008.08.001, 18761399.
    • (2008) Toxicol In Vitro , vol.22 , pp. 1749-1753
    • Li, Z.1    Li, J.2    Mo, B.3    Hu, C.4    Liu, H.5    Qi, H.6    Wang, X.7    Xu, J.8
  • 55
    • 61449206288 scopus 로고    scopus 로고
    • Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells
    • 10.1002/ijc.24015, 2670478, 19101986
    • Singh-Gupta V, Zhang H, Banerjee S, Kong D, Raffoul JJ, Sarkar FH, Hillman GG. Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer 2009, 124:1675-1684. 10.1002/ijc.24015, 2670478, 19101986.
    • (2009) Int J Cancer , vol.124 , pp. 1675-1684
    • Singh-Gupta, V.1    Zhang, H.2    Banerjee, S.3    Kong, D.4    Raffoul, J.J.5    Sarkar, F.H.6    Hillman, G.G.7
  • 56
    • 28844492580 scopus 로고    scopus 로고
    • Chemosensitization and radiosensitization of tumors by plant polyphenols
    • 10.1089/ars.2005.7.1630, 16356126
    • Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 2005, 7:1630-1647. 10.1089/ars.2005.7.1630, 16356126.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1630-1647
    • Garg, A.K.1    Buchholz, T.A.2    Aggarwal, B.B.3
  • 58
    • 50649120139 scopus 로고    scopus 로고
    • Isoflavones and gamma irradiation inhibit cell growth in human salivary gland cells
    • 10.1016/j.canlet.2008.04.051, 18585854
    • Katz J, Blake E, Medrano TA, Sun Y, Shiverick KT. Isoflavones and gamma irradiation inhibit cell growth in human salivary gland cells. Cancer Lett 2008, 270:87-94. 10.1016/j.canlet.2008.04.051, 18585854.
    • (2008) Cancer Lett , vol.270 , pp. 87-94
    • Katz, J.1    Blake, E.2    Medrano, T.A.3    Sun, Y.4    Shiverick, K.T.5
  • 59
    • 33646727546 scopus 로고    scopus 로고
    • Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    • 10.1186/1471-2407-6-107, 1464148, 16640785
    • Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 2006, 6:107. 10.1186/1471-2407-6-107, 1464148, 16640785.
    • (2006) BMC Cancer , vol.6 , pp. 107
    • Raffoul, J.J.1    Wang, Y.2    Kucuk, O.3    Forman, J.D.4    Sarkar, F.H.5    Hillman, G.G.6
  • 62
    • 33745880691 scopus 로고    scopus 로고
    • Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    • 10.1667/RR3590.1, 16808622
    • Wang Y, Raffoul JJ, Che M, Doerge DR, Joiner MC, Kucuk O, Sarkar FH, Hillman GG. Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model. Radiat Res 2006, 166:73-80. 10.1667/RR3590.1, 16808622.
    • (2006) Radiat Res , vol.166 , pp. 73-80
    • Wang, Y.1    Raffoul, J.J.2    Che, M.3    Doerge, D.R.4    Joiner, M.C.5    Kucuk, O.6    Sarkar, F.H.7    Hillman, G.G.8
  • 63
    • 33751264196 scopus 로고    scopus 로고
    • Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB
    • 10.1158/0008-5472.CAN-06-2333, 17079479
    • El-Rayes BF, Ali S, Ali IF, Philip PA, Abbruzzese J, Sarkar FH. Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. Cancer Res 2006, 66:10553-10559. 10.1158/0008-5472.CAN-06-2333, 17079479.
    • (2006) Cancer Res , vol.66 , pp. 10553-10559
    • El-Rayes, B.F.1    Ali, S.2    Ali, I.F.3    Philip, P.A.4    Abbruzzese, J.5    Sarkar, F.H.6
  • 64
    • 0036945663 scopus 로고    scopus 로고
    • Mechanisms of cancer chemoprevention by soy isoflavone genistein
    • 10.1023/A:1021210910821, 12549765
    • Sarkar FH, Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 2002, 21:265-280. 10.1023/A:1021210910821, 12549765.
    • (2002) Cancer Metastasis Rev , vol.21 , pp. 265-280
    • Sarkar, F.H.1    Li, Y.2
  • 65
    • 0242496947 scopus 로고    scopus 로고
    • Soy isoflavones and cancer prevention
    • 10.1081/CNV-120023773, 14628433
    • Sarkar FH, Li Y. Soy isoflavones and cancer prevention. Cancer Invest 2003, 21:744-757. 10.1081/CNV-120023773, 14628433.
    • (2003) Cancer Invest , vol.21 , pp. 744-757
    • Sarkar, F.H.1    Li, Y.2
  • 66
    • 18144386028 scopus 로고    scopus 로고
    • The role of isoflavones in cancer chemoprevention
    • 10.2741/1430, 15353308
    • Sarkar FH, Li Y. The role of isoflavones in cancer chemoprevention. Front Biosci 2004, 9:2714-2724. 10.2741/1430, 15353308.
    • (2004) Front Biosci , vol.9 , pp. 2714-2724
    • Sarkar, F.H.1    Li, Y.2
  • 68
    • 50449099855 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin
    • 10.1124/mol.108.046201, 2638506, 18577686
    • Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol 2008, 74:654-661. 10.1124/mol.108.046201, 2638506, 18577686.
    • (2008) Mol Pharmacol , vol.74 , pp. 654-661
    • Kasinski, A.L.1    Du, Y.2    Thomas, S.L.3    Zhao, J.4    Sun, S.Y.5    Khuri, F.R.6    Wang, C.Y.7    Shoji, M.8    Sun, A.9    Snyder, J.P.10
  • 69
    • 34250702156 scopus 로고    scopus 로고
    • Revisiting the ancient concept of botanical therapeutics
    • 10.1038/nchembio0707-360, 17576417
    • Schmidt BM, Ribnicky DM, Lipsky PE, Raskin I. Revisiting the ancient concept of botanical therapeutics. Nat Chem Biol 2007, 3:360-366. 10.1038/nchembio0707-360, 17576417.
    • (2007) Nat Chem Biol , vol.3 , pp. 360-366
    • Schmidt, B.M.1    Ribnicky, D.M.2    Lipsky, P.E.3    Raskin, I.4
  • 70
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • 10.1021/np068054v, 17309302
    • Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007, 70:461-477. 10.1021/np068054v, 17309302.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 71
    • 84863009779 scopus 로고    scopus 로고
    • Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways
    • 10.1007/s11033-011-1273-5, 21947854
    • Zong H, Wang F, Fan QX, Wang LX. Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways. Mol Biol Rep 2012, 39:4803-4808. 10.1007/s11033-011-1273-5, 21947854.
    • (2012) Mol Biol Rep , vol.39 , pp. 4803-4808
    • Zong, H.1    Wang, F.2    Fan, Q.X.3    Wang, L.X.4
  • 72
    • 69849091814 scopus 로고    scopus 로고
    • Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription
    • 10.1016/j.phymed.2009.04.008, 19524420
    • Liu Q, Loo WT, Sze SC, Tong Y. Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine 2009, 16:916-922. 10.1016/j.phymed.2009.04.008, 19524420.
    • (2009) Phytomedicine , vol.16 , pp. 916-922
    • Liu, Q.1    Loo, W.T.2    Sze, S.C.3    Tong, Y.4
  • 73
    • 17644397025 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB
    • 10.1002/ijc.20856, 15688415
    • Pozo-Guisado E, Merino JM, Mulero-Navarro S, Lorenzo-Benayas MJ, Centeno F, Alvarez-Barrientos A, Fernandez-Salguero PM. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. Int J Cancer 2005, 115:74-84. 10.1002/ijc.20856, 15688415.
    • (2005) Int J Cancer , vol.115 , pp. 74-84
    • Pozo-Guisado, E.1    Merino, J.M.2    Mulero-Navarro, S.3    Lorenzo-Benayas, M.J.4    Centeno, F.5    Alvarez-Barrientos, A.6    Fernandez-Salguero, P.M.7
  • 74
    • 80054754782 scopus 로고    scopus 로고
    • Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells
    • Seo HS, Choi HS, Choi HS, Choi YK, Um JY, Choi I, Shin YC, Ko SG. Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells. Anticancer Res 2011, 31:3301-3313.
    • (2011) Anticancer Res , vol.31 , pp. 3301-3313
    • Seo, H.S.1    Choi, H.S.2    Choi, H.S.3    Choi, Y.K.4    Um, J.Y.5    Choi, I.6    Shin, Y.C.7    Ko, S.G.8
  • 75
    • 16644367866 scopus 로고    scopus 로고
    • Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways
    • Valachovicova T, Slivova V, Bergman H, Shuherk J, Sliva D. Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways. Int J Oncol 2004, 25:1389-1395.
    • (2004) Int J Oncol , vol.25 , pp. 1389-1395
    • Valachovicova, T.1    Slivova, V.2    Bergman, H.3    Shuherk, J.4    Sliva, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.