Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 5, 2014, Pages 1298-1310

  Nayak, Mukti Kant ^a   Agrawal, Anurodh S ^a   Bose, Sudeshna ^b   Naskar, Shaon ^c   Bhowmick, Rahul ^a   Chakrabarti, Saikat ^b   Sarkar, Sagartirtha ^c   Chawla Sarkar, Mamta ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^c UNIVERSITY OF CALCUTTA   (India)

Author keywords

Anti influenza virus; Flavonoids; Interferons; Non structural protein 1; PI3K Akt

Indexed keywords

AMINO ACID; ANTIVIRUS AGENT; BAICALIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; NONSTRUCTURAL PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; FLAVONOID; IMMUNOLOGIC FACTOR; INS1 PROTEIN, INFLUENZA VIRUS; PROTEIN BINDING; VIRUS PROTEIN;

2009 H1N1 INFLUENZA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CELL LYSATE; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IMMUNE RESPONSE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A H1N1; INNATE IMMUNITY; LUNG HOMOGENATE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RNA BINDING; SITE DIRECTED MUTAGENESIS; UPREGULATION; VIROGENESIS; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; BAGG ALBINO MOUSE; IMMUNOLOGY; METABOLISM; VIRAL PLAQUE ASSAY; VIRUS LOAD;

ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; FLAVONOIDS; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MALE; MICE; MICE, INBRED BALB C; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; VIRAL LOAD; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PLAQUE ASSAY;

EID: 84898460639     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt534     Document Type: Article

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