메뉴 건너뛰기




Volumn 5, Issue , 2014, Pages

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; OXYGEN; POLYCOMB GROUP PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 84898606069     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4649     Document Type: Article
Times cited : (72)

References (64)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84861526824 scopus 로고    scopus 로고
    • Checkpoint control and cancer
    • Medema, R. H. & Macurek, L. Checkpoint control and cancer. Oncogene 31, 2601-2613 (2012).
    • (2012) Oncogene , vol.31 , pp. 2601-2613
    • Medema, R.H.1    MacUrek, L.2
  • 7
    • 84865433349 scopus 로고    scopus 로고
    • DNA damage checkpoints in stem cells, ageing and cancer
    • Sperka, T., Wang, J. & Rudolph, K. L. DNA damage checkpoints in stem cells, ageing and cancer. Nat. Rev. Mol. Cell Biol. 13, 579-590 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 579-590
    • Sperka, T.1    Wang, J.2    Rudolph, K.L.3
  • 8
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of ink4/arf in cancer and aging
    • DOI 10.1016/j.cell.2006.10.003, PII S0092867406012840
    • Kim, W. Y. & Sharpless, N. E. The regulation of INK4/ARF in cancer and aging. Cell 127, 265-275 (2006). (Pubitemid 44572384)
    • (2006) Cell , vol.127 , Issue.2 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 9
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • DOI 10.1038/nrm1987, PII NRM1987
    • Gil, J. & Peters, G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat. Rev. Mol. Cell Biol. 7, 667-677 (2006). (Pubitemid 44268212)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.9 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 10
    • 65249093055 scopus 로고    scopus 로고
    • Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus
    • Chen, H. et al. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev. 23, 975-985 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 975-985
    • Chen, H.1
  • 11
    • 77957583439 scopus 로고    scopus 로고
    • Bmi1is essential in Twist1-induced epithelial-mesenchymal transition
    • Yang, M. H. et al. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat. Cell Biol. 12, 982-992 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 982-992
    • Yang, M.H.1
  • 12
    • 84860552122 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer
    • Nacerddine, K. et al. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J. Clin. Invest. 122, 1920-1932 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1920-1932
    • Nacerddine, K.1
  • 14
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • DOI 10.1038/16476
    • Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A. & van Lohuizen, M. The oncogene and Polycomb-group gene Bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168 (1999). (Pubitemid 29050921)
    • (1999) Nature , vol.397 , Issue.6715 , pp. 164-168
    • Jacobs, J.L.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 16
    • 65249121864 scopus 로고    scopus 로고
    • Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
    • Dhawan, S., Tschen, S. I. & Bhushan, A. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 23, 906-911 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 906-911
    • Dhawan, S.1    Tschen, S.I.2    Bhushan, A.3
  • 21
    • 1342332096 scopus 로고    scopus 로고
    • Polycomb CBX7 has a unifying role in cellular lifespan
    • DOI 10.1038/ncb1077
    • Gil, J., Bernard, D., Martinez, D. & Beach, D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 6, 67-72 (2004). (Pubitemid 38425732)
    • (2004) Nature Cell Biology , vol.6 , Issue.1 , pp. 67-72
    • Gil, J.1    Bernard, D.2    Martinez, D.3    Beach, D.4
  • 22
    • 0141922983 scopus 로고    scopus 로고
    • Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1
    • DOI 10.1016/S1097-2765(03)00277-6
    • Smith, K. S. et al. Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Mol. Cell. 12, 393-400 (2003). (Pubitemid 37238926)
    • (2003) Molecular Cell , vol.12 , Issue.2 , pp. 393-400
    • Smith, K.S.1    Chanda, S.K.2    Lingbeek, M.3    Ross, D.T.4    Botstein, D.5    Van Lohuizen, M.6    Cleary, M.L.7
  • 23
    • 84863252826 scopus 로고    scopus 로고
    • EZH2 couples pancreatic regeneration to neoplastic progression
    • Mallen-St Clair, J. et al. EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev. 26, 439-444 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 439-444
    • Mallen-St Clair, J.1
  • 24
    • 84896649333 scopus 로고    scopus 로고
    • Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability
    • Wen, W. et al. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene 33, 421-428 (2013).
    • (2013) Oncogene , vol.33 , pp. 421-428
    • Wen, W.1
  • 25
    • 84873120891 scopus 로고    scopus 로고
    • RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumour development
    • Su, W. J. et al. RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumour development. Proc. Natl Acad. Sci. USA 110, 1720-1725 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 1720-1725
    • Su, W.J.1
  • 26
    • 84881232015 scopus 로고    scopus 로고
    • Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumour initiation
    • Calao, M. et al. Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumour initiation. Oncogene 32, 3616-3626 (2012).
    • (2012) Oncogene , vol.32 , pp. 3616-3626
    • Calao, M.1
  • 27
    • 53049085085 scopus 로고    scopus 로고
    • BMI-1 promotes ewing sarcoma tumourigenicity independent of CDKN2A repression
    • Douglas, D. et al. BMI-1 promotes ewing sarcoma tumourigenicity independent of CDKN2A repression. Cancer Res. 68, 6507-6515 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 6507-6515
    • Douglas, D.1
  • 30
    • 78650587058 scopus 로고    scopus 로고
    • Epigenetic factors in cancer development: Polycomb group proteins
    • Piunti, A. & Pasini, D. Epigenetic factors in cancer development: polycomb group proteins. Future Oncol. 7, 57-75 (2011).
    • (2011) Future Oncol. , vol.7 , pp. 57-75
    • Piunti, A.1    Pasini, D.2
  • 31
    • 0034064361 scopus 로고    scopus 로고
    • The INK4a/ARF locus in murine tumourigenesis
    • Serrano, M. The INK4a/ARF locus in murine tumourigenesis. Carcinogenesis 21, 865-869 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 865-869
    • Serrano, M.1
  • 32
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumour cells proliferation
    • Qi, W. et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumour cells proliferation. Proc. Natl Acad. Sci. USA 109, 21360-21365 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 21360-21365
    • Qi, W.1
  • 33
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe, M. T. et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 492, 108-112 (2012).
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1
  • 34
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson, S. K. et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat. Chem. Biol. 8, 890-896 (2012).
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 890-896
    • Knutson, S.K.1
  • 36
    • 0037320925 scopus 로고    scopus 로고
    • Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    • Su, I. H. et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat. Immunol. 4, 124-131 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 124-131
    • Su, I.H.1
  • 37
    • 0037441645 scopus 로고    scopus 로고
    • Rapid generation of inducible mouse mutants
    • Seibler, J. et al. Rapid generation of inducible mouse mutants. Nucleic Acids Res. 31, e12 (2003).
    • (2003) Nucleic Acids Res. , vol.31
    • Seibler, J.1
  • 38
    • 8144230178 scopus 로고    scopus 로고
    • Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
    • DOI 10.1038/sj.emboj.7600402
    • Pasini, D., Bracken, A. P., Jensen, M. R., Lazzerini Denchi, E. & Helin, K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23, 4061-4071 (2004). (Pubitemid 39472427)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4061-4071
    • Pasini, D.1    Bracken, A.P.2    Jensen, M.R.3    Denchi, E.L.4    Helin, K.5
  • 39
    • 3042801308 scopus 로고    scopus 로고
    • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
    • DOI 10.1016/j.molcel.2004.06.020, PII S1097276504003478
    • Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57-67 (2004). (Pubitemid 38850219)
    • (2004) Molecular Cell , vol.15 , Issue.1 , pp. 57-67
    • Cao, R.1    Zhang, Y.2
  • 40
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron, R. & Reinberg, D. The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349 (2011).
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 41
    • 7744228427 scopus 로고    scopus 로고
    • Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
    • de Napoles, M. et al. Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev. Cell 7, 663-676 (2004).
    • (2004) Dev. Cell , vol.7 , pp. 663-676
    • De Napoles, M.1
  • 43
    • 63049138876 scopus 로고    scopus 로고
    • Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro
    • Francis, N. J., Follmer, N. E., Simon, M. D., Aghia, G. & Butler, J. D. Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro. Cell 137, 110-122 (2009).
    • (2009) Cell , vol.137 , pp. 110-122
    • Francis, N.J.1    Follmer, N.E.2    Simon, M.D.3    Aghia, G.4    Butler, J.D.5
  • 44
    • 55549103314 scopus 로고    scopus 로고
    • A model for transmission of the H3K27me3 epigenetic mark
    • Hansen, K. H. et al. A model for transmission of the H3K27me3 epigenetic mark. Nat. Cell Biol. 10, 1291-1300 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1291-1300
    • Hansen, K.H.1
  • 45
    • 84856529117 scopus 로고    scopus 로고
    • Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation
    • Duhamel, S. et al. Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. Cancer Res. 72, 626-635 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 626-635
    • Duhamel, S.1
  • 46
    • 0032814141 scopus 로고    scopus 로고
    • C-myc overexpression uncouples DNA replication from mitosis
    • Li, Q. & Dang, C. V. c-Myc overexpression uncouples DNA replication from mitosis. Mol. Cell Biol. 19, 5339-5351 (1999). (Pubitemid 29339893)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.8 , pp. 5339-5351
    • Li, Q.1    Dang, C.V.2
  • 47
    • 34249066085 scopus 로고    scopus 로고
    • Pcna, the maestro of the replication fork
    • DOI 10.1016/j.cell.2007.05.003, PII S0092867407005946
    • Moldovan, G. L., Pfander, B. & Jentsch, S. PCNA, the maestro of the replication fork. Cell 129, 665-679 (2007). (Pubitemid 46802385)
    • (2007) Cell , vol.129 , Issue.4 , pp. 665-679
    • Moldovan, G.-L.1    Pfander, B.2    Jentsch, S.3
  • 48
    • 84876475810 scopus 로고    scopus 로고
    • Polycomb complex recruitment in pluripotent stem cells
    • Barrero, M. J. & Izpisua Belmonte, J. C. Polycomb complex recruitment in pluripotent stem cells. Nat. Cell Biol. 15, 348-350 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 348-350
    • Barrero, M.J.1    Izpisua, B.J.C.2
  • 49
    • 84885454866 scopus 로고    scopus 로고
    • A rapid and efficient method to purify proteins at replication forks under native conditions
    • Leung, K. H., El Hassan, M. A. & Bremner, R. A rapid and efficient method to purify proteins at replication forks under native conditions. BioTechniques 55, 204-206 (2013).
    • (2013) BioTechniques , vol.55 , pp. 204-206
    • Leung, K.H.1    El Hassan, M.A.2    Bremner, R.3
  • 51
    • 64249120749 scopus 로고    scopus 로고
    • Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation
    • Doksani, Y., Bermejo, R., Fiorani, S., Haber, J. E. & Foiani, M. Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell 137, 247-258 (2009).
    • (2009) Cell , vol.137 , pp. 247-258
    • Doksani, Y.1    Bermejo, R.2    Fiorani, S.3    Haber, J.E.4    Foiani, M.5
  • 52
    • 84865547058 scopus 로고    scopus 로고
    • Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing
    • Bianco, J. N. et al. Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing. Methods 57, 149-157 (2012).
    • (2012) Methods , vol.57 , pp. 149-157
    • Bianco, J.N.1
  • 54
    • 79952281751 scopus 로고    scopus 로고
    • 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
    • Lukas, C. et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat. Cell Biol. 13, 243-253 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 243-253
    • Lukas, C.1
  • 55
    • 11244288222 scopus 로고    scopus 로고
    • Higher frequency of p53 gene mutations in diffuse large B-cell lymphoma with MALT component
    • Tai, Y. C., Tan, J. A. & Peh, S. C. Higher frequency of p53 gene mutations in diffuse large B-cell lymphoma with MALT component. Pathol. Int. 54, 811-818 (2004).
    • (2004) Pathol. Int. , vol.54 , pp. 811-818
    • Tai, Y.C.1    Tan, J.A.2    Peh, S.C.3
  • 58
    • 67649439003 scopus 로고    scopus 로고
    • Facilitating replication under stress: An oncogenic function of MYC?
    • Herold, S., Herkert, B. & Eilers, M. Facilitating replication under stress: an oncogenic function of MYC? Nat. Rev. Cancer 9, 441-444 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 441-444
    • Herold, S.1    Herkert, B.2    Eilers, M.3
  • 59
    • 84864293396 scopus 로고    scopus 로고
    • Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
    • Zheng, L. et al. Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat. Commun. 3, 815 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 815
    • Zheng, L.1
  • 60
    • 84867814679 scopus 로고    scopus 로고
    • Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes
    • Lehmann, L. et al. Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes. J. Biol. Chem. 287, 35784-35794 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 35784-35794
    • Lehmann, L.1
  • 61
    • 34248169728 scopus 로고    scopus 로고
    • The polycomb group protein Suz12 is required for embryonic stem cell differentiation
    • DOI 10.1128/MCB.01432-06
    • Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M. & Helin, K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell Biol. 27, 3769-3779 (2007). (Pubitemid 46726184)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.10 , pp. 3769-3779
    • Pasini, D.1    Bracken, A.P.2    Hansen, J.B.3    Capillo, M.4    Helin, K.5
  • 62
    • 77949730783 scopus 로고    scopus 로고
    • Cdk2 suppresses cellular senescence induced by the c-myc oncogene
    • Campaner, S. et al. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat. Cell Biol. 12, 54-59 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 54-59
    • Campaner, S.1
  • 63
    • 84874266225 scopus 로고    scopus 로고
    • Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells
    • Vella, P. et al. Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol. Cell 49, 645-656 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 645-656
    • Vella, P.1
  • 64
    • 3242886361 scopus 로고    scopus 로고
    • Single DNA molecule analysis: Applications of molecular combing
    • Lebofsky, R. & Bensimon, A. Single DNA molecule analysis: applications of molecular combing. Brief Funct. Genomic. Proteomic. 1, 385-396 (2003).
    • (2003) Brief Funct. Genomic. Proteomic. , vol.1 , pp. 385-396
    • Lebofsky, R.1    Bensimon, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.