A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation

Cancer Chemotherapy and Pharmacology

Volumn 71, Issue 5, 2013, Pages 1191-1199

  Plummer, Ruth ^a   Lorigan, Paul ^b   Steven, Neil ^c   Scott, Lucy ^d   Middleton, Mark R ^e   Wilson, Richard H ^f   Mulligan, Evan ^a   Curtin, Nicola ^a   Wang, Diane ^g   Dewji, Raz ^h   Abbattista, Antonello ^g   Gallo, Jorge ^g   Calvert, Hilary ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d BEATSON WEST OF SCOTLAND CANCER CENTRE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^g PFIZER INC   (United States)

^h PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Chemopotentiation; DNA repair; Melanoma; PARP; Phase II

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; RUCAPARIB; TEMOZOLOMIDE;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ANOREXIA; ARTICLE; BACKACHE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; CANCER PATIENT; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; CONNECTIVE TISSUE DISEASE; CONSTIPATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DOSE REDUCTION; DRUG ERUPTION; DRUG FATALITY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG POTENTIATION; DYSPEPSIA; FATIGUE; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; INFECTION; INFESTATION; LETHARGY; LEUKOPENIA; LIMB PAIN; LUNG TOXICITY; LYMPHATIC SYSTEM DISEASE; LYMPHOCYTOPENIA; MALE; MEDIASTINUM DISEASE; METABOLIC DISORDER; METASTATIC MELANOMA; MULTIPLE CYCLE TREATMENT; MUSCULOSKELETAL DISEASE; NAUSEA; NEUROTOXICITY; NEUTROPENIA; NUTRITIONAL DISORDER; OVERALL SURVIVAL; PANCYTOPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RHINOPHARYNGITIS; SEPSIS; SKIN TOXICITY; SORE THROAT; SURVIVAL RATE; THORAX DISEASE; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DACARBAZINE; DISEASE-FREE SURVIVAL; DRUG SYNERGISM; FEMALE; HUMANS; INDOLES; MALE; MELANOMA; MIDDLE AGED; POLY(ADP-RIBOSE) POLYMERASES; SKIN NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84877920585     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2113-1     Document Type: Article

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