메뉴 건너뛰기




Volumn 26, Issue 5, 2014, Pages 250-256

Poly(ADP-ribose)polymerase (PARP) Inhibitors: From Bench toBedside

Author keywords

Chemo potentiation; DNA damage response; Poly(ADP ribose)polymerase (PARP); Radio potentiation; Synthetic lethality

Indexed keywords

ANTINEOPLASTIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; DNA; RADIOPROTECTIVE AGENT;

EID: 84898051796     PISSN: 09366555     EISSN: 14332981     Source Type: Journal    
DOI: 10.1016/j.clon.2014.02.007     Document Type: Article
Times cited : (23)

References (59)
  • 1
    • 0036270993 scopus 로고    scopus 로고
    • DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis
    • Bernstein C., Bernstein H., Payne C.M., Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res 2002, 511:145-178.
    • (2002) Mutat Res , vol.511 , pp. 145-178
    • Bernstein, C.1    Bernstein, H.2    Payne, C.M.3    Garewal, H.4
  • 2
    • 0035902108 scopus 로고    scopus 로고
    • Genone maintenance mechanisms for preventing cancer
    • Hoeijmakers J.H. Genone maintenance mechanisms for preventing cancer. Nature 2001, 411:360-374.
    • (2001) Nature , vol.411 , pp. 360-374
    • Hoeijmakers, J.H.1
  • 3
    • 0037243405 scopus 로고    scopus 로고
    • Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway
    • Middleton M.R., Margison G.P. Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway. Lancet Oncol 2003, 1:37-44.
    • (2003) Lancet Oncol , vol.1 , pp. 37-44
    • Middleton, M.R.1    Margison, G.P.2
  • 4
    • 70350222210 scopus 로고    scopus 로고
    • Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair
    • Bolderson E., Richard D.J., Zhou B.B., Khanna K.K. Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clin Cancer Res 2009, 20:6314-6320.
    • (2009) Clin Cancer Res , vol.20 , pp. 6314-6320
    • Bolderson, E.1    Richard, D.J.2    Zhou, B.B.3    Khanna, K.K.4
  • 5
    • 34250377983 scopus 로고    scopus 로고
    • Therapeutic potential of drugs to modulate DNA repair in cancer
    • Curtin N. Therapeutic potential of drugs to modulate DNA repair in cancer. Expert Opin Therapeut Targets 2007, 11:783-799.
    • (2007) Expert Opin Therapeut Targets , vol.11 , pp. 783-799
    • Curtin, N.1
  • 6
    • 0033815382 scopus 로고    scopus 로고
    • Review of mammalian DNA repair and translational implications
    • Hansen K., Kelly M. Review of mammalian DNA repair and translational implications. JPharmacol Exp Ther 2000, 295:1-9.
    • (2000) JPharmacol Exp Ther , vol.295 , pp. 1-9
    • Hansen, K.1    Kelly, M.2
  • 8
    • 12144291692 scopus 로고    scopus 로고
    • Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
    • Hegi M.E., Diserens A.C., Godard S., et al. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 2004, 10:1871-1874.
    • (2004) Clin Cancer Res , vol.10 , pp. 1871-1874
    • Hegi, M.E.1    Diserens, A.C.2    Godard, S.3
  • 9
    • 0029892791 scopus 로고    scopus 로고
    • DNA repair in eukaryotes
    • Wood R.D. DNA repair in eukaryotes. Ann Rev Biochem 1996, 65:135-167.
    • (1996) Ann Rev Biochem , vol.65 , pp. 135-167
    • Wood, R.D.1
  • 11
    • 0029915034 scopus 로고    scopus 로고
    • Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome)
    • Lynch H.T., Smyrk T., Lynch J.F. Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome). Int J Cancer 1996, 69:38-43.
    • (1996) Int J Cancer , vol.69 , pp. 38-43
    • Lynch, H.T.1    Smyrk, T.2    Lynch, J.F.3
  • 12
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • Fink D., Aebi S., Howell S. The role of DNA mismatch repair in drug resistance. Clin Cancer Res 1998, 4:1-6.
    • (1998) Clin Cancer Res , vol.4 , pp. 1-6
    • Fink, D.1    Aebi, S.2    Howell, S.3
  • 13
    • 33645532464 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
    • Bryant H.E., Helleday T. Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res 2006, 34:1685-1691.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1685-1691
    • Bryant, H.E.1    Helleday, T.2
  • 14
    • 33746100822 scopus 로고    scopus 로고
    • Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer
    • Tutt A.N., Lord C.J., McCabe N., et al. Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb Symp Quant Biol 2005, 70:139-148.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 139-148
    • Tutt, A.N.1    Lord, C.J.2    McCabe, N.3
  • 15
    • 0002160618 scopus 로고
    • Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
    • Chambon P., Weil J., Mandel P. Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem Biophy Res Commun 1963, 11:39-44.
    • (1963) Biochem Biophy Res Commun , vol.11 , pp. 39-44
    • Chambon, P.1    Weil, J.2    Mandel, P.3
  • 16
    • 0014210222 scopus 로고
    • Polymerization of the adenosine 5'-diphosphate ribose moiety of NAD by rat liver nuclear enzyme
    • Sugimura T., Fujimura S., Hasegawa S., Kawamura Y. Polymerization of the adenosine 5'-diphosphate ribose moiety of NAD by rat liver nuclear enzyme. Biochim Biophys Acta 1967, 138:438-441.
    • (1967) Biochim Biophys Acta , vol.138 , pp. 438-441
    • Sugimura, T.1    Fujimura, S.2    Hasegawa, S.3    Kawamura, Y.4
  • 17
    • 0000102949 scopus 로고
    • Poly(ADP-ribose) polymerase: a molecular nick-sensor
    • de Murcia G., Menissier de Murcia J. Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem Sci 1994, 19:172-176.
    • (1994) Trends Biochem Sci , vol.19 , pp. 172-176
    • de Murcia, G.1    Menissier de Murcia, J.2
  • 18
    • 0024456894 scopus 로고
    • Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA
    • Menissier-de Murcia J., Molinete M., Gradwohl G., Simonin F., de Murcia G. Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA. JMol Biol 1989, 210:229-233.
    • (1989) JMol Biol , vol.210 , pp. 229-233
    • Menissier-de Murcia, J.1    Molinete, M.2    Gradwohl, G.3    Simonin, F.4    de Murcia, G.5
  • 19
    • 0023475837 scopus 로고
    • CDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase
    • Cherney B.W., McBride O.W., Chen D.F., et al. cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase. Proc Natl Acad Sci USA 1987, 84:8370-8374.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8370-8374
    • Cherney, B.W.1    McBride, O.W.2    Chen, D.F.3
  • 20
    • 31044446360 scopus 로고    scopus 로고
    • PARP inhibitors for cancer therapy
    • Curtin N. PARP inhibitors for cancer therapy. Expert Rev Mol Med 2005, 7:1-20.
    • (2005) Expert Rev Mol Med , vol.7 , pp. 1-20
    • Curtin, N.1
  • 21
    • 10744226451 scopus 로고    scopus 로고
    • Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
    • Calabrese C.R., Almassy R., Barton S., et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. JNatl Cancer Inst 2004, 96:56-67.
    • (2004) JNatl Cancer Inst , vol.96 , pp. 56-67
    • Calabrese, C.R.1    Almassy, R.2    Barton, S.3
  • 22
    • 0025921994 scopus 로고
    • Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells
    • Arundel-Suto C.M., Scavone S.V., Turner W.R., Suto M.J., Sebolt-Leopold J.S. Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells. Radiat Res 1991, 126:367-371.
    • (1991) Radiat Res , vol.126 , pp. 367-371
    • Arundel-Suto, C.M.1    Scavone, S.V.2    Turner, W.R.3    Suto, M.J.4    Sebolt-Leopold, J.S.5
  • 23
    • 34249006299 scopus 로고    scopus 로고
    • ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
    • Donawho C.K., Luo Y., Luo Y., et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res 2007, 13:2728-2737.
    • (2007) Clin Cancer Res , vol.13 , pp. 2728-2737
    • Donawho, C.K.1    Luo, Y.2    Luo, Y.3
  • 24
    • 70649089202 scopus 로고    scopus 로고
    • PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications
    • Drew Y., Plummer R. PARP inhibitors in cancer therapy: two modes of attack on the cancer cell widening the clinical applications. Drug Resist Update 2009, 12:153-156.
    • (2009) Drug Resist Update , vol.12 , pp. 153-156
    • Drew, Y.1    Plummer, R.2
  • 26
    • 19444375973 scopus 로고    scopus 로고
    • Chemopotentiation by PARP inhibitors in cancer therapy
    • Tentori L., Graziani G. Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacol Res 2005, 52:25-33.
    • (2005) Pharmacol Res , vol.52 , pp. 25-33
    • Tentori, L.1    Graziani, G.2
  • 27
    • 18944390248 scopus 로고    scopus 로고
    • Poly(ADP-Ribose)polymerase and the therapeautic effects of its inhibitors
    • Jagtap P., Szabo C. Poly(ADP-Ribose)polymerase and the therapeautic effects of its inhibitors. Nat Rev Drug Discov 2005, 4:421-440.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 421-440
    • Jagtap, P.1    Szabo, C.2
  • 28
    • 59449085305 scopus 로고    scopus 로고
    • Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors
    • Plummer R., Jones C., Middleton M., et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2008, 14:7917-7923.
    • (2008) Clin Cancer Res , vol.14 , pp. 7917-7923
    • Plummer, R.1    Jones, C.2    Middleton, M.3
  • 29
    • 0034027358 scopus 로고    scopus 로고
    • Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents
    • Bignami M., O'Driscoll M., Aquilina G., Karran P. Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. Mutat Res 2000, 462:71-82.
    • (2000) Mutat Res , vol.462 , pp. 71-82
    • Bignami, M.1    O'Driscoll, M.2    Aquilina, G.3    Karran, P.4
  • 30
    • 0028826231 scopus 로고
    • Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors
    • Boulton S., Pemberton L.C., Porteous J.K., et al. Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors. Br J Cancer 1995, 72:849-856.
    • (1995) Br J Cancer , vol.72 , pp. 849-856
    • Boulton, S.1    Pemberton, L.C.2    Porteous, J.K.3
  • 31
    • 0242588748 scopus 로고    scopus 로고
    • Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor
    • Miknyoczki S.J., Jones-Bolin S., Pritchard S., et al. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther 2003, 2:371-382.
    • (2003) Mol Cancer Ther , vol.2 , pp. 371-382
    • Miknyoczki, S.J.1    Jones-Bolin, S.2    Pritchard, S.3
  • 32
    • 0037220314 scopus 로고    scopus 로고
    • Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor
    • Tentori L., Portarena I., Barbarino M., et al. Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. Mol Pharmacol 2003, 63:192-202.
    • (2003) Mol Pharmacol , vol.63 , pp. 192-202
    • Tentori, L.1    Portarena, I.2    Barbarino, M.3
  • 33
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant H.E., Schultz N., Thomas H.D., et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005, 434:913-917.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 34
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H., McCabe N., Lord C.J., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434:917-921.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 35
    • 76249127431 scopus 로고    scopus 로고
    • Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427
    • Khan K., Araki K., Wang D., et al. Head and neck cancer radiosensitization by the novel poly(ADP-ribose) polymerase inhibitor GPI-15427. Head Neck 2010, 32:381-391.
    • (2010) Head Neck , vol.32 , pp. 381-391
    • Khan, K.1    Araki, K.2    Wang, D.3
  • 36
    • 59549097382 scopus 로고    scopus 로고
    • Invitro and invivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016
    • Russo A.L., Kwon H.C., Burgan W.E., et al. Invitro and invivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. Clin Cancer Res 2009, 15:607-612.
    • (2009) Clin Cancer Res , vol.15 , pp. 607-612
    • Russo, A.L.1    Kwon, H.C.2    Burgan, W.E.3
  • 37
    • 84877920585 scopus 로고    scopus 로고
    • Aphase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation
    • Plummer R., Lorigan P., Steven N., et al. Aphase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation. Cancer Chemother Pharmacol 2013, 71:1191-1199.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 1191-1199
    • Plummer, R.1    Lorigan, P.2    Steven, N.3
  • 38
    • 0036570292 scopus 로고    scopus 로고
    • Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma
    • Quinn J.A., Pluda J., Dolan M.E., et al. Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. JClin Oncol 2002, 20:2277-2283.
    • (2002) JClin Oncol , vol.20 , pp. 2277-2283
    • Quinn, J.A.1    Pluda, J.2    Dolan, M.E.3
  • 39
    • 27244442921 scopus 로고    scopus 로고
    • Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma
    • Quinn J.A., Desjardins A., Weingart J., et al. Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. JClin Oncol 2005, 23:7178-7187.
    • (2005) JClin Oncol , vol.23 , pp. 7178-7187
    • Quinn, J.A.1    Desjardins, A.2    Weingart, J.3
  • 40
    • 0343953050 scopus 로고    scopus 로고
    • Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer
    • Schilsky R.L., Dolan M.E., Bertucci D., et al. Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer. Clin Cancer Res 2000, 6:3025-3031.
    • (2000) Clin Cancer Res , vol.6 , pp. 3025-3031
    • Schilsky, R.L.1    Dolan, M.E.2    Bertucci, D.3
  • 41
    • 33645085569 scopus 로고    scopus 로고
    • Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors
    • Ranson M., Middleton M.R., Bridgewater J., et al. Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2006, 12:1577-1584.
    • (2006) Clin Cancer Res , vol.12 , pp. 1577-1584
    • Ranson, M.1    Middleton, M.R.2    Bridgewater, J.3
  • 42
    • 77955877185 scopus 로고    scopus 로고
    • Aphase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer
    • abstract 1019
    • Isakoff S.J., Overmoyer B., Tung N.M., et al. Aphase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer. JClin Oncol 2010, 28(Suppl.). abstract 1019.
    • (2010) JClin Oncol , vol.28 , Issue.SUPPL.
    • Isakoff, S.J.1    Overmoyer, B.2    Tung, N.M.3
  • 43
    • 70349778026 scopus 로고    scopus 로고
    • Aphase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma
    • Bedikian A.Y., Papadopoulos N.E., Kim K.B., et al. Aphase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma. Cancer Invest 2009, 9:1-8.
    • (2009) Cancer Invest , vol.9 , pp. 1-8
    • Bedikian, A.Y.1    Papadopoulos, N.E.2    Kim, K.B.3
  • 44
    • 84859864115 scopus 로고    scopus 로고
    • Aphase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors
    • Rajan A., Carter C.A., Kelly R.J., et al. Aphase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors. Clin Cancer Res 2012, 18:2344-2351.
    • (2012) Clin Cancer Res , vol.18 , pp. 2344-2351
    • Rajan, A.1    Carter, C.A.2    Kelly, R.J.3
  • 45
    • 80052238687 scopus 로고    scopus 로고
    • Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas
    • Kummar S., Chen A., Ji J., et al. Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas. Cancer Res 2011, 71:5626-5634.
    • (2011) Cancer Res , vol.71 , pp. 5626-5634
    • Kummar, S.1    Chen, A.2    Ji, J.3
  • 46
    • 79952281417 scopus 로고    scopus 로고
    • Aphase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours
    • Khan O.A., Gore M., Lorigan P., et al. Aphase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours. Br J Cancer 2011, 104:750-755.
    • (2011) Br J Cancer , vol.104 , pp. 750-755
    • Khan, O.A.1    Gore, M.2    Lorigan, P.3
  • 47
    • 84863236347 scopus 로고    scopus 로고
    • Aphase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
    • Kummar S., Ji J., Morgan R., et al. Aphase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res 2012, 18:1726-1734.
    • (2012) Clin Cancer Res , vol.18 , pp. 1726-1734
    • Kummar, S.1    Ji, J.2    Morgan, R.3
  • 48
    • 77955856734 scopus 로고    scopus 로고
    • Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first- or second-line treatment of patients with metastatic triple-negative breast cancer: results from the safety cohort of a phase I/II multicenter trial
    • abstract 1018
    • Dent R.A., Lindeman G.J., Clemons M., et al. Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first- or second-line treatment of patients with metastatic triple-negative breast cancer: results from the safety cohort of a phase I/II multicenter trial. JClin Oncol 2010, 28(Suppl.). abstract 1018.
    • (2010) JClin Oncol , vol.28 , Issue.SUPPL.
    • Dent, R.A.1    Lindeman, G.J.2    Clemons, M.3
  • 49
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J., Osborne C., Pippen J., et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. NEngl J Med 2011, 364:205-214.
    • (2011) NEngl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 50
    • 59349099497 scopus 로고    scopus 로고
    • First in human phase I study of BSI-201, a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in subjects with advanced solid tumors
    • Kopetz S., Mita M., Mok I., et al. First in human phase I study of BSI-201, a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in subjects with advanced solid tumors. JClin Oncol 2008, 26(Suppl.):3577.
    • (2008) JClin Oncol , vol.26 , Issue.SUPPL. , pp. 3577
    • Kopetz, S.1    Mita, M.2    Mok, I.3
  • 51
    • 84862907868 scopus 로고    scopus 로고
    • Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor
    • Liu X., Shi Y., Maag D.X., et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res 2012, 18:510-523.
    • (2012) Clin Cancer Res , vol.18 , pp. 510-523
    • Liu, X.1    Shi, Y.2    Maag, D.X.3
  • 53
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong P., Boss D., Yap T., et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. NEngl J Med 2009, 361(2):123-134.
    • (2009) NEngl J Med , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.1    Boss, D.2    Yap, T.3
  • 54
    • 84892965735 scopus 로고    scopus 로고
    • Aphase I dose-escalation and PK study of continuous oral rucaparib in patients with advanced solid tumors
    • abstract 2585
    • Kristeleit R.S., Shapiro G.I., LoRusso P., et al. Aphase I dose-escalation and PK study of continuous oral rucaparib in patients with advanced solid tumors. JClin Oncol 2013, 31. abstract 2585.
    • (2013) JClin Oncol , vol.31
    • Kristeleit, R.S.1    Shapiro, G.I.2    LoRusso, P.3
  • 55
    • 84880777712 scopus 로고    scopus 로고
    • The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
    • Sandhu S.K., Schelman W.R., Wilding G., et al. The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. Lancet Oncol 2013, 14:882-892.
    • (2013) Lancet Oncol , vol.14 , pp. 882-892
    • Sandhu, S.K.1    Schelman, W.R.2    Wilding, G.3
  • 56
    • 84880316545 scopus 로고    scopus 로고
    • First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors
    • abstract 2580
    • De Bono J.S., Mina L.A., Gonzalez M., et al. First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors. JClin Oncol 2013, 31. abstract 2580.
    • (2013) JClin Oncol , vol.31
    • De Bono, J.S.1    Mina, L.A.2    Gonzalez, M.3
  • 57
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
    • Gelmon K.A., Tischkowitz M., Mackay H., et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011, 12:852-861.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 58
    • 77957944911 scopus 로고    scopus 로고
    • Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers
    • Powell C., Mikropoulos C., Kaye S.B., et al. Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. Cancer Treat Rev 2010, 36:566-575.
    • (2010) Cancer Treat Rev , vol.36 , pp. 566-575
    • Powell, C.1    Mikropoulos, C.2    Kaye, S.B.3
  • 59
    • 80052023514 scopus 로고    scopus 로고
    • Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers
    • Harrington K.J., Billingham L.J., Brunner T.B., et al. Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers. Br J Cancer 2011, 105:628-639.
    • (2011) Br J Cancer , vol.105 , pp. 628-639
    • Harrington, K.J.1    Billingham, L.J.2    Brunner, T.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.